scholarly journals Anatomical Asplenia in Cat Eye Syndrome:An Expansion of the Disease Spectrum

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
DeepakBabu Chellapandian ◽  
Adele Schneider
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Neisseria Meningitidis ◽  
Bacterial Infections ◽  
Type B ◽  
Disease Spectrum ◽  
Cat Eye Syndrome ◽  
Increased Risk ◽  
Life Threatening ◽  
Penicillin Prophylaxis

We report a patient with Cat eye syndrome (CES) associated with anatomical asplenia. To the best of our knowledge, there have been no prior reports of this association. Screening for asplenia in CES is potentially important, as asplenia places patients at increased risk for life-threatening bacterial infections. Hence patients with CES without a spleen may require the same routine precautions as any other asplenic patients, with penicillin prophylaxis and immunizations to protect against encapsulated organisms such asStreptococcus pneumoniae, Haemophilus influenzaetype b, andNeisseria meningitidis.

Bacterial Vaccines for Splenectomized Patients

1988 ◽  
Vol 22 (3) ◽  
pp. 192-197 ◽  
Author(s):  
Kondjeni T. Kafidi ◽  
John C. Rotschafer
Keyword(s):  
Streptococcus Pneumoniae ◽  
Adverse Effects ◽  
Neisseria Meningitidis ◽  
Antibody Production ◽  
Pathogenic Bacteria ◽  
Risk Groups ◽  
The Body ◽  
Increased Risk ◽  
Life Threatening ◽  
Encapsulated Bacteria

The spleen is an important organ in the defense of the body against pathogenic bacteria. Major functions of the spleen include antibody production and mechanical filtration of blood. Anatomically or functionally asplenic individuals are at increased risk of fulminant infection by encapsulated bacteria, particularly Streptococcus pneumoniae, Hemophilus influenzae, and Neisseria meningitidis. Polysaccharide vaccines are available against some strains of these pathogenic bacteria. More data are required to define specific age and risk groups. A search for better and more immunogenic vaccines, which may prove effective in a wider variety of patients, is currently under way. Although the current vaccines are not always effective and future revaccination may increase the incidence of adverse effects, most asplenic persons should receive the currently available vaccines to minimize their risk of life-threatening infection.

Optimising the use of conjugate vaccines to prevent disease caused by Haemophilus influenzae type b, Neisseria meningitidis and Streptococcus pneumoniae

Vaccine ◽  
2008 ◽  
Vol 26 (35) ◽  
pp. 4434-4445 ◽  
Author(s):  
Caroline L. Trotter ◽  
Jodie McVernon ◽  
Mary E. Ramsay ◽  
Cynthia G. Whitney ◽  
E. Kim Mulholland ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Neisseria Meningitidis ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Conjugate Vaccines

scholarly journals A Laboratory-Based Surveillance Study of Invasive Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae Diseases in a Serbian Pediatric Population—Implications for Vaccination

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1059
Author(s):  
Snezana Delic ◽  
Vera Mijac ◽  
Ina Gajic ◽  
Dusan Kekic ◽  
Lazar Ranin ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Neisseria Meningitidis ◽  
Potential Benefit ◽  
Pediatric Population ◽  
Type B ◽  
Invasive Diseases ◽  
Sequence Types ◽  
Major Sequence

The aim of this study was to present the epidemiology of invasive diseases caused by Neisseria meningitidis and Streptococcus pneumoniae in the pre-vaccine period, and Haemophilus influenzae in the post-vaccine period in a pediatric population from Serbia. Among the meningococci, serogroup B dominated (83%), followed by serogroup C (11.3%). High antigenic diversity was found, with fine type P1.5-1,10-4 being the most frequent. Moderate susceptibility to penicillin was common (55%). Within pneumococci, serotypes 19F, 14, 6B, 6A, 18C, 23F, 3, and 7F prevailed, while 19A was rare (3.6%). The coverages of PCV10 and PCV13 were 68% and 84%, respectively. Major sequence types were ST320, ST15, ST273, ST271, and ST81. Non-susceptibility to penicillin (66.7%), cefotaxime (37%), and macrolides (55%) was predominantly detected in vaccine-related serotypes. Among the 11 invasive H. influenzae isolates collected, there were six Hib, three non-type b, and two non-typeable strains (ntHi) that were antibiotic susceptible. These results imply a potential benefit of future Men-B vaccine implementations. For pneumococci, as PCV10 was recently introduced, a significant reduction of morbidity and antibiotic resistance might be expected. The efficiency of Hib vaccination is evident, but a shift towards non-type b and ntHi strains may be anticipated.

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