The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by Thin Layer Chromatography
Keyword(s):
Mercaptopurine and its derivatives are used in the treatment of leukemia. To estimate their lipophilicity, a simple and novel thin layer chromatography method was developed. The mobile phase was the mixture of acetonitrile and water. The acetonitrile content varied by 5% from 50% to 80%. The linear relationship between and for substances with known lipophilicity was found. The lipophilicity of purine derivatives was worked out from the calibration curve. The most lipohilic compound was methylazathioprine (0.64).
2017 ◽
Vol 30
(4)
◽
pp. 307-312
2016 ◽
Vol 8
(12)
◽
pp. 190
2017 ◽
Vol 31
(14)
◽
pp. 1713-1716
◽
2002 ◽
Vol 457
(2)
◽
pp. 187-198
◽
1969 ◽
Vol 43
◽
pp. 376-381
◽
2017 ◽
Vol 9
(9)
◽
pp. 126
2010 ◽
Vol 93
(3)
◽
pp. 778-782
◽
2007 ◽
Vol 62
(3)
◽
pp. 255-259
◽