scholarly journals Sarcomatoid Carcinoma of the Prostate

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Onur Açıkgöz ◽  
Eymen Gazel ◽  
Neslihan İnci Zengin ◽  
Yusuf Kasap ◽  
Ahmet Çamtosun ◽  
...  
Keyword(s):  
Sarcomatoid Carcinoma ◽  
Malignant Neoplasm ◽  
Pathological Examination ◽  
Transurethral Resection Of Prostate ◽  
Carcinoma Of The Prostate ◽  
Pet Ct ◽  
Undifferentiated Adenocarcinoma ◽  
Poorly Differentiated ◽  
Obturator Lymph Node ◽  
Aggressive Clinical Course

Sarcomatoid carcinoma of the prostate is among the rarest malignant neoplasm types and has been well known for its aggressive clinical course. Patient was admitted with the symptoms of lower urinary tract. Transurethral resection of prostate (TUR-P) was carried out. Revealing Gleason 5 + 3 = 8 prostate adenocarcinoma in TUR-P material. Thereby, a Radical Prostatectomy procedure was planned. In operation, frozen examination revealed adenocarcinoma metastasis to the obturator lymph node. The operation was terminated. In the postoperative 3rd month, the patient was re-admitted with acute urinary system symptoms. A cystoscopy performed and complete resection of the mass was performed. The pathological examination reported that the tumor was compatible with undifferentiated adenocarcinoma owing to presence of poorly differentiated tumoral cells and detection of adenocarcinoma in a relatively small (1%) focus. 4 month after the operation, the patient underwent another cyctoscopic examination which revealed the prostatic lounge and most of the bladder lumen to be filled with tumoral tissue. The tumoral tissues was resected incompletely. This material was diagnosed to be “Sarcomatoid Malignant Tumor” upon the new evidences of progressive dedifferentiation and predominant sarcomatoid appearance, compared with the former TUR-P materials. Subsequent PET-CT scan depicted multiple metastasis. The patient was referred to oncology department. In conclusion, sarcomatoid carcinoma is a malignant variant that brings along diagnostic and treatment difficulties.

370 Pure Primary Small Cell Carcinoma of the Prostate: A Rare Entity

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
C Desai ◽  
A Bhojwani ◽  
J Parkin
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Clinical Symptoms ◽  
Positive Family History ◽  
Malignant Neoplasm ◽  
Small Cell ◽  
Whole Body ◽  
Carcinoma Of The Prostate ◽  
Patient Reported ◽  
Prostate Cancers

Abstract Introduction We report a case of small cell carcinoma of the prostate (SCCP) which is a rare, high-grade malignant neoplasm accounting for 1% of all prostate cancers (CPa). Case Presentation A 56-year-old male patient initially presented to primary care with a six-month history of frequency, nocturia and pain in the perineal region when seated. A positive family-history for CPa was noted, serum PSA was 11.58, and a rectal examination found a large, irregular mass. He was treated with antibiotics for possible prostatitis and referred to the colorectal team. MRI rectum confirmed a mass between the prostate and rectum, which was found to be pure SCCP on biopsy. Whole-body scanning found multiple lung and pelvic metastases. The patient was commenced on six cycles of Etoposide and Carboplatin therapy. The patient reported that his pelvic discomfort has improved following the first cycle. Conclusions SCCP metastasizes early and therefore the clinical presentation is often in an advanced stage. It is noted that there is limited value of serum PSA for SCCP diagnosis. Instead, pathological examinations and MRI rectum are vital. In terms of treatment, chemotherapy provides relief of the clinical symptoms and its use is in in accordance with the 2016 National Comprehensive Cancer Network guidelines.

scholarly journals 68Ga-PSMA-11 PET/CT in Newly Diagnosed Carcinoma of the Prostate: Correlation of Intraprostatic PSMA Uptake with Several Clinical Parameters

2017 ◽  
Vol 58 (12) ◽  
pp. 1943-1948 ◽  
Author(s):  
Stefan A. Koerber ◽  
Maximilian T. Utzinger ◽  
Clemens Kratochwil ◽  
Claudia Kesch ◽  
Matthias F. Haefner ◽  
...  
Keyword(s):  
Clinical Parameters ◽  
Newly Diagnosed ◽  
Carcinoma Of The Prostate ◽  
Pet Ct

Sarcoidosis and Sarcoid Reactions in Endometrial Cancer Cases Masquerading Advanced Stage Malignancy

2021 ◽  
Vol 17 ◽  
Author(s):  
Serkan Akis ◽  
Canan Kabaca ◽  
Esra Keles ◽  
Handan Cetiner ◽  
Hatice Akay
Keyword(s):  
Endometrial Cancer ◽  
Lymph Nodes ◽  
Inflammatory Diseases ◽  
Uterine Cavity ◽  
Standardized Uptake Value ◽  
Granulomatous Inflammation ◽  
Pathological Examination ◽  
Pet Ct ◽  
Granulomatous Lesions ◽  
Granulomatous Lymphadenitis

Background: Sarcoidosis is usually diagnosed by ruling out other granulomatous inflammatory diseases. Rarely, it may be suspected with a pathological examination after surgical intervention for another disease. The sarcoid reaction is noninfectious granulomatous lymphadenitis which can occur at nodes draining a neoplasm. We demonstrated granulomatous lesions masquerading metastasis by Positron Emission Tomography/Computed Tomography (PET/CT) in endometrial cancer. We presented two cases of endometrial cancer with sarcoidosis and sarcoid-like reactions because of their challenging clinical and radiological findings. Cases: In case 1, there was diffuse granulomatous inflammation (no metastasis) in lymph nodes (n=92) and giant cells containing calcifications (Schaumann bodies). In case 2, PET/CT revealed hypermetabolism with malignancy suspicion in the pelvic lymph nodes (maximum standardized uptake value= 13) and pathological evaluation reported a 4.5 cm tumor within the uterine cavity without any nodal metastasis. Results: PET/CT has no role in the evaluation of differential diagnosis between granulomatous lymphadenitis and metastatic disease. Conclusions: Granulomatous lesions might mimic the metastasis of coexisting malignant diseases.

scholarly journals HISTOPATHOLOGICALANALYSIS OF INCIDENTAL PROSTATE CARCINOMA IN TRANSURETHRAL RESECTION OF PROSTATE SPECIMENS: A FIVE-YEAR RETROSPECTIVE STUDY

2020 ◽  
pp. 79-80
Author(s):  
Alfy Ann George ◽  
Anitha Das P.H ◽  
I. Praseeda ◽  
Baby Mathew
Keyword(s):  
Prostate Cancer ◽  
Retrospective Study ◽  
Prostate Carcinoma ◽  
Transurethral Resection ◽  
Retrospective Review ◽  
Transurethral Resection Of Prostate ◽  
Incidental Prostate Cancer ◽  
Poorly Differentiated Adenocarcinoma ◽  
Detailed Review ◽  
Poorly Differentiated

Aim: To identify the rate of incidental prostate cancer in patients undergone Transurethral resection of prostate(TURP) over a period of 5 years in our center. Methods: A Retrospective review was conducted using Histopathological department database on all TURP specimens over a period of 5 years from January 2015 to December 2019. Results: Out of 570 cases of TURP during our study period, 1.9% had incidental prostate cancer. Most of these positive cases had a Gleasons score of 10, which represent poorly differentiated Adenocarcinoma. Conclusion: The value of pathologic review of TURP specimens is limited but a detailed review helps to reduce under detection of prostate cancer.

scholarly journals A RARE CASE STUDY OF MEDULLARY CARCINOMA OF DESCENDING COLON REPORTED ON HISTOPATHOLOGY

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Rajvala Choudhary ◽  
Chandrika Gupta ◽  
Lakhami Chand Sinsinwar ◽  
Sapna Shrivastava ◽  
Sanjeev Singh Choudhary
Keyword(s):  
Strong Association ◽  
Medullary Carcinoma ◽  
Interesting Case ◽  
World Health ◽  
Histologic Subtype ◽  
Undifferentiated Adenocarcinoma ◽  
Poorly Differentiated ◽  
Carcinoma Of Colon ◽  
Health Organization ◽  
Deficient Mismatch Repair

Medullary carcinoma (MC) of the colon is a rare and unique histologic subtype of colorectal cancer whichcharacterized by poor glandular differentiation and intraepithelial lymphocytic infiltrate. This has now been incorporated as a separate entity in the World Health Organization (WHO) classification of colorectal cancers.It is commonly associated with deficient mismatch repair proteins and has a strong association with Lynch syndrome. Diagnosis is challenging as it does not have the usual immunohistochemical stains on pathology seen in colorectal adenocarcinoma. Here, we discuss an interesting case of MC of the colon that was metastatic on presentation and constituted a diagnostic challenge1. Keywords: medullary carcinoma, colorectal carcinomas (CRC), medullary carcinoma of colon,poorly differentiated adenocarcinoma, undifferentiated adenocarcinoma.

Dedifferentiated Liposarcoma With a Paraganglioma-like Histologic Pattern: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (7) ◽  
pp. 788-791
Author(s):  
Dating Liu ◽  
Guillermo Quinonez ◽  
Steven Latosinsky
Keyword(s):  
Neuron Specific Enolase ◽  
Malignant Neoplasm ◽  
Neuroendocrine Differentiation ◽  
Growth Patterns ◽  
Dedifferentiated Liposarcoma ◽  
Tissue Mass ◽  
Histologic Pattern ◽  
History Of ◽  
Poorly Differentiated ◽  
Well Differentiated

Abstract A 53-year-old man presented with a 4-month history of increasing abdominal discomfort and distension. A large retroperitoneal mass was found on imaging. Image-guided needle core biopsy demonstrated a poorly differentiated malignant neoplasm. A 30 × 32 × 33-cm soft tissue mass was removed. Microscopically, the tumor consisted of predominantly epithelioid malignant cells arranged in a paraganglioma-like growth pattern. Immunohistochemically, these cells were strongly positive for neuron-specific enolase. Stains for synaptophysin and chromogranin, however, were negative. There was no ultrastructural evidence of neuroendocrine differentiation. Adjacent sarcomatous areas were composed of spindled cells arranged in storiform and fibrosarcoma-like growth patterns. A small area of well-differentiated liposarcoma was identified, and a diagnosis of dedifferentiated liposarcoma was established. To the best of our knowledge, this represents the first reported case of dedifferentiated liposarcoma with a paraganglioma-like histologic pattern. A brief review focusing on the morphologic variations of dedifferentiated liposarcoma is also presented.

scholarly journals Intrahepatic sarcomatoid cholangiocarcinoma

2018 ◽  
pp. bcr-2018-225017 ◽  
Author(s):  
Sara Sintra ◽  
Rui Costa ◽  
Carlos Filipe ◽  
Adélia Simão
Keyword(s):  
Primary Tumour ◽  
Sarcomatoid Carcinoma ◽  
Malignant Neoplasm ◽  
Liver Mass ◽  
Immunohistochemical Examination ◽  
Abdominal Ct ◽  
Rare Tumour ◽  
Positive Expression ◽  
Proper Diagnosis ◽  
Peripheral Enhancement

Sarcomatoid carcinoma is a rare tumour composed of intermingled malignant epithelial and mesenchymal cells, and it has been reported in various organs including the liver. Sarcomatoid cholangiocarcinoma (CCC) is an extremely rare liver primary tumour. Here, we report a case of an elderly man who was admitted to our hospital after head trauma. He performed a head CT that diagnosed cerebral metastasis. On abdominal CT, he presented a 10×8×9 cm-sized hypodense liver mass in the VII and VIII segments, with peripheral enhancement. Histological and immunohistochemical examination of the tumour showed a malignant neoplasm with both carcinomatous and sarcomatous components and positive expression of cytokeratin and vimentin antibodies. The patient was diagnosed with intrahepatic sarcomatoid CCC at an advanced stage and died 45 days after the diagnosis. We emphasise the importance of immunohistochemistry which may provide a clue to proper diagnosis.

scholarly journals Poorly differentiated neuroendocrine rectal carcinoma with uncommon immune-histochemical features and clinical presentation with a subcutaneous metastasis, treated with first line intensive triplet chemotherapy plus bevacizumab FIr-B/FOx regimen: an experience of multidisciplinary management in clinical practice

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Gemma Bruera ◽  
◽  
Antonio Giuliani ◽  
Lucia Romano ◽  
Alessandro Chiominto ◽  
...  
Keyword(s):  
Rectal Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Locally Advanced ◽  
Complete Response ◽  
Neuroendocrine Cells ◽  
Perineal Pain ◽  
Pathological Examination ◽  
First Line ◽  
Triplet Chemotherapy ◽  
Poorly Differentiated

Abstract Background Neuroendocrine tumors (NETs) are heterogeneous, widely distributed tumors arising from neuroendocrine cells. Gastrointestinal (GI)-NETs are the most common and NETs of the rectum represent 15, 2% of gastrointestinal malignancies. Poorly differentiated neuroendocrine carcinomas of the GI tract are uncommon. We report a rare case of poorly differentiated locally advanced rectal neuroendocrine carcinoma with nodal and a subcutaneous metastasis, with a cytoplasmic staining positive for Synaptophysin and Thyroid Transcription Factor-1. Case presentation A 72-year-old male presented to hospital, due to lumbar, abdominal, perineal pain, and severe constipation. A whole-body computed tomography scan showed a mass of the right lateral wall of the rectum, determining significant reduction of lumen caliber. It also showed a subcutaneous metastasis of the posterior abdominal wall. Patient underwent a multidisciplinary evaluation, diagnostic and therapeutic plan was shared and defined. The pathological examination of rectal biopsy and subcutaneous nodule revealed features consistent with small-cell poorly differentiated neuroendocrine carcinoma. First line medical treatment with triplet chemotherapy and bevacizumab, according to FIr-B/FOx intensive regimen, administered for the first time in this young elderly patient affected by metastatic rectal NEC was highly active and tolerable, as previously reported in metastatic colo-rectal carcinoma (MCRC). A consistent rapid improvement in clinical conditions were observed during treatment. After 6 cycles of treatment, CT scan and endoscopic evaluation showed clinical complete response of rectal mass and lymph nodes; patient underwent curative surgery confirming the pathologic complete response at PFS 9 months. Discussion and conclusions This case report of a locally advanced rectal NEC with an unusual subcutaneous metastasis deserves further investigation of triplet chemotherapy-based intensive regimens in metastatic GEP NEC.

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