scholarly journals Enhancing the Participation of African Americans in Health-Related Genetic Research: Findings of a Collaborative Academic and Community-Based Research Study

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Sandra Millon Underwood ◽  
Aaron G. Buseh ◽  
Sheryl T. Kelber ◽  
Patricia E. Stevens ◽  
Leolia Townsend
Keyword(s):  
African Americans ◽  
Genetic Research ◽  
Willingness To Participate ◽  
Community Based ◽  
Community Based Research ◽  
Related Research ◽  
Factors Associated ◽  
Health Related Research ◽  
Health Related ◽  
Research Findings

The involvement of African Americans in research has long been expressed as a concern by the scientific community. While efforts have been undertaken to identify factors inhibiting the participation of African Americans in health-related research, few efforts have been undertaken to have highlight factors associated with their engagement of health-related research. An exploratory study of factors presumed to be associated with participation in health-related research was conducted among a nonprobability sample of African Americans (n=212) from a large urban community in the Midwest. The study was guided by a framework that hypothesized the influence of knowledge, beliefs, and perceptions about genetics and the involvement of providers in decision-making on willingness to participate in health-related genetic research. The results revealed that knowledge, beliefs, and perceptions about genetics and the involvement of providers were associated with willingness to engage in health-related genetic research (P<.05). The most interesting, however, was that 88.7% of the participants who had not previously been involved in a health-related study who expressed a willingness to participate reported that they “had never been asked.” Study findings suggest the need for research that further examines factors associated with the involvement of African Americans in health-related genetic research.

Spirituality and Willingness to Participate in Health-Related Research Among African Americans

2018 ◽  
Vol 29 (1) ◽  
pp. 400-414 ◽  
Author(s):  
Elizabeth Ojukwu ◽  
Lauren R. Powell ◽  
Sharina D. Person ◽  
Milagros C. Rosal ◽  
Stephenie C. Lemon ◽  
...  
Keyword(s):  
African Americans ◽  
Willingness To Participate ◽  
Related Research ◽  
Health Related Research ◽  
Health Related

scholarly journals Barriers to Participation in Genomic Health Research by African Americans and Other Minority Populations : A Systematic Review (P04-116-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Karyn Onyeneho ◽  
Linda Thompson ◽  
Priscilla Okunji ◽  
Gina Brown ◽  
Thomas Fungwe
Keyword(s):  
Systematic Review ◽  
Health Disparities ◽  
African Americans ◽  
Health Research ◽  
Cultural Beliefs ◽  
Genomic Research ◽  
Minority Populations ◽  
Related Research ◽  
Health Related Research ◽  
Health Related

Abstract Objectives The paucity of data for African-Americans (AAs) participating in health-related research (e.g., genomic research in nutrition) is often attributed to difficulty in recruitment and retention. The reasons for such unwillingness to participate remains unclear and could account for health disparities. Studies demonstrate that AAs may be more difficult to recruit and retain in genomic studies due to psychosocial impacts, cultural beliefs and other issues. Historically, these factors have shown to both affect participation and adversely influence health disparities, which may lead to premature death, reduced quality of life, missed economic opportunities, and inequalities. The purpose of this study was to conduct a systematic review to answer the following question: What are the barriers to acceptance of genomic health research among AAs and other minority populations? Methods This systematic review investigates acceptance barriers in AAs participating in health-related research involving DNA. A total of 37 articles met inclusion criteria for this review. Acceptance to participate in health-related research involving DNA were examined from articles published in PubMed and Scopus between 2008–2018. Results were based on feedback collected by trained research assistants and phlebotomists during interviews conducted in groups, face-to-face, via telephone, and responses collected from survey questionnaires. Results AA participation in health-related research is influenced by various pervasive factors including, but not limited to, perceived and/or actual experiences of mistrust and deceptiveness with investigators, misuse of genomic data, unethical research practices, healthcare system distrust, privacy concerns, socioeconomic influences, cultural beliefs and other influences associated with psychosocial factors. Conclusions Results of this review are consistent with literature which shows diminishing participation of AAs in health-related research is attributable to a range of factors leading to growing concerns about health disparities. It is important to address these factors among diverse populations, and AAs in particular, who have not largely been represented in health-related research to promote better health outcomes and understand how to prevent and treat diseases. Funding Sources Howard University.

scholarly journals Internalization of Phospholipid-Coated Gold Nanoparticles

Crystals ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 544
Author(s):  
Lindsay J. Shearer ◽  
Nils O. Petersen
Keyword(s):  
Gold Nanoparticles ◽  
A549 Cells ◽  
Cell Types ◽  
Endocytic Pathway ◽  
Cell Entry ◽  
Potential Drug ◽  
Cell Type ◽  
Related Research ◽  
Health Related Research ◽  
Health Related

Gold nanoparticles are used in health-related research; however, their effectiveness appears to depend on how well they are internalized and where they are destined to travel. Internalization in cells is efficient if the gold nanoparticles are biocompatible, where one possible pathway of cell entry and processing is clathrin-mediated endocytosis. In this work we studied the co-localization of phospholipid-coated gold nanoparticles (PCAuNPs) with markers of the endocytic pathway (Rab and LAMP-1 proteins) in C2C12 and A549 cells and found that the internalization was consistent with clathrin-mediated endocytosis and was cell type dependent. We further found that the time evolution of uptake and disposal of these PCAuNPs was similar for both cell types, but aggregation was more significant in A549 cells. Our results support the use of these PCAuNPs as models for potential drug delivery platforms.

scholarly journals Addressing disorder in scholarly communication: Strategies from NISO 2021

2021 ◽  
pp. 1-15
Author(s):  
Jodi Schneider ◽  
Michele Avissar-Whiting ◽  
Caitlin Bakker ◽  
Hannah Heckner ◽  
Sylvain Massip ◽  
...  
Keyword(s):  
Scientific Information ◽  
Scholarly Communication ◽  
Open Science ◽  
Fake News ◽  
Science Standards ◽  
Validation And Verification ◽  
Related Research ◽  
Health Related Research ◽  
Health Related ◽  
Conference Session

Open science and preprints have invited a larger audience of readers, especially during the pandemic. Consequently, communicating the limitations and uncertainties of research to a broader public has become important over the entire information lifecycle. This paper brings together reports from the NISO Plus 2021 conference session “Misinformation and truth: from fake news to retractions to preprints”. We discuss the validation and verification of scientific information at the preprint stage in order to support sound and open science standards, at the publication stage in order to limit the spread of retracted research, and after publication, to fight fake news about health-related research by mining open access content.

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