scholarly journals Common Polymorphism in theLRP5Gene May Increase the Risk of Bone Fracture and Osteoporosis

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Guang-Yue Xu ◽  
Yong Qiu ◽  
Hai-Jun Mao
Keyword(s):  
Bone Fracture ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Bone Diseases ◽  
Case Control Studies ◽  
Mineral Density ◽  
Increased Risk ◽  
Density Lipoprotein Receptor ◽  
Independent Case

The low-density lipoprotein receptor-related protein 5 gene (LRP5) was identified to be linked to the variation in bone mineral density and types of bone diseases. The present study was aimed at examining the association ofLRP5rs3736228 C>T gene with bone fracture and osteoporosis by meta-analysis. A systematic electronic search of literature was conducted to identify all published studies in English or Chinese on the association of theLRP5gene with bone fracture and osteoporosis risks. All analyses were calculated using the Version 12.0 STATA software. Odds ratios (ORs) and their corresponding 95% confidence interval (95% CI) were calculated. An updated meta-analysis was currently performed, including seven independent case-control studies. Results identified that carriers of rs3736228 C>T variant in theLRP5gene were associated with an increased risk of developing osteoporosis and fractures under 4 genetic models but not under the dominant model (OR = 1.19, 95% CI = 0.97~1.46, andP=0.103). Ethnicity-subgroup analysis implied thatLRP5rs3736228 C>T mutation was more likely to develop osteoporosis and fractures among Asians and Caucasians in majority of subgroups. These results suggest that there is a modest effect of theLRP5rs3736228 C>T on the increased susceptibility of bone fracture and osteoporosis.

scholarly journals Meta-Analysis of Low Density Lipoprotein Receptor (LDLR) rs2228671 Polymorphism and Coronary Heart Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Huadan Ye ◽  
Qianlei Zhao ◽  
Yi Huang ◽  
Lingyan Wang ◽  
Haibo Liu ◽  
...  
Keyword(s):  
Ethnic Difference ◽  
Cholesterol Metabolism ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Case Control ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Case Control Studies ◽  
Density Lipoprotein Receptor

Low density lipoprotein receptor (LDLR) can regulate cholesterol metabolism by removing the excess low density lipoprotein cholesterol (LDL-C) in blood. Since cholesterol metabolism is often disrupted in coronary heart disease (CHD),LDLRas a candidate gene of CHD has been intensively studied. The goal of our study is to evaluate the overall contribution ofLDLRrs2228671 polymorphism to the risk of CHD by combining the genotyping data from multiple case-control studies. Our meta-analysis is involved with 8 case-control studies among 7588 cases and 9711 controls to test the association betweenLDLRrs2228671 polymorphism and CHD. In addition, we performed a case-control study ofLDLRrs2228671 polymorphism with the risk of CHD in Chinese population. Our meta-analysis showed that rs2228671-T allele was significantly associated with a reduced risk of CHD (P=0.0005, odds ratio (OR) = 0.83, and 95% confidence interval (95% CI) = 0.75–0.92). However, rs2228671-T allele frequency was rare (1%) and was not associated with CHD in Han Chinese (P=0.49), suggesting an ethnic difference ofLDLRrs2228671 polymorphism. Meta-analysis has established rs2228671 as a protective factor of CHD in Europeans. The lack of association in Chinese reflects an ethnic difference of this genetic variant between Chinese and European populations.

scholarly journals Association Between Lipid Biomarkers and Osteoporosis: A Cross-Sectional Study

2020 ◽  
Author(s):  
Qianqian Zhao ◽  
Bo Kan ◽  
Lijuan Wang ◽  
Shanshan Xue ◽  
Hanqing Cai ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Lipoprotein Cholesterol ◽  
Mineral Density ◽  
Serum Samples ◽  
Cross Sectional ◽  
Total Hip ◽  
Increased Risk

Abstract Background: Osteoporosis and cardiovascular diseases (CVDs) are two major public health problems. Osteoporosis and CVDs may be linked but the association between lipid profile and osteoporosis is still controversial. The purpose of this study was to examine the associations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) with osteoporosis.Methods: Using inpatients’ electronic medical records (EMR) and dual X-ray absorptiometry (DXA) database stored at The Second Hospital of Jilin University, we included 481 patients with complete and valid lipid and bone mineral density (BMD) data in 2017. Serum samples were used to measure TC, LDL-C, HDL-C and TG. Femoral neck and total hip BMD were measured by DXA; osteoporosis was defined as femoral neck or total hip T-score ≤ -2.5. Multivariable logistic regression models were used to test the associations of TC, LDL-C, HDL-C and TG with osteoporosis.Results: The mean age for included patients was 62.7 years (SD = 8.6 years); 60.1 % of them were female. Each standard deviation (SD) increase in TC (Odds Ratio [OR]: 1.43; 95% Confidence Interval [CI]: 1.03-1.99) and TG (OR: 1.60; 95% CI: 1.12-2.30) were associated with increased risk of osteoporosis; LDL-C and HDL-C levels were not associated with osteoporosis. Age, sex and body mass index (BMI) did not interact the relationships of TC and TG with osteoporosis (all P > 0.10). Conclusions: Higher TC and TG levels were associated with greater risk of osteoporosis.

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