scholarly journals Effect of Prenatal Polycyclic Aromatic Hydrocarbons Exposure on Birth Outcomes: The Polish Mother and Child Cohort Study

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Kinga Polanska ◽  
Gerhard Dettbarn ◽  
Joanna Jurewicz ◽  
Wojciech Sobala ◽  
Per Magnus ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Birth Outcomes ◽  
Environmental Pollutants ◽  
Environmental Tobacco Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Gas Chromatography Mass Spectrometry ◽  
Anthropometric Measures ◽  
Cotinine Level ◽  
Pah Exposure ◽  
The Impact

The aim of this study was to assess the impact of PAH exposure on various anthropometric measures of birth outcomes. The study population consisted of 210 nonsmoking pregnant women. Urine samples collected between 20th and 24th week of pregnancy were used for analysis of the following PAH metabolites: 1-, 2-, 3-, 4-, and 9-hydroxyphenanthrene (1-, 2-, 3-, 4-, and 9-OH-PHE), 1-hydroxypyrene (1-OH-PYR), 1,6 + 1,8-dihydroxypyrene (DI-OH-PYR), phenanthrenetrans-1,2-dihydrodiol (PHE-1,2-diol), and phenanthrenetrans-9,10-dihydrodiol (PHE-9,10-diol) by gas chromatography-mass spectrometry. Environmental tobacco smoke exposure (ETS) was assessed by cotinine level in saliva using a stable isotope dilution LC-ESI-MS/MS method. The mean PAH metabolite concentrations were in the range of 0.15 µg/g creatinine for 9-OH-PHE to 5.9 µg/g creatinine for PHE-9,10-diol. It was shown that none of the individual PAH exposure markers demonstrate a statistically significant influence on birth outcomes. Interestingly a statistically significant association was found between the sum of OH-PHE along with cotinine level and the cephalization index after adjusting for potential confounders (P=0.04). This study provides evidence that combined exposure of pregnant women to common environmental pollutants such as PAH and ETS might adversely affect fetal development. Thus, reduction of human exposure to these mixtures of hazardous compounds would in particular result in substantial health benefits for newborns.

scholarly journals Questionnaire-Based Environmental Tobacco Smoke Exposure and Hair Nicotine Levels in 6-month-old Infants: A Validation Study in Indonesia

2020 ◽  
Vol 7 ◽  
pp. 2333794X2096928
Author(s):  
Siti Rahayu Nadhiroh ◽  
Kusharisupeni Djokosujono ◽  
Diah Mulyawati Utari ◽  
Armedy Ronny Hasugian
Keyword(s):  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Area Under The Curve ◽  
Cross Sectional Study ◽  
Environmental Tobacco Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Gas Chromatography Mass Spectrometry ◽  
Cross Sectional ◽  
Cutoff Value ◽  
Hair Samples

Objectives. Using hair nicotine as the gold standard, this study aimed to establish cutoff points and validate the questionnaire-based environmental tobacco smoke (ETS) exposure and ETS statuses of Indonesian infants. Methods. A cross-sectional study design was conducted among families who were participants of the Peer Health Cohort Study in Jakarta, Indonesia. Households with 6-month-old infants joined this study. The presence and amount of ETS exposure were assessed by both questionnaire and hair sampling for nicotine determination. Head hair samples were collected from 102 infants and measured by optimized gas chromatography-mass spectrometry (GC/MS). Infants were grouped as ETS-exposed if they lived with at least 1 smoker at home. We used the receiver operating characteristic (ROC) curve to assess the sensitivity and specificity of cutoff values of hair nicotine. Results. There were 78 (76.5%) infants exposed to ETS based on the questionnaire. The nicotine concentrations in hair were significantly higher in infants with ETS exposure than in those without ETS exposure ( P < .001). The area under the curve for nicotine was 0.774. A hair nicotine cutoff value of 2.37 ng/mg, with a sensitivity of 67.95% and specificity of 83.33%, was identified as the optimal cutoff value for separating exposed from non-exposed to ETS in infants. Conclusion. The hair nicotine value of infants aged 6 months is useful in confirming the questionnaire on smoking in the household and exposure to ETS. Moreover, it also could be used to distinguish ETS-exposed from non-ETS-exposed infants.

Simultaneous analysis of bisphenol A fractions in maternal and fetal compartments in early second trimester of pregnancy

2019 ◽  
Vol 47 (7) ◽  
pp. 765-770 ◽  
Author(s):  
Monika Zbucka-Krętowska ◽  
Urszula Łazarek ◽  
Wojciech Miltyk ◽  
Iwona Sidorkiewicz ◽  
Piotr Pierzyński ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Chromosomal Abnormalities ◽  
Maternal Plasma ◽  
Environmental Pollutant ◽  
Maternal Exposure ◽  
Gas Chromatography Mass Spectrometry ◽  
Permeability Factor ◽  
The Impact

Abstract Background Bisphenol A (BPA) is an estrogenic, endocrine-disrupting compound widely used in the industry. It is also a ubiquitous environmental pollutant. Its presence was confirmed in human fetuses, which results from maternal exposure during pregnancy. The mechanisms behind maternal-fetal transfer, and relationships between pregnant women and fetal exposures remain unclear. The aim of this study was to assess the impact of maternal exposure to BPA on the exposure of the fetus. Methods Maternal plasma and amniotic fluid samples were collected from 52 pregnant women undergoing amniocentesis for prenatal diagnosis of chromosomal abnormalities. BPA was measured by gas chromatography-mass spectrometry (GC-MS). The permeability factor – a ratio of fetal-to-maternal BPA concentration – was used as a measure delineating the transplacental transfer of BPA. Results The median concentration of maternal plasma BPA was 8 times higher than the total BPA concentration in the amniotic fluid (8.69 ng/mL, range: 4.3 ng/mL–55.3 ng/mL vs. median 1.03 ng/mL, range: 0.3 ng/mL–10.1 ng/mL). There was no direct relationship between the levels of BPA in maternal plasma and amniotic fluid levels. The permeability factor, in turn, negatively correlated with fetal development (birth weight) (R = −0.54, P < 0.001). Conclusion Our results suggest that the risk of fetal BPA exposure depends on placental BPA permeability rather than the levels of maternal BPA plasma concentration and support general recommendations to become aware and avoid BPA-containing products.

scholarly journals Association Between Prenatal Phthalate Exposure and Anthropometric Measures of Newborns in a Sample of Iranian Population

2020 ◽  
Author(s):  
Mohammad Darvishmotevalli ◽  
Maryam Moradnia ◽  
Reza Hosseini ◽  
Bijan Bina ◽  
Awat Feizi ◽  
...  
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Maternal Education ◽  
Family Income ◽  
Smoking Habit ◽  
Gas Chromatography Mass Spectrometry ◽  
Urinary Concentration ◽  
Anthropometric Measures ◽  
Phthalate Metabolites ◽  
Cleaning Products

Abstract Background: This study aimed to examine the associations between the urinary concentrations of phthalate metabolites among a sample of Iranian pregnant women with anthropometric measures of neonates. Methods: Urine samples were obtained from 121 pregnant women at their first trimester of pregnancy; the levels of monobutyl phthalate (MBP), mono-benzyl phthalate (MBzP), mono-2-ethylhexyl phthalate (MEHP), and mono (2-ethyl-5hydroxyhexyl) phthalate (MEHHP) metabolites were determined by gas chromatography mass spectrometry (GC/MS). The correlation between the urinary concentration of these metabolites and some socio-demographic factors of the participants (maternal education, age, family income, pre-pregnancy body mass index), their lifestyle variables (smoking habit, food pattern, and physical activity), cleaning products use data (cosmetic and household cleaning products) with anthropometric measures of neonates were investigated. Results: MBzP, MBP, MEHP, and MEHHP were detected in 100% of participants with the concentration ranged from 120 to 860 μg/g creatinine. Significant correlations were observed between the urinary levels of maternal MBzP (adjusted β =0.3 (0.001), p=0.03) and MEHHP and (adjusted β =0.3 (0.001), p=0.04) with the birth weight of female neonates. MBP (adjusted β = -0.3(0.02), p=0.04) and MBzP (adjusted β =-0.3 (0.001), p=0.02) were found negatively associated with head circumference in male and female newborns, respectively. Significant differences existed in the birth weight of infants whose mothers used plastic packaging for pickle and those who had history of passive smoking (p-value< 0.05). Conclusions: the studied metabolites had higher concentration in the Iranian pregnant women urine compared to the other countries. Higher levels of prenatal exposure to phthalate metabolites may adversely impact the health status of newborns.

scholarly journals Maternal syphilis treatment and pregnancy outcomes: a retrospective study in Jiangxi Province, China

2020 ◽  
Author(s):  
Zhihua Wan ◽  
Huan Zhang ◽  
Haigang Xu ◽  
Yang Hu ◽  
Cai Tan ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Pregnant Women ◽  
Birth Outcomes ◽  
Pregnancy Outcomes ◽  
First Trimester ◽  
Jiangxi Province ◽  
Adequate Treatment ◽  
Syphilis Treatment ◽  
Maternal Syphilis ◽  
The Impact

Abstract BackgroundStudies investigating the associations of maternal syphilis treatment with birth outcomes mainly concentrated in economically developed areas. Limited data are available in economically underdeveloped areas, such as Jiangxi Province. The study aims to investigate the impact of maternal treatment on birth outcomes in Jiangxi Province, China.MethodsData were obtained from the China’s Information System of Prevention of Mother-to-Child Transmission in Jiangxi Province. All syphilis infected pregnant women who delivered ≥28 gestational weeks and were registered in this system between 1 January 2013 and 31 December 2019 were enrolled. Pregnancy outcomes were evaluated by group-specific analyses according to their treatment status, adequacy and initiation time.Results4210 syphilis infected pregnant women were included in the analyses. Infants born to untreated mothers (n = 1364) were at significantly higher risk for stillbirth (adjusted odds ratio (aOR) = 1.74, 95% CI, 1.01-3.00, P = 0.045), preterm birth (aOR = 1.27, 95% CI, 1.02-1.59, P = 0.034) and low birth weight (LBW) (aOR = 1.44; 95% CI, 1.11-1.86, P = 0.006) than those born to treated mothers (n = 2846) after adjustment for confounding factors. A significantly higher risk of stillbirth (aOR = 3.68; 95% CI, 1.62-8.34, P = 0.002), preterm birth (aOR = 2.26; 95% CI, 1.71-3.00, P < 0.001), LBW (aOR = 2.23; 95% CI, 1.59-3.14, P < 0.001) and congenital syphilis (CS) (aOR = 3.63; 95% CI, 1.80-7.31, P < 0.001) was found in infants exposed to mothers treated inadequately (n = 1299) than those treated adequately (n = 1547). No pregnant women who initiated the treatment in the first trimester (n = 682) delivered a neonatal CS case. Compared with mothers who initiated treatment in the first trimester (n = 682), those initiated in the third trimester (n = 1234) suffered an increased risk of stillbirth (aOR = 4.48; 95% CI, 1.31-15.30, P = 0.017), preterm birth (aOR = 2.34; 95% CI, 1.61-3.40, P < 0.001) and LBW (aOR = 3.25; 95% CI, 1.97-5.37, P < 0.001). ConclusionsMaternal treatment, especially early and adequate treatment, plays a crucial role in mitigating adverse pregnancy outcomes among syphilis infected women.

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