scholarly journals Role of Fine Needle Aspiration in the Diagnosis of the Rare Disease of Langerhans Cell Histiocytosis in a Child

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Seema Lale ◽  
Daniel Soto ◽  
Patricia G. Wasserman
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Parasitic Infection ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Kimura’S Disease ◽  
Cat Scratch Disease ◽  
Multinucleated Giant Cells ◽  
Dermatopathic Lymphadenitis ◽  
Massive Lymphadenopathy

Langerhan’s cell histiocytosis (LCH) results from the proliferation of immunophenotypically and functionally immature, morphologically rounded Langerhan’s cells along with eosinophils, macrophages, lymphocytes, and, commonly, multinucleated giant cells. Here we report a case in a 6-year-old boy of differential diagnoses including dermatopathic lymphadenitis (DL), parasitic infection, Kimura’s disease, hypersensitivity reactions, cat-scratch disease, sinus histiocytosis with massive lymphadenopathy (SHML), hyperplasic lymph nodes, and lymphoma.

Fine-Needle Aspiration Cytology in the Diagnosis of Breast Paraffinoma

2021 ◽  
pp. 1-5
Author(s):  
Kenneth Y.Y. Kok ◽  
Pemasiri Upali Telisinghe ◽  
Sonal Tripathi
Keyword(s):  
Breast Carcinoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Diagnostic Procedures ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Multinucleated Giant Cells ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

<b><i>Introduction:</i></b> Paraffin injections for breast augmentation once a popular form of mammoplasty are now considered obsolete. It had been abandoned by clinicians because of its associated serious complications. The practice is however still available and is being practiced by nonmedically qualified people. Paraffin injection results in the formation of multiple foreign-body granulomas known as breast paraffinoma. The clinical features of breast paraffinoma can mimic and be mistaken for breast carcinoma or inflammatory breast carcinoma. The use of fine-needle aspiration cytology (FNAC) in the evaluation of patients with breast paraffinoma has not been fully evaluated. <b><i>Methods:</i></b> Retrospective review was performed on 30 patients who presented with breast paraffinoma between June 1, 2010, and June 30, 2020, who also had FNAC as part of their breast lump evaluation. <b><i>Results:</i></b> FNAC of 73.3% patients showed multinucleated giant cells and macrophages or histiocytes containing engulfed clear, empty intracytoplasmic vacuoles of varying sizes. In 13.3% of the patients, macrophages or histiocytes with engulfed clear intracytoplasmic vacuoles of varying sizes were seen. In 6.7% of patients, multinucleated giant cells containing engulfed vacuoles of varying sizes were seen, and in 6.7% of patients, hypocellular smears with large amount of clear spaces were seen. Oily droplets were seen in the background of all the smears, and there were no malignant cells seen. These features were compatible with breast paraffinoma. <b><i>Conclusion:</i></b> Most patients with breast paraffinoma can be managed conservatively and they do not require further treatment; FNAC with its characteristic features can provide the reliable diagnosis of breast paraffinoma and therefore sparing these patients from more invasive diagnostic procedures.

In vitro and in vivo assessment of CaP materials for bone regenerative therapy. The role of multinucleated giant cells/osteoclasts in bone regeneration

2019 ◽  
Vol 108 (1) ◽  
pp. 282-297 ◽  
Author(s):  
Ana Carolina Cestari Bighetti ◽  
Tania Mary Cestari ◽  
Paula Sanches Santos ◽  
Ricardo Vinicius Nunes Arantes ◽  
Suelen Paini ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Giant Cells ◽  
Regenerative Therapy ◽  
Multinucleated Giant Cells ◽  
In Vivo Assessment

Including Langerhans cell histiocytosis in the differential diagnosis of skin tumors with osteoclast-like multinucleated giant cells

2017 ◽  
Vol 44 (7) ◽  
pp. 659-661
Author(s):  
Tina Ho ◽  
Jennifer Oliver-Krasinski ◽  
Pierre Russo ◽  
Jesse Taylor ◽  
Jenna Streicher ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Langerhans Cell Histiocytosis ◽  
Giant Cells ◽  
Langerhans Cell ◽  
Skin Tumors ◽  
Multinucleated Giant Cells

HIV-associated Waldeyer's ring lymphoid hyperplasias: Characterization of multinucleated giant cells and the role of Epstein-Barr virus

1999 ◽  
Vol 30 (11) ◽  
pp. 1383-1388 ◽  
Author(s):  
Silloo B Kapadia ◽  
Clayton A Wiley ◽  
Virawudh Soontornniyomkij ◽  
Guoji Wang ◽  
Steven H Swerdlow
Keyword(s):  
Epstein Barr Virus ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Barr Virus ◽  
Waldeyer’S Ring ◽  
Epstein Barr

Multinucleated giant cells in Langerhans cell histiocytosis

2016 ◽  
Vol 174 (1) ◽  
pp. 7-7 ◽  
Author(s):  
Ryu Yanagisawa ◽  
Yoshifumi Ogiso ◽  
Yosuke Miyairi ◽  
Kazuo Sakashita ◽  
Hiroaki Shigeta
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Giant Cells ◽  
Langerhans Cell ◽  
Multinucleated Giant Cells

scholarly journals Adipoclast: a multinucleated fat-eating macrophage

BMC Biology ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Antoni Olona ◽  
Subhankar Mukhopadhyay ◽  
Charlotte Hateley ◽  
Fernando O. Martinez ◽  
Siamon Gordon ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Plasma Membrane ◽  
Cell Membrane ◽  
Cell Fusion ◽  
Metabolic Activity ◽  
Current Knowledge ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Review Current

AbstractCell membrane fusion and multinucleation in macrophages are associated with physiologic homeostasis as well as disease. Osteoclasts are multinucleated macrophages that resorb bone through increased metabolic activity resulting from cell fusion. Fusion of macrophages also generates multinucleated giant cells (MGCs) in white adipose tissue (WAT) of obese individuals. For years, our knowledge of MGCs in WAT has been limited to their description as part of crown-like structures (CLS) surrounding damaged adipocytes. However, recent evidence indicates that these cells can phagocytose oversized lipid remnants, suggesting that, as in osteoclasts, cell fusion and multinucleation are required for specialized catabolic functions. We thus reason that WAT MGCs can be viewed as functionally analogous to osteoclasts and refer to them in this article as adipoclasts. We first review current knowledge on adipoclasts and their described functions. In view of recent advances in single cell genomics, we describe WAT macrophages from a ‘fusion perspective’ and speculate on the ontogeny of adipoclasts. Specifically, we highlight the role of CD9 and TREM2, two plasma membrane markers of lipid-associated macrophages in WAT, which have been previously described as regulators of fusion and multinucleation in osteoclasts and MGCs. Finally, we consider whether strategies aiming to target WAT macrophages can be more selectively directed against adipoclasts.

Fine Needle Aspiration of Salivary Gland Lesions with Multinucleated Giant Cells

2008 ◽  
Vol 52 (6) ◽  
pp. 671-680 ◽  
Author(s):  
Yahya Daneshbod ◽  
Bijan Khademi ◽  
Maryam Kadivar ◽  
Parvin Ganjei-Azar
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Multinucleated Giant Cells ◽  
Fine Needle

scholarly journals Atypical Histiocytoid Cells and Multinucleated Giant Cells in Fine-Needle Aspiration Cytology of the Thyroid Predict Lymph Node Metastasis of Papillary Thyroid Carcinoma

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 816 ◽  
Author(s):  
Ji Eun Choi ◽  
Ja Seong Bae ◽  
Dong-Jun Lim ◽  
So Lyung Jung ◽  
Chan Kwon Jung
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Odds Ratio ◽  
Cervical Lymph Node ◽  
Cervical Lymph Node Metastasis ◽  
Giant Cells ◽  
Needle Aspiration ◽  
Multinucleated Giant Cells ◽  
Node Metastasis ◽  
Needle Aspiration Cytology

Preoperative detection of cervical lymph node metastasis in papillary thyroid carcinoma (PTC) is crucial for determining the surgical strategy to prevent locoregional recurrence of the disease. We identified the cytological predictors of lymph node metastasis in 222 consecutive patients with PTC using fine-needle aspiration cytology (FNAC) of the thyroid. Cervical lymph node metastases occurred in 99 (44.6%) of 222 PTC patients. Lymph node metastasis was significantly associated with tumor multifocality (p = 0.003), and high cellularity (p = 0.021), atypical histiocytoid cells (p < 0.001), and multinucleated giant cells (p < 0.001) in thyroid FNAC. The BRAF V600E mutation was marginally associated with lymph node metastasis (p = 0.054). Multivariate analysis revealed that atypical histiocytoid cells (odds ratio = 2.717; p = 0.001) and multinucleated giant cells (odds ratio = 3.070; p = 0.031) were independent predictors of lymph node metastasis in patients with PTC. In a subgroup analysis of 164 patients with microcarcinomas, atypical histiocytoid cells (odds ratio = 2.761; p = 0.005) was an independent predictor of lymph node metastasis. Cytological detection of atypical histiocytoid cells and multinucleated giant cells on thyroid FNAC can be used to preoperatively predict cervical lymph node metastasis in patients with PTC.

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