scholarly journals Lung Metastasis after an Eighteen-Years-Long Disease-Free Period since Uterine Leiomyosarcoma Diagnosis

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
M. Guazzaroni ◽  
D. Tosti ◽  
M. Rascioni ◽  
M. Mataloni ◽  
D. Citraro ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Pulmonary Metastases ◽  
Smooth Muscle Actin ◽  
Metastatic Potential ◽  
Uterine Leiomyosarcoma ◽  
Muscle Actin ◽  
Uterine Sarcomas ◽  
Disease Free Interval ◽  
Free Interval ◽  
Disease Free

Uterine leiomyosarcoma (ULMS) is an uncommon malignancy that accounts for one-third of uterine sarcomas and represents 1% of all uterine malignancies, with an incidence averaging 0.5–1/100,000/year. The prognosis is poor due to its intrinsic aggressiveness and its characteristic high metastatic potential with reported distant metastatic spread in lung, abdomen, soft tissue, and brain. We present the case of a 67-year-old woman with lung metastasis after eighteen years since uterine leiomyosarcoma diagnosis and its following surgical resection. The diagnosis of pulmonary metastases was obtained by reviewing the histology of the previous uterine tumor: the tumor cells were immunoreactive for CD10, PR, and smooth muscle actin (SMA), but negative for desmin, S100, CD34, CD 117, cytokeratins AE1AE3, CD68R, and ER. To our knowledge, this disease-free interval is the longest among previous reports of pulmonary metastasis of uterine leiomyosarcoma.

Outcomes after resection of synchronous or metachronous hepatic and pulmonary colorectal metastases

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 4059-4059
Author(s):  
G. Miller ◽  
P. Biernacki ◽  
N. Kemeny ◽  
M. Gonen ◽  
R. Downey ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Cox Regression ◽  
Pulmonary Metastases ◽  
Hepatic Metastases ◽  
Colorectal Metastases ◽  
Patient Treatment ◽  
Disease Free Interval ◽  
Free Interval ◽  
Disease Free ◽  
Pulmonary Colorectal Metastases

4059 Background: Surgical resection of isolated hepatic or pulmonary colorectal metastases prolongs survival in selected patients. However, the benefits of resection and appropriate selection criteria in patients who develop both hepatic and pulmonary metastases are ill-defined. Methods: Data were prospectively collected from 131 patients with colorectal cancer who underwent resection of both hepatic and pulmonary metastases over a 20-year period. Median follow-up was 6.6 years from the time of resection of the primary tumor. Patient, treatment, and outcome variables were analyzed using log-rank, Cox regression, and Kaplan-Meier methods. Results: The site of first metastasis was the liver in 65% of patients, lung in 11%, and both simultaneously in 24%. Multiple hepatic metastases were present in 51% of patients and multiple pulmonary metastases were found in 48%. Hepatic lobectomy or trisegmentectomy was required in 61% of patients while most lung metastases (80%) were treated with wedge excisions. Median survival from resection of the primary disease, first site of metastasis, and second site of metastasis was 6.9, 5.0, and 3.3 years, respectively. After resection of disease at the second site of metastasis, the 1, 3, 5, and 10 year disease-specific survival rates were 91, 55, 31 and 19%, respectively. An analysis of prognostic factors revealed that survival was significantly longer when the disease-free interval between the development of the first and second sites of metastases exceeded one year, in patients with a single liver metastasis, and in patients younger than 55 years. Conclusions: Surgical resection of both hepatic and pulmonary colorectal metastases is associated with prolonged survival in selected patients. Patients with a longer disease free interval between metastases and those with single liver lesions had the best outcomes. [Table: see text] No significant financial relationships to disclose.

Prognostic factors for colorectal cancer patients with pulmonary metastases

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e15107-e15107
Author(s):  
W. Li ◽  
W. Zhang ◽  
S. Cai ◽  
J. Yin ◽  
J. Li
Keyword(s):  
Multivariate Analysis ◽  
Prognostic Factors ◽  
Primary Tumor ◽  
Pulmonary Metastases ◽  
Good Survival ◽  
Primary Tumor Site ◽  
Disease Free Interval ◽  
Metastatic Site ◽  
Free Interval ◽  
Disease Free

e15107 Background: Pulmonary is the second common metastastic site of CRC with a good survival after metastasectomy, however the general situation of pulmonary metastases from CRC has received little attention, especially for unresectable ones. The aim of this study was to determine factors that may influence survival and disease free interval from primary radical surgery to pulmonary metastases (DFI). Methods: From 01/2000 to 11/2008, a total of 206 pts with pulmonary metastases (colon72, rectal ca131, 3 unknown) were collected retrospectively and the clinical data were analyzed using Kaplan-Meier survival curves, univariate and multivariate analysis. Results: 128 pts (62.1%) had lung disease as the first metastatic site and 33 pts (26.7%) had synchronous liver involvement. Only 17 patients (8.3%) followed pulmonary metastatic resection, and others underwent palliative medical treatment including the chemotherapy and intervention. Median survival was 16.0 months (range 12.240–19.760) with a 18% 5-year survival. Of the totally 160 patients who had synchronous pulmonary metastases after radical primary tumor surgery, the mDFI was 20 months (range 16.738–23.262) months. Rectal cancer had a high chance (65%) for lung recurrence with longer DFI (21 vs 14 mo, P=0.02), but no difference of survival was shown compared to colon cancer. Factors that significantly predicted a poor prognosis on univariate analysis included vessel invasion (P=0.022) and high T stage (P=0.009), but neither of them was the independent prognostic factors after multivariate analysis. The factors influencing the DFI of metachronous pulmonary metastases included primary tumor site, pathological morphology, tumor infiltration stage and regional lymph node stage (P<0.05). There was a trend of better survival of patients receiving resection surgery after pulmonary metastases than receiving chemotherapy alone though no statistical significant was reached (mOS:34 vs 16 mo, P=0.125). But to patients who receiving metastatic site resection, chemotherapy after surgery improved the survival (P=0.042). Conclusions: No independent prognostic factors of survival had been found. The invasive tumor with high stage may have a shorter disease free interval of pulmonary metastases after primary surgery. No significant financial relationships to disclose.

Gene signatures of pulmonary metastases of renal cell carcinoma reflect the disease-free interval and the number of metastases per patient

2009 ◽  
Vol 125 (2) ◽  
pp. 474-482 ◽  
Author(s):  
Daniela Wuttig ◽  
Barbara Baier ◽  
Susanne Fuessel ◽  
Matthias Meinhardt ◽  
Alexander Herr ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Pulmonary Metastases ◽  
Disease Free Interval ◽  
Gene Signatures ◽  
Free Interval ◽  
Disease Free

Survival outcomes after surgical resection of pulmonary metastases of head and neck tumours

2016 ◽  
Vol 130 (3) ◽  
pp. 291-295 ◽  
Author(s):  
S Hosokawa ◽  
K Funai ◽  
K Sugiyama ◽  
G Takahashi ◽  
J Okamura ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck ◽  
Surgical Resection ◽  
Pulmonary Metastases ◽  
Clinical Staging ◽  
Disease Free Interval ◽  
Head And Neck Malignancies ◽  
Free Interval ◽  
Pathological Subtype ◽  
Disease Free

AbstractBackground:There is limited information available regarding the benefits and outcomes of resection of pulmonary metastases arising from head and neck cancers.Methods:A retrospective review was performed of 21 patients who underwent resection of pulmonary metastases of primary head and neck malignancies at Hamamatsu University Hospital. Clinical staging, treatment methods, pathological subtype (particularly squamous cell carcinoma), disease-free interval and overall survival were evaluated.Results:The 5- and 10-year overall survival rates of the study participants were 67.0 per cent and 55.0 per cent, respectively, as determined by the Kaplan–Meier method. The prognosis for patients with a disease-free interval of less than 24 months was poor compared to those with a disease-free interval of greater than 24 months (p = 0.0234).Conclusion:Patients with short disease-free intervals, and possibly those who are older than 60 years, should be categorised as having severe disease. However, pulmonary metastases from head and neck malignancies are potentially curable by surgical resection.

scholarly journals Prognostic factors in 291 patients with pulmonary metastases submitted to thoracotomy

1995 ◽  
Vol 113 (3) ◽  
pp. 910-916 ◽  
Author(s):  
Benedito Mauro Rossi ◽  
Ademar Lopes ◽  
Luiz Paulo Kowalski ◽  
Rosana Cardoso de Oliveira Regazzini
Keyword(s):  
Prognostic Factors ◽  
Bone Tumors ◽  
Pulmonary Resection ◽  
Pulmonary Metastases ◽  
Primary Treatment ◽  
Mesenchymal Tumors ◽  
Disease Free Interval ◽  
Risk Of Death ◽  
Free Interval ◽  
Disease Free

Pulmonary metastases are among the most common sites for the spread of cancer, particularly with mesenchymal tumors. Despite improvements in cancer therapy, the prognosis remains poor, except for the highly selective group of patients who are considered eligible for surgical treatment and those with chemosensitive tumors. The main objective of this study was to evaluate survival results of 291 patients who underwent thoractomy due to pulmonary metastases between 1953 and 1986. The number of metastases ranged from a minimum of 1 to as many as 30. The type of resection depended on site, size, and number of pulmonary lesions: 154 wedge resections, 49 lobectomies, and 9 pneumectomies. The tumor was not resectable in the remaining 79 patients. Of the prognostic factors analyzed, only type of pulmonary resection (wedge vs. lobectomy vs. pneumectomy vs. unresectable) and disease free interval (DFI) between primary treatment and pulmonary metastases diagnosis ( <=6 months vs. 7-12 months vs. >12 months) were selected as independent predictors of the risk of death in multivariate analysis. A reduced model for bone tumors included disease free interval, sex and histology.

Survival Following Brain Metastases in Wilms' Tumor

PEDIATRICS ◽  
1976 ◽  
Vol 58 (1) ◽  
pp. 130-132
Author(s):  
Samuel K. Morgan ◽  
Maria G. Buse
Keyword(s):  
Pulmonary Metastases ◽  
Wilms Tumor ◽  
Cerebral Metastases ◽  
Aggressive Approach ◽  
Disease Free Interval ◽  
Therapeutic Modalities ◽  
Free Interval ◽  
Rare Site ◽  
The Brain ◽  
Disease Free

The brain is apparently a very rare site for metastases in Wilms' tumor and survival of a patient with such metastases with a prolonged disease-free interval following therapy has not been previously reported to our knowledge.1-4 The purpose of this paper is to report a child with Wilms' tumor who first developed bilateral pulmonary metastases, and later cerebral metastases to two sites and who recovered, and has been presumably disease-free for four years and off therapy for two years. The currently employed combination of therapeutic modalities for Wilms' tumor were utilized. The importance of an aggressive approach to this common childhood malignancy is reemphasized.

scholarly journals Metastasectomy of Pulmonary Metastases from Osteosarcoma: Prognostic Factors and Indication for Repeat Metastasectomy

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Eri Matsubara ◽  
Takeshi Mori ◽  
Takamasa Koga ◽  
Hidekatsu Shibata ◽  
Koei Ikeda ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Pulmonary Metastases ◽  
Pulmonary Metastasectomy ◽  
Repeat Surgery ◽  
Disease Free Interval ◽  
Potential Predictor ◽  
Free Interval ◽  
Maximal Diameter ◽  
Metastatic Osteosarcoma ◽  
Disease Free

Purpose. To identify prognostic factors for metastatic osteosarcoma patients and establish indication for repeat metastasectomy. Methods. Data from 37 patients with pulmonary metastasis from osteosarcoma who underwent metastasectomy in our institute from 1979 to 2013 were retrospectively reviewed. Results. Prognostic factors analyzed were age, sex, maximal diameter of the tumor at first pulmonary metastasectomy, total number of resected pulmonary metastases at first metastasectomy, number of surgeries, and disease free interval. In our analysis, characteristics associated with an increased overall survival were age > 15 years and fewer metastases (≤3). Of the 37 patients, 13 underwent repeat metastasectomy after the first metastasectomy. Of the 7 patients that underwent only two metastasectomies, three remained disease-free. In contrast, all six patients that underwent three or more metastasectomies died of relapse. Patients who had five or less lesions at second metastasectomy showed better survival compared to those who had six or more lesions. Conclusion. Age > 15 years and number of metastases at first metastasectomy were independent prognostic factors. Metastasectomy may provide curative treatment even in cases requiring repeat surgery. The number of metastases at second metastasectomy may be a potential predictor of the need for repeat surgery.

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