scholarly journals Nonpigmented Metastatic Melanoma in a Two-Year-Old Girl: A Serious Diagnostic Dilemma

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Gulden Diniz ◽  
Hulya Tosun Yildirim ◽  
Selcen Yamaci ◽  
Nur Olgun
Keyword(s):  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Metastatic Melanoma ◽  
Subcutaneous Tissue ◽  
Melanocytic Nevus ◽  
Congenital Melanocytic Nevus ◽  
Diagnostic Dilemma ◽  
Flow Cytometric ◽  
Increased Risk ◽  
Congenital Melanocytic Nevi

Although rare, malignant melanoma may occur in children. Childhood melanomas account for only 0.3–3% of all melanomas. In particular the presence of congenital melanocytic nevi is associated with an increased risk of development of melanoma. We herein report a case of malignant melanoma that developed on a giant congenital melanocytic nevus and made a metastasis to the subcutaneous tissue of neck in a two-year-old girl. The patient was hospitalized for differential diagnosis and treatment of cervical mass with a suspicion of hematological malignancy, because the malignant transformation of congenital nevus was not noticed before. In this case, we found out a nonpigmented malignant tumor of pleomorphic cells after the microscopic examination of subcutaneous lesion. Nonpigmented metastatic melanoma was diagnosed by several immunohistochemical and flow cytometric studies. She was offered palliative chemotherapy; however, her parents did not accept treatment. The patient died within 9 months of diagnosis. We emphasized here that the possibility of malignant melanoma in the differential diagnosis of childhood tumors should be kept in mind.

scholarly journals Giant congenital melanocytic nevi (garment variety): a case report

2021 ◽  
Vol 8 (9) ◽  
pp. 1625
Author(s):  
Om Prakash Singh ◽  
Vikas Kumar ◽  
Rahul Kumar
Keyword(s):  
Malignant Melanoma ◽  
Psychological Intervention ◽  
Skin Lesions ◽  
Melanocytic Nevus ◽  
Congenital Melanocytic Nevus ◽  
Melanocytic Nevi ◽  
Black Skin ◽  
Giant Congenital Melanocytic Nevi ◽  
And Migration ◽  
Congenital Melanocytic Nevi

Giant congenital melanocytic nevi (GCMN) are large brown-to-black skin lesions caused due to genetic mutations which lead to defective proliferation, differentiation and migration of melanoblasts which are precursor cells of melanocytes. There is a mutation in the NRAS gene causing abnormal proliferation of embryonic melanoblasts. Congenital melanocytic nevus is primarily a clinical diagnosis. The malignant melanoma and neurocutaneous melanosis are the two major complications associated with GCMN. The risk of transformation of GCMN to malignant melanoma varies between 0 and 3.8%. About 1% of live births presents with a CMN. The incidence of GCMN is estimated at less than 1: 20,000 newborns. The variety ‘garment-like’ of GCMN is even scarcer, 1: 5,00,000. GCMN has got major psychosocial impact on the patient and his family due to its unsightly appearance. Treatment includes surgical and non-surgical procedures, psychological intervention and clinical follow-up, with special attention to changes in color, texture on the surface of the lesion. We presented a case of 1-day-old female neonate born with GCMN in our hospital.

scholarly journals Medium-Sized Congenital Melanocytic Nevus with Halo Phenomenon: A Report of Two Cases

2021 ◽  
Vol 5 (4) ◽  
pp. 426-429
Author(s):  
Antara Afrin ◽  
Lori Kim ◽  
Kurt Ashack ◽  
Thomas Klis ◽  
Michelle Bain
Keyword(s):  
Malignant Melanoma ◽  
Clinical Finding ◽  
Melanocytic Nevus ◽  
Medium Size ◽  
Congenital Melanocytic Nevus ◽  
Malignant Growth ◽  
Melanocytic Nevi ◽  
Congenital Melanocytic Nevi

Congenital melanocytic nevi with halo phenomenon in children is a rare clinical finding. We report two cases of children who developed depigmentation within medium-size congenital melanocytic nevi. Clinicians should be suspicious when confronted with this phenomenon due to the risk of development into malignant melanoma. Herein, we review these rare cases of medium-sized halo congenital melanocytic nevi with and without associated vitiligo, with emphasis that depigmentation does not necessarily indicate malignant growth.

scholarly journals Congenital Melanocytic Hairy Nevi in a Child from North-Western Nigeria

2020 ◽  
pp. 28-34
Author(s):  
Fatima Bello Jiya ◽  
Maryam Amodu- Sanni ◽  
Nma Muhammed Jiya ◽  
Dada Muhammed Aquib ◽  
Muhammed Umar ◽  
...  
Keyword(s):  
Melanocytic Nevus ◽  
Temporal Region ◽  
Healthy Children ◽  
Congenital Melanocytic Nevus ◽  
Melanocytic Nevi ◽  
Lower Back ◽  
The Face ◽  
Congenital Melanocytic Nevi ◽  
North Western ◽  
Apparently Healthy

Aim: To present the first report of a large congenital melanocytic nevus with satellite nevi in an apparently healthy child from Sokoto, North-Western Nigeria. Presentation of Case: A three year old girl was brought to the paediatric out-patient clinic of Paediatrics department of Usmanu Danfodiyo University Teaching Hospital (UDUTH) Sokoto with complaints of darkened skin colour on the left side of the face and scalp, the left arm, lower back, buttocks, and thighs, and excessive hair growth over the same side of the face since birth. There were no neurological symptoms Physical examination findings revealed a well-nourished, not ill looking child. She had a hyper pigmented patch on the left side of the face extending from the lower jaw to the scalp, measuring 21 cm in its longest length, with hypertrichosis on the same site, and two distinct, firm, painless nodular lesions on the left temporal region measuring 3 mm and 4mm respectively. On the lower one-third of the left arm was a hairy, velvety area of hyperpigmentation measuring 2X3 cm in diameter. Other affected sites were the lower back, the gluteal region and the thighs. Her neurologic and other systemic examinations were normal. A diagnosis of large congenital facial melanocytic hairy nevus with multiple satellite nevi was made. Discussion: Congenital melanocytic nevi are benign proliferations of melanocytic cells said to be present at birth or in the first two years of life. Large lesions are rare, they measure 20 cm or more and are said to occur more commonly on the trunk and thighs. The exact pathogenesis of congenital melanocytic nevi is yet, unknown. It is thought to occur as a result of a morphological error in the neuroectoderm during embryogenesis. Treatment of patients with large congenital melanocytic nevus may include surgical or non-surgical procedures as well as psychological interventions. Large lesions, multiple satellite lesions or paravertebral and axial locations are sometimes associated with the risk of neurological complications and malignant transformation. Conclusion: Large congenital melanocytic nevi are uncommon skin lesions that can occur in apparently healthy children. Individualization of the patients with regards to treatment options and long term monitoring are imperative.

scholarly journals Giant Congenital Melanocytic Nevus (GCMN) - A New Hope for Targeted Therapy?

2017 ◽  
Vol 5 (4) ◽  
pp. 549-550 ◽  
Author(s):  
Georgi Tchernev ◽  
Ilia Lozev ◽  
Ivan Pidakev ◽  
Torello Lotti ◽  
Uwe Wollina ◽  
...  
Keyword(s):  
Melanocytic Nevus ◽  
Whole Body ◽  
Occurrence Rate ◽  
Lateral Part ◽  
Congenital Melanocytic Nevus ◽  
Older Children ◽  
Melanocytic Nevi ◽  
Pigmented Lesion ◽  
Surgical Methods ◽  
Congenital Melanocytic Nevi

We present a 6-month-old male patient, who was consulted with dermatologist by his parents, because of a pigmented lesion, present since birth, covering almost the all skin of the back and buttocks.  A sharply bordered, unequally coloured congenital pigmented nevus, measuring approximately 21 cm in diameter was observed in the whole body skin examination. The lesion was affecting the lower 2/3 of the skin of the back and the top half of the gluteus area, extending to the lateral part of the tors, forward the abdomen and the upper lateral part of the hips, composed by multiple darker-pigmented nests and several lighter areas, with single depigmented zones, hairy surface, irregularly infiltrated on palpation. Congenital melanocytic nevi are presented in approximately 1% of newborns, while giant congenital melanocytic nevi (GCMN) are the most uncommon subtype of them; with occurrence rate 1 in 50,000 births. They affect 2% of a total body surface or presenting in a diameter larger than 20 cm in older children. Although not common, the possible malignant transformation remains one of the most important considerations related to them, as the related lifetime risk of melanoma is 4% to 10%. Treatment recommendations include non-surgical methods as dermabrasion only within the first two weeks of life, for prevention the possible melanocytic deeper migration, while serial surgical excisions or tissue expanders could be useful treatment tool even in later stages. Nevertheless, cosmetic result is not always satisfactory, and the risk of malignant changes remains, in cases of previous melanocytic migration in deeper layer. Recent article suggests the potential role in the treatment of GCMN with NRAS inhibitor trametinib, approved for treatment of advanced melanoma, associated with underlying NRAS mutations. Although promising, the drug could be useful in paediatric patients, only with associated NRAS gene mutation. It is still unclear whether it could be helpful, independent of the NRAS status.

Malignant melanoma originating in a medium-sized congenital melanocytic nevus : A case report

Skin Cancer ◽  
2019 ◽  
Vol 33 (3) ◽  
pp. 173-178
Author(s):  
Yu SASAKI ◽  
Akiko KISHI ◽  
Aki YOSHIDA ◽  
Kuniaki OHARA ◽  
Kanako BABA ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Melanocytic Nevus ◽  
Congenital Melanocytic Nevus

Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: Two case reports

2011 ◽  
Vol 22 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Nilufer ONAK KANDEMIR ◽  
Burak BAHADIR ◽  
Sibel BEKTAS ◽  
Figen BARUT ◽  
Gamze YURDAKAN ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Case Reports ◽  
Melanocytic Nevus ◽  
Congenital Melanocytic Nevus

scholarly journals The Role of EUS in the Differential Diagnosis of Polypoid Lesions of the Gallbladder: Update

2020 ◽  
Vol 25 (1) ◽  
pp. 34-39
Author(s):  
Young Koog Cheon
Keyword(s):  
Differential Diagnosis ◽  
Color Doppler ◽  
Diagnostic Methods ◽  
Diagnostic Dilemma ◽  
Increased Risk ◽  
Risk Of Malignancy ◽  
Potentially Malignant ◽  
Recording Analysis ◽  
Malignant Lesions

Although most gallbladder (GB) polyps are benign, some early carcinomas of the GB share the same appearance as benign polyps. Currently, GB polyps larger than 1 cm should be surgically removed because of the increased risk of malignancy. Distinguishing between nonneoplastic, neoplastic, and potentially malignant lesions is a major diagnostic dilemma, and the therapeutic options for these lesions remain controversial. Endoscopic ultrasonography (EUS) is considered to be superior to conventional US for imaging GB lesions, because EUS can provide highresolution images of small lesions with higher ultrasound frequencies. However, differential diagnosis remains difficult, especially for small GB polyps. Thus, various diagnostic methods using EUS have been introduced to overcome difficulty for differential diagnosis between neoplastic and non-neoplastic polyps. Contrastenhanced harmonic EUS is useful for observing microvascular patterns and additional enhancement images of GB polyps. This is needed a post-recording analysis due to a short enhancement time. Real-time color Doppler-EUS provides the Doppler flow of vessels without a time limit.

Malignant Melanoma Arising From a Giant Congenital Melanocytic Nevus in a 3-Year Old

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Meredith Kugar ◽  
Arya Akhavan ◽  
Idorenyin Ndem ◽  
David Ollila ◽  
Paul Googe ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Melanocytic Nevus ◽  
Congenital Melanocytic Nevus ◽  
Giant Congenital Melanocytic Nevus
Sign in / Sign up

Export Citation Format

Share Document