Perceived Immune Status and Sleep: A Survey among Dutch Students

Reduced immune functioning may have a negative impact on sleep and health, and vice versa. A survey among Dutch young adults (18–35 years old) was administered to collect information on perception of reduced immunity and its relationship to sleep disorders, sleep duration, and quality. Sleep disorders were assessed with the SLEEP-50 questionnaire subscales of sleep apnea, insomnia, circadian rhythm disorder, and daily functioning. Dutch young adults (N= 574) completed the survey. Among them, subjects (N= 209; 36.4%) reported perceived reduced immunity. Relative to those with a normal immune status, subjects reporting reduced immunity had significantly higher scores(p=0.0001)on sleep apnea (2.6 versus 3.6), insomnia (5.1 versus 6.8), and circadian rhythm disorder (2.1 versus 2.7). Subjects reporting reduced immunity also had significantly poorer daily functioning scores (5.4 versus 7.6,p=0.0001). No differences were observed in total sleep time, but those reporting reduced immunity had significantly poorer ratings of sleep quality (6.8 versus 7.2,p=0.0001). Our findings suggest that perceived reduced immunity is associated with sleep disturbances, impaired daily functioning, and a poorer sleep quality. Experimental studies including the assessment of immune biomarkers and objective measures of sleep (polysomnography) should confirm the current observations.

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Diagnosis of sleep and circadian rhythm disorder

New Oxford Textbook of Psychiatry ◽

10.1093/med/9780198713005.003.0110 ◽

2020 ◽

pp. 1124-1136

Author(s):

Kirstie Anderson

Keyword(s):

Circadian Rhythm ◽

Sleep Disorders ◽

Sleep Disorder ◽

Eye Movement ◽

Nrem Sleep ◽

Rapid Eye Movement ◽

Sleep Diaries ◽

Circadian Rhythm Disorder ◽

Rhythm Disorder

The diagnosis of sleep and circadian rhythm disorders provides a detailed framework to correctly diagnose the primary sleep disorders that a psychiatrist will see in daily practice, including common sleep-related movement disorders. This includes the specific sleep history, the role of sleep diaries, validated questionnaires, and how to interpret the scores and the role of both home and inpatient sleep studies (polysomnography). The most recent diagnostic criteria within the International Classification of Sleep Disorder, third edition (ICSD-3) are used for the four major categories of sleep disorder: hypersomnia, insomnia, parasomnia, and circadian rhythm disorder. Common sleep disorders such as obstructive sleep apnoea (OSA), restless legs syndrome (RLS), narcolepsy, and both non-rapid eye movement (NREM) sleep parasomnia and rapid eye movement (REM) parasomnia are described. It is written for qualified specialist doctors.

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Study of the modulatory mechanism of the miR-182-Clock axis in circadian rhythm disturbance after hypoxic–ischemic brain damage

European Journal of Inflammation ◽

10.1177/2058739220929159 ◽

2020 ◽

Vol 18 ◽

pp. 205873922092915

Author(s):

Dezhan Li ◽

Wei Huang ◽

Fang Yang ◽

Bin Li ◽

Shanshan Cai

Keyword(s):

Circadian Rhythm ◽

Pineal Gland ◽

Circadian Clock ◽

Sleep Disorders ◽

Clock Genes ◽

Ischemic Brain ◽

The Core ◽

Circadian Rhythm Disorder ◽

Pineal Function ◽

Rhythm Disorder

Hypoxic–ischemic encephalopathy (HIE) in neonates can lead to severe chronic neurological deficit, including mental retardation, epilepsy, and sleep–wake cycle (SWC) disorder. Among these defects, little is known about the molecular mechanism of circadian rhythm disorder after HIE. Therefore, further study of sleep problems and its mechanism in HIE children will provide new ideas for clinical treatment of HIE children. For pediatric patients with cerebral ischemia, somnipathy often occurs due to visual and airway abnormalities. From May 2010 to August 2013, 128 newborns with history of HIE were followed up. Meanwhile, 88 normal full-term newborns in the same period were taken as the control group. The clinical data of the patients were collected and the sleep status was assessed by questionnaire. To establish the hypoxic–ischemic brain injury model of neonatal rats and analyze the mechanism of mir-182 in the circadian rhythm disorder caused by pineal function injury. The core clock genes during the regulation of the circadian clock were explored by bioinformatics methods. Patients’ sleep quality was affected by the circadian rhythm and respiratory problems; the pineal gland can regulate the core clock genes in the circadian clock during regulation. miR-182 was highly expressed in the pineal gland after hypoxic–ischemic brain damage (HIBD). Children with mild and moderate HIE showed significant sleep disorders in varying degrees, which provided a clinical basis for improving the long-term prognosis of children with HIE through targeted treatment of sleep disorders. MiR-182 is highly expressed in the pineal gland and is related to the expression of CLOCK protein. CLOCK gene is the target gene of miR-182, which provides a new target for the treatment of rhythm disorder related to the damage of pineal function caused by HIBD.

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Exposure to melamine cyanuric acid in adult mice induced thyroid dysfunction and circadian rhythm disorder

Ecotoxicology and Environmental Safety ◽

10.1016/j.ecoenv.2021.112992 ◽

2021 ◽

Vol 228 ◽

pp. 112992

Author(s):

Sijie Wang ◽

Songdi Wang ◽

Chenxi Wang ◽

Daofu Feng ◽

Xizeng Feng

Keyword(s):

Circadian Rhythm ◽

Thyroid Dysfunction ◽

Cyanuric Acid ◽

Adult Mice ◽

Circadian Rhythm Disorder ◽

Rhythm Disorder

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Sleep and Cancer

Psycho-Oncology ◽

10.1093/med/9780190097653.003.0038 ◽

2021 ◽

pp. 291-297

Author(s):

Amy E. Lowery-Allison ◽

E. Devon Eldridge-Smith

Keyword(s):

Circadian Rhythm ◽

Sleep Apnea ◽

Sleep Disorders ◽

Cancer Care ◽

Empirical Support ◽

Special Consideration ◽

Chronic Insomnia ◽

Barriers To Treatment ◽

Special Groups ◽

3P Model

Sleep disorders are common, yet underdiagnosed, in cancer care. This chapter focuses on three of the most prevalent disorders: sleep apnea, circadian rhythm disruption, and insomnia, with insomnia being the main focus. Causes and consequences are discussed through the lens of Spielman’s 3P model of chronic insomnia. The chapter discusses the challenges of screening and diagnosing sleep disorders in cancer and gives recommendations for establishing and improving these practices. It also reviews interventions used to treat insomnia and the varying degrees of empirical support that currently exist. Finally, the chapter discusses barriers to treatment and special groups of individuals that require special consideration.

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