scholarly journals 3D-Printed Scaffolds and Biomaterials: Review of Alveolar Bone Augmentation and Periodontal Regeneration Applications

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Farah Asa’ad ◽  
Giorgio Pagni ◽  
Sophia P. Pilipchuk ◽  
Aldo Bruno Giannì ◽  
William V. Giannobile ◽  
...  
Keyword(s):  
Bone Graft ◽  
Alveolar Bone ◽  
Periodontal Regeneration ◽  
Oral Diseases ◽  
3D Scaffold ◽  
Socket Preservation ◽  
3D Printed ◽  
Implant Therapy ◽  
Bone Graft Substitutes ◽  
Grafting Materials

To ensure a successful dental implant therapy, the presence of adequate vertical and horizontal alveolar bone is fundamental. However, an insufficient amount of alveolar ridge in both dimensions is often encountered in dental practice due to the consequences of oral diseases and tooth loss. Although postextraction socket preservation has been adopted to lessen the need for such invasive approaches, it utilizes bone grafting materials, which have limitations that could negatively affect the quality of bone formation. To overcome the drawbacks of routinely employed grafting materials, bone graft substitutes such as 3D scaffolds have been recently investigated in the dental field. In this review, we highlight different biomaterials suitable for 3D scaffold fabrication, with a focus on “3D-printed” ones as bone graft substitutes that might be convenient for various applications related to implant therapy. We also briefly discuss their possible adoption for periodontal regeneration.

scholarly journals Histomorphometric Evaluation of Socket Preservation Using Autogenous Tooth Biomaterial and BM-MSC in Dogs

Scanning ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Jin-Hyun Kim ◽  
Puneet Wadhwa ◽  
HongXin Cai ◽  
Dong-Hyung Kim ◽  
Bing Cheng Zhao ◽  
...  
Keyword(s):  
Bone Graft ◽  
Alveolar Bone ◽  
Control Group ◽  
Ridge Preservation ◽  
Graft Material ◽  
Socket Preservation ◽  
Bone Graft Material ◽  
Premolar Extraction ◽  
Bone Width ◽  
Significant Difference

This study is aimed at assessing the dimensional alterations occurring in the alveolar bone after premolar extraction in dogs with histomorphometric and histological analysis. After atraumatic premolar extraction, tooth-derived bone graft material was grafted in the extraction socket of the premolar region in the lower jaws of six dogs in two experimental groups. In the second experimental group, BM-MSCs were added together with the graft. The control was left untreated on the opposite side. After twelve weeks, all six animals were sacrificed. Differences in alveolar bone height crests lingually and buccally, and alveolar bone width at 1, 3, and 5 mm infracrestally, were examined. Histologic study revealed osteoconductive properties of tooth biomaterial. A statistically significant difference was detected between the test and control groups. In the test groups, a reduced loss of vertical and horizontal alveolar bone dimensions compared with the control group was observed. Tooth bone graft material may be considered useful for alveolar ridge preservation after tooth extraction, as it could limit the natural bone resorption process.

124. 3D-printed hyperelastic bone® composite scaffolds as bone graft substitutes

2019 ◽  
Vol 19 (9) ◽  
pp. S60-S61
Author(s):  
Joseph G. Lyons ◽  
Allison Greene ◽  
Jonathan T. Yamaguchi ◽  
David J. Ellenbogen ◽  
Mitchell Hallman ◽  
...  
Keyword(s):  
Bone Graft ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Bone Graft Substitutes

scholarly journals REGENERATION WITH AUTOGENOUS BONE GRAFT IN ANGULAR DEFECT

2021 ◽  
Vol 10 (3) ◽  
pp. 2871-2873
Author(s):  
Manish Dev Sejwal
Keyword(s):  
Periodontal Disease ◽  
Bone Graft ◽  
Periodontal Regeneration ◽  
Tissue Reaction ◽  
Autogenous Bone Graft ◽  
Osteogenic Potential ◽  
Autogenous Bone ◽  
Bony Defect ◽  
Periodontal Tissues ◽  
Grafting Materials

Untreated periodontal disease destroys the attachment apparatus and tooth supporting tissues, resulting in tooth loss. Periodontal treatment aims to stop the progression of periodontal disease while also regenerating periodontal tissues that have been lost due to periodontal disease. Periodontal regeneration appears to occur after treatment with autogenous bone grafts, according to data from clinical and histological research. Because it contains cells that engage in osteogenesis, autogenous bone possesses osteogenic potential. Autografts are also bioabsorbable (they are eventually replaced by the patient's own bone), nonallergenic (they produce little tissue reaction without an immunological reaction), simple to utilize, and inexpensive. Around autogenous bone graft particles, rapid revascularization occurs, and the graft can release growth and differentiation agents. When compared to open flap debridement, autogenous cancellous bone from the jaw is not suited for repairing intrabony periodontal abnormalities. An autogenous cortical bone (ACB) graft derived from the surgical site close to the intraosseous defect is beneficial because it eliminates the requirement for a second surgical site for repairing intraosseous periodontal deficiencies. For tissue regeneration, many therapeutic techniques are employed. Various grafting materials, such as autografts, allografts, xenografts, and alloplasts, have been used and therapeutically utilized among them. A case report on periodontal regeneration employing autogenous bone in the treatment of a periodontal intra-bony defect in the lower left molars is presented in this study.

scholarly journals Terapi Bedah Flep dan Cangkok Tulang pada Periodontitis Agresif di Regio Gigi Anterior Mandibula

2012 ◽  
Vol 19 (1) ◽  
pp. 67
Author(s):  
Levina Mulya ◽  
Sri Lelyati C Masulili
Keyword(s):  
Case Report ◽  
Bone Graft ◽  
Alveolar Bone ◽  
Periodontal Regeneration ◽  
Bone Destruction ◽  
Aggressive Periodontitis ◽  
Flap Surgery ◽  
Pocket Depth ◽  
Anterior Teeth ◽  
Hereditary Factors

Background: Aggressive periodentitis is a multifactorial disease that usuallyOccurs at a young age with the disease spreading fast and found the bacteria. Commonly aggressive periodontitis associated with hereditary factors and lack of immune system so as to reveal any family history with the same disease, and found savere alveolar bone destruction that may ultimately lead to tooth loss. Aggressive periodontitis and generalized aggressive periodontitis. The development of aggressive periodontitis is difficult to predict, so the mechanical therapy is not sufficient, and required antibiotic therapy or surgical therapy. Aim: the purpose of this case report is to explain the procedures and result of surgical treatment of the flap surgery with bone graft in anterior teeth of the patients with generalized aggressive periodontitis. Case report: Cases one and two with complaints of anterior teeth mobility. On clinical examination teeth mobility two and three degree, absolute pocket depth 4-6 mm. Radiograpic examination bone loss reached one third apical in all region. The diagnosis of both cases in generalized aggressive periodontitis. Treatment: After initial theraphy heve been evaluated, flap surgery with bone graft done in booth cases. Control evaluation after 6 month from surgery, in clinically reduced pocket depth 1-2m and tooth mobility, in radiographically increased bone height and bone fill. Conclusion: Flap surgery with bone graft in generalized aggressive periodontitis can assist periodontal regeneration.

Novel Innovations in Bone Graft Substitutes for Periodontal Regeneration: A Review

2021 ◽  
pp. 13-22
Author(s):  
C. K. Sreelakshmi Bharadwaj ◽  
Rashmi Paramashivaiah ◽  
M. L. V. Prabhuji
Keyword(s):  
Bone Graft ◽  
Periodontal Regeneration ◽  
Bone Graft Substitutes

scholarly journals Effectiveness of Platelet Rich Plasma and Bone Graft in the Treatment of Intrabony Defects: A Clinico-radiographic Study

2018 ◽  
Vol 12 (1) ◽  
pp. 133-154 ◽  
Author(s):  
Mohammad Jalaluddin ◽  
Jayachandran Mahesh ◽  
Rethi Mahesh ◽  
Ipsita Jayanti ◽  
Mohamed Faizuddin ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Bone Graft ◽  
Alveolar Bone ◽  
Periodontal Regeneration ◽  
Periodontal Pocket ◽  
Controlled Study ◽  
Radiographic Evaluation ◽  
Significant Difference ◽  
Group A ◽  
Group B

Background & Objectives: Periodontal disease is characterized by the presence of gingival inflammation, periodontal pocket formation, loss of connective tissue attachment and alveolar bone around the affected tooth. Different modalities have been employed in the treatment and regeneration of periodontal defects which include the use of bone grafts, PRP and other growth factors.The purpose of this prospective, randomized controlled study was to compare the regenerative efficacy of PRP and bonegraft in intrabony periodontal defects. Methodology: This randomized control trial was carried out in the Department of Periodontics & Oral Implantology, Kalinga Institute of Dental Sciences and Hospital, KIIT University, Bhubaneswar. The study sample included 20 periodontal infrabony defects in 20 patients, 12 males and 8 females. The patients were aged between 25 -45 years(with mean age of 35 years). The 20 sites selected for the study were was randomly divided into 2 groups of 10 sites each. Group A: PRP alone, Group B: Bone Graft. Statistical Anaysis & Results: Statistical Analysis Was Done Using SPSS (Version 18.0): Statistical analysis was done usingpaired ‘t’ tests and ANOVA that revealed a significant reduction ingingival index, plaque index, probing pocket depth and gain in clinical attachment level at various time intervalswithin both the groups. Radiographic evaluation revealed statistically significant defect fill (p<0.001) at the end of 6months within both the groups. However, there was astatistically significant difference seen in group B radiographically, when compared to group A. Conclusion: Both the groups showed promising results in enhancing periodontal regeneration; however the resultswith bonegraftwere comparatively better, although not statistically significant when compared to PRP alone.

scholarly journals Dimensional Ridge Preservation with a Novel Highly Porous TiO2Scaffold: An Experimental Study in Minipigs

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Hanna Tiainen ◽  
Anders Verket ◽  
Håvard J. Haugen ◽  
S. Petter Lyngstadaas ◽  
Johan Caspar Wohlfahrt
Keyword(s):  
Experimental Study ◽  
Bone Graft ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Ridge Preservation ◽  
Convex Shape ◽  
Prosthetic Reconstruction ◽  
Defect Site ◽  
Bone Graft Substitutes ◽  
Highly Porous

Despite being considered noncritical size defects, extraction sockets often require the use of bone grafts or bone graft substitutes in order to facilitate a stable implant site with an aesthetically pleasing mucosal architecture and prosthetic reconstruction. In the present study, the effect of novel TiO2scaffolds on dimensional ridge preservation was evaluated following their placement into surgically modified extraction sockets in the premolar region of minipig mandibles. After six weeks of healing, the scaffolds were wellintegrated in the alveolar bone, and the convex shape of the alveolar crest was preserved. The scaffolds were found to partially preserve the dimensions of the native buccal and lingual bone walls adjacent to the defect site. A tendency towards more pronounced vertical ridge resorption, particularly in the buccal bone wall of the nongrafted alveoli, indicates that the TiO2scaffold may be used for suppressing the loss of bone that normally follows tooth extraction.

scholarly journals Fabrication of Three-Dimensional Composite Scaffold for Simultaneous Alveolar Bone Regeneration in Dental Implant Installation

2020 ◽  
Vol 21 (5) ◽  
pp. 1863 ◽  
Author(s):  
Hun-Jin Jeong ◽  
So-Jung Gwak ◽  
Kyoung Duck Seo ◽  
SaYa Lee ◽  
Jeong-Ho Yun ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Dental Implant ◽  
Alveolar Bone ◽  
Insertion Site ◽  
High Porosity ◽  
Hybrid Scaffold ◽  
Implant Surgery ◽  
3D Printed ◽  
Dental Implant Surgery

Dental implant surgeries involve the insertion of implant fixtures into alveolar bones to replace missing teeth. When the availability of alveolar bone at the surgical site is insufficient, bone graft particles are filled in the insertion site for successful bone reconstruction. Bone graft particles induce bone regeneration over several months at the insertion site. Subsequently, implant fixtures can be inserted at the recipient site. Thus, conventional dental implant surgery is performed in several steps, which in turn increases the treatment period and cost involved. Therefore, to reduce surgical time and minimize treatment costs, a novel hybrid scaffold filled with bone graft particles that could be combined with implant fixtures is proposed. This scaffold is composed of a three-dimensionally (3D) printed polycaprolactone (PCL) frame and osteoconductive ceramic materials such as hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). Herein, we analyzed the porosity, internal microstructure, and hydrophilicity of the hybrid scaffold. Additionally, Saos-2 cells were used to assess cell viability and proliferation. Two types of control scaffolds were used (a 3D printed PCL frame and a hybrid scaffold without HA/β-TCP particles) for comparison, and the fabricated hybrid scaffold was verified to retain osteoconductive ceramic particles without losses. Moreover, the fabricated hybrid scaffold had high porosity and excellent microstructural interconnectivity. The in vitro Saos-2 cell experiments revealed superior cell proliferation and alkaline phosphatase assay results for the hybrid scaffold than the control scaffold. Hence, the proposed hybrid scaffold is a promising candidate for minimizing cost and duration of dental implant surgery.

scholarly journals Effective dose of propolis extract combined with bovine bone graft on the number of osteoblasts and osteoclasts in tooth extraction socket preservation

2020 ◽  
Vol 53 (1) ◽  
pp. 40
Author(s):  
Teguh Setio Yuli Prabowo ◽  
Utari Kresnoadi ◽  
Hanoem Eka Hidayati
Keyword(s):  
Bone Graft ◽  
Effective Dose ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Bovine Bone ◽  
Extraction Socket ◽  
Lower Incisor ◽  
Socket Preservation ◽  
Propolis Extract ◽  
Group I

Background: Maintaining a good ridge is required during prosthodontic treatment. Hence, adequate alveolar bone support is considered an important factor in pursuing successful dentures. Propolis extract combined with bovine bone graft is a recent and innovative material in the process of socket preservation, as the caffeic acid phenethyl ester (CAPE) it contains can suppress the inflammatory process. Purpose: This study aims to determine the effective dose of propolis extract combined with bovine bone graft on the number of osteoblasts and osteoclasts in socket preservation. Methods: Twenty-eight Cavia cobaya animals were divided into four groups of seven. Group I was given 25 grams of PEG, while Group II were given a propolis extract at a dose of 0.5% combined with bovine bone graft. Group III were given a propolis extract at a dose of 1% combined with bovine bone graft and Group IV were given a propolis extract at a dose of 2% combined with bovine bone graft. On day 30, the lower incisor of each subject was extracted and induced with PEG and propolis (dose 0.5%, 1%, 2%). Histopathological examinations of osteoblasts and osteoclasts were measured with a 400x magnification light microscope. One-way ANOVA and Tukey HSD tests were performed to analyse data statistically. Results: The propolis extract combined with bovine bone graft not only increased the number of osteoblasts but also reduced the number of osteoclasts. The most effective dose for the propolis extract combined with bovine bone graft was 2%. Conclusion: The propolis extract combined with bovine bone graft could be effective in tooth extraction socket preservation at a dose of 2%.

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