Esophageal Intramural Pseudodiverticulosis and Concomitant Eosinophilic Esophagitis: A Case Series

Background. Esophageal intramural pseudodiverticulosis (EIPD) is an idiopathic benign chronic disease characterized by flask-like outpouchings of the esophageal wall. It is unknown whether there is a genuine association between EIPD and eosinophilic esophagitis (EoE).Aims. To investigate a possible relationship between EIPD and EoE.Methods. Patients with radiographic or endoscopic evidence of pseudodiverticulosis were identified from the database at a single academic center. Cases were analyzed in three areas: clinical information, endoscopic findings, and course.Results. Sixteen cases of esophageal pseudodiverticulosis were identified. Five patients had histologic evidence of eosinophilic esophagitis. Patients with EoE had pseudodiverticula in the mid-to-distal esophagus while those with EIPD had pseudodiverticula predominantly in the proximal esophagus (p<0.001). EoE with pseudodiverticulosis occurred in younger patients (p<0.019). Food bolus obstructions were more common in patients with EoE and pseudodiverticulosis than in EIPD (p<0.034).Conclusions. This is the first case series supporting a potential association between EoE and pseudodiverticulosis. We also identify characteristic features of pseudodiverticulosis that may raise clinical suspicion of underlying eosinophilic esophagitis.

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Updates from China: clinical and research experience of homeopathy in the pandemic

International Journal of High Dilution Research - ISSN 1982-6206 ◽

10.51910/ijhdr.v20i1.1081 ◽

2021 ◽

Vol 20 (1) ◽

pp. 08-08

Author(s):

Ka Lun Aaron To ◽

Yuen Ying Yvonne Fok

Keyword(s):

Hong Kong ◽

Symptomatic Relief ◽

Case Series ◽

Clinical Information ◽

Research Experience ◽

Prospective Longitudinal Study ◽

First Case ◽

Study Results ◽

Prospective Longitudinal ◽

Gelsemium Sempervirens

Background: Hong Kong is one of the regions which is most affected by the COVID-19 pandemic in China. In homeopathy, common pathognomonic symptoms are less informative, while homeopathic symptoms are always more helpful for homeopathic prescriptions. Aims: The first case series from Hong Kong was presented and the homeopathic repertorization symptoms observed in the 18 confirmed/suspected cases of COVID-19 in Hong Kong in early 2020 was reported. Methodology: A standard questionnaire on common homeopathic symptoms was filled in by all diagnosed/suspected COVID-19 patients, with or without the help of a consulting-room assistant, before the consultation. Repertorization symptoms from the case series were reported from 18 consecutive patients who used homeopathy as an adjunctive measure, in addition to the conventional or traditional chinese medicine, for symptomatic relief from COVID-19. Anonymized clinical information for research and academic purposes was used and approved by patients. The authors focused mainly on the homeopathic symptoms, i.e. the more individualised and characteristic symptoms which were available in the homeopathic repertories. In the presentation, the demographics, prevelance of homeopathic medicines, common repertorization symptoms in each of the top-ranked remedies, and differentiating symptoms for each top-ranked remedy were presented. Differentiating features were defined as homeopathic symptoms that were present in at least 50% of cases for the top-ranked remedy and in no more than 2 cases for other top-ranked remedies. The data collection project was further extended under the Clificol COVID-19 Support Project, a multinational, combined retrospective, and prospective longitudinal study. Results and discussion: Homeopathic symptoms of 18 cases were presented. All of the cases were categorized as mild. Eighteen common symptoms screened out of 79 selected repertorization symptoms constituted two sets of homeopathic symptom pictures: Bryonia alba (n = 4) and Gelsemium sempervirens (n = 12). Eight and seven differentiating features, respectively, were identified for Bryonia alba and Gelsemium sempervirens. Most updated data from the ongoing COVID-19 Support project was also presented. Conclusion: The common symptoms of 18 mild COVID-19 cases constituted two sets of homeopathic symptom pictures, indicating Bryonia alba or Gelsemium sempervirens; they were indicated in 4 and 12 cases, respectively, out of the 18 in total.

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Tu1228 Esophageal Intramural Pseudodiverticulosis and Concomitant Eosinophilic Esophagitis: A Novel Case Series

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2016.03.1207 ◽

2016 ◽

Vol 83 (5) ◽

pp. AB584

Author(s):

Michael A. Scaffidi ◽

Ankit Garg ◽

Brandon Ro ◽

Christopher Wang ◽

Errol Colak ◽

...

Keyword(s):

Eosinophilic Esophagitis ◽

Case Series ◽

Esophageal Intramural Pseudodiverticulosis

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Eosinophilic Esophagitis or Asthma of the Esophagus: First Case Series Report From Chile

Gastrointestinal Endoscopy ◽

10.1016/s0016-5107(05)00837-0 ◽

2005 ◽

Vol 61 (5) ◽

pp. AB146 ◽

Cited By ~ 1

Author(s):

Rodrigo Zapata ◽

M. Olivero ◽

Pedro Aponte ◽

Roque Saenz ◽

Claudio Navarrete ◽

...

Keyword(s):

Eosinophilic Esophagitis ◽

Case Series ◽

First Case ◽

Case Series Report ◽

Series Report

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Clinicopathological study of blue nevi of the gastrointestinal (GI) tract: first case series

Journal of Clinical Pathology ◽

10.1136/jclinpath-2020-206757 ◽

2020 ◽

pp. jclinpath-2020-206757

Author(s):

Naziheh Assarzadegan ◽

Kevan Salimian ◽

Danielle Hutchings ◽

Annika Lisbeth Windon ◽

Lysandra Voltaggio ◽

...

Keyword(s):

Case Series ◽

Clinical Information ◽

Endoscopic Examination ◽

Gi Tract ◽

Pigmented Lesions ◽

First Case ◽

Clinicopathological Findings ◽

Pathology Reports ◽

Middle Aged Adults

AimBlue nevus (BN) is a benign melanocytic proliferation that is typically cutaneous. Extracutaneous BN is infrequent and is reported in the mucosa of various organs. Gastrointestinal (GI) tract BN is rare. Here, we describe the clinicopathological findings of the largest series of GI tract BNs.MethodsA search of our Pathology Data System (1984–2019) identified six GI tract blue nevi. Clinical information, pathology reports and available H&E-stained section slides were reviewed.ResultsLesions predominated in the middle-aged adults (mean 54, range 27–80) with a slight female predominance (66%). Most cases arose in the rectum and colon (83%), with one gastric lesion (17%). Four cases were identified during endoscopic examination performed either for screening or for unrelated symptoms (66%). Two patients presented with rectal bleeding (33%) unassociated with the BN. Endoscopically, most lesions appeared as superficial hyperpigmented areas (83%). One case was described as abnormal mucosa (17%). Microscopically, the mucosa was involved in all of the cases (100%). One case showed submucosal extension in addition to the mucosal component (17%). Lesions showed a proliferation of bland spindle cells with abundant granular pigment. No nuclear atypia or mitoses were identified. Immunostains showed immunoreactivity for melanocytic markers. Follow-up information available for five patients showed no recurrences to date (mean follow-up 1 year).ConclusionsBN is a benign melanocytic proliferation. It is important to be aware of the occurrence of such lesions outside of the skin and consider the possibility of BN when pigmented lesions are encountered in the GI tract.

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Cystoisospora belli infection: the first case series in Thailand

10.26226/morressier.56d5ba2fd462b80296c953a9 ◽

2016 ◽

Author(s):

Benjawan Skulsujirapa

Keyword(s):

Case Series ◽

First Case

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Sodium-Glucose Cotransporter-2 Inhibitors in Patients with Hereditary Podocytopathies, Alport Syndrome, and FSGS: A Case Series to Better Plan a Large-Scale Study

Cells ◽

10.3390/cells10071815 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1815

Author(s):

Jan Boeckhaus ◽

Oliver Gross

Keyword(s):

Glomerular Filtration ◽

Alport Syndrome ◽

Large Scale ◽

Case Series ◽

Hereditary Diseases ◽

Glomerular Filtration Barrier ◽

Early Effect ◽

Filtration Barrier ◽

First Case ◽

Sodium Glucose Cotransporter

Hereditary diseases of the glomerular filtration barrier are characterized by a more vulnerable glomerular basement membrane and dysfunctional podocytes. Recent clinical trials have demonstrated the nephroprotective effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in chronic kidney disease (CKD). SGLT2-mediated afferent arteriole vasoconstriction is hypothesized to correct the hemodynamic overload of the glomerular filtration barrier in hereditary podocytopathies. To test this hypothesis, we report data in a case series of patients with Alport syndrome and focal segmental glomerulosclerosis (FSGS) with respect of the early effect of SGLT2i on the kidney function. Mean duration of treatment was 4.5 (±2.9) months. Mean serum creatinine before and after SGLT-2i initiation was 1.46 (±0.42) and 1.58 (±0.55) mg/dL, respectively, with a median estimated glomerular filtration rate of 64 (±27) before and 64 (±32) mL/min/1.73 m2 after initiation of SGLT2i. Mean urinary albumin-creatinine ratio in mg/g creatinine before SGLT-2i initiation was 1827 (±1560) and decreased by almost 40% to 1127 (±854) after SGLT2i initiation. To our knowledge, this is the first case series on the effect and safety of SGLT2i in patients with hereditary podocytopathies. Specific large-scale trials in podocytopathies are needed to confirm our findings in this population with a tremendous unmet medical need for more effective, early on, and safe nephroprotective therapies.

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Clinical, Laboratory and Histological Features of Dipeptidyl Peptidase-4 Inhibitor Related Noninflammatory Bullous Pemphigoid

Journal of Clinical Medicine ◽

10.3390/jcm10091916 ◽

2021 ◽

Vol 10 (9) ◽

pp. 1916

Author(s):

Ágnes Kinyó ◽

Anita Hanyecz ◽

Zsuzsanna Lengyel ◽

Dalma Várszegi ◽

Péter Oláh ◽

...

Keyword(s):

Bullous Pemphigoid ◽

Clinical Laboratory ◽

Case Series ◽

Dipeptidyl Peptidase ◽

Area Index ◽

Histological Features ◽

Dipeptidyl Peptidase 4 ◽

First Case ◽

Dipeptidyl Peptidase 4 Inhibitor ◽

The Mean

Bullous pemphigoid (BP) is an autoimmune blistering disease of elderly patients that has shown increasing incidence in the last decades. Higher prevalence of BP may be due to more frequent use of provoking agents, such as antidiabetic dipeptidyl peptidase-4 inhibitor (DPP4i) drugs. Our aim was to assess DPP4i-induced bullous pemphigoid among our BP patients and characterize the clinical, laboratory and histological features of this drug-induced disease form. In our patient cohort, out of 127 BP patients (79 females (62.2%), 48 males (37.7%)), 14 (9 females and 5 males) were treated with DPP4i at the time of BP diagnosis. The Bullous Pemphigoid Disease Area Index (BPDAI) urticaria/erythema score was significantly lower, and the BPDAI damage score was significantly higher in DPP4i-BP patients compared to the nonDPP4i group. Both the mean absolute eosinophil number and the mean periblister eosinophil number was significantly lower in DPP4i-BP patients than in nonDPP4i cases (317.7 ± 0.204 vs. 894.0 ± 1.171 cells/μL, p < 0.0001; 6.75 ± 1.72 vs. 19.09 ± 3.1, p = 0.0012, respectively). Our results provide further evidence that DPP4i-associated BP differs significantly from classical BP, and presents with less distributed skin symptoms, mild erythema, normal or slightly elevated peripheral eosinophil count, and lower titers of BP180 autoantibodies. To our knowledge, this is the first case series of DPP4i-related BP with a non-inflammatory phenotype in European patients.

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Challenging Presentations of Seven Cases of Gastrointestinal Basidiobolomycosis in Sudan: Clinical Features, Histology, Imaging, and Recommendations

Journal of Laboratory Physicians ◽

10.1055/s-0040-1721149 ◽

2020 ◽

Vol 12 (04) ◽

pp. 281-284

Author(s):

Sawsan A. Mohammed ◽

Azza A. Abdelsatir ◽

Mohamed Abdellatif ◽

Suliman Hussein Suliman ◽

Omer Mohammed Ibrahim Elbasheer ◽

...

Keyword(s):

Gastrointestinal Tract ◽

Fungal Infection ◽

Clinical Features ◽

Subcutaneous Tissue ◽

Case Series ◽

First Case

AbstractsBasidiobolomycosis is a fungal infection caused by Basidiobolus ranarum which affects the skin and subcutaneous tissue and rarely the gastrointestinal tract. We report seven cases of gastrointestinal basidiobolomycosis with interesting clinical, radiological, and histological presentations. To our knowledge, this is the first case series of abdominal basidiobolomycosis to be reported from Sudan.

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FIRST CASE SERIES OF VENOUS SINUS STENTING IN IIH PATIENTS IN WALES

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp-2015-312379.25 ◽

2015 ◽

Vol 86 (11) ◽

pp. e4.113-e4

Author(s):

Gauhar Abbas Malik ◽

Yogish Joshi

Keyword(s):

Intracranial Hypertension ◽

Case Series ◽

Headache Disorder ◽

Venous Sinus ◽

First Line ◽

Venous Stenting ◽

First Case ◽

Sinus Stenosis

BackgroundIdiopathic Intracranial Hypertension (IIH), is defined by increased cerebral spinal fluid (CSF) pressure in the absence of other causes of intracranial hypertension. There has been recent interest in the role of intracranial venous sinus stenosis in IIH. The raised pressures in IIH are argued to worsen by the secondary appearance of the venous sinus stenosis.Objective5 patients have undergone endovascular pressure measurement in Wales and their clinical details including history, examination, initial management, neuroimaging pre- and post venous stenting, and follow-up (6–24 months) to provide the first case study of patients undergoing Venous sinus stenting in Wales.Methods5 patients with IIH refractory to first line treatments underwent venography and manometry and 4 patients underwent stenting of the venous sinuses after this procedure had shown a pressure gradient proximal to stenosis in the lateral sinuses.ResultsThree patients were rendered asymptomatic, two were improved including one patient unmasking a different headache disorder following treatment.ConclusionsStenting in venous stenosis provides a further treatment option to patients refractory to first line treatments with IIH. This case series highlights in selected cases treatment is promising with good outcomes.

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