scholarly journals A Palpable Painless Axillary Mass as the Clinical Manifestation of Castleman’s Disease in a Patient with Hepatitis C Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Athanasia K. Papazafiropoulou ◽  
Angeliki M. Angelidi ◽  
Antonis A. Kousoulis ◽  
Georgios Christofilidis ◽  
Chariklia Sagia ◽  
...  
Keyword(s):  
Hepatitis C ◽  
White Male ◽  
Castleman’S Disease ◽  
Young Patients ◽  
Low Grade ◽  
Castleman's Disease ◽  
Complete Excision ◽  
Axillary Mass ◽  
Painless Mass ◽  
The Right

Introduction. Castleman’s disease (CD) is a rare lymphoproliferative disorder. CD is divided into two clinical subtypes: the most common unicentric and the less usual multicentric subtype. The majority of unicentric CD affects the mediastinum, while neck, abdomen, and axilla are less common locations.Case Presentation. Herein, we describe a rare case of unicentric CD in the right axilla in a 36-year-old white male with a medical history of hepatitis C virus infection admitted to our hospital due to palpation of a painless mass in the right axilla. Complete excision of the lesion was performed and, one year after the diagnosis, patient was free of the disease.Conclusions. Although infrequent, it is important to include CD in the differential diagnosis when evaluating axillary lymphadenopathy particularly in young patients with a low-grade inflammation process and chronic disease even in the absence of an abnormal blood picture or organomegaly.

scholarly journals Rare case of a liposarcoma in the brachial plexus

2016 ◽  
Vol 98 (7) ◽  
pp. e106-e108 ◽  
Author(s):  
D Kosutic ◽  
K Gajanan
Keyword(s):  
Brachial Plexus ◽  
Low Grade ◽  
Connective Tissues ◽  
Adequate Treatment ◽  
Long Term Follow Up ◽  
History Of ◽  
Axillary Mass ◽  
Painless Mass ◽  
The Right ◽  
Slow Growing

Introduction A liposarcoma is a rare cancer of connective tissues that resemble fat cells under light microscopy. Case History A 73-year old female patient presented to our tertiary cancer centre with an eight-year history of a large, slow-growing painless mass in the right axilla. Magnetic resonance imaging showed a lipomatous, well-circumscribed mass of dimension 30 × 16 × 10cm extending towards the right clavicle and causing deformation to the right chest wall and right breast. Surgery revealed a large tumour that had stretched all three cords of the brachial plexus. Histopathology was consistent with a diagnosis of a low-grade liposarcoma. After a period of neuropraxia, the patient returned to normal activities 4 months after surgery. Conclusions Although extremely rare, low-grade liposarcomas of the brachial plexus should be considered in the differential diagnosis of a slow-growing axillary mass. Referral to a tertiary sarcoma centre is essential for an appropriate diagnosis, adequate treatment, and long-term follow-up.

scholarly journals Castleman’s disease: an entity forgotten in ENT

2021 ◽  
Vol 7 (5) ◽  
pp. 905
Author(s):  
Mohamed Riyas Ali ◽  
Vikram Wadhwa ◽  
Ravi Meher ◽  
Reena Tomar ◽  
Karishma Singh ◽  
...  
Keyword(s):  
Castleman’S Disease ◽  
Treatment Modalities ◽  
Retropharyngeal Space ◽  
Castleman's Disease ◽  
Complete Excision ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Systemic Lymphadenopathy ◽  
Rare Site ◽  
Usual Site

<p class="abstract">Castleman’s disease (CD) usually presents as localized or systemic lymphadenopathy or as an extra nodal mass. The usual site of presentation are mediastinum, retroperitoneum, axilla and mesentery. Only 3 cases of CD have been reported in retro pharyngeal space. We report a case of 20 year old male patient with retropharyngeal mass. He presented with difficulty in swallowing, change in voice and respiratory distress. The mass was removed in-toto transorally after performing elective tracheostomy. The histopathological findings were consistent with hyaline vascular type of CD. He was decannulated after two day and postoperative period was uneventful. Postoperative CT imaging confirmed the complete excision of tumor and patient is on follow up, with no signs of recurrence. The presentation of tumour in the retropharyngeal space which is a rare site of occurrence add to the uniqueness of this case. Unicentric CD has an excellent prognosis and surgery is the management of choice. Its clinical features, histological subtypes, treatment modalities and prognosis are discussed.</p>

scholarly journals Castleman's Disease: An Intrapulmonary Form with Intrafissural Development

2009 ◽  
Vol 9 ◽  
pp. 940-945 ◽  
Author(s):  
Hajer Racil ◽  
Sana Cheikh Rouhou ◽  
Olfa Ismail ◽  
Saoussen Hantous-Zannad ◽  
Nawel Chaouch ◽  
...  
Keyword(s):  
Contrast Enhancement ◽  
Castleman’S Disease ◽  
Lower Lobe ◽  
Unknown Etiology ◽  
Castleman's Disease ◽  
Curative Surgery ◽  
Abnormal Shadow ◽  
History Of ◽  
Chest X Ray ◽  
The Right

Castleman's disease (CD) is an uncommon, mainly benign, lymphoproliferative disorder of unknown etiology, mostly involving the mediastinum. Parenchymal lung involvement of the disease is exceedingly rare. We describe a case of CD in a 23-year-old woman with a 4-year history of recurring dyspnea and nonproductive cough, whose chest X-ray showed an abnormal shadow of the right hilum. Chest computed tomography confirmed the presence of a tissue-density mass of the right lower lobe, demonstrating poor contrast enhancement, associated with multiple laterotracheal and mediastinal lymphadenopathies. The patient underwent curative surgery, revealing a right hilar compressive mass, with an intrafissural development between the superior and middle lobes. Pneumonectomy was performed due to profuse bleeding. This case of CD is particular because of its unusual intrapulmonary location and its intrafissural development. Poor contrast enhancement is atypical in CD.

Primary Broad Ligament Cystadenocarcinoma With Mucinous Component: A Case Report With Immunohistochemical Study

2005 ◽  
Vol 129 (2) ◽  
pp. 244-246 ◽  
Author(s):  
Karima Mrad ◽  
Maha Driss ◽  
Salma Abdelmoula ◽  
Samia Sassi ◽  
Monia Hechiche ◽  
...  
Keyword(s):  
Broad Ligament ◽  
Immunohistochemical Analysis ◽  
Cystic Mass ◽  
Low Grade ◽  
Cytokeratin 20 ◽  
Complete Excision ◽  
Mucin Production ◽  
Mucinous Component ◽  
Early Tumor ◽  
The Right

Abstract Primary cystadenocarcinoma that arises in the broad ligament is extremely rare, especially when it is mucinous. We report the case of a 59-year-old woman with a cystic mass of the right broad ligament who underwent a complete excision of the mass (7 × 7 × 3 cm) with hysterectomy, right salpingo-oophorectomy, omentectomy, appendicectomy, and peritoneal biopsies. Pathologic examination showed a low-grade cystadenocarcinoma with a mucinous component limited to the broad ligament. Despite the chemotherapy (cisplatinum and cyclophosphamide) performed, early tumor recurrence occurred after approximately 6 months. Our observation revealed an abundant mucin production with pools of mucin similar to those of pseudomyxoma peritonei and an inflammatory infiltrate with prominent lipid phagocytosis. Immunohistochemical analysis demonstrated a strong and diffuse positivity for both cytokeratin 7 and epithelial membrane antigen. A less extensive staining with carcinoembryonic antigen and a focal unequivocal positivity with cytokeratin 20, particularly in mucin-secreting cells, were also observed. This finding could indicate a metaplastic process toward colonic phenotype similar to primary ovarian tumors.

scholarly journals Localized Castleman’s Disease in the Breast in a Young Woman

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Rafael Parra-Medina ◽  
José Ismael Guio ◽  
Patricia López-Correa
Keyword(s):  
Lymphoproliferative Disorder ◽  
Histopathological Examination ◽  
Castleman’S Disease ◽  
Unknown Etiology ◽  
Castleman's Disease ◽  
Axillary Lymphadenopathy ◽  
The Right ◽  
Slow Growing ◽  
Hyaline Vascular Variant

Castleman’s disease (CD) is a rare lymphoproliferative disorder of unknown etiology. It typically occurs in adulthood but it may also develop in childhood. Clinically, this disease may be classified as localized (unicentric) or systemic (multicentric). Six cases of breast CD have been described in the literature, and all have been reported in adults. Herein we describe the case of a 15-year-old female who presented with a slow-growing tumor in the right breast. The tumor was excised and histopathological examination demonstrated hyaline vascular variant CD. After two years of follow-up, the patient was asymptomatic without evidence of cervical or axillary lymphadenopathy.

scholarly journals A case of Castleman's disease in the right pulmonary hilum that was observed for 10 years.

2002 ◽  
Vol 16 (7) ◽  
pp. 784-788 ◽  
Author(s):  
Kengo Nishimura ◽  
Takeshi Tokushima ◽  
Mikihisa Fukuta ◽  
Kaoru Nakai
Keyword(s):  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Pulmonary Hilum ◽  
The Right

scholarly journals Castleman’s Disease Presenting as a Parotid Mass in the Pediatric Population: A Report of 2 Cases

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Sean W. Delaney ◽  
Shengmei Zhou ◽  
Dennis Maceri
Keyword(s):  
Pediatric Population ◽  
Castleman’S Disease ◽  
Neck Region ◽  
Surgical Excision ◽  
Needle Aspiration ◽  
Castleman's Disease ◽  
Pathologic Examination ◽  
Diagnostic Challenge ◽  
Angiofollicular Lymph Node Hyperplasia ◽  
Complete Excision

Introduction. Angiofollicular lymph node hyperplasia (Castleman’s disease) is a nonmalignant lymphoproliferative disorder that generally involves the lymph nodes of young adults, most commonly in the mediastinum. Rarely, Castleman’s disease may present in the parotid gland. The disease can be further classified into unicentric or multicentric forms, with considerable differences in presentation, treatment, and prognosis.Case(s). We present cases of two pediatric patients, aged 7 and 11, who both presented with a slow-growing, painless parotid mass. In each case, the mass was excised via a superficial parotidectomy and the diagnosis made postoperatively upon further pathologic examination. At 6 months of follow-up, both had fully intact facial nerve function and no evidence of recurrence.Discussion. Castleman’s disease presents a diagnostic challenge in the head and neck region, as radiographic characteristics and fine needle aspiration results are often inconclusive. Definitive diagnosis requires surgical excision for pathologic examination. The unicentric form generally presents as a painless mass and can be successfully treated with complete excision. The multicentric form is associated with constitutional symptoms and its treatment remains controversial.Conclusion. Although rare, clinicians should be aware of both forms of Castleman’s disease when creating a differential diagnosis for parotid masses.

scholarly journals SEORANG WANITA DENGAN TB PARU KASUS BARU DAN TB EKSTRA PARU MULTIPLE

2019 ◽  
Vol 5 (1) ◽  
pp. 10
Author(s):  
Gandhi Estrada Atmanto ◽  
Daniel Maranatha
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Laboratory Data ◽  
Clinical Judgement ◽  
Clinical Aspects ◽  
Low Grade ◽  
Pulmonary Tb ◽  
Extra Pulmonary ◽  
Primary Focus ◽  
Painless Mass ◽  
The Right

Background; Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (Acid-Fast Bacilli/AFB) that still be a world burden. Extra Pulmonary TB occurred when there were infection and development of Mycobacterium tuberculosis outside lungs, which about 10% cases was Milliary TB. There will be reported case with Lung TB New Case coexistence with Multiple Extra Pulmonary TB. Case; A female, 39 y.o., came to the Soetomo General Teaching Hospital with chief complaint body weakness since 12 months ago following with cough, decrease of appetite, decrease of body weight, low grade fever, and night sweating. The cough was on and off, not productive, and didn`t improve with usual therapy. Her other complaint were painless mass at the left supraclavicular area, swollen and pain at the right knee, and pain at the backbones. Patient had subsequently given Anti Tuberculosis Drugs (ATD) with Streptomycin injection based on clinical judgement. Discussion;  In several cases, Primary Focus as the result of AFB infection in the lung can spread to the other organs. The diagnosis had been made from comprehensive summary of clinical aspects, radiology data, laboratory data, and Histopathology data. Consideration of ATD choice based on grouping of TB diseases (Pulmonary/Extra Pulmonary), severity level of Extra Pulmonary TB and clinical judgement Conclusion; Had reported female patient diagnosed with Lung TB New Case, Osteomyelitis TB, Spondilitis TB, and Lymphadenitis TB. Based on therapeutic evaluation there was improvement condition of the patient after administration of ATD and injection of Streptomycin.

scholarly journals Osseous Metaplasia in Castleman's Disease: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Maral Mokhtari ◽  
Perikala Vijayananda Kumar
Keyword(s):  
Lymphoid Tissue ◽  
Lymphoproliferative Disorder ◽  
Castleman’S Disease ◽  
Osseous Metaplasia ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Axillary Mass ◽  
Bone Trabeculae ◽  
Mixed Types

Background. Castleman's disease is a benign lymphoproliferative disorder. The disease may be localized or multicentric. Three histologic variants are recognized: hyaline vascular, plasma cell, and mixed types.Case. A 20-year-old man presented with large left axillary mass. The histologic examination of the resected mass showed follicular pattern with large nodules of mantle cells arranged concentrically around atrophic and vascularized germinal centers. There was also some benign-appearing bone trabeculae interspersed with lymphoid tissue. The diagnosis of Castleman's disease, hyaline-vascular type with osseous metaplasia, was made.

Unusual location for Castleman's disease

2008 ◽  
Vol 123 (1) ◽  
Author(s):  
H G Rao ◽  
I Street ◽  
R Capper
Keyword(s):  
Case Report ◽  
Castleman’S Disease ◽  
Cervical Lymphadenopathy ◽  
Castleman's Disease ◽  
Complete Excision ◽  
Unusual Location ◽  
Posterior Triangle ◽  
Left Neck ◽  
Life Threatening

AbstractObjective:We present the first reported case of persistent, posterior triangle lymphadenopathy in a child, caused by Castleman's disease.Case report:A seven-year-old boy presented with a painless swelling in the posterior triangle of his left neck, with no compression of the surrounding structures. A histological diagnosis of Castleman's disease was made. Eventual treatment was by complete excision. At six-month follow up, there were no signs of recurrence.Conclusion:The causes of persistent cervical lymphadenopathy in children are many. Most are not significant, but some are life-threatening. Castleman's disease should be considered as a possible diagnosis in persistent childhood lymphadenopathy.

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