Echocardiography as a Screening Test for Myocardial Scarring in Children with Hypertrophic Cardiomyopathy

Introduction. Hypertrophic cardiomyopathy (HCM) is burdened with morbidity and mortality including tachyarrhythmias and sudden cardiac death. These complications are attributed in part to the formation of proarrhythmic scars in the myocardium. The presence of extensive LGE is a risk factor for adverse outcomes in HCM. Late gadolinium enhancement (LGE) cardiac magnetic resonance imaging (cMRI) is the standard for the noninvasive evaluation of myocardial scars. However, echocardiography represents an attractive screening tool for myocardial scarring. The aim of this study was to compare the suitability of echocardiography to detect myocardial scars to the standard of cMRI-LGE.Methods. The cMRI studies and echocardiograms from 56 consecutive children with HCM were independently evaluated for the presence of cMRI-LGE and echocardiographic evidence of scarring by expert readers.Results. Echocardiography had a high sensitivity (93%) and negative predictive value (94%) in comparison to LGE. The false positive rate was high, leading to a low specificity (37%) and a low positive predictive value (35%).Conclusions. Given the poor specificity and positive predictive value, echocardiography is not a suitable screening test for the presence of myocardial scarring in children with HCM. However, children without echocardiographic evidence of myocardial scarring may not need to undergo cardiac magnetic resonance imaging to “rule in” LGE.

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Cardiac computed tomographic imaging to evaluate myocardial scarring/fibrosis in patients with hypertrophic cardiomyopathy: a comparison with cardiac magnetic resonance imaging

The International Journal of Cardiovascular Imaging ◽

10.1007/s10554-012-0048-y ◽

2012 ◽

Vol 29 (1) ◽

pp. 191-197 ◽

Cited By ~ 21

Author(s):

Jennifer I. Berliner ◽

Aya Kino ◽

James C. Carr ◽

Robert O. Bonow ◽

Lubna Choudhury

Keyword(s):

Magnetic Resonance Imaging ◽

Cardiac Magnetic Resonance ◽

Hypertrophic Cardiomyopathy ◽

Magnetic Resonance ◽

Cardiac Magnetic Resonance Imaging ◽

Tomographic Imaging ◽

Resonance Imaging ◽

Computed Tomographic ◽

Myocardial Scarring ◽

Computed Tomographic Imaging

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Corrigendum to “Positive predictive value for diffusion-weighted magnetic resonance imaging in pediatric cholesteatoma: A retrospective study” [Int. J. Pediatr. Otorhinolaryngol. 2020, 139:110416. doi: 10.1016/j.ijporl.2020.110416. Epub 2020 Sep 30.PMID: 33027732]

International Journal of Pediatric Otorhinolaryngology ◽

10.1016/j.ijporl.2021.110692 ◽

2021 ◽

Vol 144 ◽

pp. 110692

Author(s):

Rémi Hervochon ◽

Monique Elmaleh ◽

Martine Francois ◽

Alix Marhic ◽

Abdullah Bahakim ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Retrospective Study ◽

Magnetic Resonance ◽

Positive Predictive Value ◽

Predictive Value ◽

Resonance Imaging ◽

Diffusion Weighted ◽

Weighted Magnetic Resonance Imaging ◽

Pediatric Cholesteatoma

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Comparison of semi-automated quantification methods of late gadolinium enhancement with cardiac magnetic resonance imaging in patients with hypertrophic cardiomyopathy

Archives of Cardiovascular Diseases Supplements ◽

10.1016/j.acvdsp.2018.10.116 ◽

2019 ◽

Vol 11 (1) ◽

pp. 54

Author(s):

M. Sirol ◽

J. Gratieux ◽

S. Urtado ◽

Philippe Charron ◽

N. Mansencal ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Cardiac Magnetic Resonance ◽

Late Gadolinium Enhancement ◽

Hypertrophic Cardiomyopathy ◽

Magnetic Resonance ◽

Cardiac Magnetic Resonance Imaging ◽

Resonance Imaging ◽

Gadolinium Enhancement ◽

Automated Quantification

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Correlation of clinical examination, ultrasound, magnetic resonance imaging and arthroscopy as diagnostic tools in shoulder pathology

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20200473 ◽

2020 ◽

Vol 6 (2) ◽

pp. 247

Author(s):

Sondipon Biswas ◽

Naman Kanodia ◽

Rajat Tak ◽

Siddharth Agrawal ◽

Kiran Shankar Roy

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Rotator Cuff ◽

Positive Predictive Value ◽

Negative Predictive Value ◽

Predictive Value ◽

Gold Standard ◽

Shoulder Arthroscopy ◽

Resonance Imaging ◽

Shoulder Pathologies

Background: Shoulder pathologies can cause significant pain, discomfort, and affect the activity of daily living. The aim of this study was to compare the efficacy of clinical examination, ultrasound, magnetic resonance imaging (MRI) with shoulder arthroscopy in diagnosing various shoulder pathologies, considering shoulder arthroscopy as the gold standard tool.Methods: This was a prospective, comparative study conducted over 35 patients, between 18-75 years of age presenting with chronic shoulder pain or instability of more than 2 months duration. All patients were examined clinically, followed by high resolution ultrasound, MRI, arthroscopy of the affected shoulder.Results: The sensitivity and specificity of ultrasonography (USG) for diagnosing full thickness tear was 100% each and for MRI was 88% and 100% respectively. For subacromial impingement USG had sensitivity of 66.67%, specificity of 94.12%, positive predictive value of 50% and negative predictive value of 88.89%. For rotator cuff tear USG had sensitivity of 92.86%, specificity of 50%, positive predictive value of 81.25% and negative predictive value of 75% considering shoulder arthroscopy as gold standard.Conclusions: USG and MRI both are sensitive techniques for diagnosing of rotator cuff pathologies. USG has high accuracy in diagnosing partial thickness tears as compare to MRI. MRI proved to be superior in estimation of site and extent of tear. Considering shoulder arthroscopy as gold standard, it can be reserved for patients with suspicious of USG/MRI findings or those who may need surgical intervention simultaneously.

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