scholarly journals Polydopamine-Assisted Surface Modification for Bone Biosubstitutes

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Shishu Huang ◽  
Nuanyi Liang ◽  
Yang Hu ◽  
Xin Zhou ◽  
Noureddine Abidi
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Coating Layer ◽  
Tissue Scaffolds ◽  
Surface Modifier ◽  
Biomaterial Surface ◽  
Superior Surface ◽  
Unique Surface

Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule. This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering. A comparison between PDA-assisted coating techniques and traditional surface modification applied to bone tissue engineering is first presented. Secondly, the chemical composition and the underlying formation mechanism of PDA coating layer as a unique surface modifier are interpreted and discussed. Furthermore, several typical examples are provided to evidence the importance of PDA-assisted coating techniques in the construction of bone biosubstitutes and the improvement of material biocompatibility. Nowadays, the application of PDA as a superior surface modifier in multifunctional biomaterials is drawing tremendous interests in bone tissue scaffolds to promote the osteointegration for bone regeneration.

Chitosan in Surface Modification for Bone Tissue Engineering Applications

2019 ◽  
Vol 14 (12) ◽  
pp. 1900171 ◽  
Author(s):  
Balakrishnan Abinaya ◽  
Tandiakkal Prakash Prasith ◽  
Badrinath Ashwin ◽  
Syamala Viji Chandran ◽  
Nagarajan Selvamurugan
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications

Surface modification of PLGA/β-TCP scaffold for bone tissue engineering: Hybridization with collagen and apatite

2007 ◽  
Vol 201 (24) ◽  
pp. 9549-9557 ◽  
Author(s):  
Long Pang ◽  
Yunyu Hu ◽  
Yongnian Yan ◽  
Li Liu ◽  
Zhuo Xiong ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue

Surface modification of magnesium with a novel composite coating for application in bone tissue engineering

2022 ◽  
pp. 128078
Author(s):  
Jorgimara de O. Braga ◽  
Diogo M.M. dos Santos ◽  
Fernando Cotting ◽  
Vanessa F.C. Lins ◽  
Nádia M. Leão ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Coating

Surface modification of chitosan film via polydopamine coating to promote biomineralization in bone tissue engineering

2017 ◽  
Vol 33 (2) ◽  
pp. 134-145 ◽  
Author(s):  
Yang Liu ◽  
Zhongxun Zhang ◽  
Huilin Lv ◽  
Yong Qin ◽  
Linhong Deng
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Photoelectron Spectroscopy ◽  
Chitosan Film ◽  
Hydrophobic Surface ◽  
Modified Chitosan ◽  
Potential Applications

Chitosan-based material has been widely used as bone substitute due to its good biocompatibility and biodegradability. However, the hydrophobic surface of chitosan film constrains the osteogenesis mineralization in the process of bone regeneration. For this reason, we develop a novel polydopamine-modified chitosan film suitable for bone tissue engineering applications by a simple and feasible route in this study. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirm the process of surface modification. For comparison, surface wettability, the capacity of mineralization in vitro, and biocompatibility of the chitosan film and the polydopamine-modified chitosan film were assessed. Research results indicate that the polydopamine-modified chitosan film has good hydrophilicity. It is very evident that the polydopamine treatment significantly influences the biomineralization capacity of the chitosan-based substrates, which enhance the growth rate of apatite on the modified chitosan film. Besides, MC3T3-E1 osteoblast experiments demonstrate that the cells can adhere and grow well on the polydopamine-modified chitosan film. It is anticipated that this polydopamine-modified chitosan film, which can be prepared in large quantities simply, should have potential applications in bone tissue engineering.

Electrospun Poly(ε-Caprolactone)/Bovine Hydroxyapatite (BHA) Composite Nanofibers for Bone Tissue Engineering

2016 ◽  
Vol 720 ◽  
pp. 228-233 ◽  
Author(s):  
Memduh Kagan Keler ◽  
Sibel Daglilar ◽  
Oguzhan Gunduz
Keyword(s):  
Tissue Engineering ◽  
Mechanical Behavior ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Nanofibers ◽  
Crystalline Polymer ◽  
Tissue Scaffolds ◽  
Bovine Hydroxyapatite ◽  
Degradation Properties ◽  
Composite Designs

Tissue engineering applications have opened a different future-promising era for critical injuries, defects and diseases. Bone tissue engineering is the part of tissue engineering which aims to stir up new practical bone re-formation via the interactive combination of biomaterials and cells. Poly (e-caprolactone) (PCL) is a unique semi crystalline polymer material which handles several important features such as biocompatibility, high biomedical durability and degradation properties. Bovine hydroxyapatite (BHA) is another biocompatible material which provides to get ultimate mechanical behavior in composite designs. Because of their high biocompatibility, PCL and BHA were integrated the electrospinning system together. The system was revised for multi-feeding needle equipment. Eight dissimilar tissue scaffolds were produced and investigated for this recent work.

An introduction to bone tissue engineering

2019 ◽  
Vol 43 (2) ◽  
pp. 69-86 ◽  
Author(s):  
Željka Perić Kačarević ◽  
Patrick Rider ◽  
Said Alkildani ◽  
Sujith Retnasingh ◽  
Marija Pejakić ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Structure ◽  
Tissue Scaffolds ◽  
Pathogen Transmission ◽  
The Body ◽  
Bioactive Molecules ◽  
Advantages And Disadvantages ◽  
Degradation Rates

Bone tissue has the capability to regenerate itself; however, defects of a critical size prevent the bone from regenerating and require additional support. To aid regeneration, bone scaffolds created out of autologous or allograft bone can be used, yet these produce problems such as fast degradation rates, reduced bioactivity, donor site morbidity or the risk of pathogen transmission. The development of bone tissue engineering has been used to create functional alternatives to regenerate bone. This can be achieved by producing bone tissue scaffolds that induce osteoconduction and integration, provide mechanical stability, and either integrate into the bone structure or degrade and are excreted by the body. A range of different biomaterials have been used to this end, each with their own advantages and disadvantages. This review will introduce the requirements of bone tissue engineering, beginning with the regeneration process of bone before exploring the requirements of bone tissue scaffolds. Aspects covered include the manufacturing process as well as the different materials used and the incorporation of bioactive molecules, growth factors and cells.

scholarly journals Preparation and Properties of Biphasic Calcium Phosphate Scaffolds Multiply Coated with HA/PLLA Nanocomposites for Bone Tissue Engineering Applications

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Lei Nie ◽  
Jinping Suo ◽  
Peng Zou ◽  
Shuibin Feng
Keyword(s):  
Tissue Engineering ◽  
Compressive Strength ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Coating Layer ◽  
Multilayer Coating ◽  
High Porosity ◽  
Negative Effects ◽  
Porous Network ◽  
Layer Number

A well-developed BCP scaffolds coated with multilayer of HA/PLLA nanocomposites with interconnectivity, high porosity, and moderate compressive strength as well as good biocompatibility were fabricated for bone tissue engineering. After being multiply coated with HA/PLLA nanocomposites, the scaffolds maintained the BCP framework structure, and the porous network structure of scaffolds remained unchanged; however, the compressive strength was increased with the increase of coating layer number of HA/PLLA nanocomposites. The prepared scaffolds showed lower variation of pH values in SBF solution, and an increase of coating layer number led to the decrease of the biodegradation rate at different days. Moreover, the multilayer coating scaffolds had good cytocompatibility, showing no negative effects on cells growth and proliferation. Furthermore, the bone-like apatite layer was built obviously in the interface of scaffold after 21 days after implantation in SD rat muscle. In conclusion, the BCP scaffold coated with multilayer of HA/PLLA nanocomposites could be a candidate as an excellent substitute for damaged or defect bone in bone tissue engineering.

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