scholarly journals A Comparison of Measures of Endothelial Function in Patients with Peripheral Arterial Disease and Age and Gender Matched Controls

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Richard B. Allan ◽  
Simon V. Vun ◽  
J. Ian Spark
Keyword(s):  
Endothelial Function ◽  
Reactive Hyperemia ◽  
Arterial Disease ◽  
Peripheral Artery ◽  
Flow Mediated Dilatation ◽  
Hyperaemic Response ◽  
Artery Disease ◽  
And Gender ◽  
Peripheral Arterial ◽  
And Control

This study compared flow-mediated dilatation (FMD), peripheral artery tonometry (PAT), and serum nitric oxide (NO) measures of endothelial function in patients with peripheral artery disease (PAD) against age/gender matched controls. 25 patients (mean age: 72.4 years, M : F 18 : 7) with established PAD and an age/gender matched group of 25 healthy controls (mean age: 72.4 years, M : F 18 : 7) were studied. Endothelial function was measured using the % FMD, reactive hyperemia index (RHI) using PAT and serum NO (μmol). Difference for each method between PAD and control patients and correlation between the methods were investigated. FMD and RHI were lower in patients with PAD (median FMD for PAD = 2.16% versus control = 3.77%,p=0.034and median RHI in PAD = 1.64 versus control = 1.92,p=0.005). NO levels were not significantly different between the groups (PAD median = 7.70 μmol, control median = 13.05 μmol,p=0.662). These results were obtained in elderly patients and cannot be extrapolated to younger individuals. FMD and PAT both demonstrated a lower hyperaemic response in patients with PAD; however, FMD results in PAD patients were unequivocally reduced whereas half the PAD patients had RHI values above the established threshold for endothelial dysfunction. This suggests that FMD is a more appropriate method for the measurement of NO-mediated endothelial function.

scholarly journals Marine and plant-based n-3 PUFA and atherosclerotic cardiovascular disease

2019 ◽  
Vol 79 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Christian S. Bork ◽  
Stine K. Venø ◽  
Anne N. Lasota ◽  
Søren Lundbye-Christensen ◽  
Erik B. Schmidt
Keyword(s):  
Ischaemic Stroke ◽  
Arterial Disease ◽  
Atherosclerotic Cardiovascular Disease ◽  
Peripheral Artery ◽  
Ascvd Risk ◽  
Artery Disease ◽  
Atherosclerotic Process ◽  
Peripheral Arterial

n-3 PUFA may exert favourable effects on several processes that may inhibit the atherosclerotic process. However, the role of n-3 PUFA in lowering the risk of atherosclerotic CVD (ASCVD) has been fiercely debated. In the present paper, we summarise the main findings from previous follow-up studies of intake and studies using adipose tissue as an objective biomarker to investigate exposure to n-3 PUFA in relation to ASCVD risk and discuss some perspectives for further research. The majority of previous studies investigating intake of marine- and plant-based n-3 PUFA have focused on CHD while other ASCVD such as ischaemic stroke and peripheral artery disease have been less studied. However, recent data from Danish Diet, Cancer and Health cohort suggest that marine n-3 PUFA may be inversely associated with risk of myocardial infarction, ischaemic stroke and peripheral arterial disease caused by atherosclerosis. The effect of the plant-derived n-3 PUFA α-linolenic acid on ASCVD is less clear and several gaps in the literature remain to be explored.

scholarly journals Anticoagulation in Patients with Ischaemic Heart Disease and Peripheral Arterial Disease: Clinical Implications of COMPASS Study

2018 ◽  
Vol 13 (2) ◽  
pp. 115 ◽  
Author(s):  
Josep Gradolí ◽  
Verónica Vidal ◽  
Adrian JB Brady ◽  
Lorenzo Facila ◽  
◽  
...  
Keyword(s):  
Cardiovascular Events ◽  
Arterial Disease ◽  
Platelet Inhibition ◽  
Clinical Implications ◽  
Peripheral Artery ◽  
Everyday Clinical Practice ◽  
Major Cardiovascular Events ◽  
Novel Oral Anticoagulant ◽  
Artery Disease ◽  
Peripheral Arterial

Patients with established cardiovascular disease may suffer further cardiovascular events, despite receiving optimal medical treatment. Although platelet inhibition plays a central role in the prevention of new events, the use of anticoagulant therapies to reduce events in atheromatous disease has, until recently, been overlooked. The recent Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease (COMPASS) study showed an important reduction in cardiovascular events without increasing the risk of fatal and intracranial bleeding when using rivaroxaban, a novel oral anticoagulant, combined with aspirin. This article reviews the available evidence regarding the use of anticoagulant therapies for prevention of cardiovascular events, the results of the COMPASS study and how these results may affect patient management in everyday clinical practice.

scholarly journals Association between Peripheral Arterial Disease and Coronary Artery Disease among Tobacco User Diabetic Patients

2017 ◽  
Vol 32 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Syed Dawood Md Taimur ◽  
M Maksumul Haq ◽  
MA Rashid ◽  
SM Keramat Ali ◽  
Md Shahjahan ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Diabetic Patients ◽  
Peripheral Artery ◽  
Tobacco User ◽  
Group I ◽  
Artery Disease ◽  
Peripheral Arterial

Background: Peripheral arterial disease (PAD) is a marker of increased risk for cardiovascular events and of poorer prognosis in patients with coronary artery disease (CAD). The prevalence of unknown PAD amongst patients with ACS varies between studies according to the mode of diagnosis.Aims: To evaluate the prevalence of peripheral arterial disease (PAD) in diabetic ACS patients with or without tobacco user by using ankle brachial index (ABI).We also assess the probable predictors of PAD among these patients.Methodology: This prospective observational study was conducted in the Department of Cardiology, Ibrahim Cardiac Hospital and Research Institute, Dhaka, Bangladesh starting from 1st January 2016 to 30th April 2016 over a period of four months. A total of 60 patients were studied. They were grouped on the basis of their smoking habit. Diabetic patients with ACS and tobacco user (smoke and smoke less) in group I and without tobacco user in group II.Results: The mean age of the studied patients was 56.63 ± 8.95 years, range from 25-90 years. 73.30% was male and 26.70% was female. Twenty three patients of tobacco user in group-I (n=30) had peripheral artery disease and ten patients of group-II (n=30) had peripheral artery disease. It was statistically significant (p=0.003).Conclusion: There is correlation between peripheral arterial disease and coronary artery disease. Diagnosis and supervision of patients with PAD is important for preventing the local progression of the disease and effective secondary prevention of future coronary and cerebrovascular events.Bangladesh Heart Journal 2017; 32(1) : 3-9

Dobutamine stress cardiovascular magnetic resonance imaging in patients with peripheral artery disease

2011 ◽  
Vol 152 (8) ◽  
pp. 285-291 ◽  
Author(s):  
Róbert Kirschner ◽  
Zsolt Pécsvárady ◽  
J. Róbert Bedros ◽  
Levente Tóth ◽  
Krisztián Kiss ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Peripheral Artery Disease ◽  
Wall Motion ◽  
Arterial Disease ◽  
Dobutamine Stress ◽  
Cardiovascular Mri ◽  
Peripheral Artery ◽  
Target Heart Rate ◽  
Artery Disease ◽  
Peripheral Arterial

Patients with peripheral arterial disease often have coronary heart disease, as well. However, their assessment with classical noninvasive cardiology methods is often non-diagnostic or limited. The aim of this study was to analyze the feasibility and the risks of dobutamine stress cardiovascular MRI for cardiac evaluation of patients with peripheral arterial disease. 21 patients with peripheral artery disease (mean±SD age 64.3±7.7 years) were studied prospectively with dobutamine stress cardiovascular MRI. The protocol was completed by all of 21 patients. The target heart rate was attained in 95.2% of the studies. No serious adverse event occurred. The image quality scores (1-4) for all ventricular wall segments were high (median, interquartile range) (4 [4-4]). Five patients (23.8%) have inducible wall motion abnormality. Interobserver agreement was almost perfect for wall motion scores (κ = 0.87, p<0.0001). Dobutamine stress cardiovascular MRI is feasible with low risk for the cardiological assessment of patients with peripheral arterial disease. Orv. Hetil., 2011, 152, 285–291.

scholarly journals Peripheral arterial disease – an underappreciated clinical problem

Medicina ◽  
2008 ◽  
Vol 44 (4) ◽  
pp. 328
Author(s):  
Edita Mašanauskienė ◽  
Albinas Naudžiūnas
Keyword(s):  
Peripheral Arterial Disease ◽  
Peripheral Artery Disease ◽  
Ankle Brachial Index ◽  
Clinical Problem ◽  
Arterial Disease ◽  
Cardiovascular Complications ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Doctor's Office ◽  
Peripheral Arterial

Peripheral artery disease is a common vascular disorder. In contrast to coronary and cerebral artery disease, peripheral arterial disease remains an underappreciated condition that despite being serious and extremely prevalent is rarely diagnosed and even less frequently treated. Early diagnosis of peripheral artery disease and individual assessment of risk factors are important in preventing further cardiovascular complications. The ankle-brachial index is a simple, reliable tool for diagnosing peripheral artery disease. Many studies underscore the importance of using the ankle-brachial index to identify persons with peripheral artery disease, since peripheral artery disease is frequently undiagnosed or asymptomatic. Measurement of the ankle-brachial index is simple enough to be performed in any doctor’s office, and it is one of the most reliable indices of peripheral artery disease.

scholarly journals Gender Differences in the Medical Treatment of Peripheral Artery Disease

2021 ◽  
Vol 10 (13) ◽  
pp. 2855
Author(s):  
Damien Lanéelle ◽  
Gabriella Sauvet ◽  
Jérôme Guillaumat ◽  
Jean Eudes Trihan ◽  
Guillaume Mahé
Keyword(s):  
Peripheral Arterial Disease ◽  
Medical Treatment ◽  
Peripheral Artery Disease ◽  
Severe Disease ◽  
Arterial Disease ◽  
Peripheral Artery ◽  
Primary Health ◽  
Cardiovascular Morbidity And Mortality ◽  
Artery Disease ◽  
Peripheral Arterial

Background/Objectives: Peripheral arterial disease is a frequent and severe disease with high cardiovascular morbidity and mortality. However, female patients appear to be undertreated. Objectives: The primary goal was to compare the prescription of optimal medical treatment (OMT) of peripheral arterial disease between women and men in primary health care. Material and methods: An observational retrospective study was based on the data collected from general practitioners (GP) office in Brittany. Results: The study included 100 patients, aged 71 ± 10 years old, with 24% of women. Compared to men, women received the OMT less frequently (29.2% vs. 53.9%, p = 0.038), especially after 75 years old. Antiplatelet therapy was largely prescribed (100%), statins less frequently (70.8% women vs. 85.5% men), and prescription of renin-angiotensin-aldosterone system inhibitors was still not optimal in the two genders (41.7% women vs. 61.9% men). Active smoking is important for both women and men (33% and 30% respectively). Conclusion: Optimal medical treatment of peripheral artery disease is insufficiently prescribed, especially in women in this region of France.

The use of near-infrared spectroscopy in the diagnosis of peripheral artery disease: A systematic review

Vascular ◽  
2021 ◽  
pp. 170853812110251
Author(s):  
Tomas Baltrūnas ◽  
Valerija Mosenko ◽  
Artūras Mackevičius ◽  
Vilius Dambrauskas ◽  
Ingrida Ašakienė ◽  
...  
Keyword(s):  
Blood Flow ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Tissue Oxygenation ◽  
Arterial Disease ◽  
Diabetic Patients ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Peripheral Arterial

Background Peripheral arterial disease is a stenosis or occlusion of peripheral arteries that results in compromised blood flow and muscle ischemia. The available diagnostic methods are mostly used to measure and visualize blood flow and are not useful in the evaluation of perfusion, especially in diabetic patients, which is now considered to be a research priority by most of the vascular societies around the world as this is still a relatively poorly studied phenomenon. Objective The aim of this review is to explore the clinical significance of muscle tissue oxygenation monitoring in lower-extremity peripheral artery disease diagnosis using the near-infrared spectroscopy method. Methods A systematic search in PubMed, CINAHL, and Cochrane databases was performed to identify clinical near-infrared spectroscopy (NIRS) studies in English and Russian, published until September 2019, involving muscle tissue oxygenation in peripheral arterial disease (PAD). The manuscripts were reviewed by two researchers independently and scored on the quality of the research using MINORS criteria. Results After screening 443 manuscripts, 23 studies ( n = 1580) were included. NIRS-evaluated recovery time seems to be more accurate than ankle-brachial index in diabetic patients to differentiate between moderate and severe claudication. Consistent findings across all the included studies showed that both the oxygenation and deoxygenation rates as well as the recovery times varied from patient to patient and therefore were not suitable for standardization. Conclusions The clinical relevance of routine use of NIRS to diagnose PAD is unproven; therefore, its use is not currently part of standard-of-care for patients with PAD since the absolute values seem to vary significantly, depending on the outside conditions. More data need to be provided on the possible use of NIRS monitoring intraoperatively where the conditions can be more controlled.

scholarly journals Diagnosis of Peripheral Artery Disease using Cnn Classifier

2020 ◽  
Vol 8 (5) ◽  
pp. 5421-5425
Keyword(s):  
Peripheral Arterial Disease ◽  
Peripheral Artery Disease ◽  
Early Stage ◽  
Arterial Disease ◽  
Input Image ◽  
The Body ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Peripheral Arterial ◽  
Specific Symptoms

Peripheral Arterial Disease is common to all elderly peoples, which reduces the blood flow to the limbs. Due to PAD, the affected person unable to walk and gives pain while they try to walk. This PAD does not have any specific symptoms to affected persons in the earlier stage. This paper presents a solution to find the disease in which stage the person was affected. The Peripheral arterial disease is evaluated using convolution neural network classifier to identify in early stage to take treatments. The affected persons image (particular part of the body. Eg. Leg) is compared with the dataset. The dataset contains the collection of images that contains both normal and Peripheral arterial disease affected images. The CNN classifier compares with the dataset and shows that the given input image is in normal stage or it is affected by the Peripheral Artery disease. The accuracy level is high. This methodology helps to find the disease in earlier stage

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