PECAM-1 Leu125Val (rs688) Polymorphism and Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus

Objectives. Platelet endothelial cell adhesion molecule-1 (PECAM-1) plays a key role in the transendothelial migration of circulating leukocytes during inflammation and in the maintenance of vascular endothelial integrity. We hypothesized that genetic variation inPECAM-1gene could be associated with diabetic nephropathy (DN) and with the level of soluble PECAM-1 in Caucasians with type 2 diabetes mellitus (T2DM).Design and Methods. We analyzed the rs688 single nucleotide polymorphism ofPECAM-1gene C373G (Leu125Val) at exon 3, which encodes the first extracellular Ig-like domain that mediates the homophilic binding of PECAM-1, in 276 T2DM subjects with documented DN (cases) and 375 T2DM subjects without DN (controls), using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy. Level of plasma soluble PECAM-1 (sPECAM-1) was measured by ELISA in a subpopulation of 120 diabetics with DN.Results. We found no association between the Leu125Val polymorphism and DN in subjects with T2DM. Likewise, the Leu125Val polymorphism was not associated with serum sPECAM-1 levels in a subpopulation of 120 diabetics with DN.Conclusion. The Leu125Val polymorphism of PECAM-1 and the level of sPECAM-1 are not associated with DN in T2DM subjects of Slovenian origin.

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Leukocyte–endothelial cell adhesion molecule 1 (LECAM-1) polymorphism is associated with diabetic nephropathy in type 2 diabetes mellitus

Journal of Diabetes and its Complications ◽

10.1016/s1056-8727(01)00226-4 ◽

2002 ◽

Vol 16 (5) ◽

pp. 333-337 ◽

Cited By ~ 12

Author(s):

Kenji Kamiuchi ◽

Goji Hasegawa ◽

Hiroshi Obayashi ◽

Akane Kitamura ◽

Michiyo Ishii ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Cell Adhesion ◽

Endothelial Cell ◽

Cell Adhesion Molecule ◽

Cell Adhesion Molecule 1 ◽

Endothelial Cell Adhesion

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Level of hydrogen sulfide in patients with type 2 diabetes mellitus depending on the presence of diabetic nephropathy

Acta Medica Leopoliensia ◽

10.25040/aml2017.04.012 ◽

2017 ◽

Vol 23 (4) ◽

pp. 12-14

Author(s):

D.Yu. Kutsyk ◽

◽

Ye.Ya. Sklyarov ◽

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Hydrogen Sulfide

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Faculty Opinions recommendation of A randomized controlled study of finerenone versus placebo in Japanese patients with type 2 diabetes mellitus and diabetic nephropathy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727146123.793527044 ◽

2017 ◽

Author(s):

Luis Ruilope ◽

Enrique Morales

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Japanese Patients ◽

Randomized Controlled Study ◽

Controlled Study ◽

Randomized Controlled

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PGNMID in a patient with diabetes mellitus

Journal of Onco-Nephrology ◽

10.1177/2399369320984782 ◽

2021 ◽

pp. 239936932098478

Author(s):

Joana Marques ◽

Patrícia Cotovio ◽

Mário Góis ◽

Helena Sousa ◽

Fernando Nolasco

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Renal Disease ◽

Renal Involvement ◽

Organ Damage ◽

Therapeutic Implications ◽

Stage Renal Disease

Diabetic nephropathy is a well known complication of diabetes mellitus and the leader cause of end -stage renal disease worldwide. Nonetheless, other forms of renal involvement can occur in diabetic population. Since it has prognostic and therapeutic implications, differentiating non-diabetic renal disease from diabetic nephropathy is of great importance. We report an 80-year-old man with well-controlled type 2 diabetes mellitus and hypertension, who presented with rapid deterioration of renal function, nephrotic proteinuria, microscopic hematuria and leukocyturia. The atypical clinical presentation prompted us to perform a kidney biopsy. A diagnosis of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (light chain only variant) was made, with however some chronic histological aspects which made us took a conservative therapeutic attitude. We emphasize that other causes of chronic proteinuric kidney disease should be considered in patients with type 2 diabetes mellitus, based on clinical suspicion, absence of other organ damage and mostly if an atypical presentation is seen. We review the spectrum of monoclonal gammopathies of renal significance, focusing on this rare and newly describe entity.

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Increased resting metabolic rate in patients with type 2 diabetes mellitus accompanied by advanced diabetic nephropathy

Metabolism ◽

10.1016/j.metabol.2004.06.004 ◽

2004 ◽

Vol 53 (11) ◽

pp. 1395-1398 ◽

Cited By ~ 9

Author(s):

Kiyoko Nawata ◽

Motoi Sohmiya ◽

Mikiko Kawaguchi ◽

Masateru Nishiki ◽

Yuzuru Kato

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Metabolic Rate ◽

Resting Metabolic Rate

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Serum lipoprotein(a) levels and diabetic nephropathy among Japanese patients with type 2 diabetes mellitus

Journal of Diabetes and its Complications ◽

10.1016/j.jdiacomp.2016.02.006 ◽

2016 ◽

Vol 30 (5) ◽

pp. 923-927 ◽

Cited By ~ 10

Author(s):

Hidenori Senba ◽

Shinya Furukawa ◽

Takenori Sakai ◽

Tetsuji Niiya ◽

Teruki Miyake ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Japanese Patients ◽

Serum Lipoprotein ◽

Lipoprotein A

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704 Depression and Diabetic Nephropathy in Type 2 Diabetes Mellitus

Asian Journal of Psychiatry ◽

10.1016/s1876-2018(11)60349-3 ◽

2011 ◽

Vol 4 ◽

pp. S90

Author(s):

Y. Themeli ◽

M. Barbullushi ◽

A. Idrizi ◽

V. Bajrami ◽

K. Zaimi ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy

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TheType 2 Deiodinase Thr92Ala PolymorphismIs Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Journal of Diabetes Research ◽

10.1155/2016/5928726 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 7

Author(s):

Xiaowen Zhang ◽

Jie Sun ◽

Wenqing Han ◽

Yaqiu Jiang ◽

Shiqiao Peng ◽

...

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Glycemic Control ◽

Meta Analysis ◽

Increased Risk ◽

Design And Methods ◽

Hba1c Levels

Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM patients as marked by the HbA1C levels.Design and Methods.The terms “rs225014,” “thr92ala,” “T92A,” or “dio2 a/g” were used to search for eligible studies in the PubMed, Embase, and Cochrane databases and Google Scholar. A systematic review and meta-analysis of studies including both polymorphism testing and glycated hemoglobin (HbA1C) assays were performed.Results. Four studies were selected, totaling 2190 subjects. The pooled mean difference of the studies was 0.48% (95% CI, 0.18–0.77%), indicating that type 2 diabetics homozygous for the Dio2 Thr92Ala polymorphism had higher HbA1C levels.Conclusions. Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in T2DM patients. To confirm this conclusion, more studies of larger populations are needed.

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