scholarly journals Clinical Trial Assessing the Efficacy of Gabapentin Plus B Complex (B1/B12) versus Pregabalin for Treating Painful Diabetic Neuropathy

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Alberto Mimenza Alvarado ◽  
Sara Aguilar Navarro
Keyword(s):  
Diabetic Neuropathy ◽  
Pain Intensity ◽  
Statistical Difference ◽  
Painful Diabetic Neuropathy ◽  
Efficacy And Safety ◽  
Analog Scale ◽  
Safety And Efficacy ◽  
Significant Statistical Difference ◽  
Severe Intensity ◽  
Reduction Of Pain

Introduction. Painful diabetic neuropathy (PDN) is a prevalent and impairing disorder. The objective of this study was to show the efficacy and safety of gabapentin (GBP) plus complex B vitamins: thiamine (B1) and cyanocobalamine (B12) compared to pregabalin in patients with moderate to severe intensity PDN.Method. Multicenter, randomized, blind study. Two hundred and seventy patients were evaluated, 147 with GBP/B1/B12 and 123 with PGB, with a 7/10 pain intensity on the Visual Analog Scale (VAS). Five visits (12 weeks) were scheduled. The GBP/B1 (100 mg)/B12 (20 mg) group started with 300 mg at visit 1 to 3600 mg at visit 5. The PGB group started with 75 mg/d at visit 1 to 600 mg/d at visit 5. Different safety and efficacy scales were applied, as well as adverse event assessment.Results. Both drugs showed reduction of pain intensity, without significant statistical difference (P=0.900). In the GBP/B1/B12 group, an improvement of at least 30% on VAS correlated to a 900 mg/d dose, compared with PGB 300 mg/d. Likewise, occurrence of vertigo was lower in the GBP/B1-B12 group, with a significant statistical difference,P=0.014.Conclusions. Our study shows that GPB/B1-B12 combination is as effective as PGB. Nonetheless, pain intensity reduction is achieved with 50% of the minimum required gabapentin dose alone (800 to 1600 mg/d) in classic NDD trials. Less vertigo and dizziness occurrence was also observed in the GBP/B1/B12 group. This trial is registered with ClinicalTrials.govNCT01364298.

scholarly journals Qualitative and quantitative aspects of pain in lateral posterior thoracotomy patients

2006 ◽  
Vol 14 (5) ◽  
pp. 708-712 ◽  
Author(s):  
Thaiza Teixeira Xavier ◽  
Gilson de Vasconcelos Torres ◽  
Vera Maria da Rocha
Keyword(s):  
Pain Intensity ◽  
Statistical Difference ◽  
Descriptive Study ◽  
Pain Scale ◽  
Study Group ◽  
Men And Women ◽  
Evaluation Form ◽  
Qualitative And Quantitative ◽  
Significant Statistical Difference ◽  
Lateral Posterior

Descriptive study that proposed to compare the qualitative and quantitative behavior of the pain in lateral posterior thoracotomy patients. The sample was consisted of 18 individuals with an average age of 44 years. The instruments used were physiotherapy evaluation form, numerical pain scale and McGill questionnaire for pain. The pain on the numerical pain scale was considered moderate(5) for both sexes. The descriptors of the McGill questionnaire choosen by the patients with higher frequency were: in the sensorial component, beat4, pointed1, shock2, final and pull2; in the afetive component, tired1, bored1, punishald1 and miserable1 and in the evaluative component was flat. The characteristics of pain in the sensorial group were more evidents on male group. No significant statistical difeferences were observed between quantitative answers concerning pain between the men and women. On the qualitative aspects , was observed an predominancy of the same descriptors of pain in afetive component for both sexes. Pain intensity was categorized as moderate. No significant statistical difference were observed between the pain on the post-operatory lateral posterior thoracotomy. These data demonstrate a necessity for an analysis with a larger study group.

scholarly journals Efficacy and Safety of Lacosamide in Painful Diabetic Neuropathy

Diabetes Care ◽  
2010 ◽  
Vol 33 (4) ◽  
pp. 839-841 ◽  
Author(s):  
D. Ziegler ◽  
T. Hidvegi ◽  
I. Gurieva ◽  
S. Bongardt ◽  
R. Freynhagen ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Painful Diabetic Neuropathy ◽  
Efficacy And Safety

scholarly journals Efficacy and Safety of TENS and Duloxetine in Patients with Painful Diabetic Neuropathy: A Single Blind Randomized Clinical Trial

2021 ◽  
Vol 29 (136) ◽  
pp. 286-292
Author(s):  
Bahram Naderi Nabi ◽  
Alia Saberi ◽  
Babak Bakhshayesh Eghbali ◽  
Mozaffar Hosseininezhad ◽  
Gelareh Biazar ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Diabetic Neuropathy ◽  
Randomized Clinical Trial ◽  
Painful Diabetic Neuropathy ◽  
Efficacy And Safety ◽  
Single Blind

scholarly journals Influence of different width/height ratio of maxillary anterior teeth in the attractiveness of gingival smiles

2012 ◽  
Vol 17 (5) ◽  
pp. 115-122 ◽  
Author(s):  
Ana Carolina Guimarães Borges ◽  
Mayra Reis Seixas ◽  
Andre Wilson Machado
Keyword(s):  
Visual Analog Scale ◽  
Statistical Difference ◽  
Height Ratio ◽  
Analog Scale ◽  
Significant Statistical Difference ◽  
Anterior Teeth ◽  
Significant Difference ◽  
Caucasian Women ◽  
Lower Arch ◽  
Exposure Methods

OBJECTIVE: To evaluate, among laypersons and orthodontists, the influence of the width/height proportions of upper anterior teeth on the smile attractiveness, in photographs of close up smile from three adult Caucasian women, with 4 mm of gingival exposure. METHODS: The photographs of close up smiles were digitally manipulated and six images were created from each smile with teeth's width/height proportions in 65%, 70%, 75%, 80%, 85% and 90%. Then, all these images were manipulated again and a black mask covering all teeth from the lower arch was created. The figures were then assessed by 60 evaluators, 30 orthodontists and 30 laypersons, who assigned, in a visual analog scale, the level of attractiveness of each image. RESULTS: The obtained results, in general, showed that the proportions of 75%, 80% and 85% received the highest scores while the proportion of 65% received the lowest scores, for both groups of examiners (p < 0.05). When orthodontists and laypersons were compared, it was not found, in most situations, a significant statistical difference between their assessments (p > 0.05). Yet, the comparison between scores assigned to smiles with and without inferior teeth showed that, for all situations, there was no statistically significant difference between them (p > 0.05). CONCLUSION: For patients with gingival smile, the width/height proportions of upper anterior teeth considered more esthetic were the ones of 75%,80% and 85% for laypersons and orthodontists, and the presence or absence of inferior teeth did not affect the attractiveness level of the assessed smiles.

scholarly journals 10-kHz spinal cord stimulation treatment for painful diabetic neuropathy: results from post-hoc analysis of the SENZA-PPN study

2020 ◽  
Vol 10 (5) ◽  
pp. 291-300 ◽  
Author(s):  
Vincent Galan ◽  
James Scowcroft ◽  
Paul Chang ◽  
Sean Li ◽  
Peter Staats ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Diabetic Neuropathy ◽  
Spinal Cord Stimulation ◽  
Painful Diabetic Neuropathy ◽  
Sensory Testing ◽  
Analog Scale ◽  
Prospective Multicenter Study ◽  
Peripheral Polyneuropathy ◽  
Post Hoc

Aim: Previous studies of 10 kHz spinal cord stimulation demonstrated its safety and efficacy for treatment of neuropathic pain of the trunk and/or limbs. This study analyzed data from a subset of subjects with painful diabetic neuropathy enrolled in a prospective, multicenter study of peripheral polyneuropathy with various etiologies. Materials & methods: Of the eight subjects that had permanent devices, seven attended the 12-month follow-up assessment. Results & conclusion: At 12 months, 6/7 subjects were treatment responders (≥50% pain relief) and had pain remission (visual analog scale ≤ 3.0 cm). Worsening of neurologic deficits was not reported in any subject. Instead, 5/7 subjects showed improvements in sensory testing and/or reflexes. These results support further investigation of 10 kHz spinal cord stimulation as a safe and effective treatment for intractable painful diabetic neuropathy.

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