Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid

Background: Voriconazole is an antifungal drug used as one of the first-line treatments for invasive aspergillosis. This drug is extensively metabolized, predominantly via cytochrome P450 enzymes. An interaction between flucloxacillin and voriconazole, leading to subtherapeutic voriconazole concentrations, has previously been reported. We aimed to demonstrate that flucloxacillin independently influences voriconazole exposure. Methods: Patients from three Belgian hospitals, treated with a combination of voriconazole and flucloxacillin, were included in this retrospective study. Voriconazole concentrations were collected both in a timeframe with and without flucloxacillin co-treatment. Multivariate analyses were performed to study the independent effect of flucloxacillin treatment on voriconazole exposure and the possible influence of the flucloxacillin dose. Results: Thirty-three patients were included in this study and 145 trough concentrations (51 with, and 94 without concomitant flucloxacillin treatment) were analyzed. The median (IQR) voriconazole trough concentration sampled during flucloxacillin co-treatment was 0.5 (0–1.8) mg/L, whereas samples without flucloxacillin co-treatment had a median (IQR) voriconazole trough concentration of 3.5 (1.7–5.1) mg/L (p = 0.002), while receiving similar voriconazole doses. Subtherapeutic concentrations (<1 mg/L) were observed in 69% and 7% of the samples with flucloxacillin co-treatment versus samples without flucloxacillin co-treatment, respectively. Conclusion: This study shows that flucloxacillin co-treatment independently decreases voriconazole exposure. Caution is needed when these two drugs are administered simultaneously.

Recent Advances in Photoalignment Liquid Crystal Polarization Gratings and Their Applications

Liquid crystal (LC) circular polarization gratings (PGs), also known as Pancharatnam–Berry (PB) phase deflectors, are diffractive waveplates with linearly changed optical anisotropy axes. Due to the high diffraction efficiency, polarization selectivity character, and simple fabrication process, photoalignment LC PGs have been widely studied and developed especially in polarization management and beam split. In this review paper, we analyze the physical principles, show the exposure methods and fabrication process, and present relevant promising applications in photonics and imaging optics.

Increasing Social Media Presence for Graduate Medical Education Programs

Virtual residency interviews during COVID-19 pandemic created a need for residency programs to use social media to increase their visibility and connect with potential applicants. This was, however, new and a road never travelled for many programs. This report describes how our General Surgery Residency Program increased its presence through social media by using various exposure methods and approaches, including diversifying presence and developing candid personalized content. Results suggest that these methods have increased our exposure and reach from an average of 7 people per post to posts reaching over 4500 people. Moreover, the video posts introducing our residents and faculty provided the highest activity and reach. Thus, appropriate use of social media with described interventions and new content creation could exponentially increase the visibility of a residency program. Moreover, educating faculty and residents on the use and importance of social media could increase their interest and participation as well.

Holographic Grating Enhancement of TI/PMMA Polymers in the Dark Diffusion Process

The dark diffusion enhancement process (DDEP) caused by photopolymerization during the pre-exposure of TI/PMMA (titanocene dispersed methyl methacrylate matrix) polymers was theoretically analyzed and experimentally investigated, revealing the holographic grating enhancement of TI/PMMA polymers in the post-exposure process without additional operations. The diffusion of photo-initiators and photoproducts dominated the grating enhancement process after exposure. We adopted two pre-exposure methods, long-time (second level) and short-time (millisecond level) laser exposure, at 532 nm, to investigate the DDEP during the post-exposure process. A five-fold enhancement in grating strength was achieved in consecutive long-time pre-exposures, while a two-fold grating development was examined after short-time exposure. Additionally, the exposure durations and repetition rates influenced the grating increment of the DDEP. This study provided a basis for the feasibility of holographic application in TI/PMMA photopolymers via the dark diffusion effect.

The impact of K-beauty social media influencers, sponsorship, and product exposure on consumer acceptance of new products

This research identified the different ways in which K-beauty social media influencers (SMIs) impact consumers’ tendencies to accept new products by closely investigating their sponsorship displays and product exposure methods. We conducted an experiment to examine how influencers’ posts affect Chinese millennial consumers’ acceptance of new products. We used a 2 (influencer type: celebrity versus general public) × 2 (sponsorship display status: display versus no display) × 2 (product exposure method: exposure versus no exposure) factorial design. The findings reveal that the social media posts that made consumers most likely to accept a new product were created by a general public influencer and did not include a display of any sponsorship affiliation with the product. Additionally, there was a significant interplay between the influencer type, sponsorship display status, and product exposure method regarding consumers’ acceptance intention toward a new product. A consumer was most likely to accept and purchase a new product when three factors (general public influencer, sponsorship displayed, and product exposed) were combined. Based on the findings, we draw important implications and present marketing strategies for companies in the beauty industry that use SMI marketing.

A Review on Epidemiological and Clinical Studies on Buckwheat Allergy

Background: Cultivated buckwheat include two species originating from China: common buckwheat (Fagopyrum esculentum) and tartary buckwheat (Fagopyrum tartaricum). Buckwheat can cause IgE-mediated allergy, including severe allergic reactions and anaphylaxis. Exposure can occure when eating buckwheat food (food allergen), when producing or handling buckwheat food (occupational exposure) or when sleeping on buckwheat husk pillows (houeshold environmental exposure). Methods: A search on buckwheat allergy in the medical datbase PubMed from 1970–2020. Result: A number of allergenic proteins have been identified in common buckwheat (e.g., Fag e 1, Fag e 2 and Fag e 3) and in tartary buckwheat (e.g., Fag t 1, Fag t 2, Fag t 3). Clinically relevant cross-reactivity has been described between buckwheat and peanut, latex, coconut, quinoa, and poppy seed. The prevalence of buckwheat allergy in the population can be estimated as 0.1–0.4% in Japan, Korea and buckwheat consuming areas of China. Among patients in allergy clinics in different countries, 2–7% has confirmed buckwheat allergy. School studies from Japan and Korea found 4–60 cases of buckwheat-related anaphylaxis per 100,000 school children. The incidence of severe allergic reactions to buckwheat, including anaphylaxis, can be estimated as 0.1–0.01 cases per 100,000 person-years. Conclusions: Buckwheat allergy is a neglected allegy deserving further attention but severe allergic reactions are rare.

Thermal Exposure Methods Intensification by the Use of Catalysts

The article reviewed the catalysts used for upgrading high-viscosity oil in the reservoir. It is concluded that the most widespread and effective catalysts are oil-soluble complexes based on transition metals.