Ulcerative Colitis and Its Association withSalmonellaSpecies

Ulcerative colitis (UC) is characterized by presence of ulcer in colon and bloody diarrhea. The present study explores the possibility of association betweenSalmonellaand ulcerative colitis. The present study comprised 59 cases of UC, 28 of colon cancer (CC), 127 of irritable bowel syndrome (IBS), and 190 of healthy control. The serological study was done by Widal and Indirect Haemagglutination Assay (IHA) for ViAb. Nested PCR was performed targetingfliC,staA,andstkGgene for Typhi and Paratyphi A, respectively. A total of 15.3% patients were positive forSalmonella“O” antigen among them 18.6% UC, 35.5% CC, 12.6% IBS, and 15.3% healthy control. A total of 36.9% patients were positive for “H” antigen including 39.0%, 57.1%, and 67.7% UC, CC, and IBS, respectively. About 1.73% show positive agglutination for AH antigen including 3.4%, 3.6%, and 1.6%, UC, CC, and IBS. A total of 10.89% were positive for ViAb. While 6.8% of UC, 10.7% of CC, 11.0% of IBS, and 12.1% of healthy subjects were positive for the antibody, the PCR positivity rates forSalmonellaspecific sequences were 79.7% in UC, 53.6% in CC, 66.1% in IBS, and 16.3% in healthy controls. The present study suggested that higher prevalence ofSalmonellamight play important role in etiopathogenesis of UC, IBS, and CC.

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Comparison of the metabolomic profiles of irritable bowel syndrome patients with ulcerative colitis patients and healthy controls: new insights into pathophysiology and potential biomarkers

Alimentary Pharmacology & Therapeutics ◽

10.1111/apt.15141 ◽

2019 ◽

Vol 49 (6) ◽

pp. 723-732 ◽

Cited By ~ 9

Author(s):

Ammar Hassanzadeh Keshteli ◽

Karen L. Madsen ◽

Rupasri Mandal ◽

Guy E. Boeckxstaens ◽

Premysl Bercik ◽

...

Keyword(s):

Ulcerative Colitis ◽

Irritable Bowel Syndrome ◽

Healthy Controls ◽

Irritable Bowel ◽

Potential Biomarkers

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Vascular endothelial growth factor, endostatin levels and clinical features among patients with ulcerative colitis and irritable bowel syndrome and among healthy controls: a cross-sectional analytical study

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2018.0274161118 ◽

2018 ◽

Vol 136 (6) ◽

pp. 543-550 ◽

Cited By ~ 2

Author(s):

Evrim Kahramanoğlu Aksoy ◽

Hülya Çetinkaya ◽

Berna Savaş ◽

Arzu Ensari ◽

Murat Torgutalp ◽

...

Keyword(s):

Ulcerative Colitis ◽

Vascular Endothelial Growth Factor ◽

Irritable Bowel Syndrome ◽

Growth Factor ◽

Analytical Study ◽

Vascular Endothelial ◽

Healthy Controls ◽

Cross Sectional ◽

Irritable Bowel ◽

Endothelial Growth Factor

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Sa1883 – Alterations in Functional and Microstructural Default Mode Network Connectivity in Ulcerative Colitis and Irritable Bowel Syndrome Patients Compared to Healthy Controls Correlates with Anxiety Measures

Gastroenterology ◽

10.1016/s0016-5085(19)37949-1 ◽

2019 ◽

Vol 156 (6) ◽

pp. S-441

Author(s):

Joanna Turkiewicz ◽

Ravi Bhatt ◽

Arpana Gupta ◽

Charles N. Bernstein ◽

Emeran A. Mayer

Keyword(s):

Ulcerative Colitis ◽

Irritable Bowel Syndrome ◽

Default Mode Network ◽

Network Connectivity ◽

Healthy Controls ◽

Default Mode ◽

Irritable Bowel

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Circulating neurotransmitter levels in irritable bowel syndrome: correlation of laboratory tests and clinical findings

South Russian Journal of Therapeutic Practice ◽

10.21886/2712-8156-2020-1-2-72-77 ◽

2020 ◽

Vol 1 (2) ◽

pp. 72-77

Author(s):

R. V. Vidiker ◽

N. V. Trubina ◽

A. R. Babaeva

Keyword(s):

Ulcerative Colitis ◽

Irritable Bowel Syndrome ◽

Healthy Subjects ◽

Clinical Manifestations ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Blood Levels ◽

Blood Concentrations ◽

Low Levels ◽

Irritable Bowel

Objective: to estimate blood levels of serotonin and melatonin neurotransmitters in patients with irritable bowel syndrome and to evaluate the role of neurohumoral imbalance in the development and clinical manifestations of irritable bowel syndrome phenotypes.Materials and methods: the study included 60 patients (range, 18 – 45 years) diagnosed with irritable bowel syndrome according to the Roman IV criteria for irritable bowel syndrome (2016). 20 patients with a confirmed diagnosis of ulcerative colitis (UC) were assigned to a comparison group. The control group was composed of 45 apparently healthy subjects. All subjects were assigned to subgroups based on the prominent clinical presentation: irritable bowel syndrome with constipation (IBS-C), irritable bowel syndrome with diarrhea (IBS-D) and mixed irritable bowel syndrome (IBS-M). In addition to all the necessary procedures (clinical, laboratory and instrumental), blood concentrations of endogenous serotonin and melatonin were measured using enzyme-linked immunosorbent assay (ELISA).Results: the concentrations of endogenous serotonin and melatonin were significantly lower in patients with irritable bowel syndrome as compared with those having ulcerative colitis or healthy individuals. The detection rates of lowering serotonin levels were 53.3 % and 65 % — for melatonin. Low levels of melatonin were detected both in IBS-D and IBS-C patients. 69.57 % of IBS-D patients had elevated levels of serotonin as compared with the reference values for healthy subjects. We found a strong correlation between the severity of bloating and abdominal pain on the one hand, and low levels of endogenous serotonin and melatonin, on the other hand.Conclusion: our findings suggest that serotonin and melatonin neurotransmitters play a significant role in the pathophysiology and clinical manifestations of estimate blood levels of serotonin and melatonin neurotransmitters in patients with irritable bowel syndrome.

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