scholarly journals Volumetric Magnetic Resonance Imaging Study of Brain and Cerebellum in Children with Cerebral Palsy

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Piotr Kułak ◽  
Elżbieta Maciorkowska ◽  
Elżbieta Gościk

Introduction. Quantitative magnetic resonance imaging (MRI) studies are rarely used in the diagnosis of patients with cerebral palsy. The aim of present study was to assess the relationships between the volumetric MRI and clinical findings in children with cerebral palsy compared to control subjects.Materials and Methods. Eighty-two children with cerebral palsy and 90 age- and sex-matched healthy controls were collected.Results. The dominant changes identified on MRI scans in children with cerebral palsy were periventricular leukomalacia (42%) and posthemorrhagic hydrocephalus (21%). The total brain and cerebellum volumes in children with cerebral palsy were significantly reduced in comparison to controls. Significant grey matter volume reduction was found in the total brain in children with cerebral palsy compared with the control subjects. Positive correlations between the age of the children of both groups and the grey matter volumes in the total brain were found. Negative relationship between width of third ventricle and speech development was found in the patients. Positive correlations were noted between the ventricles enlargement and motor dysfunction and mental retardation in children with cerebral palsy.Conclusions. By using the voxel-based morphometry, the total brain, cerebellum, and grey matter volumes were significantly reduced in children with cerebral palsy.

2008 ◽  
Vol 20 (4) ◽  
pp. 609-615 ◽  
Author(s):  
C. M. Modlesky ◽  
S. A. Kanoff ◽  
D. L. Johnson ◽  
P. Subramanian ◽  
F. Miller

2010 ◽  
Vol 258 (3) ◽  
pp. 471-478 ◽  
Author(s):  
Rajniti Prasad ◽  
Nishant Verma ◽  
A. Srivastava ◽  
B. K. Das ◽  
O. P. Mishra

2009 ◽  
Vol 51 (1) ◽  
pp. 39-45 ◽  
Author(s):  
MARNIE N ROBINSON ◽  
LYNDAL J PEAKE ◽  
MICHAEL R DITCHFIELD ◽  
SUSAN M REID ◽  
ANNA LANIGAN ◽  
...  

2019 ◽  
Vol 9 (1) ◽  
pp. 52-60
Author(s):  
V. V. Dulnev ◽  
Т. A. Slyusar’

Background. In children with cerebral palsy, high risk of cognitive impairments connected with sensory disintegration – delayed visual and auditory perception.The objective – assessment of temporary and amplitude characteristics brainstem auditory evoked potentials of children with cerebral palsy.Materials and methods. Neurological examination, retrospective analysis of magnetic resonance imaging data of brain and 2-channel brainstem auditory evoked potentials registration with left- and right-ear stimulation and analysis was performed for 60 children aged 4–17 years, with mean age 11.80 ± 0.56 years.Results. There are no significant difference in brainstem auditory evoked potentials latencies of children’s with cerebral palsy age subgroups. A significantly increasing of III–V peak latencies of brainstem auditory evoked potentials and also I–III and I–V interpeak latencies was observed in children with cerebral palsy in comparison of control group. Latencies of different brainstem auditory evoked potentials peaks were significantly higher in children with uni- and bilateral form of cerebral palsy and speech impairment. Group with periventricular leucomalation (on magnetic resonance imaging) is characterized by significantly increased brainstem auditory evoked potentials latencies and normal interpeak intervals. These abnormalities may be linked to non-progressive impairment of brainstem acoustic afferentation.Conclusion. Impairment of brainstem auditory evoked potentials maturation and it’s difference in various cerebral palsy forms may be potentially clinical applicable for assessment of the children and early detection of sensory impairment.


2021 ◽  
Author(s):  
Prastiya Indra Gunawan ◽  
Riza Noviandi ◽  
Sunny Mariana Samosir

Abstract Background Cerebral palsy (CP) leads to a common static motor neurological disease in children that can be demonstrated with varied neuroimaging findings. Magnetic Resonance Imaging (MRI) has a vital role of determining the presence of brain injury and its extent, with any possibility of determining pathogenic pattern and disease severity. The objective of the study is to evaluate the neuroimaging findings in CP and their correlation to disease severity. Method The research was case-control study, consecutive and complete records of all patients who had a clinical diagnosis of CP and performed a head MRI between 2018 and 2019 were enrolled in this study. Cases group were children diagnosed as severe CP with The Gross Motor Function Classification System (GMFCS) IV-V. Control group were children confirmed as CP with GMFCS I-III. Brain imaging was examined by MRI, in which the abnormalities were classified into grey matter or white matter injury, focal vascular disorder and brain malformation. Kruskal-Wallis statistical analysis was applied to identify the correlation. Results Almost 60 cases were reviewed. White matter injury, malformation and focal vascular insult were not correlated significantly to CP severity (OR = 0.73; 95% CI = 0.2-2.2; p = 0.78 and OR = 0.61; 95% CI = 0.2-1.9; p = 0.57 and OR = 2.034; 95% CI = 0.51-0.76; p = 0.63, respectively). Grey matter injury was more frequent discovered in severe CP (50%) and increased the risk of CP severity (OR = 9; 95% CI = 2.2 – 36; p = 0.002). Conclusion Grey matter injury is considered the most frequent abnormalities of Brain MRI in CP and it could increase the risk of severity.


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