scholarly journals Comparison of Two Different OCT Systems: Retina Layer Segmentation and Impact on Structure-Function Analysis in Glaucoma

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Livia M. Brandao ◽  
Anna A. Ledolter ◽  
Andreas Schötzau ◽  
Anja M. Palmowski-Wolfe
Keyword(s):  
Structure Function ◽  
Linear Models ◽  
Function Analysis ◽  
Open Angle Glaucoma ◽  
Statistical Significance ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Layer Segmentation

Purpose. To compare two different spectral-domain optical coherence tomography (OCT) systems in regard to full macular thickness (MT) and ganglion cell layer-inner plexiform layer (GCIPL) measures and in regard to structure-function correlation when compared to standard automated perimetry (SAP).Methods. Seventeen primary open angle glaucoma patients and 16 controls (one eye per subject) were enrolled. MT and GCIPL thicknesses were measured by Cirrus and Spectralis OCTs. Octopus Perimeter 101 (G2 protocol) reports sensitivity in mean defect (dB). Differences between measurements were assessed with Student’st-test and Bland Altman. Diagnostic performance was also compared between each parameter calculating the areas under the operator receiver (ROC). Linear models were used to investigate structure-function association between OCT and SAP.Results. Disagreement between OCTs in both MT and GCIPL values was significant. Spectralis values were thicker than Cirrus. Average difference between OCTs was 21.64 μm (SD 4.5) for MT and 9.8 μm (SD 5.4) for GCIPL (p<0.001). Patients differed significantly from controls in both OCTs, in both measurements. MT and GCIPL were negatively associated with MD (p<0.001).Conclusions. Although OCT values were not interchangeable, both machines differentiated patients from controls with statistical significance. Structure-function analysis results were comparable, when either OCT was compared to SAP.

Higher contrast thresholds for vanishing optotype recognition in macular visual fields among glaucoma patients: a structure–function analysis

2021 ◽  
pp. bjophthalmol-2021-318972
Author(s):  
Yun Wen ◽  
Zidong Chen ◽  
Shuo Chen ◽  
Kaixin Tan ◽  
Yang Kong ◽  
...  
Keyword(s):  
Structure Function ◽  
Function Analysis ◽  
Open Angle Glaucoma ◽  
Visual Fields ◽  
Plexiform Layer ◽  
Contrast Threshold ◽  
Inner Plexiform Layer ◽  
Contrast Thresholds ◽  
The Impact ◽  
Glaucoma Group

Background/aimsWe aimed to explore the impact of glaucomatous macular damage, specifically retinal ganglion cell (RGC) loss, on macular pattern vision measured by the vanishing optotype (VO) recognition contrast threshold.MethodsSeventy-two patients (mean age, 33.51±7.05 years) with primary open-angle glaucoma and 36 healthy controls (mean age, 30.25±6.70 years) were enrolled. VO recognition contrast thresholds of each participant were measured at the 16 preset test locations covering the central 5° visual field (VF). Macular sensitivity (MS) was tested by macular threshold test of Humphrey Field Analyzer. Macular RGC plus inner plexiform layer (GCIPL) thickness was also measured by spectral domain optical coherence tomography.ResultsThe VO contrast threshold demonstrated weak-to-moderate correlations (rho=−0.275 to −0.653) with MS (p<0.001). There was a significantly higher VO contrast threshold in glaucoma group (p<0.0001). At similar levels of MS, patients with glaucoma with GCIPL damage showed remarkably higher VO contrast thresholds than those with preserved GCIPL (p=0.0079). The structure–function relationships between VO contrast threshold and GCIPL thickness (rho=−0.725 to −0.802) were remarkably stronger than those between MS and GCIPL thickness (rho=0.210 to 0.448). VO contrast threshold showed stronger correlation with average GCIPL thickness (rho=−0.362 to −0.778) than MS (rho=0.238 to 0.398) at multiple test locations in glaucoma group.ConclusionsGlaucomatous eyes have higher contrast thresholds for VO recognition in fovea-around VF. Stronger structure–function relationships indicate that VO contrast threshold is more vulnerable to RGC damage.

scholarly journals Association between Combined Structure Function Index and Glaucoma Severity

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Shumpei Ogawa ◽  
Yoshimasa Tanabe ◽  
Yoshinori Itoh ◽  
Takahiko Noro ◽  
Hisato Gunji ◽  
...  
Keyword(s):  
Structure Function ◽  
Open Angle Glaucoma ◽  
Normal Tension Glaucoma ◽  
Mean Deviation ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Function Index ◽  
Combined Structure ◽  
Three Stages ◽  
The Relationship

The aim of this study was to investigate the relationship between combined structure function index (CSFI) and standard automated perimetry (SAP) parameters such as mean deviation (MD) and visual field index (VFI) in open-angle glaucoma (OAG). We retrospectively reviewed medical records from September 2009 to July 2015, which included 195 eyes of 195 patients with OAG or normal-tension glaucoma who underwent SAP and optical coherence tomography on the same day (male: female, 128 : 67; mean age, 61.4 ± 11.3 years; mean spherical equivalent, −2.39 ± 2.3 D). We divided participants into three stages based on MD value: early, MD > −6 dB; middle, −6 dB ≥ MD ≥ −12 dB; and advanced, MD < 12 dB. We then evaluated correlations between CSFI and SAP parameters in each stage using Pearson’s correlation coefficient. Mean CSFI (%), mean MD (dB), and VFI (%) in each stage were early (22.4, −2.13, and 94.0); middle (47.9, −8.78, and 75.4); and advanced (68.3, −17.32, and 49.0), respectively. Correlations between CSFI and whole, early, middle, and advanced MD were −0.88 (p<0.001), −0.68, −0.24, and −0.76, respectively. Correlations between CSFI and whole, early, middle, and advanced VFI were −0.86 (p<0.001), −0.59, −0.20, and −0.83, respectively. Consistency between CSFI and SAP indices in middle-stage glaucoma was low.

scholarly journals Impact of Visual Field Testing on Intraocular Pressure Change Trends in Healthy People and Glaucoma Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Mengwei Li ◽  
Bingxin Zheng ◽  
Qi Wang ◽  
Xinghuai Sun
Keyword(s):  
Intraocular Pressure ◽  
Visual Field ◽  
Repeated Measures ◽  
Healthy Subjects ◽  
Open Angle Glaucoma ◽  
Field Testing ◽  
Automated Perimetry ◽  
Open Angle ◽  
Standard Automated Perimetry ◽  
The Impact

Purpose. To compare the impact of visual field (VF) testing on intraocular pressure (IOP) change trends between healthy subjects and glaucoma patients. Methods. We recruited healthy volunteer subjects who did not have previous ocular diseases and open-angle glaucoma patients who were medically controlled well. IOP in both eyes of each participant was measured by using a noncontact tonometer at five time points: before, immediately after (0 minute), and 10, 30, and 60 minutes after the standard automated perimetry. Repeated measures ANOVA was used to analyze the effect of VF testing on IOP change trends in healthy and glaucoma eyes. Results. Forty healthy subjects (80 eyes) and 31 open-angle glaucoma patients (62 eyes) were included for the study. The baseline IOP of healthy and glaucoma eyes was 16.11 ± 3.01 mmHg and 15.78 ± 3.57 mmHg, respectively. After the VF testing, the IOP in healthy eyes was decreased by 1.5% at 0 minute, 6.5% at 10 minutes (P<0.001), 6.6% at 30 minutes (P<0.001), and 7.0% at 1 hour (P<0.001), indicating that this reduction was sustained for at least 1 hour. However, the IOP in glaucoma eyes was increased by 12.7% at 0 minute (P<0.001) and, then, returned towards initial values 1 hour after the VF testing. Conclusions. IOP change trends after VF field testing between healthy subjects and glaucoma patients were quite different. VF testing led to a mild and relatively sustained IOP decrease in healthy subjects, whereas IOP in open-angle glaucoma patients tended to significantly increase immediately after VF testing and, then, returned to pretest values after 1 hour. These findings indicate that the factors of VF testing should be considered in the clinical IOP measurements.

Comparison of vascular–function and structure–function correlations in glaucomatous eyes with high myopia

2019 ◽  
Vol 104 (6) ◽  
pp. 807-812
Author(s):  
Seung Hyen Lee ◽  
Eun Ji Lee ◽  
Tae-Woo Kim
Keyword(s):  
Visual Field ◽  
Vascular Function ◽  
High Myopia ◽  
Open Angle Glaucoma ◽  
Retinal Vessel ◽  
Retinal Nerve Fibre Layer ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Cross Sectional ◽  
Visual Field Damage

Background/aimsTo determine the usefulness of peripapillary retinal vessel density (VD) measured using optical coherence tomography (OCT) angiography (OCTA) in the evaluation of glaucomatous visual field damage in highly myopic eyes with primary open-angle glaucoma (POAG).MethodsThis cross-sectional observational study enrolled a total of 124 myopic POAG eyes consisting of 40 eyes showing a segmentation error (SE) in OCT scans and 84 eyes without an SE. The peripapillary retinal VD, circumpapillary retinal nerve fibre layer thickness (RNFLT) and visual field sensitivity loss (VFSL) were assessed using OCTA, spectral-domain OCT and standard automated perimetry, respectively. The topographical correlations between the VD and VFSL, and between the RNFLT and VFSL were determined in subgroups divided according to the presence of an SE.ResultsThe peripapillary retinal VD showed significant topographical correlation with VFSL both in the highly myopic POAG eyes without an SE globally (R=0.527, p<0.001), and in temporal (R=0.593), temporal-superior (R=0.543), nasal-inferior (R=0.422) and temporal-inferior sectors (R=0.600, all p<0.001), and in those with an SE globally (R=0.343, p=0.030), and in temporal (R=0.494, p=0.001), temporal-superior (R=0.598, p<0.001), and temporal-inferior sectors (R=0.424, p=0.006). The correlation with VFSL did not differ between the VD and RNFLT in the eyes without an SEConclusionPeripapillary VD as measured with OCTA showed a topographical correlation with VFSL in highly myopic POAG eyes regardless of the presence of an OCT SE OCTA may be a useful adjunct for evaluating glaucomatous visual field damage in high myopia, where the OCT results are frequently confounding.

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