scholarly journals The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Anthony Paulo Sunjaya ◽  
Angela Felicia Sunjaya ◽  
Sukmawati Tansil Tan
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
High Sensitivity ◽  
Common Type ◽  
Routine Examination ◽  
Cancer Society ◽  
Immunohistochemistry Staining ◽  
The World ◽  
Local Destruction

Basal Cell Carcinoma (BCC) is the most common type of malignant cancer found in the world today with a 3–10% increase in incidence each year. The American Cancer Society reported that 8 out of 10 patients with skin cancer are suffering from BCC with over 2 million new cases each year. BCC needs to be detected at the early stages to prevent local destruction causing disabilities to patients and increasing treatment costs. Furthermore, BCC patients who have undergone surgery are still at risk for recurrence, especially when the surgery performed fails to remove all the BCC cells, even when conventional histopathological testing after surgery has reported a surgically free margin. This review aims to evaluate studies on the use of BerEP4 immunohistochemistry staining on pathological sections of various types of BCC as well as its shortfalls. BerEP4 is a monoclonal antibody which detects specific epithelial-glycoprotein-adhesion-molecules (EpCAM) found on BCC cells. Various studies have shown that BerEP4 has a high sensitivity and specificity in detecting only BCC cells. The use of BerEP4 immunohistochemistry testing for the routine examination of cases of BCC is expected to be able to increase and improve early diagnosis as well as prevent recurrence after surgery.

Update on Epidemiology of Non-Melanocytic Skin Tumors

2019 ◽  
Vol 70 (8) ◽  
pp. 3050-3052
Author(s):  
Lorena Vita Mare ◽  
Elena Porumb Andrese ◽  
Ana Maria Monu ◽  
Mihaela Gabriela Adam ◽  
Laura Gheuca Solovastru ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Common Type ◽  
Skin Tumors ◽  
The World ◽  
Cancer Types ◽  
Carcinoma Squamous Cell

Non-melanocytic skin tumors are the most common type of cancer, with increasing incidence and morbidity rates and around the world. Materials and methods: We performed a 5-year retrospective study regarding non-melanocytic skin cancer types � basal cell carcinoma, squamous cell carcinoma and metatypical carcinoma, that included 259 patients hospitalized in St. Spiridon Emergency Clinical Hospital�s Dermatology-Venereology Clinic, during 2013-2018, meaning 2.77% of all admitted patients. Results: This article describes the most common types of non-melanocytic skin cancer in our area: BCC was diagnosed in 87% of the patients, SCC in 12% and metatypical cancer in 1%. Our findings are in accordance with data reports over the last few years.

Basal cell carcinoma of the middle ear—a natural history

1988 ◽  
Vol 102 (10) ◽  
pp. 932-934 ◽  
Author(s):  
H. Z. Joachims ◽  
Y.Ben Arieh
Keyword(s):  
Natural History ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Middle Ear ◽  
Basal Cell ◽  
Facial Palsy ◽  
Distant Metastases ◽  
Irradiation Therapy ◽  
Local Destruction ◽  
Parietal Bones

AbstractThe natural course of basal cell carcinoma of the middle ear is described. This tumour is extremely rarely found in the middle ear and only two cases have been reported to date. The appearance of the tumour was heralded by earache and deafness, followed years later by wide local destruction of the temporal and parietal bones, base of skull, facial palsy and multiple distant metastases.The patient refused both surgical and irradiation therapy and died 10 years after the initial diagnosis.

scholarly journals Giant Basal Cell Carcinoma: A Case Report

2018 ◽  
Vol 35 (2) ◽  
pp. 149-155
Author(s):  
Danijela Popović ◽  
Andrija Jović ◽  
Danica Tiodorović ◽  
Nataša Vidović ◽  
Ivana Graovac
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Human Population ◽  
Common Type ◽  
Rare Type ◽  
Clinical Variants ◽  
Aggressive Tumors ◽  
Giant Basal Cell Carcinoma

Abstract Basal cell carcinoma (BCC) is the most common type of skin cancer and the most common type of tumor in the human population in general. Clinical variants of BCC include nodular, superficial, pigmented, morpheaform, cystic, metatypical types and fibroepithelioma of Pinkus. Giant BCC is a rare type of carcinoma, accounting for less than 1% of all cases of BCC. Most often they occur on the trunk. BCC belongs to the group of aggressive tumors, leading to the invasion of deeper tissues, and examples of metastasis of this type of tumor can be found in the reference literature. In this case report, we present a case of a 76-year-old female patient with a giant ulcerous form of basal cell carcinoma on the back.

scholarly journals Immunohistochemical Expression of CK19, AR, PHLDA1, CD10 and Ki67 in the Differentiation between Trichoepithelioma and Basal Cell Carcinoma: A Systematic Review

2021 ◽  
Vol 55 (5) ◽  
Author(s):  
Eileen Liesl A. Cubillan ◽  
Jolene Kristine G. Gatmaitan-Dumlao
Keyword(s):  
Systematic Review ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Odds Ratio ◽  
High Sensitivity ◽  
High Specificity ◽  
Diagnostic Odds Ratio ◽  
Biological Behavior ◽  
Significant Difference

Background. Basal cell carcinoma (BCC) and trichoepithelioma (TE) are follicular adnexal neoplasms that arise from the follicular germ but with divergent biological behavior. The gold standard in the differentiation is through histopathological examination using hematoxylin and eosin (H and E) stain. There are cases, however, when the distinction is not straightforward. Objective. To assess the association and diagnostic accuracy of the immunohistochemical (IHC) expressions of CD10, Ki67, CK19, androgen receptor (AR), and PHLDA1 in distinguishing between basal cell carcinoma and trichoepithelioma. Methods. We conducted a comprehensive search on cross-sectional studies on human tissue from 2000 to 2020 in MEDLINE (PubMed), CENTRAL and EMBASE for comparative studies and reference lists. The data were summarized and analyzed using Microsoft Excel and RevMan. We used Chi-square test for independence, summary receiver operator curves (sROC), and diagnostic odds ratio (OR). Results. We included 15 articles containing 686 BCC and 367 TE in the systematic review. The pooled staining of biomarkers showed a significant difference in the staining of CK19 (p<0.05) and AR (p<0.0001), and PHLDA1 (p<0.0001). Diagnostic odds ratio was used to confirm these associations. AR was found to have the highest odds in the diagnosis of BCC (OR 27.92, 95% CI 10.69, 72.86). The pattern of staining of CD10 is significant (p<0.001) with staining of both tumor and stroma (OR 8.09, 95% CI 4.57, 13.53) and staining of tumor alone (OR 8.15, 95% CI 4.56, 14.35) (p<0.001) in the diagnosis of BCC. CD10 stromal staining, on the other hand, is significantly associated with the diagnosis of TE (OR 7.26, 95% CI 5.06, 10.44) (p<0.0001). There is no significant association between Ki67 staining (OR 1.22, 95% CI 0.48, 3.09) (p=0.67) and the diagnosis of BCC. The forest plot and sROC showed that AR had high specificity across all included studies in the diagnosis of basal cell carcinoma, while PHLDA1 demonstrated high specificity and high sensitivity in diagnosing trichoepithelioma. Conclusion. The biomarkers AR and PHLDA1 are useful as an initial panel to distinguish between BCC and TE, given that both showed high sensitivity as well as significant association with BCC and TE respectively. CD10 and CK19 may also be used with AR and PHLDA1 for further confirmation.

scholarly journals A Systematic Review and Meta-Analysis of the Accuracy of in VivoReflectance Confocal Microscopy for the Diagnosis of Primary Basal Cell Carcinoma

2019 ◽  
Vol 8 (9) ◽  
pp. 1462 ◽  
Author(s):  
Lupu ◽  
Popa ◽  
Voiculescu ◽  
Caruntu ◽  
Caruntu
Keyword(s):  
Systematic Review ◽  
Confocal Microscopy ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Sensitivity And Specificity ◽  
Basal Cell ◽  
Meta Analysis ◽  
High Sensitivity ◽  
Diagnostic Odds Ratio ◽  
Likelihood Ratios

Basal cell carcinoma (BCC) is the most common cancer worldwide and its incidence is constantly rising. Early diagnosis and treatment can significantly reduce patient morbidity and healthcare costs. The value of reflectance confocal microscopy (RCM) in non-melanoma skin cancer diagnosis is still under debate. This systematic review and meta-analysis were conducted to assess the diagnostic accuracy of RCM in primary BCC. PubMed, Google Scholar, Scopus, and Web of Science databases were searched up to July 05, 2019, to collect articles concerning primary BCC diagnosis through RCM. The studies’ methodological quality was assessed by the QUADAS-2 tool. The meta-analysis was conducted using Stata 13.0, RevMan 5.0, and MetaDisc 1.4 software. We included 15 studies totaling a number of 4163 lesions. The pooled sensitivity and specificity were 0.92 (95% CI, 0.87–0.95; I2= 85.27%) and 0.93 (95% CI, 0.85–0.97; I2= 94.61%), the pooled positive and negative likelihood ratios were 13.51 (95% CI, 5.8–31.37; I2= 91.01%) and 0.08 (95% CI, 0.05–0.14; I2= 84.83%), and the pooled diagnostic odds ratio was 160.31 (95% CI, 64.73–397.02; I2=71%). Despite the heterogeneity and risk of bias, this study demonstrates that RCM, through its high sensitivity and specificity, may have a significant clinical impact on the diagnosis of primary BCC.

scholarly journals Basal cell carcinoma masquerading as lupus vulgaris - A case report

2021 ◽  
Vol 7 (2) ◽  
pp. 172-174
Author(s):  
Geo Danny C ◽  
Abhinesh N ◽  
Shreya Srinivasan ◽  
Avinash Pravin
Keyword(s):  
Case Report ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Lupus Vulgaris ◽  
Non Melanoma Skin Cancer ◽  
The World ◽  
Melanoma Skin

Basal cell carcinoma is the most commonly occurring non melanoma skin cancer in the world and overall incidence is still increasing. Metastases is rare in Basal cell carcinoma. Herein we present a case report of Basal cell carcinoma mimicking Lupus vulgaris

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