scholarly journals TMEM187-IRAK1Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Olfa Khalifa ◽  
Nathalie Balandraud ◽  
Nathalie Lambert ◽  
Isabelle Auger ◽  
Jean Roudier ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Protective Effect ◽  
Meta Analysis ◽  
Geographic Origin ◽  
Significant Risk ◽  
Tunisian Population ◽  
French Population ◽  
Major Allele ◽  
First Time ◽  
Arthritis Susceptibility

Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containingTMEM187andIRAK1(rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. The rs13397 G and rs1059703 T major alleles were significantly increased in RA patients (n=408) compared with age-matched controls (n=471) in both Tunisian and French women. These results were confirmed by a meta-analysis replication study including two independent Greek and Korean cohorts. The rs1059702 C major allele was significantly associated with RA, only with French women. In the French population, the GTC haplotype displayed a protective effect against RA, while the ATC, GCC, and GTT haplotypes conferred significant risk for RA. No association for these haplotypes was found in the Tunisian population. Our results replicated for the first time the association of the three Xq28 polymorphisms with RA risk in Tunisian and French populations and suggested that RA susceptibility is associated withTMEM187-IRAK1polymorphisms in women. Our data further support the involvement of X chromosome in RA susceptibility and evidence ethnicities differences that might be explained by differences in the frequencies of SE HLA-DRB1 alleles between both populations.

Association between KIR gene polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis

2015 ◽  
Vol 76 (8) ◽  
pp. 565-570 ◽  
Author(s):  
Xiaona Li ◽  
Qing Xia ◽  
Dazhi Fan ◽  
Guoqi Cai ◽  
Xiao Yang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Rheumatoid Arthritis Susceptibility ◽  
Kir Gene ◽  
Arthritis Susceptibility

scholarly journals Association between the interleukin (IL)-17A rs2275913 polymorphism and rheumatoid arthritis susceptibility: a meta-analysis and trial sequential analysis

2021 ◽  
Vol 49 (10) ◽  
pp. 030006052110532
Author(s):  
Ping Chen ◽  
Yuhao Li ◽  
Liangliang Li ◽  
Guixin Zhang ◽  
Feng Zhang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Sequential Analysis ◽  
Web Of Science ◽  
Meta Analysis ◽  
Trial Sequential Analysis ◽  
Dominant Model ◽  
Registration Number ◽  
The Relationship ◽  
Allelic Model ◽  
Arthritis Susceptibility

Objective This meta-analysis was conducted to investigate the relationship between the interleukin (IL)-17A rs2275913 polymorphism and rheumatoid arthritis (RA) susceptibility. Methods Eligible studies were retrieved from PubMed, Embase, and Web of Science. The fixed- or random-effects model was used to calculate the pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) on the basis of heterogeneity. Results Overall, 11 studies containing 4019 RA patients and 4137 controls were included in this meta-analysis. The results suggested a significant association between the IL-17A rs2275913 polymorphism and RA susceptibility in the overall population (allelic model A vs. G: OR = 0.89, 95%CI: 0.83–0.95; heterozygote model GA vs. GG: OR = 0.87, 95%CI: 0.78–0.96; homozygote model AA vs. GG: OR = 0.82, 95%CI: 0.71–0.96; dominant model GA + AA vs. GG: OR = 0.86, 95%CI: 0.78–0.94). In the subgroup analyses, the IL-17A rs2275913 polymorphism was significantly associated with RA risk in Europeans (allelic model A vs. G: OR = 0.87, 95%CI: 0.78–0.97; heterozygote model GA vs. GG: OR = 0.79, 95%CI: 0.68–0.93; dominant model GA + AA vs. GG: OR = 0.79, 95%CI: 0.68–0.92), but not in Africans or Americans. Conclusion This study suggests that the IL-17A rs2275913 polymorphism is significantly associated with RA susceptibility in Europeans. INPLASY registration number: INPLASY202170056.

scholarly journals IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Menglei Yu ◽  
Jingyi Hou ◽  
Minghui Zheng ◽  
Yi Cao ◽  
Yamuhanmode Alike ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Case Control ◽  
Similar Relationship ◽  
Case Control Studies ◽  
Pubmed Database ◽  
Interleukin 21 ◽  
Citrullinated Protein ◽  
Arthritis Susceptibility

Abstract Interleukin-21 (IL-21) is a cytokine that plays a crucial role in pathogenesis and activity of the rheumatoid arthritis (RA). Meanwhile, genetic polymorphisms in the IL-21 gene may alter its expression. Previous studies have reported conflicting results assessing the association between the IL-21 rs6822844 G/T polymorphism and RA risk. Thus, it’s necessary to perform a meta-analysis to definite above relationship. PubMed database was searched for all papers published until October 20, 2019. Nine case–control studies with 9998 cases and 10742 controls were retrieved based on the search criteria at last. Odds ratio (95% confidence interval) was used to calculate the strength of this association. Publication bias was detected using both Begg’s and Egger’s tests. Overall, the IL-21 rs6822844 G/T polymorphism was found to be significantly associated with decreased RA risk (e.g. T-allele versus G-allele: OR = 0.81, 95% CI = 0.72–0.91, P < 0.001). In addition, decreased RA risk was also detected both in Asians (eg: TT+TG versus GG: OR = 0.42, 95% CI = 0.31–0.56, P < 0.001) and Caucasians (eg: TT+TG versus GG: OR = 0.85, 95% CI = 0.80–0.91, P < 0.001). A similar trend in association was found in the source of the control and genotype method subgroups. Furthermore, subgroup analysis of rheumatoid factor status revealed a protective relationship between the IL-21 rs6822844 G/T polymorphism and RF+/RF- RA risk. A similar relationship was noted in the anti-citrullinated protein antibody status subgroup. The results of the present study suggest that the IL-21 rs6822844 G/T polymorphism was significantly associated with decreased RA susceptibility.

Interaction of HLA-DRB1*09:01 and *04:05 with Smoking Suggests Distinctive Mechanisms of Rheumatoid Arthritis Susceptibility Beyond the Shared Epitope

2013 ◽  
Vol 40 (7) ◽  
pp. 1054-1062 ◽  
Author(s):  
So-Young Bang ◽  
Hye-Soon Lee ◽  
Kyung Wha Lee ◽  
Sang-Cheol Bae
Keyword(s):  
Rheumatoid Arthritis ◽  
Significant Interaction ◽  
Shared Epitope ◽  
Smoking Status ◽  
Significant Risk ◽  
Typing Method ◽  
Risk Alleles ◽  
Distinct Mechanism ◽  
Citrullinated Peptide ◽  
Arthritis Susceptibility

Objective.Although HLA-DRB1 shared epitope (SE) alleles and HLA-DRB1*09:01 have repeatedly been shown to be associated with susceptibility to rheumatoid arthritis (RA), the effect of each allele on levels of anticyclic citrullinated peptide autoantibodies (anti-CCP) and interaction with cigarette smoking in RA remains to be fully defined. We investigated whether HLA-DRB1 risk alleles influence anti-CCP levels and whether each allele interacts with smoking in anti-CCP-positive or -negative RA.Methods.All patients with RA (n = 1924) and controls (n = 1119) were Korean. The HLA-DRB1 4-digit genotyping was performed by standard PCR-sequencing based typing method. OR and biologic interactions as departures from additivity or multiplicity were analyzed by logistic regression.Results.SE alleles were significantly associated with increased anti-CCP levels. Conversely, HLA-DRB1*09:01 was associated with reduced levels, in both SE-positive and SE-negative patients. Each of SE alleles interacted significantly with smoking, whereas HLA-DRB1*09:01 did not. Interactions between the 2 most significant risk alleles, HLA-DRB1*04:05 and HLA-DRB1*09:01, (attributable proportion = 0.68, 95% CI 0.46–0.89, multiplicity p = 0.012) significantly increased RA susceptibility regardless of anti-CCP and smoking status. Smoking increased the risk for RA by significant interaction with the heterozygote HLA-DRB1*04:05/*09:01.Conclusion.HLA-DRB1*09:01 differs from SE alleles with regard to anti-CCP levels and interaction with smoking, suggesting a distinct mechanism of HLA-DRB1*09:01 in the pathogenesis of RA that may bypass anti-CCP formation. Also, a significant increase of the HLA-DRB1*04:05/ *09:01 heterozygote in RA susceptibility may be attributable to the synergistic contribution of 2 different pathways in which 2 alleles participate independently.

scholarly journals The Relationship Between Padi4 -94G/A Polymorphism and Rheumatoid Arthritis: A Meta-analysis in Multi Ethnic Groups

2020 ◽  
Author(s):  
Changchun Jian ◽  
Jingsong Pu
Keyword(s):  
Rheumatoid Arthritis ◽  
Ethnic Groups ◽  
Meta Analysis ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Peptidylarginine Deiminase ◽  
Increased Risk ◽  
Different Populations ◽  
The Relationship ◽  
Strength Of Association

Abstract Background: A number of studies have reported the association between peptidylarginine deiminase 4 (PADI4) -94G/A polymorphisms and rheumatoid arthritis (RA) risk in different populations, however, the results remained inconclusive. Objecitve: We therefore aim to address this association by performed an updated meta-analysis in multi ethnic groups. Methods: The PubMed and Chinese related databases were searched up to January 2019. The strength of association between PADI -94G/A polymorphism and RA susceptibility was assessed with odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 22 studies with 14514 RA cases and 21138 controls were finally included in the analysis. Six ethnic groups such as China, Japan, USA, UK, Sweden and Spain were contained. In the overall population, it revealed that PADI -94G/A polymorphism was significantly associated with an increased risk of RA. In the subgroup analyses by ethnicity, significant association was found in China as well as in Japan and USA. Conclusions: This meta-analysis demonstrates that the PADI4 -94G/A polymorphisms may represent a significant risk factor for RA in China, in Japan and USA. Further studies are needed to clarify this finding, since most available studies were conducted among Chinese and Japanese in this study.

scholarly journals Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa

2020 ◽  
Vol 40 (8) ◽  
Author(s):  
Meriem Hechmi ◽  
Hamza Dallali ◽  
Meriem Gharbi ◽  
Haifa Jmel ◽  
Meriem Fassatoui ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
North Africa ◽  
Meta Analysis ◽  
Geographic Origin ◽  
Northern Region ◽  
Additive Models ◽  
Tunisian Population ◽  
Genotype Distribution ◽  
Apolipoprotein A5 ◽  
Apoa5 Gene

Abstract Apolipoprotein A5 (APOA5) has been linked to metabolic syndrome (MetS) in several populations. In North Africa, only the Tunisian and Moroccan populations were investigated. Our aim is to assess the association between APOA5 gene variant (rs662799) and haplotypes with MetS in Tunisian population and to perform a meta-analysis in North Africa. A total of 594 Tunisian participants were genotyped for polymorphism rs662799 using KASPar technology. Two polymorphisms rs3135506 and rs651821 in APOA5 gene genotyped in our previous study, were used in addition to rs662799 to assess the haplotype association with MetS. The genotype of 875 participants was used for the meta-analysis. Statistical analyses were performed with R software. The rs662799 increases the risk of MetS under the dominant (P=0.018) and the additive models (P=0.028) in the Tunisian population. After stratification of the cohort following the sex and the geographic origin, a positive association of rs662799 with MetS was found for participant from the Northern region and for the women group. Only the haplotype AGT showed a significant association with MetS by decreasing the risk of the disease. The meta-analysis reported a significant association of rs662799 and rs3135506 with MetS. Our results showed a significant association between the APOA5 gene variants rs662799 and haplotypes with MetS and its traits in Tunisia. An impact of the sex and the geographic origin on the genotype distribution was highlighted. Our funding emphasizes the role of APOA5 in the development of MetS in North Africa.

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