Deep Venous Thrombosis and Bilateral Pulmonary Embolism Revealing Silent Celiac Disease: Case Report and Review of the Literature

Celiac disease (CD) is a systemic, chronic autoimmune disease that occurs in genetically predisposed individuals following dietary gluten exposure. CD can present with a wide range of gastrointestinal and extraintestinal manifestations and requires lifelong adherence to a gluten-free diet [GFD]. Venous thromboembolism (VTE) as a presentation of celiac disease is unusual and rarely reported. We present a case of a 46-year-old man who was admitted for shortness of breath and pleuritic chest pain and was found to have iron deficiency anemia, deep venous thrombosis, and bilateral pulmonary emboli (PE). After work-up for his anemia, the patient was diagnosed with CD. Comprehensive investigation for inherited or acquired prothrombotic disorders was negative. It is becoming increasingly recognized that CD is associated with an increased risk for VTE. PE, however, as a presentation of CD is exceedingly rare and to the best of our knowledge this is the third case report of such an occurrence and the only case report of a patient from North America. It is important to recognize that the first symptoms or signs of celiac disease might be extraintestinal. Furthermore, VTE as a presentation of CD is rare but life-threatening.

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Coronavirus Disease (COVID-19) Associated Rhinocerebral Mucormycosis and Complications: A Case Report

International Journal of Clinical Research ◽

10.38179/ijcr.v2i1.102 ◽

2021 ◽

Vol 2 (1) ◽

pp. 93-99

Author(s):

Soad Al Osta ◽

Gibran Atwi ◽

Nourhan El Ahmar ◽

Noha Bejjani ◽

Fayez Abillama ◽

...

Keyword(s):

Case Report ◽

Fungal Infections ◽

Sinus Thrombosis ◽

Subsequent Development ◽

Rhinocerebral Mucormycosis ◽

Cranial Nerve Palsies ◽

Increased Risk ◽

Disease Case ◽

Wide Range ◽

Facial Swelling

Background: Mucormycosis is a rare fatal infection caused by a ubiquitous fungus from the order of Mucorales, which can have varying clinical presentations. Immunocompromised patients are particularly susceptible to mucormycosis and can suffer fatal consequences if not treated adequately. COVID-19 infection with its immunomodulatory properties has been associated with a wide range of secondary bacterial and fungal infections. We present a case of rapidly progressive rhinocerebral mucormycosis post-COVID-19 infection with the subsequent development of several complications associated with the disease. Case Report: A 62-year-old male patient with a history of hypertension and diabetes mellitus type II, presented 14 days post-COVID-19 recovery with right facial swelling, erythema, and right eye proptosis. Throughout his disease, the patient developed blindness and cranial nerve palsies. He was also found to have palatal necrotic lesions, consistent with the diagnosis of mucormycosis. The patient’s disease was complicated by Garcin syndrome, meningitis, orbital apex syndrome, cavernous sinus thrombosis, brain infarction, and hemorrhage. Despite all measures and interventions, the patient died. Conclusion: COVID-19 infection and its treatments are associated with an increased risk of secondary fungal infections like mucormycosis. As such, a high index of suspicion is needed amongst healthcare workers for the early diagnosis and treatment of such opportunistic infections since prompt treatment is associated with a marked improvement in outcome. Furthermore, optimal glucose control and judicious use of corticosteroids in COVID-19 patients decreases the risk of developping such life threatening superinfections.

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Coincidence of Malignancy and Congenital Thrombophilia as the Cause of Deep Venous Thrombosis - Case Report and Review of the Literature

Acta Medica Martiniana ◽

10.2478/acm-2014-0008 ◽

2014 ◽

Vol 14 (2) ◽

pp. 16-24

Author(s):

Stanclakova L. ◽

Stasko J. ◽

Jedlnakova Z. ◽

Sokol J. ◽

Plamenova I. ◽

...

Keyword(s):

Case Report ◽

Venous Thrombosis ◽

Deep Venous Thrombosis ◽

Clinical Manifestation ◽

Genetic Disorder ◽

Factor V Leiden ◽

Clinical Aspects ◽

Increased Risk ◽

Mechanical Methods ◽

Fv Leiden

Abstract Introduction: Deep venous thrombosis (DVT, phlebothrombosis) is a very important clinical problem with its resultant fatal pulmonary embolism (PE) as one of the possible consequences. Factor V Leiden (FV Leiden) is a genetic disorder characterized by a poor anticoagulant response to activated protein C (APC) and an increased risk of venous thromboembolism (VTE). Homozygous carriers of the FV Leiden mutation are estimated to have an 80-fold increased lifetime relative risk of VTE. Most homozygous carriers present with VTE before 40 years of age, but some can live thrombosis-free until the sixth or seventh decade of life or even remain asymptomatic for life. Case-controlled studies of patients with cancer revealed a four-fold increase in thromboembolic occurrence in acute leukaemia, with the risk of thrombosis persisting even after remission of the disease. Case Report: The authors present a case report of the 61-year-old patient with leukaemic transformation of myelodysplastic syndrome (MDS) to acute myeloid leukaemia (AML) and development of DVT of the left leg (LL) as the first clinical manifestation of homozygous FV Leiden carrier. Due to his diagnosis it was not possible to indicate surgical treatment of DVT. After initial treatment with subcutaneous low molecular weight heparin (LMWH) and continuous intravenous application of unfractionated heparin (UFH) the deficiency of antithrombin III (AT III) potentiating the persistence of his hypercoagulable state developed. Treatment with the new oral anticoagulant - rivaroxaban, vasoprotective and antithrombotic drugs in the combination with mechanical methods of VTE prophylaxis led to a reduction in edema of left thigh and calf by 3.5 cm and 4 cm, respectively. Son of the patient experienced DVT at the age of 27 years, too. Conclusion: In this report, we describe a case of the patient with DVT during the leukaemic transformation of MDS to AML as a relatively late first clinical manifestation of homozygous FV Leiden mutation. At the same time the article deals with the clinical aspects of discussed thrombophilia in the relatives of the patient, as well as with the etiopathogenesis, pharmacologic treatment options and possible complications of DVT (PE, pulmonary hypertension and post-thrombotic syndrome).

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Acute Deep Venous Thrombosis Unmasking Underlying Wilson’s Disease: Case Report

The American Journal of Gastroenterology ◽

10.14309/00000434-201410002-01328 ◽

2014 ◽

Vol 109 ◽

pp. S390

Author(s):

FNU Jaydev ◽

Eyad Baghal ◽

Amara Nidimusili ◽

Marwan Saad

Keyword(s):

Case Report ◽

Venous Thrombosis ◽

Deep Venous Thrombosis ◽

Wilson’S Disease ◽

Wilson's Disease ◽

Disease Case

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Mechanical Thrombectomy for Life-Threatening Cerebral Venous Thrombosis: A Case Report

Case Reports in Neurology ◽

10.1159/000507343 ◽

2020 ◽

Vol 12 (Suppl. 1) ◽

pp. 63-69

Author(s):

Kar Foo Lau ◽

Tsun-Haw Toh ◽

Khairul Azmi Abdul Kadir ◽

Mei-Ling Sharon Tai ◽

Kay Sin Tan

Keyword(s):

Case Report ◽

Venous Thrombosis ◽

Cerebral Venous Thrombosis ◽

Mechanical Thrombectomy ◽

Anticoagulation Therapy ◽

First Line ◽

Venous Flow ◽

Clinical Presentations ◽

Wide Range ◽

Life Threatening

Cerebral venous thrombosis (CVT) is a rare cause of stroke worldwide with a wide range of clinical presentations. Anticoagulation therapy has been regarded as the first line of management of CVT to prevent the progression of thrombosis and to re-establish the venous flow. We present a case of severe CVT who did not respond to conventional anticoagulation therapy but responded well to mechanical thrombectomy (MT). This report highlights the features of CVT to consider for early MT.

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Proximal deep venous thrombosis following PTA of the superficial femoral artery – an obligation to disclose a complication that is rarely taken into account

VASA ◽

10.1024/0301-1526.35.1.41 ◽

2006 ◽

Vol 35 (1) ◽

pp. 41-44 ◽

Cited By ~ 5

Author(s):

Klein-Weigel ◽

Pillokat ◽

Klemens ◽

Köning ◽

Wolbergs ◽

...

Keyword(s):

Venous Thrombosis ◽

Deep Venous Thrombosis ◽

Femoral Artery ◽

Superficial Femoral Artery ◽

Rare Complication ◽

Femoral Vein ◽

Vein Thrombosis ◽

Explicit Information ◽

Life Threatening ◽

Legal Consequences

We report two cases of femoral vein thrombosis after arterial PTA and subsequent pressure stasis. We discuss the legal consequences of these complications for information policies. Because venous thrombembolism following an arterial PTA might cause serious sequel or life threatening complications, there is a clear obligation for explicit information of the patients about this rare complication.

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Faculty Opinions recommendation of Increased risk of deep venous thrombosis with endovascular cooling in patients with traumatic head injury.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1087354.540382 ◽

2007 ◽

Author(s):

Jonathan Rhodes

Keyword(s):

Head Injury ◽

Venous Thrombosis ◽

Deep Venous Thrombosis ◽

Traumatic Head Injury ◽

Increased Risk ◽

Endovascular Cooling ◽

Traumatic Head

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Death of unknown cause? Post-mortem diagnosis of fulminant course of an EBV-associated secondary hemophagocytic lymphohistiocytosis

memo - Magazine of European Medical Oncology ◽

10.1007/s12254-021-00701-9 ◽

2021 ◽

Author(s):

Josia Fauser ◽

Stefan Köck ◽

Eberhard Gunsilius ◽

Andreas Chott ◽

Andreas Peer ◽

...

Keyword(s):

Immune Response ◽

Case Report ◽

Macrophage Activation ◽

Post Mortem ◽

Life Threatening ◽

Appropriate Therapy ◽

Diagnostic Work ◽

Work Up ◽

Diagnostic Work Up ◽

Secondary Hemophagocytic Lymphohistiocytosis

SummaryHLH is a life-threatening disease, which is characterized by a dysregulated immune response with uncontrolled T cell and macrophage activation. The often fulminant course of the disease needs a fast diagnostic work-up to initiate as soon as possible the appropriate therapy. We present herein the case of a 71-year-old patient with rapidly progressive hyperinflammatory syndrome, which post mortem resulted in the diagnosis of EBV-associated HLH. With this case report, we intend to highlight the relevance of the HScore in the diagnosis of HLH, to create a greater awareness for EBV as a trigger of HLH, and to demonstrate the importance of treating EBV-associated HLH as early as possible.

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