scholarly journals Death of unknown cause? Post-mortem diagnosis of fulminant course of an EBV-associated secondary hemophagocytic lymphohistiocytosis

2021 ◽  
Author(s):  
Josia Fauser ◽  
Stefan Köck ◽  
Eberhard Gunsilius ◽  
Andreas Chott ◽  
Andreas Peer ◽  
...  
Keyword(s):  
Immune Response ◽  
Case Report ◽  
Macrophage Activation ◽  
Post Mortem ◽  
Life Threatening ◽  
Appropriate Therapy ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up ◽  
Secondary Hemophagocytic Lymphohistiocytosis

SummaryHLH is a life-threatening disease, which is characterized by a dysregulated immune response with uncontrolled T cell and macrophage activation. The often fulminant course of the disease needs a fast diagnostic work-up to initiate as soon as possible the appropriate therapy. We present herein the case of a 71-year-old patient with rapidly progressive hyperinflammatory syndrome, which post mortem resulted in the diagnosis of EBV-associated HLH. With this case report, we intend to highlight the relevance of the HScore in the diagnosis of HLH, to create a greater awareness for EBV as a trigger of HLH, and to demonstrate the importance of treating EBV-associated HLH as early as possible.

scholarly journals Chikungunya virus and dengue virus coinfection: a case report from Bangladesh

2018 ◽  
Vol 12 (1) ◽  
pp. 42-43
Author(s):  
Muhammad Abdur Rahim ◽  
Shahana Zaman ◽  
Samira Rahat Afroze ◽  
Hasna Fahmima Haque ◽  
Farhana Afroz ◽  
...  
Keyword(s):  
Case Report ◽  
Virus Infection ◽  
Dengue Virus ◽  
Chikungunya Virus ◽  
Dengue Virus Infection ◽  
Emerging Infection ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up ◽  
Body Ache

A case of concurrent chikungunya virus and dengue virus infection is reported here. The patient presented with fever and generalized body ache. Diagnostic work-up revealed chikungunya-dengue co-infection. Dengue is endemic in Bangladesh while chikungunya is a recently emerging infection. As both the viruses are transmitted by a common vector, Aedes spp., such co-infections are likely to increase in coming years.IMC J Med Sci 2018; 12(1): 42-43

scholarly journals Rhino- Orbito- Cerebral- Mucormycosis with Osteomyelitis in a Patient with Diabetes mellitus: A Case Report and Literature Review

2012 ◽  
Vol 2 (2) ◽  
pp. 124-128 ◽  
Author(s):  
Rumana Habib ◽  
Rashedul Islam ◽  
Aminur Rahman ◽  
NB Bhowmik ◽  
Amirul Haque
Keyword(s):  
Case Report ◽  
Fungal Infection ◽  
Acquired Immunodeficiency Syndrome ◽  
Hematologic Malignancies ◽  
Successful Management ◽  
Acquired Immunodeficiency ◽  
Diagnostic Work ◽  
Immunodeficiency Syndrome ◽  
Work Up ◽  
Diagnostic Work Up

Mucormycosis is a form of fulminant invasive fungal infection of the sinonasal tract that often extends to the orbit, brain, palate, and skin. It is caused by members of the order Mucorales, and it is considered to be the most fatal fungal infection known to man. It is most commonly associated with diabetic ketoacidosis, hematologic malignancies, acquired immunodeficiency syndrome acquired immunodeficiency syndrome, see AIDS. , and immunosuppressive therapy. This rare opportunistic infection exists in many forms, the most common of which is rhinocerebral mucormycosis. Treatment includes aggressive surgical debridement of the necrotic tissue combined with systemic antifungal therapy. In this case report, we describe the successful management of rhinoorbitocerebral mucormycosis, a subtype of the rhinocerebral variety, complicated by osteomyelitis of cranium. We review the diagnostic work-up and discuss the literature with respect to the presentation, pathophysiology, management, and outcome of the disease.DOI: http://dx.doi.org/10.3329/birdem.v2i2.12331(Birdem Med J 2012; 2(2):124-127)

scholarly journals Septicaemic Melioidosis Complicated by Septic Arthritis in A Bangladeshi male: A Case Report

2018 ◽  
Vol 29 (2) ◽  
pp. 94-96
Author(s):  
Hasna Fahmima Haque ◽  
Suchismita Debnath ◽  
Samira Rahat Afroze ◽  
Farhana Afroz ◽  
Muhammad Abdur Rahim ◽  
...  
Keyword(s):  
Case Report ◽  
Synovial Fluid ◽  
Septic Arthritis ◽  
Burkholderia Pseudomallei ◽  
Clinical Suspicion ◽  
High Index ◽  
Uncommon Disease ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Melioidosis is an uncommon disease in Bangladesh but in recent years increasing numbers of cases are being diagnosed. A case of septicaemic melioidosis occurring in a young Bangladeshi returning worker is reported here. The patient presented with fever and features of septic arthritis. Diagnostic work-up revealed the growth of Burkholderia pseudomallei from blood and synovial fluid cultures. This case highlights the importance of high index of clinical suspicion for melioidosis in appropriate clinical scenario.Bangladesh J Medicine Jul 2018; 29(2) : 94-96

scholarly journals Adult-Onset Severe Hypocalcemia Due Defect in Parathyroid Calcium-Sensing Receptors

2020 ◽  
Vol 5 (07) ◽  
pp. 250-251
Author(s):  
Kamel El-Reshaid ◽  
Shaikha Al-Bader
Keyword(s):  
Case Report ◽  
Adult Onset ◽  
Common Cause ◽  
Autoimmune Polyglandular Syndrome ◽  
Calcium Sensing ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Parathyroidectomy, of the 4 glands, with/without thyroidectomy is the most common cause of hypoparathyroidism. Autoimmunity is a rare etiology, either as an isolated endocrinopathy or as a component of autoimmune polyglandular syndrome 1 (APS 1). In this case report; we describe a patient with an adult-onset hypoparathyroidism and discuss its pathophysiology in relation to calcium-sensing receptors in addition to its diagnostic work up and management.

Problem solving in clinical practice: the sick infant with low sodium and high potassium

2020 ◽  
pp. edpract-2019-317756
Author(s):  
Yincent Tse ◽  
Nidhi Singhal ◽  
Leigh McDonald ◽  
Milan Gopal ◽  
Anupam Lall ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Problem Solving ◽  
High Potassium ◽  
Initial Management ◽  
Low Sodium ◽  
Life Threatening ◽  
Diagnostic Work ◽  
Work Up ◽  
Term Management ◽  
Diagnostic Work Up

Many paediatricians will be faced with a sick infant who on investigation is found to have hyponatraemia and hyperkalaemia at some time in their career. The focus of initial management includes the treatment of potentially life-threatening hyperkalaemia with concurrent investigation aiming to elucidate whether the underlying cause reflects a primarily renal or endocrine pathology. We describe the presentation of two infants who each presented with one of the more common underlying diagnoses that led to this biochemical disturbance and discuss the approach to immediate treatment, diagnostic work-up and longer term management.

Acute heart failure: diagnosis

ESC CardioMed ◽  
2018 ◽  
pp. 1911-1917 ◽  
Author(s):  
Adriaan A. Voors ◽  
Piotr Ponikowski
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Medical Condition ◽  
Specific Treatment ◽  
Length Of Hospital Stay ◽  
Clinical History ◽  
Life Threatening ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Acute heart failure is a life-threatening medical condition typically leading to urgent hospital admission. Early diagnosis is of great importance, since it will lead to earlier and better targeted treatment, leading to a decrease in length of hospital stay, and most importantly to improved clinical outcome. The initial diagnostic work-up includes a clinical history, evaluation of symptoms and signs, an electrocardiogram, chest X-ray, natriuretic peptide levels, echocardiography and perhaps lung ultrasound. After the initial work-up, a clinical classification according to blood pressure, congestion, and peripheral perfusion should be performed, since it will guide treatment. During the diagnostic work-up, treatable and life-threatening conditions always need to be considered since they need immediate and case-specific treatment.

scholarly journals Hypercalciuria: A Rare Contributing Cause of Exercise-Induced Visible Haematuria

2018 ◽  
Vol 1 (2) ◽  
pp. e33-e37
Author(s):  
Wayne Barlow ◽  
Maitrey Darrad ◽  
Simon Fletcher ◽  
Raghuram Devarajan
Keyword(s):  
Case Report ◽  
Distance Runner ◽  
Careful Attention ◽  
Specific Group ◽  
Long Distance ◽  
Renal Biopsies ◽  
Exercise Induced ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Exertional haematuria is a relatively common reported symptom. We present a case of exercise induced haematuria in a long distance runner with proven hypercalciuria. Our case report highlights that urothelial calcifications in patients with hypercalciuria have the potential to cause traumatic haematuria during high intensity exercise. Whilst diagnostic work up of haematuria still applies, careful attention to the history in this specific group of patents has the potential to avoid further invasive investigations, such as renal biopsies.

Fatal, acute Non-A, Non-B hepatitis with confluent necrosis. Case report and proposal for diagnostic work-up

Infection ◽  
1982 ◽  
Vol 10 (3) ◽  
pp. 165-167 ◽  
Author(s):  
M. Shamma'a ◽  
S. Feghali ◽  
C. Allam
Keyword(s):  
Case Report ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

scholarly journals Phenotypical variability of post-partum reversible cerebral vasoconstriction syndrome

2010 ◽  
Vol 2 (2) ◽  
pp. 16 ◽  
Author(s):  
Benjamin Matosevic ◽  
Martin Furtner ◽  
Michael Knoflach ◽  
Christoph Schmidauer ◽  
Georg Wille ◽  
...  
Keyword(s):  
Post Partum ◽  
Treatment Strategies ◽  
Reversible Cerebral Vasoconstriction Syndrome ◽  
Potential Treatment ◽  
Cerebral Vasoconstriction ◽  
Life Threatening ◽  
Diagnostic Work ◽  
Work Up ◽  
Phenotypical Variability ◽  
Diagnostic Work Up

Reversible cerebral vasoconstriction syndrome is recognized increasingly as a complication of the postpartum period. Our series of four cases illustrates its phenotypical variability, summarizes the diagnostic work-up, and outlines potential treatment strategies for this usually benign but sometimes disabling and life-threatening disease.

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