scholarly journals Granulomatosis with Polyangiitis with Myocarditis and Ventricular Tachycardia

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Ramy Magdy Hanna ◽  
Eduardo Lopez ◽  
James Wilson
Keyword(s):  
Ventricular Tachycardia ◽  
Aortic Valve Disease ◽  
Crescentic Glomerulonephritis ◽  
Granulomatosis With Polyangiitis ◽  
Acute Myocarditis ◽  
Reactive Thrombocytosis ◽  
Renal Lesions ◽  
Pulmonary Manifestations ◽  
Pulmonary Renal Syndrome ◽  
Multiple Episodes

Granulomatosis with polyangiitis (GPA), previously known as Wegener’s granulomatosis, is a pulmonary-renal syndrome affecting small and medium sized blood vessels. The disease has a prevalence in studies ranging from 3 to 15.7 cases per 100,000, with a noted increasing incidence and prevalence in more recent studies. Pulmonary manifestations include hemorrhage, lung cavitary lesions, and pulmonary fibrosis. Within the kidney, GPA is known to cause rapidly progressive pauci-immune crescentic glomerulonephritis. Rare and severe cardiovascular manifestations include pericarditis, arrhythmias, myocarditis, and aortic valve disease. Our patient is a 43-year-old female with typical pulmonary and renal lesions from GPA and also acute myocarditis, multiple episodes of ventricular tachycardia, and a severe reactive thrombocytosis.

scholarly journals Ventricular Tachycardia Induced by Weight Loss Pills

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Manan Pareek ◽  
Nils Henrik Hansson ◽  
Erik Lerkevang Grove
Keyword(s):  
Weight Loss ◽  
Ventricular Tachycardia ◽  
The Internet ◽  
Monomorphic Ventricular Tachycardia ◽  
Multiple Episodes

A previously healthy 29-year-old man was admitted with palpitations, dizziness, and near-syncope after he had recently started taking weight loss pills purchased on the internet. The pills contained caffeine and ephedrine. An electrocardiogram and telemetry revealed multiple episodes of non-sustained monomorphic ventricular tachycardia, which was successfully treated with amiodarone. In conclusion, unauthorized weight loss pills can be harmful. In particular, ephedrine-containing drugs carry a risk of ventricular tachycardia and should be discouraged.

Pulmonary Manifestations of Granulomatosis With Polyangiitis

2014 ◽  
Vol 10 (5) ◽  
pp. 288-293 ◽  
Author(s):  
Alejandro Gómez-Gómez ◽  
Marco Ulises Martínez-Martínez ◽  
Enrique Cuevas-Orta ◽  
Juan Mario Bernal-Blanco ◽  
Daniel Cervantes-Ramírez ◽  
...  
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Pulmonary Manifestations

Conjunctivitis, episcleritis and anterior uveitis as the first presenting features of granulomatosis with polyangiitis

2021 ◽  
Vol 14 (10) ◽  
pp. e243558
Author(s):  
Lucas Donato Foster ◽  
Michael Nyugen ◽  
Edward Margolin
Keyword(s):  
Anterior Uveitis ◽  
Crescentic Glomerulonephritis ◽  
Granulomatosis With Polyangiitis ◽  
Oral Prednisone ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Final Diagnosis ◽  
Ocular Inflammation ◽  
Reactive Protein ◽  
Ocular Manifestations ◽  
Organ Systems

Granulomatosis with polyangiitis (GPA) is a rare disorder characterised by inflammation of small-sized and medium-sized blood vessels that result in damage to various organ systems, but it most commonly affects the respiratory tract and kidneys. It is one of the few entities that can present with ocular inflammation as well as renal impairment at the same time. We describe a case of a 38-year-old man with conjunctivitis, episcleritis, anterior uveitis as a first manifestation of GPA. His presentation with red eye and anterior uveitis prompted further workup, which revealed acute renal failure (creatinine 442 mmol/L), elevated inflammatory markers (erythrocyte sedimentation rate of 85 mmol/hour and C reactive protein of 72 mg/L), and a c-antineutrophil cytoplasmic antibody titre >8. An urgent renal biopsy was performed demonstrating necrotising crescentic glomerulonephritis, which led to the final diagnosis of GPA. Treatment induction with intravenous methylprednisolone and plasmapheresis followed by an oral prednisone taper and intravenous rituximab infusions leading to resolution of all symptoms and normalisation of kidney function. This report highlights conditions that can present with both ocular inflammation and renal dysfunction with a focus on GPA and its ocular manifestations.

scholarly journals Crescentic Glomerulonephritis with Anti-GBM and p-ANCA Antibodies

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Tariq Javed ◽  
Parag Vohra
Keyword(s):  
Renal Failure ◽  
Renal Biopsy ◽  
Recurrence Rate ◽  
Crescentic Glomerulonephritis ◽  
Diagnosis And Treatment ◽  
Atypical Presentation ◽  
Long Term Follow Up ◽  
Pulmonary Renal Syndrome

We are presenting a case of renal failure with anti-GBM and p-ANCA antibodies positive. Patients with dual antibodies are considered to be a vasculitis-variant of anti-GBM antibody nephritis. These patients may have atypical presentation and it may delay diagnosis and treatment. Recurrence rate is higher in these patients. We reviewed the literature of cases and studies on cresenteric glomerulonephritis with anti-GBM and p-ANCA positive patients. We recommend that patients suspected with pulmonary-renal syndrome should be checked for anti-GBM and p-ANCA antibodies, should undergo renal biopsy and should should have close long term follow up to watch for recurrence.

scholarly journals Amnesia in a Patient with Rheumatoid Arthritis: A Case of Granulomatosis with Polyangiitis

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Pablo Weilg ◽  
Giancarlo Diaz-Zamora ◽  
Larry Young
Keyword(s):  
Rheumatoid Arthritis ◽  
Crescentic Glomerulonephritis ◽  
Granulomatosis With Polyangiitis ◽  
Diffuse Alveolar Damage ◽  
Oral Prednisone ◽  
Small Region ◽  
Pulse Therapy ◽  
Steroid Pulse ◽  
Acute Infarction ◽  
History Of

A 56-year-old male with a history of seropositive rheumatoid arthritis complained of polyarthritis and forgetfulness. The initial CT scan of the head without contrast was negative for acute pathologies. However, as he continued to decline despite being on oral prednisone, an MRI of the head was ordered and revealed a subtle small region of acute infarction in the left mammillary body. He was diagnosed with granulomatosis with polyangiitis in light of his positive C-ANCA antibodies, PR3 antibody, and a kidney biopsy, which showed focal necrotizing pauci-immune crescentic glomerulonephritis. Despite undergoing steroid pulse therapy, the patient developed diffuse alveolar damage which finally responded to rituximab infusion.

Recurrent Elevation of Troponin Levels in Acute Myocarditis: Is it a Sign of Ventricular Tachycardia?

2020 ◽  
Vol 87 (12) ◽  
pp. 1076-1077
Author(s):  
Can Yilmaz Yozgat ◽  
Osman Yesilbas ◽  
Selcuk Uzuner ◽  
Betul Saritas ◽  
Serap Nur Ergor ◽  
...  
Keyword(s):  
Ventricular Tachycardia ◽  
Acute Myocarditis

scholarly journals Granulomatosis with Polyangiitis Presenting as Pauci-Immune Crescentic Glomerulonephritis in Pregnancy

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Ryan Kunjal ◽  
Raafat Makary ◽  
Andreea Poenariu
Keyword(s):  
Crescentic Glomerulonephritis ◽  
Granulomatosis With Polyangiitis ◽  
African American Woman ◽  
Hyperemesis Gravidarum ◽  
American Woman ◽  
Reproductive Age ◽  
Urine Sediment ◽  
Cutaneous Manifestations ◽  
First Case ◽  
In Pregnancy

Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis rarely affects females of reproductive age. A 28-year-old African American woman presented at 8 weeks of gestation with intractable vomiting attributed to hyperemesis gravidarum. She was found to have acute kidney injury that was unresponsive to vigorous fluid resuscitation and urine sediment examination was suggestive of an underlying glomerulonephritis. Serum c-ANCA and PR3 were elevated and there was no peripheral eosinophilia. During her course she also developed one episode of small volume hemoptysis with right upper lobe infiltrates on CT Chest. There were no cutaneous manifestations of vasculitis or upper respiratory symptoms. Renal biopsy revealed a pauci-immune crescentic glomerulonephritis (PICGN). The diagnosis was consistent with granulomatosis with polyangiitis (GPA). Management initially comprised teratogen sparing agents; steroids, intravenous immunoglobulin; and plasma exchange. The response was suboptimal and she became dependent on daily renal replacement therapy. Ultimately the pregnancy was terminated allowing for traditional treatment approaches with dramatic effect. This is the first case of GPA presenting as PICGN in pregnancy and highlights the challenges of its management.

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