Correlation between Transient Pupillary Light Reflex and Retinal Function Impairment in Patients with Retinitis Pigmentosa

Purpose. To investigate the relationship between transient pupillary light reflex (PLR) and visual function in patients with retinitis pigmentosa (RP). Methods. A retrospective study was performed with 137 eyes of 73 patients with RP. Transient pupillary light reflex was measured by the vision monitor system (MonColor; Metrovision, France). Dark-adapted transient PLRs were elicited by four specific levels of stimulus luminance (−5, −3, −1, and 0 log cd/m2, blue or white light). Best-corrected visual acuity (BCVA) was recorded based on Early Treatment Diabetic Retinopathy Study (ETDRS) acuity charts. Fixation stability and retinal sensitivity of radial 10° areas were measured with microperimetry. The retinal sensitivity (RS) was divided into central RS (fovea and radial 1° areas) and peripheral RS (radial 3° and 5° areas from the fovea). The patients were further classified into 2 groups (P1 > 75% and P1 < 75%) according to fixation stability. Spearman’s correlation was performed to identify significant associations between BCVA, fixation stability, RS, and PLR. Results. Under the stimuli of the same color light, relative pupillary constriction (RPC), latency, or velocity of constriction in the same patients was statistically different in multiple luminance, respectively. Under the same luminance, blue light induced greater RPC and velocity (except for −3 log cd/m2) than white light. Most patients showed varying degrees of threshold elevation and visual function deficiency. Besides, there was a statistically significant difference in the distribution of BCVA, MRS, or fixation stability under different thresholds. The correlation between pupillary constrictive area (PCA) and retinal sensitivity was mainly determined by the peripheral region. Moreover, patients with stable fixation showed a greater correlation between PCA and RS. Conclusion. PLR induced by specific colors and luminance may serve as a promising clinical approach for assessing and monitoring rod function in advanced RP patients.

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Transient Pupillary Light Reflex in Relation to Fundus Autofluorescence and Dark-Adapted Perimetry in Typical Retinitis Pigmentosa

Ophthalmic Research ◽

10.1159/000330049 ◽

2012 ◽

Vol 47 (3) ◽

pp. 113-121 ◽

Cited By ~ 3

Author(s):

Yong Liu ◽

Dan Ning Liu ◽

Xiao Hong Meng ◽

Zheng Qin Yin

Keyword(s):

Retinitis Pigmentosa ◽

Fundus Autofluorescence ◽

Pupillary Light Reflex ◽

Light Reflex ◽

Pupillary Light

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Retinal sensitivity measured by the pupillary light reflex in RCS and albino rats

Vision Research ◽

10.1016/0042-6989(82)90081-5 ◽

1982 ◽

Vol 22 (9) ◽

pp. 1163-1171 ◽

Cited By ~ 31

Author(s):

Leonard J. Trejo ◽

Carol M. Cicerone

Keyword(s):

Pupillary Light Reflex ◽

Albino Rats ◽

Retinal Sensitivity ◽

Light Reflex ◽

Pupillary Light

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Assessment of pupillary light reflex using dynamic pupillometry in laser-treated eyes with retinal vein occlusion

European Journal of Ophthalmology ◽

10.1177/1120672120969038 ◽

2020 ◽

pp. 112067212096903

Author(s):

Huseyin Bugra Turk ◽

Gulfidan Bitirgen ◽

Gunhal Satirtav ◽

Hurkan Kerimoglu

Keyword(s):

Laser Treatment ◽

Retinal Vein Occlusion ◽

Laser Photocoagulation ◽

Pupillary Light Reflex ◽

Contraction Amplitude ◽

Light Reflex ◽

Vein Occlusion ◽

Pupillary Light ◽

Significant Difference ◽

Fellow Eyes

Purpose: This study aims to evaluate the pupillary light reflex measured with dynamic pupillometry in patients who underwent retinal laser photocoagulation due to unilateral retinal vein occlusion (RVO). Methods: A total of 48 patients with unilateral RVO were included in the study. Thirty-four patients had undergone retinal laser photocoagulation while the remaining 14 patients that did not undergo laser treatment were observed for control purposes. Of the laser-treated eyes, 14 eyes (41.2%) had central RVO (CRVO) and 20 eyes (58.8%) had branch RVO (BRVO). Among the 14 patients with RVO without laser treatment, nine eyes (64.3%) had CRVO and five eyes (35.7%) had BRVO. Pupillary light reflexes were assessed with dynamic pupillometry (MonPackOne®; Metrovision, France). The parameters of the eyes with RVO were compared with that of fellow healthy eyes. Results: Mean patient age was 65.8 ± 10.4 years and median time after photocoagulation was 25.5 months. Eyes that received laser photocoagulation had lower pupil contraction amplitude ( p = 0.037), prolonged contraction latency ( p = 0.027), slower contraction velocity ( p = 0.043), and slower dilation velocity ( p < 0.001) compared to healthy fellow eyes. Subgroup analysis revealed that eyes with CRVO had lower contraction amplitude ( p = 0.013) and slower dilation velocity ( p = 0.003), and eyes with BRVO had slower dilation velocity ( p = 0.003). Non-laser-treated eyes with RVO revealed no significant difference in any of the pupillary light reflex parameters compared to fellow eyes. Conclusion: Laser-treated eyes with RVO demonstrated changes in pupillary light reflex parameters including reduced contraction amplitude, prolonged contraction latency, and slower contraction and dilation velocities measured with dynamic pupillometry.

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