scholarly journals Listeria monocytogenes Brain Abscess: Controversial Issues for the Treatment—Two Cases and Literature Review

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Beatrice Tiri ◽  
Giulia Priante ◽  
Lavinia Maria Saraca ◽  
Lucia Assunta Martella ◽  
Stefano Cappanera ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Literature Review ◽  
Brain Abscess ◽  
Medical Therapy ◽  
Opportunistic Pathogen ◽  
Mortality Rates ◽  
Controversial Issues ◽  
Biopsy Material ◽  
Brain Abscesses ◽  
System Manifestation

Listeria monocytogenes (LM) is an opportunistic pathogen, and the most common central nervous system manifestation is meningitis while listerial brain abscesses are rare. We describe 2 cases of brain abscess due to LM and a literature review. Only 73 cases were reported in the literature from 1968 to 2017. The mean age was 51.9, and the mortality rate was 27.3%. In 19% of cases, no risk factors for neurolisteriosis were identified. Blood cultures were positive in 79.5% while CSF or brain abscess biopsy material was positive in 50.8%. In 40% was started a monotherapy regimen while in 60% a combination therapy without substantial differences in mortality. Fifty-two percent underwent neurosurgery while 45.3% has been treated only with medical therapy. The mortality rates were, respectively, 13% and 38.2%. Only 25% of patients who were treated for ≤6 weeks underwent neurosurgery, while 80% of those who were treated for ≥8 weeks were operated. The mortality rates were, respectively, 12.5% and 0%, suggesting that a combined approach of surgery and prolonged medical therapy would have an impact on mortality. We believe that it is essential to carry out this review as brain abscesses are rare, and there are no definitive indications on the optimal management, type, and duration of therapy.

Multiple cerebral abscesses because of listeria monocytogenes: three case reports and a literature review of supratentorial listerial brain abscess(es)

2003 ◽  
Vol 59 (4) ◽  
pp. 320-328 ◽  
Author(s):  
Lawrence A Cone ◽  
Millie M Leung ◽  
Richard G Byrd ◽  
Gary M Annunziata ◽  
Richard Y Lam ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Literature Review ◽  
Brain Abscess ◽  
Case Reports

scholarly journals Potential Nosocomial Acquisition of EpidemicListeria monocytogenesPresenting as Multiple Brain Abscesses Resembling Nocardiosis

2010 ◽  
Vol 21 (1) ◽  
pp. 57-60 ◽  
Author(s):  
Aleksandra Stefanovic ◽  
James Reid ◽  
A Celine Nadon ◽  
Jennifer Grant
Keyword(s):  
Listeria Monocytogenes ◽  
Brain Abscess ◽  
Antimicrobial Therapy ◽  
Hematological Malignancies ◽  
Solid Organ ◽  
Gram Stain ◽  
Current Case ◽  
Cerebellar Abscess ◽  
Immunosuppressed Patients ◽  
Brain Abscesses

Listerial brain abscesses are rare, and are found mostly in patients with underlying hematological malignancies or solid-organ transplants. A case of a patient with Crohn’s disease and multiple brain abscesses involving the left cerebellum and right sylvian fissure is described. The Gram stain and histopathology of the cerebellar abscess revealed Gram-positive, beaded rods suggestive ofNocardia. However, on culture,Listeria monocytogeneswas identified.Listeriamay appear Gram-variable and has been misidentified as streptococci, enterococci and diphtheroids. The present case is the first reported case ofL monocytogenesresemblingNocardiaon both microbiological and histopathological assessment. Reported cases of listerial brain abscesses are sporadic, while the current case was part of a nationwide listerial outbreak linked to consumption of contaminated deli meats. Broad antimicrobial therapy (including antilisterial coverage) in immunosuppressed patients presenting with brain abscess is crucial, until cultures confirm the identification of the organism.

scholarly journals Neuronavigation Combined with Nerve Electrophysiology in Excision of Brain Abscess: A Case Report and Literature Review

2017 ◽  
Vol 3 (4) ◽  
pp. 224-228
Author(s):  
Xiaoxu Shen ◽  
Dong Zhao ◽  
Qi Liu
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Literature Review ◽  
Brain Abscess ◽  
Female Patient ◽  
Neurological Deficits ◽  
Curative Effect ◽  
Monitoring Technology ◽  
Safety And Reliability ◽  
Brain Abscesses

A brain abscess is a parenchymal infection, which is a severe intracranial infectious disease. Although the incidence is low, it causes serious inflammation and neurological deficits. The current treatments for brain abscesses are primarily surgical, including abscess resection or puncture and drainage. In recent years, extensive application of neuronavigation and electrophysiological monitoring technology have improved the safety and reliability of neurosurgery. To explore the application and curative effect of neuronavigation combined with neurophysiological techniques in the treatment of brain abscesses, we retrospectively analyzed a female patient who had undergone neurological monitoring and neuronavigation-assisted surgery to remove an abscess in 2015. Diagnosis and treatment are reported.

scholarly journals Listeria monocytogenes Brain Abscess Mimicking Ischemic Stroke in an Immunocompromised Patient: A Case Report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Angeliki Tsifi ◽  
Stavroula Panagiota Lontou ◽  
Maria Triantafyllou ◽  
Sevastianos Chatzidavid ◽  
Dimitrios Theodoridis ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Brain Abscess ◽  
Corticosteroid Treatment ◽  
Antimicrobial Treatment ◽  
Oral Amoxicillin ◽  
Brain Abscesses ◽  
Recent Diagnosis ◽  
Magnetic Resonance Imaging Mri ◽  
Mri Study

Listeria monocytogenes (L. monocytogenes) is a Gram-positive bacillus that infects immunocompromised persons, neonates, pregnant women and, occasionally, previously healthy individuals. L. monocytogenes brain abscesses are particularly rare.We present a 62-year-old female on corticosteroid treatment due to a recent diagnosis of autoimmune hepatitis, who suddenly developed right hemiparesis mimicking a stroke. A brain computerized tomography (CT) scan revealed a brain abscess and the blood cultures drawn yielded L. monocytogenes. A conservative treatment without surgical intervention was selected. The patient was commenced on intravenous ampicillin and gentamicin and showed remarkable improvement. She was successfully discharged on oral amoxicillin with probenecid. Since the subsequent magnetic resonance imaging (MRI) study and CT scans exhibited reduction in the size of the abscess, the antimicrobial treatment was discontinued after a three-month period. The patient underwent regular follow-up visits with no signs of relapse.

scholarly journals Brain Abscess Caused by Nocardia: Case Report and Literature Review

2020 ◽  
Author(s):  
Guilherme Finger ◽  
Maria Eduarda Conte Gripa ◽  
Tiago Paczko Bozko Cecchini ◽  
Tobias Ludwig do Nascimento
Keyword(s):  
Case Report ◽  
Antibiotic Therapy ◽  
Brain Abscess ◽  
Clinical Signs ◽  
Occipital Lobe ◽  
High Morbidity ◽  
Rare Clinical Entity ◽  
Brain Abscesses

AbstractNocardia brain abscess is a rare clinical entity, accounting for 2% of all brain abscesses, associated with high morbidity and a mortality rate 3 times higher than brain abscesses caused by other bacteria. Proper investigation and treatment, characterized by a long-term antibiotic therapy, play an important role on the outcome of the patient. The authors describe a case of a patient without neurological comorbidities who developed clinical signs of right occipital lobe impairment and seizures, whose investigation demonstrated brain abscess caused by Nocardia spp. The patient was treated surgically followed by antibiotic therapy with a great outcome after 1 year of follow-up.

scholarly journals Mortality in Patients with Brainstem Cavernous Malformations

2021 ◽  
pp. 1-7
Author(s):  
Julia Velz ◽  
Marian Christoph Neidert ◽  
Yang Yang ◽  
Kevin Akeret ◽  
Peter Nakaji ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Postoperative Mortality ◽  
Mortality Rates ◽  
Cavernous Malformations ◽  
Patient Cohort ◽  
Actual Risk ◽  
Single Center Study

<b><i>Objective:</i></b> Brainstem cavernous malformations (BSCM)-associated mortality has been reported up to 20% in patients managed conservatively, whereas postoperative mortality rates range from 0 to 1.9%. Our aim was to analyze the actual risk and causes of BSCM-associated mortality in patients managed conservatively and surgically based on our own patient cohort and a systematic literature review. <b><i>Methods:</i></b> Observational, retrospective single-center study encompassing all patients with BSCM that presented to our institution between 2006 and 2018. In addition, a systematic review was performed on all studies encompassing patients with BSCM managed conservatively and surgically. <b><i>Results:</i></b> Of 118 patients, 54 were treated conservatively (961.0 person years follow-up in total). No BSCM-associated mortality was observed in our conservatively as well as surgically managed patient cohort. Our systematic literature review and analysis revealed an overall BSCM-associated mortality rate of 2.3% (95% CI: 1.6–3.3) in 22 studies comprising 1,251 patients managed conservatively and of 1.3% (95% CI: 0.9–1.7) in 99 studies comprising 3,275 patients with BSCM treated surgically. <b><i>Conclusion:</i></b> The BSCM-associated mortality rate in patients managed conservatively is almost as low as in patients treated surgically and much lower than in frequently cited reports, most probably due to the good selection nowadays in regard to surgery.

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