scholarly journals Comparison between the Effects of Oral and Intramuscular Administration of Shin’iseihaito (Xinyiqingfeitang) in a Streptococcus pyogenes-Induced Murine Sinusitis Model

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Masaaki Minami ◽  
Toru Konishi ◽  
Hiroshi Takase ◽  
Toshiaki Makino
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Streptococcus Pyogenes ◽  
Kampo Medicine ◽  
Intramuscular Administration ◽  
Nasal Discharge ◽  
Thymidine Uptake ◽  
Nasal Colonization ◽  
Upper Respiratory Tract ◽  
Tract Infections

Streptococcus pyogenes (S. pyogenes) is a species of Gram-positive coccoid bacteria having many virulence factors. Its capsule and exotoxins can cause upper respiratory tract infections such as sinusitis. The general treatment for S. pyogenes-induced sinusitis is administration of antibiotics such as penicillin and macrolides; however, a serious problem associated with these antibiotics is their attenuated effect. Shin’iseihaito (Xinyiqingfeitang), a formula of Japanese traditional Kampo medicine and traditional Chinese medicine, has been used for the treatment of sinusitis. In general, formulas of Japanese traditional Kampo medicine are orally administered. This is in contrast to certain formulas of traditional Chinese medicine, which are being recently administered intramuscularly or intravenously. Regarding these traditional Chinese medicine formulas, the injection methodology is reported to be more effective than oral intake. In this study, we compared the efficacy between orally and intramuscularly administered Shin’iseihaito against S. pyogenes-induced sinusitis. We evaluated the antibacterial effect of Shin’iseihaito extract (SSHT) against S. pyogenes by K-B disk diffusion assay. Furthermore, we investigated the nasal colonization of S. pyogenes, determined cytokine (TNF-α, IL-1β, and IL-6) levels, and conducted a splenocyte proliferative assay in a murine sinusitis model. SSHT displayed direct anti-S. pyogenes activity. Intramuscular administration of SSHT decreased the nasal colonization of S. pyogenes compared with oral administration. Thymidine uptake analysis revealed that the proliferation of splenocytes from S. pyogenes-infected mice under intramuscular SSHT treatment was upregulated compared to that of splenocytes from S. pyogenes-infected mice under oral SSHT treatment. We also found that TNF-α, IL-1β, and IL-6 levels in the nasal discharge from intramuscularly treated S. pyogenes-infected mice were lower than those from orally treated mice. Our findings suggest that intramuscular administration of Shin’iseihaito may be useful for the treatment of murine S. pyogenes-induced sinusitis.

A comprehensive review of pharmacokinetic and pharmacodynamic in animals: exploration of interaction with antibiotics of Shuang-Huang-Lian preparations

2021 ◽  
Vol 21 ◽  
Author(s):  
Liuyi Liang ◽  
Xin Jin ◽  
Jinjing Li ◽  
Rong Li ◽  
Xinyi Jiao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Pharmacokinetic Interaction ◽  
Pharmacological Action ◽  
New Strategy ◽  
System Review ◽  
Tract Infections ◽  
Important Significance

: As a traditional Chinese medicine, Shuang-Huang-Lian (SHL) has been widely used for treating infectious diseases of the respiratory tract such as encephalitis, pneumonia and asthma. During the past few decades, considerable research has focused on the pharmacological action, pharmacokinetic interaction with antibiotics and clinical applications of SHL. A huge and more recent body of pharmacokinetic study supports the combination of SHL and antibiotics has different effects such as antagonism and synergism. SHL has been one of the best-selling traditional Chinese medicine (TCM) products. However, there is no system review of SHL preparations, ranging from protection against respiratory tract infections to interaction with antibiotics. Since their important significance in clinical therapy, the pharmacodynamic, pharmacokinetic, and interactions with antibiotics of SHL were reviewed and discussed. In addition, this review attempts to explore the possible potential mechanism of SHL preparations in prevention and treatment of COVID-19. We are concerned about what is known of the effects of SHL against virus, bacterium, and its interactions with antibiotics, providing a new strategy for expanding the clinical research and medication of SHL preparations.

scholarly journals Discrimination and Proper Use of Polygoni Multiflori Radix, Cynanchi Wilfordii Radix, and Cynanchi Auriculati Radix in Korea: A Descriptive Review

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Beom-Joon Lee ◽  
Kyungjin Lee
Keyword(s):  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Herbal Medicines ◽  
Kampo Medicine ◽  
Traditional Korean Medicine ◽  
Traditional Herbal Medicine ◽  
Food Ingredient ◽  
Korean Medicine ◽  
Traditional Uses

Polygoni Multiflori Radix (PMR), Cynanchi Wilfordii Radix (CWR), and Cynanchi Auriculati Radix (CAR) are very popular herbal medicines in Traditional Korean Medicine, Traditional Chinese Medicine, and Kampo Medicine. However, the plant origins, efficacies, and traditional uses of these herbal medicines differ. In Korea, PMR is calledHa Su O(He Shou Wuin China), and CWR is calledBaek Ha Su OorBaek Su O(Bai Shou Wuin China).Baek Su Orefers to CWR in Korea and CAR in China. CAR has not been used as a traditional herbal medicine, and it cannot be legally used as a food or food ingredient in Korea. However, CAR is cultivated in Korea and imported from China. Because the morphology of CWR and CAR is very similar, they are often confused and misused in Korea. This review discusses the reasons for the confusion and misuse of these substances in Korea and provides the exact plant origins, efficacies, uses, components, and toxicities of PMR, CWR, and CAR so that they can be correctly understood and used.

Persistent nasal crusting due to hypohidrotic ectodermal dysplasia

1996 ◽  
Vol 110 (4) ◽  
pp. 379-382 ◽  
Author(s):  
A. H. Al-Jassim ◽  
A. C. Swift
Keyword(s):  
Respiratory Tract ◽  
Ectodermal Dysplasia ◽  
Sweat Glands ◽  
Specific Reference ◽  
Nasal Discharge ◽  
Upper Respiratory Tract ◽  
Hypohidrotic Ectodermal Dysplasia ◽  
Sparse Hair ◽  
Tract Infections ◽  
Clinical Awareness

AbstractHypohidrotic ectodermal dysplasia is an hereditary condition of the ectodermal tissues which may escape recognition because of lack of clinical awareness due to its rarity. Otorhinolaryngological features of this syndrome include chronic respiratory tract infections, persistent foul-smelling nasal discharge and crust formation, and hearing problems.The condition is usually an X-linked recessive disease affecting mainly ectodermal tissue, although nonectodermal tissue may also be affected. The notation ‘ectodermal’ is used because ectodermal tissues are always involved. The syndrome is characterized by complete or partial absence of sweat glands, sparse hair growth, absent or deformed peg teeth, sparse sebaceous glands, occasional absence of salivary and lacrimal glands, scanty mucous glands and deficient cilia.We describe two children with this disorder with specific reference to the effect on the upper respiratory tract.

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