Pretreatment Serum Uric Acid as an Efficient Predictor of Prognosis in Men with Laryngeal Squamous Cell Cancer: A Retrospective Cohort Study

Purpose. Uric acid (UA) is a major antioxidant molecule that has been hypothesized to have a protective effect against cancer-induced oxidative damage. The aim of the present study was to investigate whether preoperative levels of serum UA are associated with the prognosis of laryngeal squamous cell cancer (LSCC). Methods. A total of 814 male LSCC patients (followed up for five years) and 814 normal control subjects were enrolled from January 2007 to December 2011. The rates of total mortality and cancer mortality were 23.46% and 21.36%, respectively. The prevalence of overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) was analysed using the Kaplan-Meier method. Univariate and multivariate Cox regression models were evaluated to identify UA as a prognostic factor. Results. The serum UA and UA/Cr (creatinine) ratio levels were significantly reduced (P<0.001 for both) in the LSCC group compared with the control group. The applied multivariate Cox regression model analysis found that low levels of UA and the UA/Cr ratio were independent poor prognostic factors for OS (UA (HR 95% CI=1.458 (1.095–1.942)), UA/Cr ratio (HR 95% CI=1.337 (1.004–1.780))), DFS (UA (HR 95% CI=1.504 (1.131–2.001)), UA/Cr ratio (HR 95% CI=1.376 (1.030–1.839))), and CSS (UA (HR 95% CI=1.494 (1.109–2.012)), UA/Cr ratio (HR 95% CI=1.420 (1.049–1.923))). The patients with high UA (>0.310 mmol/l) and UA/Cr ratio (>3.97) experienced five more years of OS, DFS, and CSS than did patients with low UA (<0.310 mmol/l) and UA/Cr ratio (<3.97) levels. Conclusion. High preoperative UA serum levels were identified as an independent prognostic factor associated with improved clinical outcomes among LSCC patients.

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Perineural invasion as a prognostic factor in laryngeal squamous cell cancer: a matched-pair survival analysis

Cancer Investigation ◽

10.1080/07357907.2021.1947311 ◽

2021 ◽

pp. 1-16

Author(s):

Xiaoli Zhu ◽

Fei Duan ◽

Yingying Zhu ◽

Xiaohua Shi ◽

Shuai Sun ◽

...

Keyword(s):

Survival Analysis ◽

Prognostic Factor ◽

Squamous Cell ◽

Perineural Invasion ◽

Squamous Cell Cancer ◽

Cell Cancer ◽

Matched Pair ◽

Laryngeal Squamous Cell Cancer

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Prognostic significance of stromal eosinophilic infiltration in cancer of the larynx

Otolaryngology ◽

10.1016/j.otohns.2005.01.041 ◽

2005 ◽

Vol 132 (6) ◽

pp. 869-873 ◽

Cited By ~ 15

Author(s):

ÇBrahim Ercan ◽

Burak Çakir ◽

Tülay Baçak ◽

Tuncay Özdemir ◽

Árahim Sayin ◽

...

Keyword(s):

Prognostic Factor ◽

Squamous Cell ◽

Vascular Invasion ◽

Squamous Cell Cancer ◽

Cell Cancer ◽

Low Grade ◽

Depth Of Invasion ◽

Tumor Differentiation ◽

Laryngeal Squamous Cell Cancer

OBJECTIVE: To investigate prevalence and possible role of tumor-associated tissue eosinophilia (TATE) as a prognostic factor in laryngeal squamous cell cancer. STUDY DESIGN: Prospective case series. METHODS: Seventy-eight consecutive patients with diagnosis of squamous cell carcinoma of the larynx and who were treated surgically in our center were evaluated. The possible role of TATE as a prognostic factor in laryngeal squamous cell cancer was investigated with respect to tumor differentiation, depth of invasion, perineural and vascular invasion (histopathological parameters), and neck metastasis (clinical parameter). The relation between presence of TATE and age was also examined. RESULTS: TATE was positive in the tumors of 32% of the patients, including low grade, 20 (26%); medium grade, 4 (5%); and high grade, 1 (1%). The relationships between TATE and tumor differentiation, perineural invasion, vascular invasion, pathologic N stage, and depth of invasion were not statistically significant ( P >0.05). According to Spearman correlation analysis ( r = −0.383, P = 0.001), there is a negative correlation between TATE and age. Ages of TATE-positive patients tend to be clustered in the 5th and 6th decades of life, whereas the TATE-negative patients’ ages tend to be clustered in the 6th and 7th decades. CONCLUSIONS: TATE has no correlation with prognostic parameters in laryngeal squamous cell cancer. Presence of TATE is highly correlated with age. Incidence of TATE is very low over the age of 60 years, and this may suggest that age influences the tissue inflammatory response to tumor. Further investigation is needed to explain the associations of TATE and age and also the host response to malignancy.

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CCT α is a novel biomarker for diagnosis of laryngeal squamous cell cancer

Scientific Reports ◽

10.1038/s41598-019-47895-x ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 2

Author(s):

Jingpu Yang ◽

Zhuping Zhang ◽

Yin Zhao ◽

Jinzhang Cheng ◽

Chang Zhao ◽

...

Keyword(s):

Squamous Cell ◽

Operating Characteristic ◽

Squamous Cell Cancer ◽

Characteristic Curve ◽

Cell Cancer ◽

Diagnostic Value ◽

Control Group ◽

Over Expression ◽

Choline Phosphate ◽

Laryngeal Squamous Cell Cancer

AbstractCholine phosphate-based delivery systems can target the acidic tumor microenvironment. In this study, we set out to evaluate the diagnostic value of Choline phosphate cytidylyltransferase-α (CCTα) in laryngeal squamous cell cancer (LSCC). The expression of CCTα was detected using immunohistochemistry in 50 LSCC patients’ tissues and 16 vocal polyps as control group. Then, clinical data was collected and we used receiver operating characteristic curve (ROC) to estimate the potential of CCTα as diagnostic biomarker. We found CCTα levels to be significantly high in the tissues derived from LSCC patients, (p < 0.001). Further, we observed a positive correlation of CCTα with tumor size (p < 0.001), TNM stage (p < 0.001), lymph node metastasis (p < 0.001) as well as the grade of LSCC malignancy (p < 0.001). Furthermore, AUC was determined to be 0.939 by ROC, and the optimal cutoff value 3.100, with 76.0% sensitivity and 100% specificity. We also found an epigenetic basis of CCTα over-expression in LSCC tissues with significantly reduced methylation of CCTα in LSCC tissues, compared to vocal polyps (p < 0.001). These results support epigenetically-induced over-expression of CCTα as a potential diagnostic marker for LSCC.

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