scholarly journals Effective Treatment of a Malignant Breast Phyllodes Tumor with Doxorubicin-Ifosfamide Therapy

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Shinya Yamamoto ◽  
Shigeru Yamagishi ◽  
Toshiro Kohno ◽  
Ryosuke Tajiri ◽  
Toshikazu Gondo ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Left Lung ◽  
Phyllodes Tumor ◽  
Lung Mass ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Malignant Breast ◽  
One Year ◽  
The Right ◽  
Chemotherapy Strategy

Malignant phyllodes tumors of the breast occur infrequently and are difficult to treat with chemotherapy. Here, we present an effective chemotherapy strategy for recurrent malignant breast phyllodes tumors. A 48-year-old woman was diagnosed with a malignant phyllodes tumor in her right breast and underwent total right mastectomy. One year later, the tumor recurred in the right (a 2.2 cm mass) and left (a 10 cm mass) lungs; pleural effusion was also observed in the left lung. Eight courses of doxorubicin-ifosfamide (AI) therapy were administered. After treatment, the right lung mass and pleural effusion regressed completely and the left lung mass regressed to 2 cm. In conclusion, AI therapy is useful for treating recurrent malignant breast phyllodes tumors.

scholarly journals Large Malignant Phyllodes Tumor of the Breast: Case Report of a Young Female and Review of Literature

2020 ◽  
pp. 137-146
Author(s):  
Melissa Kyriakos Saad ◽  
Imad El Hajj ◽  
Elias Saikaly
Keyword(s):  
Malignant Tumors ◽  
Pectoralis Major Muscle ◽  
Phyllodes Tumor ◽  
World Health ◽  
Low Grade ◽  
Accurate Identification ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Post Surgery ◽  
The Right

Background: Phyllodes tumors are rare fibroepithelial neoplasm of the breast, representing 0.3 to 0.5% of all female breast neoplasms. The term ‘‘phyllodes tumor” by the World Health Organization (WHO) categorizes it into benign, borderline, and malignant tumors based on histopathological characteristics. Malignant phyllodes tumor is an uncommon but aggressive breast malignancy and accounts for approximately 25% of all phyllodes tumors.Case Presentation: A 23-year-old female patient Gravida 0 Para 0, previously healthy, with no family history of breast or ovarian cancer was referred to our institution for managing a right breast mass increasing in size over a period of 1 month associated with reddish-brown discoloration of the skin. Breast ultrasound showed an isodense oval mass measuring approximately 16x14x12cm in the right lower outer quadrant of her breast. Core biopsy and FNA done revealed a low grade phyllodes tumor. MRI of breasts showed a huge mass of the right breast occupying all quadrants, measuring 15x14.5 cm in its greatest axis with involvement of the pectoralis major muscle, with no evidence of suspicious axillary lymphadenopathy. Distant metastatic work-up with CT scan of chest abdomen and pelvis and a PET scan did not show distant metastasis. Hence, the patient underwent right total mastectomy with a final pathology compatible with malignant phyllodes tumor. She is on regular follow up and 18 months post-surgery is still disease free.Conclusion: Management of malignant phyllodes tumor remains debatable, especially when it comes to the effect of adjuvant radiotherapy and chemotherapy. From a surgical perspective, whether phyllodes tumors should be considered as epithelial breast cancers or as soft tissue sarcoma is another debate. On the other hand, although challenging, accurate identification of phyllodes tumor initially may aid in decreased recurrence.

scholarly journals Advance Malignant Phyllodes Tumor with Active Bleeding in Children: A Rare Case

2021 ◽  
Vol 15 (4) ◽  
pp. 208
Author(s):  
Dedy Hermansyah ◽  
Fernando Silalahi ◽  
Albiner Simarmata ◽  
Denny Rifsal Siregar
Keyword(s):  
Physical Examination ◽  
Rare Case ◽  
Phyllodes Tumor ◽  
Active Bleeding ◽  
Breast Lesions ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Prompt Treatment ◽  
The Right ◽  
Current Guidelines

Introduction: Phyllodes tumors are fibroepithelial breast lesions that are uncommon in women and rare among children. Due to scarcity, there are only a few large pediatric phyllodes tumor series. Current guidelines do not differentiate treatment recommendations between children and adults.Case Presentation: A 12-year-old girl presented with a lump in her right breast which grew rapidly within a month. On physical examination, we found a mass on the right breast sized ± 10 x 10 cm; the lump was fragile and bled easily. The patient’s condition was getting worse and worse. Due to this deterioration, we performed a mastectomy immediately.Conclusions: The incidence of malignant phyllodes tumor in children is very rare and required prompt treatment in emergency cases.

scholarly journals A Giant Exulcerated Phyllodes Breast Tumor - A Case Report

2020 ◽  
Vol 21 (1) ◽  
pp. 83-86
Author(s):  
Marko Spasic ◽  
Bojan Milosevic ◽  
Slobodanka Mitrovic ◽  
Nenad Markovic ◽  
Mladen Pavlovic ◽  
...  
Keyword(s):  
Radical Mastectomy ◽  
Phyllodes Tumor ◽  
High Survival ◽  
Phyllodes Tumors ◽  
Traditional Procedure ◽  
Simple Mastectomy ◽  
Malignant Breast ◽  
The Right ◽  
Positive Outlook ◽  
Tumor Types

AbstractPhyllodes tumors of the breast can be benign, malignant, or borderline. Benign and borderline tumors are rare tumor types that have a positive outlook and high survival rate, while the risk of recurrence is typical for malignant breast tumors. Giant phyllodes tumors are larger than 10 cm in diameter and demand a serious diagnostic and treatment approach.In this study we present a case of a female patient treated for an exulcerated breast carcinoma- a giant borderline phyllodes tumor of the breast. The patient presented to the department for the right breast lump with ulcerated skin and nipple abnormalities. The core biopsy was performed and the patient was diagnosed with a benign tumor. Simple mastectomy was performed and final histopathological report revealed a borderline phyllodes tumor. Diagnosis and treatment of a giant phyllodes tumor remain a great challenge for the surgeons. Establishing the preoperative diagnosis based on histopathological findings is imperative to disease management. Surgery is the mainstay of treatment and mastectomy has been the traditional procedure; in cases where suspicious findings in the axilla are revealed, radical mastectomy is performed and the axilla is to be dissected.

scholarly journals Malignant Phyllodes Tumor in an Adolescent Female: A Rare Case Report and Review of the Literature

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Gabriel S. Makar ◽  
Michael Makar ◽  
Joanna Ghobrial ◽  
Kathryn Bush ◽  
Ryan Allen Gruner ◽  
...  
Keyword(s):  
Breast Neoplasms ◽  
Rare Case ◽  
Phyllodes Tumor ◽  
Adolescent Females ◽  
Small Subset ◽  
Review Of The Literature ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Rare Case Report

Primary breast neoplasms are rare in adolescent females, most of which are benign. Phyllodes tumors constitute a remarkably small subset of breast neoplasms (0.3-0.9%) with malignant phyllodes tumors being even more uncommon. Malignant phyllodes tumors tend to progress rapidly though only 1.5% metastasize. They are also associated with a higher rate of recurrence than their benign counterparts, underlying the importance of adequate surgical margins. It is therefore imperative to be able to identify these tumors early allowing for prompt resection and close follow-up. Here, we present the rare case of a 17-year-old female presenting with a rapidly enlarging breast mass, which was ultimately found to be a malignant phyllodes tumor. We further performed a review of the literature to highlight only 22 other cases reported in adolescent females.

scholarly journals Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
R. A. Amir ◽  
Rola S. Rabah ◽  
S. S. Sheikh
Keyword(s):  
Case Report ◽  
Breast Neoplasms ◽  
Distant Metastasis ◽  
Case Reports ◽  
Phyllodes Tumor ◽  
Pancreatic Metastasis ◽  
Rare Tumor ◽  
Review Of Literature ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors

Phyllodes tumor (PT) is a rare tumor of the breast accounting for approximately 1% of all breast neoplasms. In 1838, J. Muller coined the term “cystosarcoma phyllodes” based on the leaf-like projections of the tumor extending into the cystic spaces and sarcomatous stromal growth. However, seeing as up to 70% of phyllodes tumors are benign, “cystosarcoma” was removed, and the tumor is now recognized simply as phyllodes tumor. It is mainly seen in females between the ages of 35 and 55. Although most phyllodes tumors are benign, malignant cases do uncommonly occur, 22% of which have distant metastasis typically to the lungs and bones. Rarely, this tumor metastasizes to other locations. Herein, we report a case of malignant phyllodes tumor with metastasis to the pancreas. According to our knowledge, only 3 case reports of pancreatic metastasis from malignant phyllodes tumor have been reported in literature thus far. We aim to increase awareness among physicians of this rare metastasic potential of the uncommonly encountered malignant phyllodes tumor.

scholarly journals A 93-Year-Old Man With a Left Lung Mass and Exudative Pleural Effusion

2013 ◽  
Vol 58 (2) ◽  
pp. 300-301 ◽  
Author(s):  
T. H. C. Tang ◽  
S. S. Y. Wong ◽  
W. Lam ◽  
W. Cheuk ◽  
C. K. C. Lai ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Left Lung ◽  
Lung Mass ◽  
Exudative Pleural Effusion

Malignant phyllodes tumor composed almost exclusively of a fibrosarcomatous component: a case report and review of malignant phyllodes tumors with metastases

Breast Cancer ◽  
2009 ◽  
Vol 17 (3) ◽  
pp. 218-224 ◽  
Author(s):  
Satomi Suzuki-Uematsu ◽  
Kazuko Shiraishi ◽  
Taro Ito ◽  
Naoki Adachi ◽  
Yoshihisa Inage ◽  
...  
Keyword(s):  
Case Report ◽  
Phyllodes Tumor ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors

scholarly journals Not Every Fat-Containing Lesion on Mammogram is a Benign Finding: Case Report and Review of Breast Malignant Phyllodes Tumor with Heterologous Liposarcomatous Differentiation

2019 ◽  
Vol 9 ◽  
pp. 10
Author(s):  
Neetu Soni ◽  
Nour T Aly ◽  
Aditi Vidholia ◽  
Fabiana Policeni
Keyword(s):  
Case Report ◽  
Phyllodes Tumor ◽  
Imaging Findings ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors ◽  
Epithelial Component ◽  
Sarcomatous Transformation ◽  
Increased Risk ◽  
Stromal Component ◽  
Proven Case

Phyllodes tumors (PTs) are a rare fibroepithelial tumor of the breast. Histopathological confirmation of stromal and epithelial component is required for making the diagnosis of PT, and stromal component carries an increased risk of sarcomatous transformation. We present imaging findings of a histologically proven case of malignant PT with heterologous liposarcomatous transformation of the breast.

scholarly journals Endobronchial low-grade MALT lymphoma causing unilateral hypertranslucency

2004 ◽  
Vol 61 (4) ◽  
Author(s):  
A.E. Erbaycu ◽  
I. Karasu ◽  
F.G. Özdemirkıran ◽  
N. Yücel ◽  
A. Özsöz ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Left Lung ◽  
Fiberoptic Bronchoscopy ◽  
Low Grade ◽  
Left Main ◽  
Bronchoscopic Biopsy ◽  
One Year ◽  
The Right

Mucosa-associated lymphoid tissue-derived lymphoma (MALT lymphoma) arises not only from the stomach but also from various non-gastrointestinal sites. A thirty two year old woman, suffering from breathlessness for one year, had been treated for bronchial asthma. A chest radiograph showed a mediastinum and heart transposition to the right side and emphysema of the left lung. In the thorax spiral tomography, a mass narrowing left main bronchi, five centimeters in length from the carina, was seen. A fiberoptic bronchoscopy revealed millimetric polypoid lesions those nearly totally obstructed the left main bronchi. The bronchoscopic biopsy showed a diagnosis of MALT lymphoma. She was seen for check-ups following chemotherapy but no further treatment has been carried out.

Effect of changing lung mass on lung water and permeability-surface area in sheep

1982 ◽  
Vol 52 (6) ◽  
pp. 1591-1597 ◽  
Author(s):  
J. R. Snapper ◽  
T. R. Harris ◽  
K. L. Brigham
Keyword(s):  
Cardiac Output ◽  
Surface Area ◽  
Left Lung ◽  
Lower Lobe ◽  
Close Correlation ◽  
Lung Mass ◽  
Lung Water ◽  
Arteriovenous Shunts ◽  
Permeability Surface ◽  
The Right

The effects of changing cardiac output and lung mass on pulmonary capillary surface area, lung water, and hemodynamics were studied in eight sheep. 51Cr-erythrocytes, 125I-albumin, 3H2O, and [14C]urea were injected into the right atrium, and timed samples were collected from the aorta for the calculation of cardiac output (CO), extravascular lung water (EVLW), and permeability-surface area product (PS) for [14C]urea. CO was varied by opening and closing arteriovenous shunts, and lung mass was decreased by first tying off the left lung followed by tying off the right lower lobe. Pulmonary arterial pressure (r = -0.741) and pulmonary vascular resistance (r = -0.700) increased as lung mass was decreased. CO decreased slightly (r = -0.470 while left atrial pressure was not changed (r = -0.144) by decreasing lung mass. There was a close correlation between EVLW and lung mass (r = 0.944) and between [14C]urea PS and lung mass (r = 0.672). We were able to demonstrate that [14C]urea behaves as a diffusion-limited tracer in a single pass through the lungs, since [14C]urea extraction decreased as flow per unit mass increased. These results support the clinical use of multiple-tracer studies to measure EVLW and [14C]urea PS.

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