scholarly journals An Unusual Presentation of T-Cell Lymphoblastic Lymphoma with Isolated Renal Involvement

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Sultan Aydın Köker ◽  
Alper Koker ◽  
Adem Yasin Köksoy ◽  
Yasemin Kayadibi ◽  
Ülkü Gül Şiraz ◽  
...  
Keyword(s):  
T Cell ◽  
Renal Involvement ◽  
Pediatric Nephrology ◽  
Abdominal Distension ◽  
Lymphoblastic Lymphoma ◽  
Abdominal Ultrasonography ◽  
Non Hodgkin Lymphoma ◽  
Contrast Enhanced ◽  
Renal Enlargement ◽  
Enhanced Computed Tomography

The clinical presentation of Non-Hodgkin lymphoma (NHL) is frequently associated with the involvement of the abdomen and mediastinal lymphadenopathies, but rarely the kidney, ovaries, and testicles. Here, we report a rare case of T-cell lymphoblastic lymphoma (T-LBL) presenting with bilateral nephromegaly without acute renal failure (ARF) as the first manifestation. A 30-month-old boy was admitted to the department of pediatric nephrology exhibiting abdominal distension. Physical examination revealed bilateral renal palpation up to the inguinal region. Elevated lactate dehydrogenase (LDH) levels were detected in his blood. Bilateral diffuse enlarged kidneys with increased hypoechogenicity were found on abdominal ultrasonography. In the next step, contrast-enhanced computed tomography showed diffusely enlarged kidneys, which were compressing the intestinal bowels and midline structures. Renal biopsy demonstrated precursor T-LBL. We wish to report our patient with renal T-LBL presenting with diffuse renal enlargement, which has rarely been reported in the literature.

scholarly journals Neuroendocrine tumor of the small intestine diagnosed with trans-abdominal ultrasonography: A case report

2020 ◽  
Author(s):  
Kazuma Tsujimura ◽  
Yasukatsu Takushi ◽  
Atsushi Nakachi ◽  
Tsuyoshi Teruya ◽  
Kouji Iha
Keyword(s):  
Small Intestine ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Neuroendocrine Tumor ◽  
Clinical Symptoms ◽  
Abdominal Ultrasonography ◽  
Node Metastasis ◽  
Tumor Lesion ◽  
Contrast Enhanced ◽  
Enhanced Computed Tomography

Tumors of the small intestine are rare. In addition, clinical symptoms are nonspecific and neoplasm-related symptoms occur late. We report a case of neuroendocrine tumor (NET) of the small intestine that was diagnosed early with trans-abdominal ultrasonography (US). The patient was a 61-year-old man. Abdominal contrast-enhanced computed tomography (CT) was performed because the patient complained of abdominal pain. The CT showed a tumor lesion in the mesentery. Trans-abdominal US was undertaken to evaluate this tumor lesion, and a tumor lesion of the small intestine was found nearby. A diagnosis of lymph-node metastasis of a small-intestine tumor was made as a preoperative diagnosis. A laparotomy was performed with partial resection of the ileum, together with the small-intestine mesentery including an enlarged lymph node. Histological examination revealed NET of the ileum and lymph-node metastasis. Trans-abdominal US is useful in the diagnosis of small-intestine NET.

scholarly journals Outcome of children and adolescents with lymphoblastic lymphoma

2015 ◽  
Vol 61 (5) ◽  
pp. 417-422 ◽  
Author(s):  
Maria Christina Lopes Araújo Oliveira ◽  
Keyla Christy Sampaio ◽  
Aline Carneiro Oliveira ◽  
Aieska Dantas Santos ◽  
Lúcia Porto Castro ◽  
...  
Keyword(s):  
T Cell ◽  
Children And Adolescents ◽  
De Novo ◽  
Lymphoblastic Lymphoma ◽  
Interquartile Range ◽  
Abdominal Tumor ◽  
Probability Of Survival ◽  
Non Hodgkin Lymphoma ◽  
Tertiary Center ◽  
Mediastinal Involvement

Summary Introduction: lymphoblastic lymphoma (LBL) is the second most common subtype of non-Hodgkin lymphoma in children. The aim of this study was to characterize the clinical course of children and adolescents with LBL treated at a tertiary center. Methods: this is a retrospective cohort study of 27 patients aged 16 years or younger with LBL admitted between January 1981 and December 2013. Patients were treated according to the therapy protocol used for acute lymphoblastic leucemia. Diagnosis was based on biopsy of tumor and/or cytological examination of pleural effusions. The overall survival was analyzed using the Kaplan-Meier method. Results: the median age at diagnosis was 11.6 years (interquartile range, 4.6- 13.8). LBL had T-cell origin in 16 patients (59%). The most common primary manifestation in T-cell LBL was mediastinal involvement, in 9 patients (56%). Intra-abdominal tumor was the major site of involvement in patients with precursor B-LBL. Most patients had advanced disease (18 patients – 67%) at diagnosis. Twenty-four patients (89%) achieved complete clinical remission. After a median follow-up of 43 months (interquartile range, 6.4-95), 22 patients (81%) were alive in first complete remission. Five children (18.5%) died, three of them soon after admission and two after relapsing. The probability of survival at five years for 20 patients with de novo LBL was 78% (SD 9.4). Conclusion: our findings confirm the favorable prognosis of children with LBL with an intensive chemotherapy regimen derived from ALL therapy.

scholarly journals Adult T-type lymphoblastic lymphoma presenting as hypercalcemic crisis and aplastic anemia: a case report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Mickael Essouma ◽  
Dorothée M. Soh ◽  
Mazou N. Temgoua ◽  
Ronald M. Gobina ◽  
Aristide T. Nono ◽  
...  
Keyword(s):  
T Cell ◽  
Aplastic Anemia ◽  
Hodgkin Lymphoma ◽  
Lymphoblastic Lymphoma ◽  
Short Term ◽  
Term Outcome ◽  
Hypercalcemic Crisis ◽  
Non Hodgkin Lymphoma ◽  
Short Term Outcome ◽  
Severe Hypercalcemia

Abstract Background Hypercalcemia and aplastic anemia are two uncommon presentations of non-Hodgkin lymphoma that potentially worsen the disease prognosis. Although hypercalcemia has been reported in the B-cell subtypes and some T-cell subtypes of non-Hodgkin lymphoma, it has not been described in T-cell lymphoblastic lymphoma. The same applies to aplastic anemia, which is also not described in T-type lymphomas. Case presentation We report a case of a 52-year-old Cameroonian man with acute kidney injury who presented with confusion, abdominal pain, constipation, polyuria, polydipsia, calciphylaxis, enlarged lymph nodes, tachycardia, and a blood pressure of 170/88 mmHg. Laboratory investigations revealed hypercalcemia (total/ionized 199.5/101.75 mg/L), normal serum phosphorus (40.20 mg/L), and a low intact parathyroid hormone (9.70 pg/ml). Complete blood count revealed pancytopenia. Peripheral blood smear confirmed thrombocytopenia but showed neither blasts nor flower cells. Bone marrow aspirate revealed hypocellularity with no blasts or fibrosis. Lymph node biopsy was suggestive of T-cell precursor lymphoma. T-lymphoblastic lymphoma presenting with hypercalcemic crisis and aplastic anemia was diagnosed, and the patient received the cyclophosphamide-doxorubicin-vincristine-prednisone protocol of chemotherapy together with filgrastim and whole-blood transfusion for aplastic anemia. The short-term outcome was fatal, however. Conclusions Severe hypercalcemia and aplastic anemia are potential paraneoplastic syndromes of adult T-type lymphoblastic lymphoma, with fatal short-term outcome.

Clinical Outcome of 119 Children with Non-Hodgkin Lymphoma Treated in a Single Center in China

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 5299-5299
Author(s):  
Yonghong Zhang ◽  
Ling Jin ◽  
Jing Yang ◽  
Yanlong Duan ◽  
Chunjv Zhou ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Nk Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Lymphoblastic Lymphoma ◽  
Non Hodgkin Lymphoma ◽  
Pathologic Classification

Abstract One hundred and nineteen children with non-Hodgkin lymphoma were treated between February 2003 and December 2006 in Beijing Children’s Hospital on BCH-2003-NHL protocol. The diagnosis was made by histopathology of the biopsied tissue and/or bone marrow, and disease was classified according to WHO-2001 pathologic classification. We applied modified LMB89 protocol to cases with B-cell lymphoma; modified BFM90-ALL protocol for lymphoblastic lymphoma and cutaneous T-cell/NK cell lymphoma; and modified BFM90-ALCL protocol for anaplastic large-cell lymphoma (ALCL). There were 50 cases (42%) of B cell lymphoma including 32 cases of Burkitt¡’s lymphoma, 10 cases of Burkitt-like lymphoma and 8 cases of diffuse large B cell lymphoma; 44 cases (37%) of lymphoblastic lymphoma; 19 cases (16%) of ALCL; and 6 cases (5%) of cutaneous T-cell/NK cell lymphoma. The 85 boys and 34 girls (ratio, 2.5:1) ranged in age from 2 to 15 years (median, 7.8 years) at diagnosis. B cell lymphoma typically presented as abdomen mass and acute abdomen; nasopharynx and tonsil were also common sites of involvement. Lymphoblastic lymphoma generally presented with mediastinal mass and bone marrow involvement. There was no typical presentation for ALCL. According to the St. Jude staging system, 19 cases had stage I–II, and 94 cases stage III–VI diseases (exclude 6 cases of cutaneous T-cell/NK cell lymphoma). Seven cases had CNS involvement and 25 cases involved bone marrow. The treatment duration was 2 to 8 months for B-cell lymphoma, 2.5 to 3 years for lymphoblastic lymphoma and 1 to 1.5 years for ALCL. The follow-up rate was 100% and median observation period was 23 months. The overall survival (OS) at 3 years was 90.7% and the 3-year event-free survival (EFS) estimate was 82.3%. For B-cell lymphoma, 3-year OS was 88.68% and 3-year EFS was 81.8%. For lymphoblastoma lymphoma, the rates were 89.3% and 69.4%, respectively. All cases of ALCL are alive with on undergoing treatment for relapse. Patients with ALCL achieved the best 3-year OS (100%) and had 3-year EFS of 94.2%. Grade 3 or 4 bone marrow suppression occurred in 97.5% of patients with B-cell lymphoma, 100% of those with lymphoblastic lymphoma and 89.5% of cases with ALCL. As of to date, 11 patients have died, the causes of death include infection (n=4), abandonment of therapy (n=6) and relapse (n=1). Univarate analysis showed that stage IV disease, failure to achieve complete remission after 3 months of treatment, and bulky mass are were associated with poor prognosis £all P values <0.05£©. In summary, we have achieved excellent treatment results using modified international protocols. Infection and financial problem remained the main reasons of treatment failure.

scholarly journals A Case of Septicemia due to Nonocclusive Mesenteric Ischemia Occurring in Induction Chemotherapy

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Hideki Tanaka ◽  
Kiyoaki Tsukahara ◽  
Isaku Okamoto ◽  
Rio Kojima ◽  
Kazuhiro Hirasawa ◽  
...  
Keyword(s):  
Mesenteric Ischemia ◽  
Abdominal Distension ◽  
Oropharyngeal Carcinoma ◽  
Continuous Hemodiafiltration ◽  
Nonocclusive Mesenteric Ischemia ◽  
Intestinal Necrosis ◽  
Neck Tumors ◽  
Contrast Enhanced ◽  
Serious Disease ◽  
Enhanced Computed Tomography

In nonocclusive mesenteric ischemia (NOMI), mesenteric ischemia and intestinal necrosis occur despite the absence of organic blockage in mesenteric blood vessels. As abdominal pain is often absent and few characteristic findings are seen in blood biochemistry, imaging diagnosis or other examinations, discovery is often delayed. With a mortality rate of 56–79%, NOMI is a very serious disease. However, few reports have described this pathology in association with chemotherapy regimens such as those used for malignant head and neck tumors. We encountered a case of NOMI during induction therapy combining cisplatin, docetaxel, and 5-fluorouracil. The patient was a 74-year-old man receiving chemotherapy for T2N2bM0 stage IVA oropharyngeal carcinoma. Febrile neutropenia appeared on treatment day 8. An antibacterial agent and a granulocyte colony-stimulating factor were administered, but septic shock developed and he was transferred to the intensive care unit. Abdominal distension was present and contrast-enhanced computed tomography of the abdomen suggested NOMI. Emergency surgery on day 9 resected the necrotized small intestine and created a single-hole ileostomy. The patient subsequently recovered with 2 weeks of continuous hemodiafiltration and other intensive therapies. Otolaryngological surgeons seldom encounter intestinal diseases, which are thus easily overlooked. The present case report may help in achieving early diagnosis.

scholarly journals Mildly symptomatic liraglutide-induced acute pancreatitis in a patient with type 2 diabetes mellitus: a case report

2020 ◽  
Vol 32 (1) ◽  
Author(s):  
Mohammed Ali Gameil ◽  
Ahmed Hassan Elsebaie
Keyword(s):  
Acute Pancreatitis ◽  
Diabetic Patients ◽  
Abdominal Ultrasonography ◽  
Serum Lipase ◽  
Case Presentation ◽  
Clinical Challenge ◽  
Contrast Enhanced ◽  
Glucagon Like Peptide 1 ◽  
Enhanced Computed Tomography

Abstract Background Acute pancreatitis (AP) represents a serious clinical challenge as it can threaten the patient’s life if it is missed or improperly managed. Liraglutide is one of the glucagon-like peptide 1 receptor agonists (GLP1-RA) which represent a novel class of antidiabetic medications in the Egyptian market. Hereby, we report a case of liraglutide-induced acute pancreatitis with atypical presentation. Case presentation A 53-year-old Egyptian male patient with diabetes presented to the emergency department with abdominal discomfort and vomiting without significant abdominal pain. Serum lipase and amylase were elevated more than three folds the upper normal limit (NUL 300 and 110 U/L respectively); abdominal ultrasonography was inconclusive, but contrast-enhanced computed tomography was diagnostic. A diagnosis of liraglutide-induced AP was built after exclusion of other causes. After admission, his medications were modified and improved clinically after 1 week. Conclusion Mildly symptomatic AP in diabetic patients is a clinical challenge as it can be missed. Therefore, in certain clinical situations, AP should be suspected in patients administrating liraglutide particularly for those with autonomic neuropathy.

scholarly journals A case of systemic precursor T-cell lymphoblastic lymphoma presenting with single tooth mobility

2020 ◽  
Vol 8 ◽  
pp. 2050313X2092796 ◽  
Author(s):  
Lampros Goutzanis ◽  
John Apostolidis ◽  
Chara Giatra ◽  
Evanthia Chrysomali ◽  
Dimitrios Deskos
Keyword(s):  
T Cell ◽  
Osteolytic Lesion ◽  
Large Family ◽  
Oral Pathology ◽  
Lymphoblastic Lymphoma ◽  
Second Molar ◽  
Non Hodgkin Lymphoma ◽  
Computed Tomography Scanning ◽  
Old Adult ◽  
The Right

Lymphoblastic lymphoma, seen primarily in children or young adults, is a type of non-Hodgkin lymphoma that originates from B or T lymphocyte precursors and rarely occurs in the oral cavity. A case of systemic precursor T-cell lymphoblastic lymphoma mimicking periodontitis of a lower second molar in a 20-year-old adult is currently presented. The case was initially misdiagnosed as periodontal disease and treated with tooth extraction by a dentist. Re-evaluation of the patient due to worsening of symptoms lead to cone beam computed tomography scanning that thoroughly revealed an extended osteolytic lesion of the right mandible. Afterward, a biopsy was performed, thus reaching the diagnosis of precursor T-cell lymphoblastic lymphoma. This report discusses differences in epidemiology of T-cell and B-cell lymphoblastic lymphomas, as well as their various intraoral manifestations that are mimicking a large family of oral pathology. It also focuses on conventional imaging findings that imply malignancy, which are often neglected during routine radiology interpretation.

scholarly journals LEFT PARADUODENAL HERNIA AS A RARE CAUSE OF INTESTINAL OBSTRUCTION-LAPAROSCOPIC MANAGEMENT

2020 ◽  
pp. 1-2
Author(s):  
Bhavesh Shelke ◽  
Abhijit Joshi
Keyword(s):  
Intestinal Obstruction ◽  
Laparoscopic Approach ◽  
Emergency Situation ◽  
Abdominal Distension ◽  
Paraduodenal Hernia ◽  
Contrast Enhanced ◽  
Colicky Pain ◽  
Enhanced Computed Tomography ◽  
Upper Abdomen ◽  
Contrast Enhanced Computed Tomography

We report a case of 33 years old male, presented with colicky pain in left upper abdomen on and off since 15 days, one episode of bilious vomiting and abdominal distension with constipation since 2 days. A case of intestinal obstruction was diagnosed as a Left Paraduodenal Hernia[PDH] on contrast enhanced computed tomography of the abdomen(CECT) and managed with laparoscopic repair. Through this case report, we want to give the message that PDH though rare should be considered as a differential diagnosis in a case of intestinal obstruction and can be managed successfully with laparoscopic approach even in an emergency situation.

scholarly journals Imaging findings in Fetus-in-fetu-misdiagnosed commonly as teratoma

2021 ◽  
Vol 8 (11) ◽  
pp. 1905
Author(s):  
Rajakumar R. ◽  
Annu Singhal ◽  
Sana Sana ◽  
Kavita Vani
Keyword(s):  
Rare Condition ◽  
Abdominal Distension ◽  
Malignant Potential ◽  
The Body ◽  
Retroperitoneal Mass ◽  
Girl Child ◽  
Fetus In Fetu ◽  
Contrast Enhanced ◽  
Enhanced Computed Tomography ◽  
Contrast Enhanced Computed Tomography

Fetus in fetu is a rare condition associated with abnormal embryogenesis in a diamniotic, monochorionic pregnancy, wherein one of the fetus is enclosed within the body of another normally developing fetus. It should be differentiated from a teratoma because of the later’s malignant potential. Here we report a case of 2 months old girl child who presented with complaints of abdominal distension. USG showed a solid cystic retroperitoneal mass resembling an anencephalic fetus. Contrast enhanced Computed tomography (CT) showed similar findings with visualization of bones resembling femur, sacrum and vertebrae. Findings were correlated with MRI and post-op pathology. The preoperative diagnosis of FIF is based on the observation of vertebral column or limbs in a mass on imaging modalities and our case meets the required criteria.

scholarly journals Usefulness of magnetic resonance angiography for the evaluation of varices at hepaticojejunostomy after liver transplantation

2015 ◽  
Vol 4 (5) ◽  
pp. 205846011557860 ◽  
Author(s):  
Keisuke Jimbo ◽  
Mitsuyoshi Suzuki ◽  
Tohru Fujii ◽  
Yoshikazu Ohtsuka ◽  
Hiroyuki Sugo ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Decompensated Liver Cirrhosis ◽  
Abdominal Ultrasonography ◽  
Donor Liver Transplantation ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Old Japanese ◽  
Enhanced Computed Tomography

A 7-year-old Japanese girl who had undergone living-donor liver transplantation (LT) at the age of 10 months for decompensated liver cirrhosis caused by biliary atresia presented with recurrent episodes of obscure gastrointestinal bleeding (GIB) with anemia. Over the following 6 years, she experienced five episodes of GIB requiring hospitalization. Subsequent evaluations including repeat esophagogastroduodenoscopy (EGD), colonoscopy (CS), contrast-enhanced computed tomography (CT), and Meckel’s scan all failed to reveal a bleeding source. However, varices at the site of hepaticojejunostomy were detected on abdominal ultrasonography and magnetic resonance angiography (MRA) at the age of 7 years. MRA might be more helpful than contrast-enhanced CT for identifying such bleeding.

Sign in / Sign up

Export Citation Format

Share Document