scholarly journals High-Risk Indicators of Renal Involvement in Primary Sjogren’s Syndrome: A Clinical Study of 1002 Cases

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Jing Luo ◽  
Yu-Wei Huo ◽  
Jian-Wu Wang ◽  
Hui Guo
Keyword(s):  
Risk Factors ◽  
Interstitial Nephritis ◽  
Renal Tubular Acidosis ◽  
Potential Risk ◽  
Renal Damage ◽  
Renal Involvement ◽  
Primary Sjögren’S Syndrome ◽  
Lower Limbs ◽  
Potential Risk Factors ◽  
Renal Tubular

Objective. A retrospective analysis of clinical characteristics and immunological manifestations of primary Sjogren’s syndrome (pSS) patients with or without renal involvement was conducted in order to elucidate the potential risk factors of renal damage in pSS and evaluate the condition. Methods. A total of 1002 patients, who fulfilled the 2002 classification criteria for pSS from the Second Affiliated Hospital of Shanxi Medical University, were enrolled in the cross-sectional study. Clinical, immunological, and histological characteristics were compared between pSS patients with and without renal involvement, and potential risk factors of renal involvements in pSS patients were examined by multivariate analysis. Results. Among these pSS patients, there were 162 cases (16.17%) with and 840 cases (83.83%) without renal damage. Serious edema of both lower limbs, interstitial nephritis, and renal tubular acidosis were found in the pSS with renal damage group. Compared with simple pSS patients, the levels of creatinine, cystatin C, and alpha-1-microglobulin (α1-MG) in the pSS with renal damage group were significantly increased. The difference between the two groups was statistically significant (P<0.05). The AUC of the combination of creatinine and α1-MG and creatinine, α1-MG, and creatinine was statistically larger than that of creatinine, and the biomarker of the biggest AUC is the combination of creatinine and α1-MG. Conclusion. The main clinical manifestations of pSS with renal damage were edema of the lower limbs, interstitial nephritis, and renal tubular acidosis. Creatinine and α1-MG are effective indicators for renal function in pSS, which may provide a better understanding for clinical decision-making.

Potential Risk Factors Associated With Progressive Renal Damage in Childhood Urological Diseases

1997 ◽  
pp. 1308-1311 ◽  
Author(s):  
John W. Brock ◽  
Mark Adams ◽  
Trey Hunley ◽  
A. Wada ◽  
Lisa Trusler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Potential Risk ◽  
Renal Damage ◽  
Factors Associated ◽  
Potential Risk Factors ◽  
Urological Diseases

scholarly journals Distal renal tubular acidosis as a cause of osteomalacia in a patient with primary Sjögren's syndrome

2005 ◽  
Vol 62 (10) ◽  
pp. 769-773 ◽  
Author(s):  
Aleksandra Jovelic ◽  
Dusan Stefanovic
Keyword(s):  
Vitamin D ◽  
Interstitial Nephritis ◽  
Renal Tubular Acidosis ◽  
Renal Involvement ◽  
Distal Renal Tubular Acidosis ◽  
Renal Lesion ◽  
Pelvic Bones ◽  
Long Time ◽  
Distal Tubular Acidosis ◽  
Renal Tubular

Background. One half of the patients with primary Sj?gren?s syndrome has extraglandular manifestations, including renal involvement. The most frequent renal lesion is tubulo-interstitial nephritis, which manifests clinically as distal tubular acidosis and may result in the development of osteomalacia. Case report. In a 29 - year-old female patient, with bilateral nephrolithiasis, the diagnosis of primary Sj?gren?s syndrome, tubulo-interstitial nephritis, distal renal tubular acidosis, and hypokalemia were established. She was treated for hypokalemia. Two years later she developed bone pains and muscle weakness, she wasn?t able to walk, her proximal muscles and pelvic bones were painful, with radiological signs of pelvic bones osteopenia and pubic bones fractures. The diagnosis of osteomalacia was established and the treatment started with Schol?s solution, vitamin D and calcium. In the following two months, acidosis was corrected, and the patient started walking. Conclusion. In our patient with primary Sj?gren?s syndrome and interstitial nephritis, osteomalacia was a result of the long time decompensate acidosis, so the correction of acidosis, and the supplementation of vitamin D and calcium were the integral part of the therapy.

scholarly journals Le ulcere flebostatiche recidive degli arti inferiori: analisi di un’esperienza/Recurrent venous leg ulcers: clinical analysis of an experience

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Alberto Garavello ◽  
Margherita Lo Ponte ◽  
Stefania Gilardi ◽  
Paola Fiamma ◽  
Massimo Tozzi
Keyword(s):  
Risk Factors ◽  
Potential Risk ◽  
Wound Care ◽  
Lower Limbs ◽  
Orthopedic Procedures ◽  
Ulcer Recurrence ◽  
Venous Ulcers ◽  
Potential Risk Factors ◽  
Fattori Di Rischio

Nonostante i recenti progressi in tema di wound care, le ulcere varicose degli arti inferiori restano un problema frequente, con un alto tasso di recidiva. In questo lavoro abbiamo esaminato la storia clinica, la storia chirurgica e le patologie associate di 133 pazienti affetti da ulcera varicosa degli arti inferiori, di cui 56 da ulcera recidiva o plurirecidiva. L’analisi dei fattori di rischio potenziale per recidiva ha evidenziato come la presenza di varici recidive, una pregressa trombosi venosa profonda, problemi ortopedici, interventi ortopedici, l’obesità e un’età inferiore a 60 anni siano fattori di rischio potenziale per una recidiva dell’ulcera. La combinazione di uno più fattori di rischio assume significatività per la possibilità di una recidiva; si passa dal 22,7% in assenza di fattori di rischio al 33% per i pazienti che ne presentano due, fino al 57,5% in presenza di tre fattori di rischio e all’81,3% per quattro o più. L’ulcera varicosa richiede un follow-up stretto del paziente e una terapia elastocompressiva continua, che deve vedere una stretta collaborazione del paziente e un’attenzione specifica ai fattori di rischio. Despite recent advances in wound care, varicose ulcers of lower limbs remain frequent and display a high rate of recurrence. In this paper, we examined the clinical, surgical histories and associated diseases of 133 patients with venous ulcers of the lower limbs, which were recurrent in 56 cases. The analysis of potential risk factors for recurrence showed that the presence of recurrent varicose veins, a previous deep venous thrombosis, orthopedic problems, previous orthopedic procedures, obesity and age lower than 60 are potential risk factors for ulcer recurrence. Furthermore, the association of one or more risk factors increased the likelihood of relapse, from 22.7% with no risk factors to 33% with 2 risk factors, up to 57.5% with 3 risk factors, and up to 81.3% with 4 risk factors or more. Venous ulcers require close follow-up and continuous elastic compression, close collaboration by the patient and specific focus on risk factors.

scholarly journals The Factors Affecting the Occurrence of Renal Involvement in Children with IgA Vasculitis

2020 ◽  
pp. 50-55
Author(s):  
Şafak Demirtaş ◽  
İsmail DURSUN ◽  
Ayşe Seda Pınarbaşı ◽  
Nihal Şahin ◽  
Sümeyra Özdemir Çiçek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Potential Risk ◽  
Renal Involvement ◽  
Pulmonary Involvement ◽  
Organ Involvement ◽  
Joint Involvement ◽  
Iga Vasculitis ◽  
Potential Risk Factors

Introduction: Henoch-Schönlein purpura or IgA vasculitis that involves small vessels is the most common vasculitis in childhood and the long term prognosis is contingent on the severity of renal involvement. Objectives: In this study, we aimed to determine the frequency of organ involvements and to identify potential risk factors for renal involvement in children with IgA vasculitis. Materials and Methods: This study included 416 patients with IgA vasculitis who had been followed in our department between 1990 and 2016. The patients were retrospectively reviewed in terms of type of treatment, organ involvement and clinical outcome, and potential risk factors for renal involvement were determined. Results: Overall, 416 patients with IgA vasculitis were identified, including 174 girls (41.7%) and 242 boys (58.3%). The mean age at presentation was 8.3±3.1 years. The distribution of organ involvement was: skin involvement, 100%; joint involvement, 77.1%; gastrointestinal system (GIS) involvement, 58.6%; renal involvement, 38.3%; scalp edema, 10.1%; scrotal involvement, 5.3% (9.0% in boys), central nervous system (CNS) involvement, 1.6% and pulmonary involvement, 0.25%. When risk factors for renal involvement were assessed, it was found that GIS involvement was more frequently seen in patients with nephritis (p=0.01). Age, diastolic blood pressure and GIS involvement at the onset were found to be correlated with renal involvement. GIS involvement and diastolic blood pressure were found as risk factors for renal involvement. Conclusion: Age, elevation in diastolic blood pressure and GIS involvement were important findings in prediction of nephritis. In particular, patients with GIS involvement should be cautiously monitored for renal involvement.

Premature Arterial Disease Associated with Familial Antithrombin III Deficiency

1990 ◽  
Vol 63 (01) ◽  
pp. 013-015 ◽  
Author(s):  
E J Johnson ◽  
C R M Prentice ◽  
L A Parapia
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Potential Risk ◽  
Antithrombin Iii ◽  
Arterial Disease ◽  
Coagulation System ◽  
Early Age ◽  
Arterial Thromboembolism ◽  
Potential Risk Factors ◽  
Antithrombin Iii Deficiency

SummaryAntithrombin III (ATIII) deficiency is one of the few known abnormalities of the coagulation system known to predispose to venous thromboembolism but its relation to arterial disease is not established. We describe two related patients with this disorder, both of whom suffered arterial thrombotic events, at an early age. Both patients had other potential risk factors, though these would normally be considered unlikely to lead to such catastrophic events at such an age. Thrombosis due to ATIII deficiency is potentially preventable, and this diagnosis should be sought more frequently in patients with arterial thromboembolism, particularly if occurring at a young age. In addition, in patients with known ATIII deficiency, other risk factors for arterial disease should be eliminated, if possible. In particular, these patients should be counselled against smoking.

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