scholarly journals Endogenous Bufadienolides, Fibrosis and Preeclampsia

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Vitaliy A. Reznik ◽  
Vladimir A. Kashkin ◽  
Natalia I. Agalakova ◽  
C. David Adair ◽  
Alexei Y. Bagrov
Keyword(s):  
Maternal Mortality ◽  
Endogenous Ligands ◽  
Mortality And Morbidity ◽  
New Therapy ◽  
Maternal Mortality And Morbidity ◽  
Atpase System ◽  
Leading Position ◽  
Mineralocorticoid Antagonists

Frequency of preeclampsia has no tendency to decrease, and it still takes the leading position in the structure of maternal mortality and morbidity worldwide. In this review, we present the “fibrotic concept” of the etiology and pathogenesis of preeclampsia which involves system consisting of Na/K-ATPase and its endogenous ligands including marinobufagenin. New therapy of preeclampsia includes modulation of the Na/K-ATPase system by immunoneutralization of the marinobufagenin and use of mineralocorticoid antagonists which are capable to impair marinobufagenin-Na/K-ATPase interactions.

scholarly journals Maternal Mortality and Morbidity in the United States: Where Are We Now?

2014 ◽  
Vol 23 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Andreea A. Creanga ◽  
Cynthia J. Berg ◽  
Jean Y. Ko ◽  
Sherry L. Farr ◽  
Van T. Tong ◽  
...  
Keyword(s):  
United States ◽  
Maternal Mortality ◽  
The United States ◽  
Mortality And Morbidity ◽  
Maternal Mortality And Morbidity

scholarly journals Preeclampsia: Сardiotonic Steroids, Fibrosis and a Hint to Cancerogenesis

2020 ◽  
Author(s):  
Alexei Bagrov ◽  
Nikolai Kolodkin ◽  
C. David Adair ◽  
Natalia Agalakova ◽  
Alexandr Trashkov
Keyword(s):  
Inverse Relationship ◽  
Therapeutic Strategy ◽  
Transcriptional Factor ◽  
Negative Regulator ◽  
Novel Therapy ◽  
Mortality And Morbidity ◽  
Maternal Mortality And Morbidity ◽  
Leading Position

Despite prophylaxis and attempts to select a therapy, the frequency of preeclampsia does not decrease, and it still takes the leading position in the structure of maternal mortality and morbidity worldwide. In this review, we present a new theory of the etiology and pathogenesis of preeclampsia which is based on the interaction of Na/K-ATPase and its endogenous ligands including marinobufagenin. The signaling pathway of marinobufagenin involves an inhibition of transcriptional factor Fli1, a negative regulator of collagen synthesis, followed by deposition of collagen in the vascular tissues and altered vascular functions. Moreover, in vitro and in vivo neutralization of marinobufagenin is associated with restoration of Fli1. The inverse relationship between marinobufagenin and Fli1 opens new possibilities in the treatment of cancer: since Fli1 is a proto-oncogene, a hypothesis on suppression of Fli1 by cardiotonic steroids as potential anti-tumor therapeutic strategy is discussed as well. We propose a novel therapy of preeclampsia which is based on immunoneutralization of the marinobufagenin by monoclonal antibodies, which is capable to impair marinobufagenin-Na/K-ATPase interactions.

IMPACT OF GOVERNMENT SCHEMES ON MATERNAL HEALTH: AN OBSERVATIONAL STUDY IN A TERTIARY CARE HOSPITAL IN NORTH INDIA

2021 ◽  
pp. 63-65
Author(s):  
Neena Gupta ◽  
Uruj Jahan ◽  
Subhashini Singh
Keyword(s):  
Maternal Health ◽  
Observational Study ◽  
Maternal Mortality ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Uttar Pradesh ◽  
North India ◽  
Care Hospital ◽  
Mortality And Morbidity ◽  
Maternal Mortality And Morbidity

BACKGROUND: Maternal health is an important aspect for the development of any country in terms of increasing equity and reducing poverty. For reduction of maternal mortality and morbidity Government of India launched National health mission (NHM). Some of the major initiatives under NHM are– ASHA (Accredited Social Health Activist), JSY/JSSK (Janani Suraksha Yojana / Janani Shishu Suraksha Karyakaram), National mobile medical units, National ambulance services. METHODS: A retrospective observational study was performed in department of Obstetrics and Gynaecology, G.S.V.M Medical College, Kanpur, Uttar Pradesh which is a low performing state, during the period of 2018 to 2019. A total of 5134 obstetric patients including 1032 low general condition patients were included over duration of 20 months since January 2018 to august 2019. This observational study collected information regarding number of deliveries in different years in this tertiary care hospital, effect on availability of health facilities and antenatal care to the antenatal women after introduction of JSY, ASHA and ambulance services. CONCLUSIONS: After JSY there is major difference in OPD admission and institutional delivery rate. Ambulance services had major contributory role in reducing maternal mortality and morbidity. There is need to improve performance of ASHA by proper supervision and monitoring.

Obstetrics

2019 ◽  
pp. 741-786
Author(s):  
Benjamin Oren Black ◽  
Susan Ann O’Toole
Keyword(s):  
Antenatal Care ◽  
Maternal Mortality ◽  
Medical Management ◽  
Postnatal Care ◽  
Mortality And Morbidity ◽  
Humanitarian Settings ◽  
Cultural Considerations ◽  
Maternal Mortality And Morbidity

This chapter provides the fundamental principles of care in obstetrics, taking into account important cultural considerations in humanitarian settings. The chapter lays out the general strategies to reduce maternal mortality and morbidity, and provides specific guidance for antenatal care, the medical management of the stages of labour, and postnatal care.

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