scholarly journals Safety of Intravitreal Injection of Biosimilar of Aflibercept in Rabbit Eyes

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Alireza Lashay ◽  
Hamid Riazi-Esfahani ◽  
Hooshang Faghihi ◽  
Ahmad Mirshahi ◽  
Hassan Khojasteh ◽  
...  
Keyword(s):  
Intravitreal Injection ◽  
Reference Product ◽  
Human Subjects ◽  
Retinal Toxicity ◽  
Short Term ◽  
Reference Drug ◽  
Intravitreal Aflibercept ◽  
Contralateral Eye ◽  
The Right ◽  
Histologic Changes

Purpose. To assess the safety of biosimilar intravitreal aflibercept (CinnaGen Co., Iran) compared to the reference product (Eylea®; Bayer Schweiz AG, Zurich, Switzerland) in rabbit eyes through functional and histologic studies. Methods. Forty New Zealand albino rabbits were recruited to the study and were divided into four groups to be sacrificed at 48 hours, one, two, and four weeks after injections. In each group, five rabbits received 0.05 mL (2 mg) biosimilar aflibercept in the right eye and 0.05 mL saline in the left eye as the control, and in a similar manner, the remaining five rabbits received the reference drug in the right eye and saline in the left eye. All the rabbits underwent comprehensive ophthalmic examination and electroretinography (ERG) tests at baseline and also just before enucleation at the specific predefined time points. The enucleated eyes were prepared for retinal toxicity histological examination. Results. No retinal toxicity was observed based on histologic and ERG findings in all groups. Choroidal congestion was revealed after 1 week in an eye that was injected with biosimilar aflibercept, although the similar finding was detected in the contralateral eye which received saline. Also, one subject which received the reference drug showed chronic vitritis and lymphoplasmocytic reaction of the optic disc at week 4. The remaining subjects showed no histologic changes. Conclusion. The 2 mg intravitreal injection of biosimilar aflibercept (CinnaGen Co., Iran) was found to be nontoxic in rabbit eyes in the short-term period. Further studies are required to warrant the efficacy and safety profile of the drug in human subjects.

Protecting the Desperate: The Regulation of Payday Lending

2015 ◽  
Vol 43 (1) ◽  
pp. 147-176
Author(s):  
Andrew J Serpell
Keyword(s):  
Consumer Credit ◽  
Law Reform ◽  
Payday Lending ◽  
Short Term ◽  
Payday Loans ◽  
The Law ◽  
The Right ◽  
Credit Contracts ◽  
The Cost

Payday loans are small-amount, short-term, unsecured, high-cost credit contracts provided by non-mainstream credit providers. Payday loans are usually taken out to help the consumer pay for essential items, such as food, rent, electricity, petrol, broken-down appliances or car registration or repairs. These consumers take out payday loans because they cannot — or believe that they cannot — obtain a loan from a mainstream credit provider such as a bank. In recent years there has been a protracted debate in Australia — and in several overseas jurisdictions — about how to regulate the industry. Recent amendments to the National Consumer Credit Protection Act 2009 (Cth) — referred to in this article as the 2013 reforms — are designed to better protect payday loan consumers. While the 2013 reforms provide substantially improved protection for payday loan consumers, further changes to the law may be warranted. This article raises several law reform issues which should be considered as part of the 2015 review into small amount credit contracts, including whether the caps on the cost of credit are set at the right level, whether the required content and presentation of the consumer warnings needs to be altered, whether more needs to be done to protect consumers who are particularly disadvantaged or vulnerable and whether a general anti-avoidance provision should be included in the credit legislation.

scholarly journals Considerations for Pediatric Retirement from Athletics Following Repetitive Concussive Traumatic Brain Injury: Incorporating the Right to an Open Future

2021 ◽  
Vol 18 (5) ◽  
pp. 2266
Author(s):  
Tyler S. Gibb ◽  
Kathryn Redinger ◽  
Casey Fealko ◽  
Sonia Parikh
Keyword(s):  
Clinical Evidence ◽  
Open Future ◽  
Short Term ◽  
Institutional Policies ◽  
Athletic Competition ◽  
Adolescent Athlete ◽  
Clinical Considerations ◽  
Federal Laws ◽  
The Right ◽  
Concussive Injury

Guidance regarding the decision to remove an adolescent from athletic competition immediately following an acute concussive injury and the safe return of play in the short term is widely accepted and supported by clinical evidence, local institutional policies, and state and federal laws. There is considerably less guidance regarding the decision to permanently retire an adolescent athlete for medical reasons due to concussive injuries. In this article, we discuss the clinical and non-clinical considerations that should guide clinicians in discussions regarding the adolescent athlete’s permanent retirement by emphasizing the ethical obligation to protect the child’s right to an open future as possibly determinative in otherwise ambiguous cases.

scholarly journals The Short-Term Effect of Active Skeletonized Sutural Distractor Appliance on Temporomandibular Joint Morphology of Class III Malocclusion Subjects

2021 ◽  
Author(s):  
Mohamed Zahoor Ul Huqh ◽  
Rozita Hassan ◽  
Roselinda Abdul Rahman ◽  
Asilah Yusof ◽  
Ida Bagus Narmada ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Term Effect ◽  
Class Iii ◽  
Class Iii Malocclusion ◽  
Short Term ◽  
Short Term Effect ◽  
Condylar Position ◽  
Joint Morphology ◽  
The Right ◽  
Condylar Volume

Abstract Objectives The purpose of this study was to evaluate the short-term effect of active skeletonized sutural distractor (ASSD) appliance on temporomandibular joint morphology of class III malocclusion subjects. Materials and Methods This was a prospective interventional study. Cone-beam computerized tomography (CBCT) images of 22 patients were taken before and after treatment by using Planmeca Promax 3D CBCT machine version 2.9.2 (Planmeca OY Helsinki, Finland). The condylar width, height, length, roof of glenoid fossa thickness, and all joint spaces were measured. The condylar position was determined based on Pullinger and Hollander formula. The condylar shape was determined as per Kinzinger et al. The condylar volume was calculated by using Mimics software (Materialize, Belgium). Statistical Analysis Data analysis was performed by using SPSS software version 24. Wilcoxon paired signed-rank test was used to compare the difference in temporomandibular joint morphology and condylar volume between pre- and post-treatment measurements. Chi-square test was used to compare the condylar position and shape. Results The superior (p = 0.000 on the right side, p = 0.005 on the left side) and posterior joint spaces (p = 0.000 on both sides) were decreased after the treatment, respectively. The condyles were rotated upward and backward, thereby increasing the anterior joint spaces (p = 0.000 on both sides) after the treatment. The condylar volume increases after treatment, but no significant differences were observed (p = 0.903 on the right side, p = 0.062 on the left side). Conclusion The significant changes were observed in joint spaces. The condyles were more anteriorly placed before treatment. Condylar position and shape alter in response to ASSD treatment. The condylar volume did not show any significant change.

A Multidimensional Approach to Marketing Performance Evaluation

2006 ◽  
Vol 56 (1) ◽  
pp. 71-102
Author(s):  
László Sajtos
Keyword(s):  
Market Orientation ◽  
Business Success ◽  
Financial Indicators ◽  
Multidimensional Approach ◽  
Short Term ◽  
Marketing Performance ◽  
Intangible Resources ◽  
Investment Companies ◽  
Marketing Resources ◽  
The Right

Companies usually like to claim that they are market-oriented; however, many studies reveal that businesses typically rely on short-term financial indicators, only a small percentage of firms consider time spent on consumers as important, and marketing is considered as a cost rather than an investment. Companies, however, need to understand their own and their environment's operations in order to set the right objectives, manage their tangible and intangible resources, and achieve the best possible performance. This paper focuses on performance measurement and its relation to market orientation, marketing activity, objectives and marketing resources. This research reveals that though marketing's role in the organisation seems to be significant managers' commitment to marketing often remains at an attitudinal level, and they tend to overestimate their marketing efforts. Furthermore, customer-based measures seem to be good indicators of market-orientation, still managers consider financial and market performance measures to be more important. This paper supports the finding that market orientation and business success are strongly related to one another.

STUDIES ON HABITUATION TO COLD PAIN

1966 ◽  
Vol 44 (2) ◽  
pp. 287-293 ◽  
Author(s):  
Jacques LeBlanc ◽  
Pierre Potvin
Keyword(s):  
Cold Water ◽  
Mental Arithmetic ◽  
Blood Pressure Response ◽  
Human Subjects ◽  
Cold Pain ◽  
Left Hand ◽  
Water Test ◽  
The Difference ◽  
The Right ◽  
Habituation To Cold

It was possible to produce habituation to cold in a group of human subjects by immersing the left hand in cold water for [Formula: see text] minutes twice a day for 19 days. The right hand did not adapt. Another group of subjects was exposed similarly with the difference that an anxiety test (mental arithmetic test) was always given simultaneously with the cold-water test. In this second group the original blood pressure response, i.e. for the first day, was greater than in the first group because of the cumulative effects of the two tests. After 19 days definite evidence was obtained for adaptation to these two tests administered together. However, when these tests were given separately to the second group, no adaptation was evident; adaptation occurred only to both tests given simultaneously. These results indicate that no adaptation develops to cold per se if the subjects are distracted from cold discomfort. It was also found that adaptation of one hand to cold water not only failed to induce adaptation in the opposite hand but even reinforced responses of the unadapted hand. These findings suggest a participation of the central nervous system in adaptation to cold pain, and tend to minimize the importance of local peripheral changes.

scholarly journals Actinomyces meyeriEmpyema: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Hae Won Jung ◽  
Chong Rae Cho ◽  
Ji Yoon Ryoo ◽  
Hyun Kyo Lee ◽  
So Young Ha ◽  
...  
Keyword(s):  
Pleural Fluid ◽  
Response To Treatment ◽  
Penicillin G ◽  
Review Of The Literature ◽  
Short Term ◽  
Oral Amoxicillin ◽  
History Of ◽  
Multiple Lung Nodules ◽  
The Right ◽  
Radiological Studies

Actinomyces meyeriis an uncommon cause of human actinomycosis. Here, we report a rare case of empyema caused byA. meyeri. A 49-year-old male presented with a history of 10 days of dyspnea and chest pain. A large amount of loculated pleural effusion was present on the right side and multiple lung nodules were documented on radiological studies. A chest tube was inserted and purulent pleural fluid was drained.A. meyeriwas isolated in anaerobic cultures of the pleural fluid. The infection was alleviated in response to treatment with intravenous penicillin G (20 million IU daily) and oral amoxicillin (500 mg every 8 hours) for 4 months, demonstrating that short-term antibiotic treatment was effective.

Distinguishable Brain Activation Networks for Short- and Long-Term Motor Skill Learning

2005 ◽  
Vol 94 (1) ◽  
pp. 512-518 ◽  
Author(s):  
A. Floyer-Lea ◽  
P. M. Matthews
Keyword(s):  
Motor Skill ◽  
Isometric Force ◽  
Brain Activation ◽  
Skill Learning ◽  
Anterior Cingulate ◽  
Motor Skill Learning ◽  
Short Term ◽  
Learning Stage ◽  
The Right

The acquisition of a new motor skill is characterized first by a short-term, fast learning stage in which performance improves rapidly, and subsequently by a long-term, slower learning stage in which additional performance gains are incremental. Previous functional imaging studies have suggested that distinct brain networks mediate these two stages of learning, but direct comparisons using the same task have not been performed. Here we used a task in which subjects learn to track a continuous 8-s sequence demanding variable isometric force development between the fingers and thumb of the dominant, right hand. Learning-associated changes in brain activation were characterized using functional MRI (fMRI) during short-term learning of a novel sequence, during short-term learning after prior, brief exposure to the sequence, and over long-term (3 wk) training in the task. Short-term learning was associated with decreases in activity in the dorsolateral prefrontal, anterior cingulate, posterior parietal, primary motor, and cerebellar cortex, and with increased activation in the right cerebellar dentate nucleus, the left putamen, and left thalamus. Prefrontal, parietal, and cerebellar cortical changes were not apparent with short-term learning after prior exposure to the sequence. With long-term learning, increases in activity were found in the left primary somatosensory and motor cortex and in the right putamen. Our observations extend previous work suggesting that distinguishable networks are recruited during the different phases of motor learning. While short-term motor skill learning seems associated primarily with activation in a cortical network specific for the learned movements, long-term learning involves increased activation of a bihemispheric cortical-subcortical network in a pattern suggesting “plastic” development of new representations for both motor output and somatosensory afferent information.

scholarly journals Intersectoral approaches and integrated services in achieving the right to health for refugees upon resettlement: a scoping review protocol

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e016638 ◽  
Author(s):  
Dena Javadi ◽  
Etienne V Langlois ◽  
Shirley Ho ◽  
Peter Friberg ◽  
Göran Tomson
Keyword(s):  
Scoping Review ◽  
Human Subjects ◽  
Grey Literature ◽  
Open Science ◽  
Right To Health ◽  
Refugee Health ◽  
International Standards ◽  
Vulnerable Groups ◽  
Physical And Mental Health ◽  
The Right

IntroductionGlobal insecurity and climate change are exacerbating the need for improved management of refugee resettlement services. International standards hold states responsible for the protection of the right of non-citizens to an adequate standard of physical and mental health while recognising the importance of social determinants of health. However, programmes to protect refugees’ right to health often lack coordination and monitoring. This paper describes the protocol for a scoping review to explore barriers and facilitators to the integration of health services for refugees; the content, process and actors involved in protecting refugee health; and the extent to which intersectoral approaches are leveraged to protect refugees’ right to health on resettlement, especially for vulnerable groups such as women and children.Methods and analysisPeer-reviewed (through four databases including MEDLINE, Web of Science, Global Health and PsycINFO) and grey literature were searched to identify programmes and interventions designed to promote refugee health in receiving countries. Two reviewers will screen articles and abstract data. Two frameworks for integration and intersectoral action will be applied to understand how and why certain approaches work while others do not and to identify the actors involved in achieving success at different levels of integration as defined by these frameworks.Ethics and disseminationFindings from the scoping review will be shared in relevant conferences and meetings. A brief will be created with lessons learnt from successful programmes to inform decision making in design of refugee programmes and services. Ethical approval is not required as human subjects are not involved.Trial registration numberRegistered on Open Science Framework athttps://osf.io/gt9ck/.

scholarly journals The Pulmonary Vascular Responses to Short-Term Hypoxia in Human Subjects

Circulation ◽  
1952 ◽  
Vol 5 (2) ◽  
pp. 263-270 ◽  
Author(s):  
JOSEPH T. DOYLE ◽  
JOSEPH S. WILSON ◽  
JAMES V. WARREN
Keyword(s):  
Human Subjects ◽  
Short Term ◽  
Vascular Responses
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