scholarly journals Weight Change and Its Association with Cardiometabolic Risk Markers in Overweight and Obese Women

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Liyana Ahmad Zamri ◽  
Geeta Appannah ◽  
Siti Yazmin Zahari Sham ◽  
Fazliana Mansor ◽  
Rashidah Ambak ◽  
...  
Keyword(s):  
Weight Loss ◽  
Waist Circumference ◽  
Lifestyle Intervention ◽  
Weight Change ◽  
Cardiometabolic Risk ◽  
Control Group ◽  
Risk Markers ◽  
Obese Women ◽  
Low Socioeconomic ◽  
Cardiometabolic Risk Markers

Introduction. The effect of weight loss magnitude on cardiometabolic risk markers has been sparsely studied, particularly among overweight and obese women from low socioeconomic areas. Objectives. To examine the association of weight loss magnitude with changes in cardiometabolic risk markers in overweight and obese women from low socioeconomic areas engaged in a lifestyle intervention. Methods. Analyses were performed on 243 women (mean body mass index 31.27 ± 4.14 kg/m2) who completed a 12-month lifestyle intervention in low socioeconomic communities in Klang Valley, Malaysia. Analysis of covariance (ANCOVA) was used to compare changes of cardiometabolic risk factors across weight change categories (2% gain, ±2% maintain, >2 to <5% loss, and 5 to 20% loss) within intervention and control group. Results. A graded association for changes in waist circumference, fasting insulin, and total cholesterol (p=0.002, for all variables) across the weight change categories were observed within the intervention group at six months postintervention. Participants who lost 5 to 20% of weight had the greatest improvements in those risk markers (−5.67 cm CI: −7.98 to −3.36, −4.27 μU/mL CI: −7.35, −1.19, and −0.59 mmol/L CI: −.99, −0.19, respectively) compared to those who did not. Those who lost >2% to <5% weight reduced more waist circumference (−4.24 cm CI: −5.44 to −3.04) and fasting insulin (−0.36 μU/mL CI: −1.95 to 1.24) than those who maintained or gained weight. No significant association was detected in changes of risk markers across the weight change categories within the control group except for waist circumference and adiponectin. Conclusion. Weight loss of >2 to <5% obtained through lifestyle intervention may represent a reasonable initial weight loss target for women in the low socioeconomic community as it led to improvements in selected risk markers, particularly of diabetes risk.

Effects of High-Intensity Interval Training Under Normobaric Hypoxia on Cardiometabolic Risk Markers in Overweight/Obese Women

2018 ◽  
Vol 19 (4) ◽  
pp. 356-366 ◽  
Author(s):  
Alba Camacho-Cardenosa ◽  
Marta Camacho-Cardenosa ◽  
Javier Brazo-Sayavera ◽  
Martin Burtscher ◽  
Rafael Timón ◽  
...  
Keyword(s):  
High Intensity ◽  
Cardiometabolic Risk ◽  
Interval Training ◽  
Normobaric Hypoxia ◽  
Risk Markers ◽  
Obese Women ◽  
High Intensity Interval Training ◽  
High Intensity Interval ◽  
Cardiometabolic Risk Markers

Deterioration in cardiometabolic risk markers in obese women during depot medroxyprogesterone acetate use

Contraception ◽  
2012 ◽  
Vol 85 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Penina Segall-Gutierrez ◽  
Anny H. Xiang ◽  
Richard M. Watanabe ◽  
Enrique Trigo ◽  
Frank Z. Stanczyk ◽  
...  
Keyword(s):  
Medroxyprogesterone Acetate ◽  
Cardiometabolic Risk ◽  
Risk Markers ◽  
Obese Women ◽  
Depot Medroxyprogesterone Acetate ◽  
Cardiometabolic Risk Markers

Impact of a moderate-intensity walking program on cardiometabolic risk markers in overweight to obese women

2013 ◽  
Vol 20 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Eléonor Riesco ◽  
Sébastien Tessier ◽  
Michel Lacaille ◽  
Francine Pérusse ◽  
Mélanie Côté ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Moderate Intensity ◽  
Risk Markers ◽  
Obese Women ◽  
Walking Program ◽  
Cardiometabolic Risk Markers

Subjective Social Status and Cardiometabolic Risk Markers by Intersectionality of Race/Ethnicity and Sex Among U.S. Young Adults

2021 ◽  
Author(s):  
Amanda C McClain ◽  
Linda C Gallo ◽  
Josiemer Mattei
Keyword(s):  
Blood Pressure ◽  
Waist Circumference ◽  
Social Status ◽  
Cardiometabolic Risk ◽  
Subjective Social Status ◽  
Least Square ◽  
Risk Markers ◽  
Race Ethnicity ◽  
Cardiometabolic Risk Markers ◽  
Hispanic White

Abstract Background Subjective social status (SSS) has shown inverse relationships with cardiometabolic risk, but intersectionalities of race/ethnicity and sex may indicate more nuanced relationships. Purpose To investigate associations of SSS with cardiometabolic risk markers by race/ethnicity and sex. Methods Data were from Wave IV (2008) of the National Longitudinal Study of Adolescent to Adult Health (n = 4,847; 24–32 years), which collected biological cardiometabolic risk markers. A 10-step ladder captured SSS; respondents indicated on which step they perceived they stood in relation to other people in the U.S. higher values indicated higher SSS (range: 1–10). We tested the relationship between SSS and individual markers using generalized least square means linear regression models, testing three-way interactions between SSS, race/ethnicity, and sex (p &lt; .10) before stratification. Results SSS–race/ethnicity–sex interactions were significantly associated with waist circumference (p ≤ .0001), body mass index (BMI; p ≤ .0001), systolic blood pressure (SBP; p ≤ .0001), diastolic blood pressure (DBP; p = .0004), and high-density lipoprotein cholesterol (HDL-C; p = .07). SSS was associated with waist circumference (β [SE]: −1.2 (0.4), p &lt; .05) and BMI (−0.6 [0.2], p &lt; .01) for non-Hispanic White females, compared with males; with HDL-C among non-Hispanic White (0.2 [0.1]; p &lt; .05) and Hispanic (0.3 (0.1); p &lt; .05) females, compared with males; with SBP for non-Hispanic Asian (1.7 [0.8]; p &lt; .05) and Multiracial (1.8 [0.8]; p &lt; .05), versus White, females; and with DBP for non-Hispanic Black (0.8 [0.3]; p &lt; .01), versus White, males. Conclusions SSS was differentially related to cardiometabolic risk markers by race/ethnicity and sex, suggesting intersectional aspects. Clinical and research applications of SSS should consider race/ethnicity- and sex-specific pathways influencing cardiometabolic risk.

Abstract 13507: The Role of Weight Loss in Mediating the Effects of a 2-year Caloric Restriction Regimen on Cardiometabolic Risk Markers in Individuals Without Obesity

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
James L Dorling ◽  
Leanne Redman ◽  
Eric Ravussin ◽  
Kim Huffman ◽  
Susan B RACETTE ◽  
...  
Keyword(s):  
Weight Loss ◽  
Caloric Restriction ◽  
Cardiometabolic Risk ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Model Assessment ◽  
Risk Markers ◽  
Mediation Analyses ◽  
Cardiometabolic Risk Markers ◽  
The Impact

Introduction: Caloric restriction (CR) improves cardiometabolic risk, even among individuals without obesity. However, it is unclear whether these aging-related benefits are mediated by weight loss. Mediation analyses inform mechanisms underlying relationships between an exposure and outcome. Using mediation analyses, our aim was to test if 2-year weight loss mediates the beneficial effects of CR on cardiometabolic risk markers in individuals without obesity. Methods: Participants without obesity were randomized 2:1 to CR or ad libitum (AL) as part of the 2-year trial, Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE). The CR group aimed to enact 25% CR for 2 years, while AL maintained habitual energy intake. Baseline and year 2 assessments included weight and cardiometabolic risk markers. Using the approaches of Valeri and VanderWeele, mediation was quantified as the natural indirect effect (NIE), defined as the impact of an exposure on an outcome through a mediator. Here, the NIE was the effect of CR (exposure) on cardiometabolic risk markers (outcome) that was accounted for by weight change (mediator). Results: In total, 117 and 71 participants in the CR and AL groups, respectively, completed the trial. The CR group achieved 11.9 (± 0.7)% CR and 7.6 (± 0.3) kg of weight loss ( P < 0.01 versus AL). Weight loss significantly mediated the CR-induced improvements in total cholesterol (NIE = -10.4 ± 3.5 mg/dL), low-density lipoprotein cholesterol (NIE = -8.5 ± 2.8 mg/dL), high-density lipoprotein cholesterol (NIE = 2.9 ± 1.3 mg/dL), triglycerides (NIE = -0.20 ± 0.05 log mg/dL), the homeostatic model assessment of insulin resistance (NIE = -0.22 ± 0.06), and C-reactive protein (NIE = -0.39 ± 0.15 log ug/mL) ( P ≤ 0.02). Weight loss did not mediate CR-induced reductions in systolic (NIE = -0.9 ± 1.4 mmHg) and diastolic (NIE = -1.0 ± 1.1 mmHg) blood pressure ( P ≥ 0.37). Conclusion: In individuals without obesity, CR-induced improvements in multiple cardiometabolic risk markers are driven by weight loss after 2 years. These findings emphasize that, even in individuals without obesity, weight loss after prolonged CR plays a role in improving cardiometabolic disease risk; however, some CR benefits still occur independent of weight loss.

Cardiometabolic risk improvement in response to a 3-yr lifestyle modification program in men: contribution of improved cardiorespiratory fitness vs. weight loss

2017 ◽  
Vol 312 (4) ◽  
pp. E273-E281 ◽  
Author(s):  
Anne-Laure Borel ◽  
Julie-Anne Nazare ◽  
Aurélie Baillot ◽  
Natalie Alméras ◽  
Angelo Tremblay ◽  
...  
Keyword(s):  
Physical Activity ◽  
Lifestyle Intervention ◽  
Healthy Eating ◽  
Cardiometabolic Risk ◽  
Liver Fat ◽  
Risk Markers ◽  
Matsuda Index ◽  
Cardiometabolic Risk Markers ◽  
Subcutaneous Adiposity

Our objective was to examine the respective contributions of changes in visceral adiposity, subcutaneous adiposity, liver fat, and cardiorespiratory fitness (CRF) to the improvements in cardiometabolic risk markers in response to a 3-yr healthy eating/physical activity lifestyle intervention. Ninety-four out of 144 viscerally obese healthy men completed a 3-yr lifestyle intervention. Body weight, body composition, and fat distribution were assessed by anthropometry and DEXA/computed tomography. CRF, adipokines, lipoprotein/lipid profile, and 75 g of oral glucose tolerance were assessed. CRF and visceral and subcutaneous adiposity significantly improved over the 3-yr intervention, with a nadir in year 1 and a partial regain in year 3. Liver fat (estimated by insulin hepatic extraction) stabilized from year 1 to year 3, whereas HOMA-IR, ISI-Matsuda index, and adiponectin continued to improve. Multivariate analysis revealed that both visceral adiposity and estimated liver fat reductions contributed to the improved ISI-Matsuda index observed over 3 yr ( r2= 0.28, P < 0.001). Three-year changes in fat mass and CRF were independently associated with changes in visceral fat (adjusted r2= 0.40, P < 0.001), whereas only changes in CRF were associated with changes in estimated liver fat (adjusted r2= 0.18, P < 0.001). A long-term (3 yr) healthy eating/physical activity intervention in men improves several cardiometabolic risk markers over the long term (3 yr) despite a partial body weight regain observed between year 1 and year 3. The improvement in CRF contributes to visceral and estimated liver fat losses over the long term, which in turn explain the benefits of the lifestyle intervention on cardiometabolic risk profile.

Pro- and anti-inflammatory adipokines are associated with cardiometabolic risk markers in Brazilian schoolchildren

2021 ◽  
Author(s):  
Mariana De Santis Filgueiras ◽  
Milene Cristine Pessoa ◽  
Josefina Bressan ◽  
Fernanda Martins de Albuquerque ◽  
Lara Gomes Suhett ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Risk Markers ◽  
Anti Inflammatory ◽  
Cardiometabolic Risk Markers
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