scholarly journals Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Monika Chorąży ◽  
Natalia Wawrusiewicz-Kurylonek ◽  
Edyta Adamska-Patruno ◽  
Olga Zajkowska ◽  
Katarzyna Kapica-Topczewska ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Genetic Variants ◽  
Age Of Onset ◽  
Clinical Manifestations ◽  
Control Group ◽  
T Cell Homeostasis ◽  
Single Nucleotide Variants ◽  
Cell Homeostasis ◽  
Cd40 Gene

Purpose. Multiple sclerosis (MS) is an autoimmune disease, and genetic factors play an important role in its pathogenesis and progression. The aim of our study was to evaluate the frequencies of alleles and genetic variants of the T-cell homeostasis-related genes, in subjects with MS, as well as to investigate the association with MS clinical manifestations and disability. Methods. 94 subjects with MS and 160 healthy individuals have been genotyped for seven common single-nucleotide variants in IL-2RA, CTLA4, CD40, and PADI4 genes. The ages of onset, duration of the disease, and clinical condition of the MS subjects were analysed. We used the Chi2 test confirmed with Fisher’s exact test for statistical analysis. Results. The frequency of allele T and CT/TT genotypes (rs7093069) in the IL2RA gene, as well as the T allele and CT/TT genotypes in rs12722598, were significantly higher in the control group. The significant differences between studied groups we also found for the G allele and GG/GA genotypes of rs3087243 in CTLA4 gene, which were more common among the control group. The heterozygous genotype TC (rs1883832) of CD40 gene was more common in the control subjects, and the frequency of the alleles and genotypes in the rs1748033 of the PADI4 gene did not differ between the studied groups. Between the studied genotypes, we did not observe any significant differences in the age of onset and duration of disease, including sex stratification. Conclusion. Our results highlight the protective role of some of the T-cell homeostasis-related genetic variants in MS development, but not in its clinical manifestation.

Disturbed regulatory T cell homeostasis in multiple sclerosis

2010 ◽  
Vol 16 (2) ◽  
pp. 58-68 ◽  
Author(s):  
Koen Venken ◽  
Niels Hellings ◽  
Roland Liblau ◽  
Piet Stinissen
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Homeostasis ◽  
Cell Homeostasis

scholarly journals Variants of Novel Immunomodulatory Fc Receptor Like 5 Gene Are Associated With Multiple Sclerosis Susceptibility in the Polish Population

2021 ◽  
Vol 12 ◽  
Author(s):  
Monika Chorazy ◽  
Natalia Wawrusiewicz-Kurylonek ◽  
Edyta Adamska-Patruno ◽  
Agata Czarnowska ◽  
Olga Zajkowska ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Age Of Onset ◽  
Clinical Manifestations ◽  
Polish Population ◽  
Single Nucleotide Variants ◽  
Single Nucleotide ◽  
Exact Test ◽  
Chi Squared ◽  
First Time

Fc receptors have been shown to play a role in several autoimmune diseases. We aimed to test, for the first time, whether some of the single nucleotide variants in the FCRL5 gene were associated with multiple sclerosis (MS) susceptibility and clinical manifestations in the Polish population. The case-control study included 94 individuals with MS and 160 healthy subjects. We genotyped two single nucleotide variants of the FCRL5 gene: rs2012199 and rs6679793. The age of onset, disease duration, and clinical condition of the MS subjects were analyzed. For statistical analysis, we used the chi-squared test confirmed with Fisher's exact test. We observed the significant differences in the distribution of investigated FCRL5 genotypes between MS subjects and healthy controls. The CC and CT genotypes, as well as the C allele of rs2012199, were significantly more common in the MS subjects, as were genotypes AA and AG, and allele A of rs6679793. We noted that decreased MS susceptibility was associated with the T allele rs2012199 (OR = 0.37, p = 0.0002) and G allele rs6679793 (OR = 0.6, p = 0.02). Our results support the role of the FCRL5 locus in MS predisposition and extend the evidence of its influence on autoimmunity.

scholarly journals Thymic Export Function and T Cell Homeostasis in Patients with Relapsing Remitting Multiple Sclerosis

2003 ◽  
Vol 171 (1) ◽  
pp. 432-437 ◽  
Author(s):  
Andreas Hug ◽  
Mirjam Korporal ◽  
Isabella Schröder ◽  
Jürgen Haas ◽  
Katharina Glatz ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
T Cell Homeostasis ◽  
Cell Homeostasis ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

T-cell homeostasis in pediatric multiple sclerosis: Old cells in young patients

Neurology ◽  
2013 ◽  
Vol 81 (9) ◽  
pp. 784-792 ◽  
Author(s):  
B. Balint ◽  
J. Haas ◽  
A. Schwarz ◽  
S. Jarius ◽  
A. Furwentsches ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Young Patients ◽  
T Cell Homeostasis ◽  
Cell Homeostasis ◽  
Pediatric Multiple Sclerosis

scholarly journals Multiple Sclerosis: A Disorder of Altered T-Cell Homeostasis

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
David G. Haegert
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
T Cell Homeostasis ◽  
Thymic Involution ◽  
Cell Homeostasis ◽  
Thymic Output ◽  
Cell Alterations ◽  
Tcr Signalling

Uncertainty exists as to whether similar or different mechanisms contribute to the pathogenesis of different subtypes of multiple sclerosis (MS). Detailed analysis of naive T cell homeostasis shows that patients with relapsing-remitting MS (RRMS) and with primary progressive MS (PPMS) have early-onset thymic involution that causes reduced thymic output. The reduced thymic output leads to secondary peripheral homeostatic alterations in naïve CD4 T-cells, which closely mimic T-cell alterations observed in an experimental animal model of diabetes mellitus. Homeostatic T-cell receptor (TCR) signalling and proliferation of naïve T cells are induced by self-peptides. Consequently, the findings of increased TCR signalling of naïve CD4 T-cells, without increased proliferation, in PPMS, and the increased homeostatic proliferation of naïve CD4 T-cells in RRMS favour the development of autoimmunity. Thus, it seems highly likely that peripheral T-cell alterations secondary to a thymic abnormality contribute to the pathogenesis of both MS subtypes.

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