scholarly journals Antihypertensive and Renal Protective Effects of Oryeongsan in Spontaneously Hypertensive Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Kiwan Kang ◽  
Minjeong Jeong ◽  
Hongjun Kim ◽  
Beomjin Lim ◽  
Sangjun Kim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Treated Group ◽  
Renal Tissue ◽  
Quality Data ◽  
Protective Effects ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Significant Difference ◽  
History Of Use

Oryeongsan (ORS), a traditional medicine used to regulate body fluids, has a long history of use as a diuretic in Korea, China, and Japan. ORS is commonly thought to lower blood pressure, but high-quality data on its effects are sparse. The purpose of this study was to determine the antihypertensive and renal protective effects of ORS in rats with hypertension. Spontaneously hypertensive rats (SHR) were divided into two groups with similar mean baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP). Then, 10 mL/kg of vehicle (distilled water) or 200 mg/kg of ORS extract were administered orally once a day for 3 weeks. SBP and DBP were measured at weeks 1, 2, and 3. At the end of the experiment, blood was collected, and kidneys were removed for histology. By the 2nd and 3rd week after initiation of treatment, the ORS-treated group had significantly lower SBP than control-treated rats (191.3 ± 6.5 vs. 206.3 ± 9.8 mmHg, p  = 0.022 at the 2nd week; 195.8 ± 7.8 vs. 217.0 ± 8.1 mmHg, p  = 0.003 at the 3rd week, respectively). The ORS-treated group trended toward having a lower DBP than control, but there was no significant difference. Blood urea nitrogen (BUN) and serum creatinine (Cr) were not different between the ORS-treated and control groups (BUN: 23.7 ± 1.1 vs. 22.7 ± 2.8 mg/dL, p  = 0.508; Cr: 19.0 ± 2.2 vs. 21.6 ± 2.1 μM, p  = 0.083, respectively). The percentage of renal tissue affected by tubulointerstitial fibrosis was significantly lower in the ORS-treated group (1.68 ± 0.60) compared to controls (3.17 ± 0.96, p  = 0.019). These findings suggest that treatment with ORS reduces SBP and ameliorates renal damage in SHR.

Effect of chlorothiazide on serial measurements of exchangeable sodium and blood pressure in spontaneously hypertensive rats

1985 ◽  
Vol 69 (5) ◽  
pp. 511-515 ◽  
Author(s):  
P. J. O. Manhem ◽  
S. A. Clark ◽  
W. B. Brown ◽  
G. D. Murray ◽  
J. I. S. Robertson
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Spontaneously Hypertensive Rats ◽  
Tap Water ◽  
Treated Group ◽  
Temporal Association ◽  
Control Group ◽  
Exchangeable Sodium ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

1. Chlorothiazide (100 mg/kg body weight) was given by gavage daily to spontaneously hypertensive rats for 4 weeks. Another group of spontaneously hypertensive rats was given only tap water and served as control. 2. Measurements of total exchangeable sodium, blood pressure and weight were performed for 2 weeks before and for 4 weeks during treatment. 3. Before treatment, exchangeable sodium, blood pressure and weight were similar in the two groups of rats. 4. Chlorothiazide significantly attenuated the blood pressure increase in spontaneously hypertensive rats, the effect being most marked during the first 2 1/2 weeks of treatment and less thereafter. 5. Rats in the chlorothiazide-treated group gained weight more slowly than did those of the control group. 6. Exchangeable sodium, expressed as mmol/kg body weight, did not differ significantly between the two groups at any stage. 7. When exchangeable sodium was expressed as mmol/rat, there was a more gradual rise in the chlorothiazide-treated animals, in accordance with their slower gain in weight. 8. There was no temporal association between the antihypertensive effect of chlorothiazide and changes in exchangeable sodium. 9. Thus whereas chlorothiazide treatment of spontaneously hypertensive rats slows the increase of both weight and exchangeable sodium, other mechanisms are apparently responsible for the antihypertensive action of the drug.

Beneficial effect of simvastatin and pravastatin treatment on adverse cardiac remodelling and glomeruli loss in spontaneously hypertensive rats

2005 ◽  
Vol 108 (4) ◽  
pp. 349-355 ◽  
Author(s):  
Daniele G. BEZERRA ◽  
Carlos A. MANDARIM-de-LACERDA
Keyword(s):  
Left Ventricle ◽  
Spontaneously Hypertensive Rats ◽  
Renal Cortex ◽  
Interstitial Fibrosis ◽  
Treated Group ◽  
Left Ventricular ◽  
Control Group ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Significant Difference

The aim of the present study was to investigate the possibility of different effects of the hydrophobic statin simvastatin and the hydrophilic statin pravastatin on the remodelling process in the overloaded left ventricle and renal cortex of SHRs (spontaneously hypertensive rats). Fifteen SHRs were treated for 40 days with simvastatin, pravastatin or placebo (water) via orogastric administration. Left ventricle and renal cortex were examined by light microscopy and stereology. LV (left ventricular) cardiomyocyte nuclei (N[cmn]) and glomeruli (N[gl]) numbers were estimated by the dissector method. BP (blood pressure) and serum triacylglycerols (triglycerides) were lower in the statin-treated groups than in the untreated control group. The volume density of the interstitial connective tissue was smaller and length density of the intramyocardial arteries, as well as the arteries/cardiomyocyte ratio, was greater in the statin-treated groups than in the control group. No difference was observed between the two statin-treated groups. The cross-sectional cardiomyocyte area was significantly smaller in the simvastatin-treated group than in the control or pravastatin-treated groups, and it was smaller in the pravastatin-treated group than in the control group. N[cmn] and N[gl] were greater in the two statin-treated groups than in the control group, but no significant difference was observed between the two statin-treated groups. In conclusion, administration of the statins simvastatin and pravastatin to SHRs effectively prevented the elevation in BP and serum triaclyglycerols, and also attenuated adverse cardiac and kidney remodelling by preventing LV hypertrophy, enhancing myocardial vascularization with the decrease in interstitial fibrosis and attenuating cardiomyocyte and glomerular loss.

scholarly journals Effects of Valsartan vs Amlodipin on renal function in salt loaded spontaneously hypertensive rats

2014 ◽  
Vol 60 (01) ◽  
pp. 53-59
Author(s):  
Kalina Gjorgjievska ◽  
Dimce Zafirov ◽  
Maja Jurhar Pavlova ◽  
Svetlana Cekovska
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Body Weight ◽  
Systolic Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Treated Group ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Treatment Groups ◽  
Renal Function Tests

The goal of this study was to compare the effects of valsartan and amlodipin on the systolic blood pressure and parameters specific to the renal function in salt loaded spontaneously hypertensive rats (SHR). 32 male SHR were used at age of 20 weeks and body weight ranging between 265-300 g. From 8 weeks of age tab water was replaced with a solution of NaCl (1%) given ad libitum. Rats were divided into 2 groups: valsartan treated group SHRVAL (n=16) in which valsartan was given at a dose of 10 mg/kg b. w. and amlodipine treated group SHRAMLO (n=16) in which amlodipine was given at a dose of 5 mg/kg b. w. For a period of 12 weeks we have evaluated the effect of the investigated drugs on systolic blood pressure, body weight and renal function tests. In salt loaded rats amlodipine was more effective in reducing the systolic blood pressure in contrast to valsartan who had more pronounced effect on renal parameters most evident in proteinuria. Since both treatment groups have different mechanism of action a combination therapy may be beneficial in improving renal function in SHR rats.

scholarly journals Pioglitazone Exerts Protective Effects Against Stroke in Stroke-Prone Spontaneously Hypertensive Rats, Independently of Blood Pressure

Stroke ◽  
2007 ◽  
Vol 38 (11) ◽  
pp. 3016-3022 ◽  
Author(s):  
Taishi Nakamura ◽  
Eiichiro Yamamoto ◽  
Keiichiro Kataoka ◽  
Takuro Yamashita ◽  
Yoshiko Tokutomi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Protective Effects ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Statistical Analysis of Homocysteine and Folate on the Regulation of Blood Pressure

2019 ◽  
Vol 9 (8) ◽  
pp. 1563-1567
Author(s):  
Zhigang Huang ◽  
Lin Shi ◽  
Ningling Sun
Keyword(s):  
Blood Pressure ◽  
Statistical Analysis ◽  
Spontaneously Hypertensive Rats ◽  
Renal Tissue ◽  
Control Group ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Weak Response ◽  
Increasing Trend ◽  
Regulation Of Blood Pressure

Objective: To investigate and statistically analyze homocysteine and folate on the regulation of blood pressure in spontaneously hypertensive rats (SHR), and explore whether the effect is related to angiotensin II type L receptor (AT1R) with bioinformatics. Methods: Eighteen SHRs were randomly divided into three groups: control group, methionine (Met) group and folate group (Met plus folate). Heart rate and blood pressure were monitored at different times. Serum Hcy levels were measured by ELISA kits. The expression of AT1R was detected by protein immunoblot. Results: Statistical analysis results indicated that mean arterial pressure (MAP) of the Met group at 4 and 6 weeks showed an increasing trend compared with the control group. And the Folate group at 4 weeks presented a decreasing trend compared with the Met group. The MAP of the other groups presented that great variation and no obvious trend. Serum Hcy levels were significantly increased in Met group, but decreased in folate group. AT1R protein were significantly decreased in Met and folate group. Conclusion: Hcy increased the MAP to a certain extent, and folic acid had a weak response to intervention to the effect. AT1R protein in renal tissue may not be a major effector in the pathway of elevated blood pressure.

Effects of antiserum against alpha-rat atrial natriuretic polypeptide in spontaneously hypertensive rats

1989 ◽  
Vol 257 (4) ◽  
pp. H1104-H1109 ◽  
Author(s):  
A. Sasaki ◽  
O. Kida ◽  
T. Kita ◽  
J. Kato ◽  
S. Nakamura ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiac Output ◽  
Spontaneously Hypertensive Rats ◽  
Physiological Role ◽  
Mean Blood Pressure ◽  
Rabbit Serum ◽  
Normal Rabbit Serum ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Significant Difference

To clarify the physiological role of endogenous atrial natriuretic polypeptide (ANP), we investigated the effects of specific rabbit antiserum against alpha-rat ANP (alpha-rANP) on hemodynamics, diuresis, and natriuresis in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). Intravenous administration of anti-alpha-rANP antiserum caused an obvious rise of mean blood pressure and cardiac output in both SHR and WKY compared with rats administered with normal rabbit serum. Although there was no significant difference in increments of mean blood pressure between SHR and WKY, the increment of cardiac output in SHR was significantly higher than that in WKY. On the other hand, significant reductions in urine output and urinary sodium and potassium excretion lasted for approximately 20 min after administration of the antiserum in both SHR and WKY compared with rats administered with normal rabbit serum. There was no significant difference in these initial maximal decrements between SHR and WKY. These results indicate that endogenous ANP has an important physiological role in the regulation of hemodynamics and water-electrolyte balance in both SHR and WKY. The greater increment of cardiac output in SHR in response to the antiserum suggests that endogenous ANP in SHR may have a stronger cardiosuppressive action that it does in WKY.

scholarly journals Bioequivalence study of four different trademarks of enalapril maleate in spontaneously hypertensive rats

2008 ◽  
Vol 23 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Nilo César do Vale Baracho ◽  
Guilherme D'Andréa Saba Arruda ◽  
Lidinei José Alves ◽  
Márcio Felipe Salomon Carneiro ◽  
Matheus Teodoro Grilo Siqueira ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Systemic Disease ◽  
Control Group ◽  
High Morbidity ◽  
Hypertensive Rats ◽  
Reference Drug ◽  
Spontaneously Hypertensive ◽  
Enalapril Maleate ◽  
Significant Difference

INTRODUCTION: High blood pressure is a systemic disease which has major clinical and psycho-social repercussions, involves a high morbidity-mortality rate and generates high costs for the health system. Its treatment involves the use of antihypertensive drugs, which are commercialized as trademark, generic or similar drugs. PURPOSE: To verify the antihypertensive effect produced by a similar dose of different trademarks of enalapril maleate in spontaneously hypertensive rats (SHR). METHODS: Fifteen mg/kg of enalapril maleate were administered by gavage in 50 SHR rats and their blood pressure was verified through tail plethysmography every three days in a period of 16 days. RESULTS: The group treated with reference drug has shown a significant reduction on blood pressure levels when compared to the control group. Thus, treatments with enalapril maleate of generic, similar-A and similar-B brands have also shown significant reduction on animals' blood pressure. CONCLUSION: The use of generic drug and similars (A and B) drugs in the same doses and for the same period of time has not shown significant difference regarding the reference drug, which suggests that the brands tested are bioequivalent.

scholarly journals Administration with Quinoa Protein Reduces the Blood Pressure in Spontaneously Hypertensive Rats and Modifies the Fecal Microbiota

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2446
Author(s):  
Huimin Guo ◽  
Yuqiong Hao ◽  
Xin Fan ◽  
Aurore Richel ◽  
Nadia Everaert ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Alpha Diversity ◽  
Treated Group ◽  
Fecal Microbiota ◽  
Potential Candidate ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Despite the well-established role of quinoa protein as the source of antihypertensive peptides through in vitro enzymolysis, there is little evidence supporting the in vivo antihypertensive effect of intact quinoa protein. In this study, in vivo study on spontaneously hypertensive rats (SHRs) was conducted by administering quinoa protein for five weeks. Gastrointestinal content identification indicated that many promising precursors of bioactive peptides were released from quinoa protein under gastrointestinal processing. Quinoa protein administration on SHRs resulted in a significant decrease in blood pressure, a significant increase in alpha diversity, and microbial structure alternation towards that in non-hypertension rats. Furthermore, blood pressure was highly negatively correlated with the elevated abundance of genera in quinoa protein-treated SHRs, such as Turicibacter and Allobaculum. Interestingly, the fecal microbiota in quinoa protein-treated SHRs shared more features in the composition of genera with non-hypertension rats than that of the captopril-treated group. These results indicate that quinoa protein may serve as a potential candidate to lower blood pressure and ameliorate hypertension-related gut dysbiosis.

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