scholarly journals DIIA: Blockchain-Based Decentralized Infrastructure for Internet Accountability

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Pengkun Li ◽  
Jinshu Su ◽  
Xiaofeng Wang ◽  
Qianqian Xing
Keyword(s):  
Real World ◽  
The Internet ◽  
Prototype System ◽  
Ddos Attacks ◽  
Real World Data ◽  
Ip Address ◽  
Network Layer ◽  
Cryptographic Key ◽  
Key Revocation ◽  
Certificate Management

The Internet lacking accountability suffers from IP address spoofing, prefix hijacking, and DDoS attacks. Global PKI-based accountable network involves harmful centralized authority abuse and complex certificate management. The inherently accountable network with self-certifying addresses is incompatible with the current Internet and faces the difficulty of revoking and updating keys. This study presents DIIA, a blockchain-based decentralized infrastructure to provide accountability for the current Internet. Specifically, DIIA designs a public-permissioned blockchain called TIPchain to act as a decentralized trust anchor, allowing cryptographic authentication of IP addresses without any global trusted authority. DIIA also proposes the revocable trustworthy IP address bound to the cryptographic key, which supports automatic key renewal and efficient key revocation and eliminates complexity certificate management. We present several security mechanisms based on DIIA to show how DIIA can help to enhance network layer security. We also implement a prototype system and experiment with real-world data. The results demonstrate the feasibility and suitability of our work in practice.

scholarly journals DDoS-Capable IoT Malwares: Comparative Analysis and Mirai Investigation

2018 ◽  
Vol 2018 ◽  
pp. 1-30 ◽  
Author(s):  
Michele De Donno ◽  
Nicola Dragoni ◽  
Alberto Giaretta ◽  
Angelo Spognardi
Keyword(s):  
Comparative Analysis ◽  
Internet Of Things ◽  
Detailed Analysis ◽  
Real World ◽  
General Framework ◽  
Denial Of Service ◽  
The Internet ◽  
Distributed Denial Of Service ◽  
Ddos Attacks ◽  
The Internet Of Things

The Internet of Things (IoT) revolution has not only carried the astonishing promise to interconnect a whole generation of traditionally “dumb” devices, but also brought to the Internet the menace of billions of badly protected and easily hackable objects. Not surprisingly, this sudden flooding of fresh and insecure devices fueled older threats, such as Distributed Denial of Service (DDoS) attacks. In this paper, we first propose an updated and comprehensive taxonomy of DDoS attacks, together with a number of examples on how this classification maps to real-world attacks. Then, we outline the current situation of DDoS-enabled malwares in IoT networks, highlighting how recent data support our concerns about the growing in popularity of these malwares. Finally, we give a detailed analysis of the general framework and the operating principles of Mirai, the most disruptive DDoS-capable IoT malware seen so far.

scholarly journals Patterns of Information-Seeking for Cancer on the Internet: An Analysis of Real World Data

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45921 ◽  
Author(s):  
Yishai Ofran ◽  
Ora Paltiel ◽  
Dan Pelleg ◽  
Jacob M. Rowe ◽  
Elad Yom-Tov
Keyword(s):  
Real World ◽  
Information Seeking ◽  
The Internet ◽  
Real World Data ◽  
World Data

Abstract #946: Assessment of Acromegaly Patients with and Without Diabetes Treated with Lanreotide Depot: 2-Year Real World Data

2016 ◽  
Vol 22 ◽  
pp. 219
Author(s):  
Roberto Salvatori ◽  
Olga Gambetti ◽  
Whitney Woodmansee ◽  
David Cox ◽  
Beloo Mirakhur ◽  
...  
Keyword(s):  
Real World ◽  
Real World Data ◽  
World Data

Safety and efficacy of direct acting oral anticoagulants and vitamin K antagonists in nonvalvular atrial fibrillation – a network meta-analysis of real-world data

VASA ◽  
2019 ◽  
Vol 48 (2) ◽  
pp. 134-147 ◽  
Author(s):  
Mirko Hirschl ◽  
Michael Kundi
Keyword(s):  
Real World ◽  
Meta Analysis ◽  
Vitamin K Antagonists ◽  
Oral Anticoagulants ◽  
Efficacy And Safety ◽  
Nonvalvular Atrial Fibrillation ◽  
Real World Data ◽  
Hazard Ratios ◽  
Direct Acting ◽  
Event Rates

Abstract. Background: In randomized controlled trials (RCTs) direct acting oral anticoagulants (DOACs) showed a superior risk-benefit profile in comparison to vitamin K antagonists (VKAs) for patients with nonvalvular atrial fibrillation. Patients enrolled in such studies do not necessarily reflect the whole target population treated in real-world practice. Materials and methods: By a systematic literature search, 88 studies including 3,351,628 patients providing over 2.9 million patient-years of follow-up were identified. Hazard ratios and event-rates for the main efficacy and safety outcomes were extracted and the results for DOACs and VKAs combined by network meta-analysis. In addition, meta-regression was performed to identify factors responsible for heterogeneity across studies. Results: For stroke and systemic embolism as well as for major bleeding and intracranial bleeding real-world studies gave virtually the same result as RCTs with higher efficacy and lower major bleeding risk (for dabigatran and apixaban) and lower risk of intracranial bleeding (all DOACs) compared to VKAs. Results for gastrointestinal bleeding were consistently better for DOACs and hazard ratios of myocardial infarction were significantly lower in real-world for dabigatran and apixaban compared to RCTs. By a ranking analysis we found that apixaban is the safest anticoagulant drug, while rivaroxaban closely followed by dabigatran are the most efficacious. Risk of bias and heterogeneity was assessed and had little impact on the overall results. Analysis of effect modification could guide the clinical decision as no single DOAC was superior/inferior to the others under all conditions. Conclusions: DOACs were at least as efficacious as VKAs. In terms of safety endpoints, DOACs performed better under real-world conditions than in RCTs. The current real-world data showed that differences in efficacy and safety, despite generally low event rates, exist between DOACs. Knowledge about these differences in performance can contribute to a more personalized medicine.

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