Curcumin-Chitosan Nanocomposite Formulation Containing Pongamia pinnata-Mediated Silver Nanoparticles, Wound Pathogen Control, and Anti-Inflammatory Potential

Background. Because of its diverse range of use in several ethics of diagnosis and care of multiple diseases, nanotechnology has seen remarkable growth and has become a key component of medical sciences. In recent years, there has been rapid advancement in medicine and biomaterials. Nanomedicine aids in illness prevention, diagnosis, monitoring, and treatment. Aim. The purpose of this work is to evaluate the antibacterial, anti-inflammatory, and cytotoxic capabilities of green produced silver nanoparticle with the addition of curcumin-assisted chitosan nanocomposite (SCCN) against wound pathogenic as reducing agents. Materials and Methods. The plant extract of Pongamia pinnata, silver nanoparticles, and its based curcumin nanoformulations was studied in this study utilizing UV visible spectrophotometer, selected area electron diffraction (SAED), and TEM. Anti-inflammatory, antimicrobial, and cytotoxic tests were performed on silver nanoparticles with the addition of curcumin-assisted chitosan nanocomposite (SCCN). Furthermore, these produced nanocomposites were coated on clinical silk and tested for antibacterial activity. Results. The produced silver nanoparticle with the addition of curcumin-assisted chitosan nanocomposite (SCCN) has significant antibacterial activities against Pseudomonas aeruginosa and staphylococcus aureus. They are as well as possess anti-inflammatory activity and furthermore prove to be biocompatible. Conclusion. This advancement in the field of biomaterials, which means nanocomposite, not only helps to reduce the harmful effects of pathogenic organisms while representing an environmentally benign material but it also shows to be a material with zero danger to humans and the environment.

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Current Development of Silver Nanoparticle Preparation, Investigation, and Application in the Field of Medicine

Journal of Nanomaterials ◽

10.1155/2015/696918 ◽

2015 ◽

Vol 2015 ◽

pp. 1-12 ◽

Cited By ~ 55

Author(s):

Maxwell Murphy ◽

Kang Ting ◽

Xinli Zhang ◽

Chia Soo ◽

Zhong Zheng

Keyword(s):

Silver Nanoparticles ◽

Silver Nanoparticle ◽

Current Development ◽

Potential Toxicity ◽

Biological Efficacy ◽

Research Areas ◽

Nanoparticle Preparation ◽

Anti Inflammatory

The invited review covers different research areas of silver nanoparticles (AgNPs), including the synthesis strategies of AgNPs, antimicrobial and anti-inflammatory properties of AgNPs, osteoconductive and osteoinductive activities of AgNP-based materials, and potential toxicity of AgNPs. The potential mechanisms of AgNP’s biological efficacy as well as its potential toxicity are discussed as well. In addition, the current development of AgNP applications, especially in the area of therapeutics, is also summarized.

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Free Radical Scavenging and Anti-Inflammatory Activity of Chlorogenic Acid Mediated Silver Nanoparticle

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2020/v32i1930715 ◽

2020 ◽

pp. 106-112

Author(s):

Anu Iswarya Jaisankar ◽

Lakshminarayanan Arivarasu

Keyword(s):

Silver Nanoparticles ◽

Green Synthesis ◽

Chlorogenic Acid ◽

Silver Nanoparticle ◽

Antioxidant Properties ◽

Radical Scavenging ◽

Hazardous Substances ◽

Oxidation Activity ◽

Antioxidant Agents ◽

Anti Inflammatory

Introduction: Nanotechnology is a field of research and innovation concerned with building 'things' - generally, materials and devices on the scale of atoms and molecules. It is a booming field of this 21st century. The role of nano technology is becoming very crucial in nearly every aspect of life ranging from cosmetics to advanced bio technological approaches. In recent years, silver nanoparticles have gained considerable attention in the field of medicine. The green synthesis of nanoparticles eliminates the generation and use of hazardous substances and thus sustains non toxicity. Chlorogenic acids are phenolic compounds formed by the esterification of cinnamic acids. They exhibit various pharmacological Properties. Our study deals with the green synthesis of Chlorogenic acid mediated silver nanoparticles and assessment of their anti inflammatory and antioxidant properties. Aim: The present study aims at assessing the antioxidant and anti inflammatory property of chlorogenic acid mediated silver nanoparticle and investigating the efficacy of Chlorogenic acid mediated Silver nanoparticle. Materials and Methods: The methodology includes Green synthesis of Chlorogenic acid mediated Silver nano particle synthesis followed by tests for Anti inflammation and Anti oxidation. Results: Both the Anti inflammatory and Anti oxidation activity of the chlorogenic acid mediated silver nanoparticle had shown a proportionate increase in activity with increasing concentration of the compound. Conclusion: Chlorogenic acid mediated silver nanoparticles have shown significant anti inflammatory and anti oxidation activity and they are considered as potent anti inflammatory and antioxidant agents.

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Green synthesis of silver nanoparticles using leaf extract of Holoptelea integrifolia and preliminary investigation of its antioxidant, anti-inflammatory, antidiabetic and antibacterial activities

Journal of Environmental Chemical Engineering ◽

10.1016/j.jece.2019.103094 ◽

2019 ◽

Vol 7 (3) ◽

pp. 103094 ◽

Cited By ~ 21

Author(s):

Vijay Kumar ◽

Simranjeet Singh ◽

Bhavana Srivastava ◽

Ragini Bhadouria ◽

Ravindra Singh

Keyword(s):

Silver Nanoparticles ◽

Green Synthesis ◽

Leaf Extract ◽

Preliminary Investigation ◽

Antibacterial Activities ◽

Anti Inflammatory

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Study on Synthesis and Antibacterial Properties of Ag NPs/GO Nanocomposites

Journal of Nanomaterials ◽

10.1155/2016/5685967 ◽

2016 ◽

Vol 2016 ◽

pp. 1-9 ◽

Cited By ~ 11

Author(s):

Lei Huang ◽

Hongtao Yang ◽

Yanhua Zhang ◽

Wei Xiao

Keyword(s):

Silver Nanoparticles ◽

Graphene Oxide ◽

Antibacterial Properties ◽

Antibacterial Activities ◽

Structure Characterization ◽

Synthesis Process ◽

Phase Method ◽

Ag Nps ◽

Selected Area Electron Diffraction ◽

20 Nm

Using graphene oxide as substrate and stabilizer for the silver nanoparticles, silver nanoparticles-graphene oxide (Ag NPs/GO) composites with different Ag loading were synthesized through a facile solution-phase method. During the synthesis process, AgNO3on GO matrix was directly reduced by NaBH4. The structure characterization was studied through X-ray diffraction (XRD), atomic force microscopy (AFM), high-resolution transmission electron microscope (HRTEM), ultraviolet-visible spectroscopy (UV-Vis), and selected area electron diffraction (SAED). The results show that Ag nanoparticles (Ag NPs) with the sizes ranging from 5 to 20 nm are highly dispersed on the surfaces of GO sheets. The shape and size of the Ag NPs are decided by the volume of initial AgNO3solution added in the GO. The antibacterial activities of Ag NPs/GO nanocomposites were investigated and the result shows that all the produced composites exhibit good antibacterial activities against Gram-negative (G−) bacterial strainEscherichia coli(E. coli) and Gram-positive (G+) strainStaphylococcus aureus(S. aureus). Moreover, the antibacterial activities of Ag NPs/GO nanocomposites gradually increased with the increasing of volume of initial AgNO3solution added in the GO and this improvement of the antibacterial activities results from the combined action of size effect and concentration effect of Ag NPs in Ag NPs/GO nanocomposites.

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Preparation of silver nanoparticles supported mesoporous silica microspheres with perpendicularly aligned mesopore channels and their antibacterial activities

RSC Advances ◽

10.1039/c5ra06358b ◽

2015 ◽

Vol 5 (75) ◽

pp. 61184-61190 ◽

Cited By ~ 16

Author(s):

Ren-Shu Huang ◽

Bao-Fei Hou ◽

Hai-Tao Li ◽

Xu-Cheng Fu ◽

Cheng-Gen Xie

Keyword(s):

Silver Nanoparticles ◽

Mesoporous Silica ◽

Silver Nanoparticle ◽

Antibacterial Activities ◽

Silica Microspheres ◽

Mesoporous Silica Microspheres

In this study, a facile and effective route for the preparation of silver nanoparticle supported surface mesoporous silica microspheres with perpendicularly aligned mesopore channels and their antibacterial activities were reported.

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Synthesis of silver nanoparticle-decorated hydroxyapatite (HA@Ag) poriferous nanocomposites and the study of their antibacterial activities

RSC Advances ◽

10.1039/c8ra08148d ◽

2018 ◽

Vol 8 (73) ◽

pp. 41722-41730 ◽

Cited By ~ 17

Author(s):

Zhihui Ni ◽

Xiuxian Gu ◽

Yali He ◽

Zhihua Wang ◽

Xueyan Zou ◽

...

Keyword(s):

Silver Nanoparticles ◽

Silver Nanoparticle ◽

Antibacterial Properties ◽

Antibacterial Activities ◽

Ag Nps

We demonstrate a facile and green rapid approach for the synthesis of uniform poriferous hydroxylapatite (HA) and poriferous silver nanoparticles (Ag NPs)-decorated hydroxylapatite (HA@Ag) nanocomposites with excellent antibacterial properties.

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Detection of intracellular silver nanoparticles using flow cytometry

ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» ◽

10.25557/0031-2991.2018.04.223-226 ◽

2018 ◽

pp. 223-226

Author(s):

С.И. Каба ◽

А.А. Соколовская

Keyword(s):

Flow Cytometry ◽

Silver Nanoparticles ◽

Endothelial Cells ◽

Silver Nanoparticle ◽

Cell Uptake ◽

Control Samples

Продемонстрировано обнаружение наночастиц серебра во внутриклеточном пространстве с помощью проточной цитофлуориметрии. В эндотелиальных клетках линии EA.hy926, инкубированных в растворе, содержащем 2 мкг/мл наносеребра, измеряли боковое светорассеяние. По сравнению с контрольными образцами этот параметр возрастал, в то время как прочие значимые характеристики не изменялись. Это подтверждает чувствительность метода к изменившемуся состоянию клеток и указывает на поглощение наночастиц серебра клетками при концентрации ниже токсической. The study demonstrated a possibility for detection of intracellular silver nanoparticles using flow cytometry. The parameter used in this work, side scattering, was measured in EA.hy926 endothelial cells incubated in a 2 mg/ml silver nanoparticle solution. This parameter was increased compared to control samples. Therefore, this technique was sensitive to changes in the cell status and suggested the cell uptake of the particles under the subtoxic conditions.

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Anti-Inflammatory and Cytotoxic Activity of Silver Nanoparticles Prepared from Horseradish Oil –An In Vitro Approach

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.sp1.408 ◽

2020 ◽

Vol 12 (sp1) ◽

Keyword(s):

Silver Nanoparticles ◽

Cytotoxic Activity ◽

Anti Inflammatory

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Arylpyrazoles: Heterocyclic Scaffold of Immense Therapeutic Application

Current Organic Chemistry ◽

10.2174/1570179417999200628035645 ◽

2020 ◽

Vol 24 (14) ◽

pp. 1555-1581

Author(s):

Garima Tripathi ◽

Anil Kumar Singh ◽

Abhijeet Kumar

Keyword(s):

Biological Activities ◽

Biologically Active ◽

Present Review ◽

Pyrazole Derivatives ◽

Therapeutic Application ◽

Diverse Range ◽

Major Class ◽

Anti Inflammatory

Among the major class of heterocycles, the N-heterocycles, such as pyrazoles, are scaffolds of vast medicinal values. Various drugs and other biologically active molecules are known to contain these N-heterocycles as core motifs. Specifically, arylpyrazoles have exhibited a diverse range of biological activities, including anti-inflammatory, anticancerous, antimicrobial and various others. For instance, arylpyrazoles are present as core moieties in various insecticides, fungicides and drugs such as Celebrex and Trocoxil. The present review will be highlighting the significant therapeutic importance of pyrazole derivatives developed in the last few years.

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