scholarly journals Diagnostic Classification of Patients with Dilated Cardiomyopathy Using Ventricular Strain Analysis Algorithm

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Mingliang Li ◽  
Yidong Chen ◽  
Yujie Mao ◽  
Mingfeng Jiang ◽  
Yujun Liu ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Dilated Cardiomyopathy ◽  
Heart Diseases ◽  
Systolic Dysfunction ◽  
Strain Analysis ◽  
Parameter Extraction ◽  
Mr Image ◽  
Normal People ◽  
Complex Methods

Dilated cardiomyopathy (DCM) is a cardiomyopathy with left ventricle or double ventricle enlargement and systolic dysfunction. It is an important cause of sudden cardiac death and heart failure and is the leading indication for cardiac transplantation. Major heart diseases like heart muscle damage and valvular problems are diagnosed using cardiac MRI. However, it takes time for cardiologists to measure DCM-related parameters to decide whether patients have this disease. We have presented a method for automatic ventricular segmentation, parameter extraction, and diagnosing DCM. In this paper, left ventricle and right ventricle are segmented by parasternal short-axis cardiac MR image sequence; then, related parameters are extracted in the end-diastole and end-systole of the heart. Machine learning classifiers use extracted parameters as input to predict normal people and patients with DCM, among which Random forest classifier gives the highest accuracy. The results show that the proposed system can be effectively utilized to detect and diagnose DCM automatically. The experimental results suggest the capabilities and advantages of the proposed method to diagnose DCM. A small amount of sample input can generate results comparable to more complex methods.

scholarly journals Sudden Cardiac Death in Hereditary Dilated Cardiomyopathy

2020 ◽  
Author(s):  
Marianna Leopoulou ◽  
Jo Ann LeQuang ◽  
Joseph V. Pergolizzi ◽  
Peter Magnusson
Keyword(s):  
Sudden Cardiac Death ◽  
Left Ventricle ◽  
Sudden Death ◽  
Risk Stratification ◽  
Dilated Cardiomyopathy ◽  
Cardiac Death ◽  
Disease Risk ◽  
Systolic Dysfunction ◽  
Preventive Strategies ◽  
Genetic Origin

Dilated cardiomyopathy (DCM) is characterized by the phenotype of a dilated left ventricle with systolic dysfunction. It is classified as hereditary when it is deemed of genetic origin; more than 50 genes are reported to be related to the condition. Symptoms include, among others, dyspnea, fatigue, arrhythmias, and syncope. Unfortunately, sudden cardiac death may be the first manifestation of the disease. Risk stratification regarding sudden death in hereditary DCM as well as preventive management poses a challenge due to the heterogeneity of the disease. The purpose of this chapter is to present the epidemiology, risk stratification, and preventive strategies of sudden cardiac death in hereditary DCM.

scholarly journals THE PREVALENCE OF THROMBOTIC EVENTS IN CHILDREN WITH HEART FAILURE ON THE BACKGROUND OF THE DILATED CARDIOMYOPATHY PHENOTYPE

2019 ◽  
Vol 21 (2) ◽  
pp. 78-84
Author(s):  
Yuliya V. Derevnina ◽  
E. N. Basargina ◽  
K. V. Savostyanov ◽  
A. A. Pushkov ◽  
O. B. Gordeeva
Keyword(s):  
Heart Failure ◽  
Left Ventricle ◽  
Dilated Cardiomyopathy ◽  
Thrombus Formation ◽  
Superior Vena ◽  
Systolic Dysfunction ◽  
Vena Cava ◽  
Mthfr Gene ◽  
Functional Class ◽  
Class Iii

Thrombotic events seem to be one of the most common and severe complications having a direct impact on the course of the disease in patients with cardiomyopathy.There were examined 94 children with dilated cardiomyopathy (DCMP) phenotype [49 children with dilated cardiomyopathy (DCMP), including 45 patients with non-compaction cardiomyopathy (NCMP) and remodeling in dilated phenotype]. Thromboses were diagnosed in 9 patients, including 7 DCMP and 2 NCMP cases. In 4 DCMP children, the thrombus was localized in the cavity of the left ventricle, one in the left atrium, the right ventricle, and the inferior vena cava. In NCMP children, intracardiac thrombus formation was not determined, one patient was diagnosed with an acute ischemic disorder of the cerebral circulation; in the second one, the thrombus was detected in the superior vena cava. Thrombosis in DCMP patients was detected against a background of a severe systolic dysfunction of the left ventricle (LVEF of below 30%), and in NCMP children with a moderate dysfunction. Also, the greatest prevalence rate of thrombotic complications was noted in Functional Class III and IV heart failure cases. At the same time, there was no established any influence of polymorphic markers G1691A of gene F5, G20210A of gene F2, C677T of MTHFR gene on the prevalence of thrombotic events. The authors believe the formation of thrombi with the severe LV dysfunction in children with cMYP should be taken into account in the determination the tactics of the treatment of such patients, as it is necessary to make a decision about administering antithrombotic therapy.

Gene expression profiling: Classification of mice with left ventricle systolic dysfunction using microarray analysis*

2010 ◽  
Vol 38 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Jim Wong ◽  
Christine Chang ◽  
Rani Agrawal ◽  
G Brant Walton ◽  
Craig Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Left Ventricle ◽  
Gene Expression Profiling ◽  
Microarray Analysis ◽  
Expression Profiling ◽  
Systolic Dysfunction

scholarly journals 1106 Twins with uncertain significant mutations, slightly different cardiomyopathies and different oucmes

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
S Blasco Turrion ◽  
I Guillen Rodriguez ◽  
A Moruno Tirado ◽  
A Mendez ◽  
I Valverde Perez
Keyword(s):  
Left Ventricle ◽  
Dilated Cardiomyopathy ◽  
Heart Diseases ◽  
Clinical Signs ◽  
Lateral Wall ◽  
Single Mutation ◽  
Twin Brother ◽  
Neonatal Icu ◽  
The Right ◽  
Left Ventricle Dysfunction

Abstract Dilated cardiomyopathy (DCM) is defined as left ventricle (LV) dilatation and dysfunction in the absence of abnormal loading conditions or coronary artery disease enough to cause global systolic impairment. It is the leading cause of heart failure and sudden cardiac death, and even in the early stages of life 5,7/1.000.000 children are diagnosed each year. Lately, genetic screening has revealed that 30-50% of the cases have a familial origin, with a high genetic heterogeneity. We present the case of a 4-month-old boy (case A) referred to our Hospital with high suspicion of dilated cardiomyopathy. He had a twin brother, pregnancy went without complications, pre-birth ultrasound and blood tests were completely normal and a caesarean birth was planned at 37 weeks of pregnancy. He also has an older sibling with no medical history. Our patient was the first to be born and was admitted to the neonatal-ICU due to tachypnea, labored breathing and desaturation. In the physical exam a 5cm hepatomegaly was detected and on the X-Ray a cardiomegaly and enlarged mediastinum were confirmed. ECG showed no electrical abnormalities besides vague repolarization changes. A TTE was done, showing remarkable left cavities enlargement with severe left ventricle dysfunction and moderate mitral regurgitation, comprising the right filling and therefore the right cardiac output. These findings were confirmed by MRI, not detecting enhancement patterns compatible with myocarditis. A genetic test was performed in the index case detecting the presence of a mutation in the desmin gene (Des C.568 + 10c) and the myosin heavy chain 7 gene (Myh7p - glu883Ala) both associated either with dilated and noncompaction cardyomiopathies. Due to the elevated chances of a familiar-DCM his twin brother was admitted to study (case B), with no symptoms or clinical signs besides an isolated bronchitis episode. The clinical examination and EKG were normal, detecting in the TTE a slightly dilated left ventricle with non-compactation morphology in the LV lateral wall, but no left ventricle dysfunction. Also, a TTE was performed in their father with similar findings: mild LV dilatation with minor systolic disfunction and uncertain non-compactation morphology in the LVl apex. Abnormalities of specific genes are now known to be responsible for different types of congenital heart diseases with important implications in genetic counseling. We want to emphasize the different manifestation of a single mutation on different members of a family, even in this two twin-brothers that, under the same probable conditions during preganancy, had slightly different cardyomyopathies but very different severity, and probable mid to long term prognosis. Abstract 1106 Figure.

scholarly journals Assessment of Right Ventricular Function and Structure in Children with Idiopathic Dilated Cardiomyopathy

2021 ◽  
pp. 28-38
Author(s):  
Drahem Mansour Ahmed El-Fiky ◽  
Shimaa Basyony El-Nemr ◽  
Osama Abd Rab El-Rasoul Tolba ◽  
Waleed Ahmed El-Shahaby
Keyword(s):  
Left Ventricle ◽  
Right Ventricular ◽  
Dilated Cardiomyopathy ◽  
Diastolic Dysfunction ◽  
Systolic Dysfunction ◽  
Tissue Doppler ◽  
Muscle Disease ◽  
Doppler Imaging ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Healthy Children

Background: Dilated cardiomyopathy (DCM) refers to dilating the ventricles and dysfunction of their systolic functions (predominantly the left ventricle) with or without congestive heart failure. In children, it is the most common form of heart muscle disease. We aimed to evaluate the right ventricular functions and structure using speckling tracking echocardiography in children with dilated cardiomyopathy and correlate this parameter with other echocardiographic findings. Methods: This observational Case-Control Study was carried out on 75 subjects. They were subdivided into two groups: Group 1: 50 patients with dilated cardiomyopathy Group 2: 25 healthy children matched for age and sex. Patients were evaluated by M-mode echocardiography, Transthoracic 2DE Examination (TTE), Tissue Doppler Examination (TDE) and Speckling Tracking Technique. Results: Left ventricle (LV) and right ventricle (RV) systolic dysfunction was evidenced by a significant decrease of mitral and tricuspid annular systolic velocities and a significant decrease of LV and RV global systolic strain and a significant decrease of LV and RV Ejection fraction (EF). LV and RV diastolic dysfunction were evidenced by a significant decrease of mitral and tricuspid annular diastolic velocities (E’/A’) and a significant increase of LV and RV Myocardial Perfusion Imaging (MPI). LV and RV global strains were significantly reduced in comparison to controls, suggesting that the dilated cardiomyopathy is a diffuse disease. Conclusion: In DCM patients, RV had significant systolic and diastolic dysfunction mainly elicited by the Tissue Doppler imaging (TDI) beside LV affection secondary to the interventricular interaction. TDI and 2D-STE add value to interpreting the findings and the dependency of RV systolic and diastolic functions on each other in DCM patients.

scholarly journals Evaluation of NT-proBNP in children with heart failure younger than 3 years old

2017 ◽  
Vol 55 (2) ◽  
pp. 69-74
Author(s):  
Daniela Iacob ◽  
Angela Butnariu ◽  
Daniel-Corneliu Leucuţa ◽  
Gabriel Samaşca ◽  
Diana Deleanu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricle ◽  
Ejection Fraction ◽  
Dilated Cardiomyopathy ◽  
Natriuretic Peptide ◽  
Congenital Heart ◽  
Systolic Function ◽  
Heart Diseases ◽  
Functional Class ◽  
Congenital Heart Diseases

Abstract Introduction. Heart failure (HF) is characterized by neuroendocrine activation. The cardiac natriuretic hormones, including atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), together with their related pro-peptides (proANP and proBNP) represent a group of peptide hormones produced by the heart. A normal NT-proBNP level has a high negative predictive value for heart failure. The use of NT-proBNP testing is helpful in diagnosing acute HF in the emergency care setting, allowing an early and optimal treatment. The purpose of this study is to assess the prognostic value of NT-proBNP in heart failure in children younger than 3 years old and to establish whether it correlates with the NYHA/Ross functional class and left ventricle systolic function. Methods. We enrolled 24 consecutive children with HF due to congenital heart diseases and dilated cardiomyopathy. The serum levels of NT-proBNP were measured, all patients underwent echocardiography and left ventricle ejection fraction was calculated. Results. The highest median value of NT-proBNP was recorded in patients with cyanotic heart diseases (248.0 fmol/mL), p = 0.610. NT-proBNP had a negative correlation with the ejection fraction of the left ventricle: Spearman's rank correlation coefficient was −0.165. Conclusions. NT-proBNP levels correlate with the severity of HF in infants and small children younger than 3 years old with heart failure due to congenital heart diseases and dilated cardiomyopathy.

scholarly journals Systemic sclerosis sine scleroderma: a case report of anterior uveitis

Reumatismo ◽  
2015 ◽  
Vol 67 (1) ◽  
Author(s):  
T. Borges ◽  
J. Vilaça ◽  
S. Ferreira ◽  
I. Chora ◽  
S. Silva ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Anterior Uveitis ◽  
Heart Diseases ◽  
Systolic Dysfunction ◽  
Skin Involvement ◽  
American College Of Rheumatology ◽  
European League Against Rheumatism ◽  
History Of ◽  
Non Ischemic Dilated Cardiomyopathy

Systemic sclerosis (SSc) sine scleroderma (ssSSc) is characterized by the absence of skin involvement, despite other manifestations of systemic sclerosis are present. It is not known whether sSSc represents a <em>forme</em> <em>fruste</em> of limited cutaneous SSc or a distinct entity, but the 2013 American College of Rheumatology/European League Against Rheumatism criteria for the classification of SSc have considered SSc without skin involvement to be a distinct subset. The authors present the case of a 70-year old female that was referred for a consultation for Raynaud’s phenomenon and a chronic anterior uveitis (CAU). She had a history of dysphagia, diffuse pulmonary emphysema and a biopsy-documented fibrosis of the upper lobes, and an idiopathic non-ischemic dilated cardiomyopathy with severe left ventricle systolic dysfunction and left bundle branch block. Anti-nuclear and anti-centromere antibodies were positive, while manometry revealed distal esophageal hypomotility. After establishing the diagnosis of ssSSc and starting immunosuppression, the ocular disease improved, while the lung and heart diseases remained stable. This case underlines that it is very important to suspect SSc when CAU is present and/or skin thickening is absent. To our knowledge, this is the first report of CAU in a patient with ssSSc.

Studies on Ultrastructure and Cytochemistry of Right Ventricular Endomyocardial Biopsy

1990 ◽  
Vol 48 (3) ◽  
pp. 256-257
Author(s):  
Xia Mingyu ◽  
Ma Wengshu ◽  
Wu Xiangh ◽  
Chen Dong
Keyword(s):  
Light Microscopy ◽  
Right Ventricular ◽  
Dilated Cardiomyopathy ◽  
Endomyocardial Biopsy ◽  
Heart Diseases ◽  
Ultrastructural Localization ◽  
Controlled Study ◽  
Myocardial Biopsy ◽  
Morphological Assessment ◽  
Rheumatic Heart

This paper describes morphological and cytochemistry changes of endomyocardial biopsy in 94 patients. The samples of myoicardium were taken from 32 patients with dilated cardiomyopathy, and sdudied with light and electron microscop. The cytochemical studies in some of these patients were performed at histological and ultrastructure level. This paper also reported the result of myocardial biopsy in 33 patients with serious dysrythmia.The result of this controlled study indicates that morphological assessment in both cardiomyopathy and congenital or rheumatic heart diseases showed no special changes. In patients of dilated cardiomyopathy, the decreased activity of myosin ATPase was secondary to cardial failure. The change of succinate dehydrogenase (SDHase) was not significant with light microscopy. But ultrastructural localization of SDHase activity is valuable. Its activity was found to be localized in endomembrane and ridge of the mitochondria, the activity of this enzyme was decrease, normal, or increase. SDHase activity was more intense in cardial myocytes well-functioning, or ultrastructurally well preserved hearts.

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