scholarly journals Moxifloxacin Monotherapy in Left-Sided Staphylococcus aureus Endocarditis

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Yucel Colkesen
Keyword(s):  
Staphylococcus Aureus ◽  
Blood Cultures ◽  
Antibiotic Regimen ◽  
Good Clinical Response ◽  
Native Valve ◽  
Native Valve Endocarditis ◽  
Therapeutic Procedures ◽  
History Of ◽  
Staphylococcus Aureus Endocarditis ◽  
Over Time

Staphylococcus aureus is the major cause of endocarditis, and its mortality has remained high despite therapeutic procedures over time. A case of left-sided native valve endocarditis caused by methicillin-sensitive Staphylococcus aureus which responded well to moxifloxacin monotherapy is described. An 83-year-old woman with a history of current hospitalization presented with fatigue and fever. Transthoracic echocardiography depicted vegetation, and blood cultures were positive for Staphylococcus aureus. After a 14-day intravenous administration of moxifloxacin, a good clinical response was achieved, and antibiotic regimen transitioned to oral moxifloxacin for an additional four-week therapy.

scholarly journals High-Dose Daptomycin plus Fosfomycin Is Safe and Effective in Treating Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus Endocarditis

2012 ◽  
Vol 56 (8) ◽  
pp. 4511-4515 ◽  
Author(s):  
José M. Miró ◽  
José M. Entenza ◽  
Ana del Río ◽  
Maria Velasco ◽  
Ximena Castañeda ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
High Dose ◽  
Native Valve ◽  
Methicillin Resistant ◽  
Content Type ◽  
Native Valve Endocarditis ◽  
Prosthetic Aortic Valve ◽  
Staphylococcus Aureus Endocarditis

ABSTRACTWe describe 3 patients with left-sided staphylococcal endocarditis (1 with methicillin-susceptibleStaphylococcus aureus[MSSA] prosthetic aortic valve endocarditis and 2 with methicillin-resistantS. aureus[MRSA] native-valve endocarditis) who were successfully treated with high-dose intravenous daptomycin (10 mg/kg/day) plus fosfomycin (2 g every 6 h) for 6 weeks. This combination was testedin vitroagainst 7 MSSA, 5 MRSA, and 2 intermediately glycopeptide-resistantS. aureusisolates and proved to be synergistic against 11 (79%) strains and bactericidal against 8 (57%) strains. This combination deserves further clinical study.

Clinical and pathogen features of infective endocarditis:A retrospective study of 111 episodes in a teaching hospital in southwest China

2019 ◽  
Author(s):  
Yuanfang Wang ◽  
Mei Kang ◽  
Ya Liu ◽  
Siyin Wu ◽  
Weili Zhang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Heart Disease ◽  
Infective Endocarditis ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Resistance Rate ◽  
Native Valve ◽  
Duke Criteria ◽  
Preventive Medication ◽  
History Of

Abstract Background Infective endocarditis (IE) is a health-threaten infectious disease. Diverse and complicated etiology and causative microorganisms make IE difficult to diagnose and treat. As we know, current investigations of clinical and pathogen features of IE in West china are scarce. In this study, we aimed to investigate the epidemiology and pathogen characteristic of IE in our region. Methods A retrospective analysis of clinical and laboratory data was performed from all blood culture positive IE patients between 2012 to 2017 in Westchina Hospital of Sichuan University。The diagnosis is traditionally based on the modified Duke criteria. Results The mean age of the patient cohort was 40.7±21.5 years (ranging from 2-78); 73 cases (65.2%) were males and 39 cases (34.8%) were females. Of the 111 cases, 100 were native valve endocarditis (NVE) while 11 were prosthetic valve endocarditis (PVE), 87 cases (78.4%) were left-heart infection. Congenital heart disease (28.6%) and rheumatic heart disease (11.6%) were most common history of heart disease. Primary clinical manifestations were fever (87.5%) and heart murmur (78.6%).Streptococci spp (20.7%) was the most common organism, followed by Staphylococcus spp(17.9%). Streptococcus viridians showed no resistance to penicillin, erythromycin and clindamycin resistance rate were 47.4% and 40%. Benzocillin resistance rate of staphylococcus aureus to was 26.3%. Vancomycin or linezolid resistance staphylococcus aureus were not found. 75 patients died while 36 patients survived at last. With respect to risk factors, history of heart disease was the only prognostic risk factor (OR: 0.239, 95%CI 0.08-0.68) Conclusions Epidemiological and clinical characteristics of infective endocarditis are various and complex, distribution of pathogen is regional difference. Our research of infective endocarditis with bloodstream infection verified regional characteristics of infective endocarditis. The variations we observed in the study will be of important value to clinical preventive medication in our region.

Atlanto-Axial Infection after Acupuncture

2016 ◽  
Vol 34 (2) ◽  
pp. 149-151 ◽  
Author(s):  
A Robinson ◽  
C R P Lind ◽  
R J Smith ◽  
V Kodali
Keyword(s):  
Staphylococcus Aureus ◽  
Cervical Spondylosis ◽  
Infectious Complications ◽  
Blood Cultures ◽  
Location Awareness ◽  
Direct Extension ◽  
History Of ◽  
Haematogenous Spread ◽  
Spread Of Infection ◽  
Atlanto Axial Joint

A 67-year-old man presented with neck cellulitis following acupuncture for cervical spondylosis. Blood cultures were positive for methicillin-sensitive Staphylococcus aureus. Increased neck pain and bacteraemia prompted MRI, which showed atlanto-axial septic arthritis without signs of infection of the tissues between the superficial cellulitic area and the atlanto-axial joint, thus making direct extension of infection unlikely. It is more likely that haematogenous spread of infection resulted in seeding in the atlanto-axial joint, with the proximity of the arthritis and acupuncture site being coincidental. Acupuncture is a treatment option for some indolent pain conditions. As such, acupuncture services are likely to be more frequently utilised. A history of acupuncture is rarely requested by the admitting doctor and seldom offered voluntarily by the patient, especially where the site of infection due to haematogenous spread is distant from the needling location. Awareness of infectious complications following acupuncture can reduce morbidity through early intervention.

scholarly journals Lifesaving Treatment of Aortic Valve Staphylococcus aureus Endocarditis: Daptomycin and Early Surgical Therapy

2020 ◽  
Author(s):  
Can Yilmaz Yozgat ◽  
Selcuk Uzuner ◽  
Yasin Ay ◽  
Hafize Otcu Temur ◽  
Burcu Bursal Duramaz ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Aortic Valve ◽  
Surgical Therapy ◽  
Initial Therapy ◽  
Native Valve ◽  
Aureus Infection ◽  
Native Valve Endocarditis ◽  
Septic Embolization ◽  
Recommended Treatment ◽  
Severe Infections

AbstractInfective endocarditis (IE) is an uncommon infection in children. The recommended treatment for native valve endocarditis secondary to methicillin-susceptible Staphylococcus aureus infection is antistaphylococcal penicillins such as nafcillin or oxacillin. If the initial therapy fails in IE, it can lead to catastrophic results. Nowadays, daptomycin is the best alternative antimicrobial agent to treat children with severe infections, when standard antimicrobial therapy does not yield a result. Herein, we describe a case of a 16-year-old boy who had aortic valve S. aureus endocarditis with septic embolization and stroke. The patient was successfully treated only with daptomycin as well as surgical therapy in the early phase of the infection.

scholarly journals Streptobacillus moniliformis mitral valve endocarditis and septic arthritis: the challenges of diagnosing rat-bite fever endocarditis

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Daisy Torres-Miranda ◽  
Madhi Moshgriz ◽  
Marc Siegel
Keyword(s):  
United States ◽  
Mitral Valve ◽  
Blood Culture ◽  
The United States ◽  
Blood Cultures ◽  
Native Valve ◽  
Native Valve Endocarditis ◽  
Streptobacillus Moniliformis ◽  
Rat Bite Fever ◽  
Mitral Valve Vegetation

Streptobacillus moniliformis, the cause of rat-bite fever (RBF) in the United States, has rarely been reported as a cause of infectious endocarditis. In the majority of previously reported cases, the diagnosis was clinically based in patients with underlying valvular abnormalities in the setting of positive blood culture for Streptobacillus moniliformis. We report a case of native valve endocarditis secondary to Streptobacillus moniliformis in a woman with a mitral valve vegetation but negative blood cultures where the diagnosis was established using molecular diagnostics on the valvular tissue.

scholarly journals Daptomycin Failure for Treatment of Pulmonary Septic Emboli in Native Tricuspid and Mitral Valve Methicillin-ResistantStaphylococcus aureusEndocarditis

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Hadeel Zainah ◽  
Marcus Zervos ◽  
Wassim Stephane ◽  
Sara Chamas Alhelo ◽  
Ghattas Alkhoury ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Mitral Valve ◽  
Treatment Failure ◽  
Native Valve ◽  
Methicillin Resistant ◽  
Septic Emboli ◽  
Native Valve Endocarditis ◽  
Pulmonary Infiltrates ◽  
Sole Agent

Daptomycin has been used with success for the treatment of right-sided methicillin-resistantStaphylococcus aureus(MRSA) endocarditis. However, its efficacy has not been completely assessed for the treatment of MRSA endocarditis when it is associated with pulmonary septic emboli. Hereby, we present a case of MRSA mitral and tricuspid native valve endocarditis with pulmonary septic emboli, which was treated with daptomycin as a sole agent, resulting in worsening pulmonary infiltrates and treatment failure.

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