A Comprehensive Review of the Potential Use of Green Tea Polyphenols in the Management of COVID-19

Green tea is produced from Camellia sinensis (L.) buds and leaves that have not gone through the oxidation and withering processes used to produce black and oolong teas. It was originated in China, but its cultivation and production have expanded to other Eastern Asian countries. Several polyphenolic compounds, including flavandiols, flavonols, flavonoids, and phenolic acids, are found in green tea and may constitute greater than 30% of the dry weight. Flavonols, especially catechins, represent the majority of green tea polyphenols. Green tea polyphenolic compounds have been reported to confer several health benefits. This review describes the potential use of green tea polyphenols in the management of coronavirus disease 2019 (COVID-19). The immunomodulatory, antibacterial, antioxidant, and anti-inflammatory effects of green tea polyphenols have also been considered in this review. In addition to describing the bioactivities associated with green tea polyphenols, this review discusses the potential delivery of these biomolecules using a nanoparticle drug delivery system. Moreover, the bioavailability and toxicity of green tea polyphenols are also evaluated.

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Expression of Concern: Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker Fatty Rats

Clinical Science ◽

10.1042/cs-20200107_eoc ◽

2020 ◽

Vol 134 (21) ◽

pp. 2789-2789

Keyword(s):

Insulin Resistance ◽

Skeletal Muscle ◽

Green Tea ◽

Insulin Signalling ◽

Tea Polyphenols ◽

Green Tea Polyphenols ◽

Metabolic Abnormalities

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Topical Green Tea Polyphenols and Caffeine as a Treatment for Acne Vulgaris

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.1.supp.54 ◽

2017 ◽

Vol 1 ◽

pp. s55

Author(s):

Sarah Y Siu ◽

Georgina M Ferzli ◽

Neil Brody

Keyword(s):

Green Tea ◽

Acne Vulgaris ◽

Tea Polyphenols ◽

Green Tea Polyphenols

Abstract Not Available

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Green tea polyphenols in the prevention of colon cancer

Frontiers in Bioscience ◽

10.2741/2233 ◽

2007 ◽

Vol 12 (1) ◽

pp. 2309 ◽

Cited By ~ 48

Author(s):

Nagi Kumar

Keyword(s):

Colon Cancer ◽

Green Tea ◽

Tea Polyphenols ◽

Green Tea Polyphenols

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Antimutagenic activity of green tea polyphenols

Mutation Research/Genetic Toxicology ◽

10.1016/0165-1218(89)90120-1 ◽

1989 ◽

Vol 223 (3) ◽

pp. 273-285 ◽

Cited By ~ 172

Author(s):

Zhi Y. Wang ◽

Shu J. Cheng ◽

Zong C. Zhou ◽

Mohammad Athar ◽

Wasiuddin A. Khan ◽

...

Keyword(s):

Green Tea ◽

Tea Polyphenols ◽

Green Tea Polyphenols ◽

Antimutagenic Activity

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Supplementation with Green Tea Polyphenols Improves Bone Microstructure and Quality in Aged, Orchidectomized Rats

Calcified Tissue International ◽

10.1007/s00223-011-9477-1 ◽

2011 ◽

Vol 88 (6) ◽

pp. 455-463 ◽

Cited By ~ 30

Author(s):

Chwan-Li Shen ◽

Jay J. Cao ◽

Raul Y. Dagda ◽

Thomas E. Tenner ◽

Ming-Chien Chyu ◽

...

Keyword(s):

Green Tea ◽

Bone Microstructure ◽

Tea Polyphenols ◽

Green Tea Polyphenols

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Complexation/encapsulation of green tea polyphenols in mixed calcium carbonate and phosphate micro-particles

Journal of Microencapsulation ◽

10.3109/02652048.2010.520091 ◽

2010 ◽

Vol 28 (1) ◽

pp. 1-9 ◽

Cited By ~ 14

Author(s):

Amal Elabbadi ◽

Nicolas Jeckelmann ◽

Olivier P. Haefliger ◽

Lahoussine Ouali

Keyword(s):

Calcium Carbonate ◽

Green Tea ◽

Tea Polyphenols ◽

Green Tea Polyphenols ◽

Micro Particles

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Influence of the gallate moiety on the interactions between green tea polyphenols and lipid membranes elucidated by molecular dynamics simulations

Biophysical Chemistry ◽

10.1016/j.bpc.2021.106592 ◽

2021 ◽

pp. 106592

Author(s):

Rong-zu Nie ◽

Mei-zhu Dang ◽

Zhen-zhen Ge ◽

Yin-qiang Huo ◽

Bo Yu ◽

...

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulations ◽

Green Tea ◽

Lipid Membranes ◽

Tea Polyphenols ◽

Green Tea Polyphenols ◽

Dynamics Simulations

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Tea Polyphenols in Promotion of Human Health

Nutrients ◽

10.3390/nu11010039 ◽

2018 ◽

Vol 11 (1) ◽

pp. 39 ◽

Cited By ~ 88

Author(s):

Naghma Khan ◽

Hasan Mukhtar

Keyword(s):

Green Tea ◽

Animal Studies ◽

Neurological Diseases ◽

Black Tea ◽

Polyphenolic Compounds ◽

Tea Polyphenols ◽

Beneficial Effects ◽

Gallocatechin Gallate ◽

Prevention Of Cancer ◽

Pharmacologically Active

Tea is the most widely used beverage worldwide. Japanese and Chinese people have been drinking tea for centuries and in Asia, it is the most consumed beverage besides water. It is a rich source of pharmacologically active molecules which have been implicated to provide diverse health benefits. The three major forms of tea are green, black and oolong tea based on the degree of fermentation. The composition of tea differs with the species, season, leaves, climate, and horticultural practices. Polyphenols are the major active compounds present in teas. The catechins are the major polyphenolic compounds in green tea, which include epigallocatechin-3-gallate (EGCG), epigallocatechin, epicatechin-3-gallate and epicatechin, gallocatechins and gallocatechin gallate. EGCG is the predominant and most studied catechin in green tea. There are numerous evidences from cell culture and animal studies that tea polyphenols have beneficial effects against several pathological diseases including cancer, diabetes and cardiovascular diseases. The polyphenolic compounds present in black tea include theaflavins and thearubigins. In this review article, we will summarize recent studies documenting the role of tea polyphenols in the prevention of cancer, diabetes, cardiovascular and neurological diseases.

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