scholarly journals Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional Study

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Dandan Sun ◽  
Quanliang Wang ◽  
Jie Kang ◽  
Jie Zhou ◽  
Ruijuan Qian ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Platelet Count ◽  
Cognitive Function ◽  
Cross Sectional Study ◽  
Nonlinear Relationship ◽  
Sectional Study ◽  
Function Score ◽  
Cross Sectional ◽  
The Relationship ◽  
Cognitive Function Score

Background. The risk of cognitive impairment in patients with atrial fibrillation is significantly increased. Its occurrence may be related to blood hypercoagulable state and immune inflammatory reaction. Platelets can mediate immune inflammatory response, but there is no evidence about the relationship between platelet count and cognitive function in patients with atrial fibrillation. Purpose. To explore whether there is a certain correlation between platelet count and cognitive function in patients with atrial fibrillation. Methods. A cross-sectional study was conducted in a single center in China, including 254 patients with atrial fibrillation. Cognitive function assessment and clinical and laboratory examinations were performed on all participants. After adjusting the related confounding factors, the relationship between platelet count and cognitive function was analyzed. Results. A total of 254 subjects with an average age of 59.71 ± 11.14 years were included. The average platelet count was 208.15 ± 68.30, and the average score of cognitive function was 19.29 ± 6.78. Result of fully adjusted binary logistic regression showed platelet count was negatively associated with the cognitive function score after adjusting confounders (hazard ratio (HR) = 0.000, 95%CI −0.01, 0.01). A nonlinear relationship was detected between platelet count and the cognitive function score, whose point was 230. The effect sizes and the confidence intervals of the left and right sides of the inflection point were 0.03 (0.01–0.05, P for nonlinearity = 0.011) and −0.03 (−0.05–0.00, P for nonlinearity = 0.023), respectively. Conclusion. Platelets have a nonlinear relationship with cognitive function in patients with atrial fibrillation. This finding suggests that, in patients with atrial fibrillation, platelets should be maintained at about 230.

scholarly journals A Pilot Study on the Effect of Anti-Thrombopoietin Antibody on Platelet Count in Patients with Type 2 Diabetes

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1667
Author(s):  
Takuya Fukuda ◽  
Masahide Hamaguchi ◽  
Takafumi Osaka ◽  
Yoshitaka Hashimoto ◽  
Emi Ushigome ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Platelet Count ◽  
Cross Sectional Study ◽  
Regression Analyses ◽  
Sectional Study ◽  
Cross Sectional ◽  
Platelet Production ◽  
The Relationship

Thrombopoietin (THPO) is a circulatory cytokine that plays an important role in platelet production. The presence of anti-THPO antibody relates to thrombocytopenia and is rarely seen in hematopoietic and autoimmune diseases. To date, there had been no reports that focused on the anti-THPO antibody in patients with type 2 diabetes mellitus (T2DM). To evaluate prevalence of the anti-THPO antibody in patients with T2DM and the relationship between anti-THPO antibody and platelet count, a cross-sectional study was performed on 82 patients with T2DM. The anti-THPO antibody was measured by ELISA using preserved sera and detected in 13 patients. The average platelet count was significantly lower in patients with the anti-THPO antibody than in those without the anti-THPO antibody. Multivariate linear regression analyses showed a significant relationship between the anti-THPO antibody and platelet count, after adjusting for other variables. To our best knowledge, this was the first report on the effect of the anti-THPO antibody on platelet count in patients with T2DM. Further investigation is needed to validate the prevalence and pathological significance of the anti-THPO antibody in patients with T2DM.

scholarly journals Relationship between silent atrial fibrillation and the maximum heart rate in the 24-hour Holter: cross-sectional study

2014 ◽  
Vol 132 (6) ◽  
pp. 359-363 ◽  
Author(s):  
Marcelo Lapa Kruse ◽  
José Cláudio Lupi Kruse ◽  
Tiago Luiz Luz Leiria ◽  
Leonardo Martins Pires ◽  
Caroline Saltz Gensas ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Heart Rate ◽  
Protective Effect ◽  
Beta Blockers ◽  
Rare Event ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Referral Service ◽  
The Relationship

CONTEXT AND OBJECTIVE: Occurrences of asymptomatic atrial fibrillation (AF) are common. It is important to identify AF because it increases morbidity and mortality. 24-hour Holter has been used to detect paroxysmal AF (PAF). The objective of this study was to investigate the relationship between occurrence of PAF in 24-hour Holter and the symptoms of the population studied.DESIGN AND SETTING: Cross-sectional study conducted at a cardiology hospital.METHODS: 11,321 consecutive 24-hour Holter tests performed at a referral service were analyzed. Patients with pacemakers or with AF throughout the recording were excluded.RESULTS: There were 75 tests (0.67%) with PAF. The mean age was 67 ± 13 years and 45% were female. The heart rate (HR) over the 24 hours was a minimum of 45 ± 8 bpm, mean of 74 ± 17 bpm and maximum of 151 ± 32 bpm. Among the tests showing PAF, only 26% had symptoms. The only factor tested that showed a correlation with symptomatic AF was maximum HR (165 ± 34 versus 147 ± 30 bpm) (P = 0.03). Use of beta blockers had a protective effect against occurrence of PAF symptoms (odds ratio: 0.24, P = 0.031).CONCLUSIONS: PAF is a rare event in 24-hour Holter. The maximum HR during the 24 hours was the only factor correlated with symptomatic AF, and use of beta blockers had a protective effect against AF symptom occurrence.

Sign in / Sign up

Export Citation Format

Share Document