scholarly journals MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Mingming Cao ◽  
Wenjing Song ◽  
Runyu Liang ◽  
Lili Teng ◽  
Mei Zhang ◽  
...  
Keyword(s):  
Potential Role ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Research Field ◽  
Pathological State ◽  
Potential Biomarker ◽  
Injury Treatment ◽  
Organ Tissue ◽  
New Research

Ischemia-reperfusion (I/R) injury is a progressive injury that aggravates the pathological state when the organ tissue restores blood supply after a certain period of ischemia, including the myocardial, brain, liver, kidney, and intestinal. With growing evidence that microRNAs (miRNAs) play an important role as posttranscription gene silencing mediators in many I/R injury, in this review, we highlight the microRNAs that are related to I/R injury and their regulatory molecular pathways. In addition, we discussed the potential role of miRNA as a biomarker and its role as a target in I/R injury treatment. Developing miRNAs are not without its challenges, but prudent design combined with existing clinical treatments will result in more effective therapies for I/R injury. This review is aimed at providing new research results obtained in this research field. It is hoped that new research on this topic will not only generate new insights into the pathophysiology of miRNA in I/R injury but also can provide a basis for the clinical application of miRNA in I/R.

Tetrahydrobiopterin attenuates ischemia-reperfusion injury following organ transplantation by targeting the nitric oxide synthase: investigations in an animal model

Pteridines ◽  
2013 ◽  
Vol 24 (1) ◽  
pp. 13-19
Author(s):  
Benno Cardini ◽  
Rupert Oberhuber ◽  
Sven R. Hein ◽  
Katrin Watschinger ◽  
Martin Hermann ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Reperfusion Injury ◽  
Animal Studies ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Pathological State ◽  
Vascular Endothelial ◽  
Oxide Synthase

AbstractIschemia-reperfusion injury is a primarily non-allospecific event leading to the depletion of the essential nitric oxide synthase cofactor and potent antioxidant tetrahydrobiopterin. Suboptimal concentrations of tetrahydrobiopterin result in a reduced biosynthesis of nitric oxide leading to vascular endothelial dysfunction. Tetrahydrobiopterin supplementation has been shown to protect from this pathological state in a plethora of cardiovascular diseases including transplant-related ischemia-reperfusion injury. Even though still controversially discussed, there is increasing evidence emerging from both human as well as animal studies that tetrahydrobiopterin-mediated actions rely on its nitric oxide synthase cofactor activity rather than on its antioxidative properties. Herein, we review the current literature regarding the role of tetrahydrobiopterin in ischemia-reperfusion injury including our experience acquired in a murine pancreas transplantation model.

scholarly journals IL-37—a putative therapeutic agent in cardiovascular diseases

QJM ◽  
2021 ◽  
Author(s):  
S McCurdy ◽  
J Yap ◽  
J Irei ◽  
J Lozano ◽  
W A Boisvert
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Diseases ◽  
Potential Role ◽  
Therapeutic Agent ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Orphan Receptor ◽  
Elevated Plasma ◽  
Coronary Syndrome

Summary Although it is a member of the Interleukin (IL)-1 family, IL-37 is unique in that it has wide-ranging anti-inflammatory characteristics. It was originally thought to prevent IL-18-mediated inflammation by binding to the IL-18-binding protein. However, upon discovery that it binds to the orphan receptor, IL-1R8, further studies have revealed an expanded role of IL-37 to include several intracellular and extracellular pathways that affect various aspects of inflammation. Its potential role specifically in cardiovascular diseases (CVD) stemmed initially from the discovery of elevated plasma IL-37 levels in human patients with acute coronary syndrome and atrial fibrillation. Other studies using mouse models of ischemia/reperfusion injury, vascular calcification and myocardial infarction have revealed that IL-37 can have a beneficial role in these conditions. This review will explore recent research on the effects of IL-37 on the pathogenesis of CVD.

TRANSPLANT RENAL ARTERY STENOSIS: POTENTIAL ROLE OF ISCHEMIA/REPERFUSION INJURY AND LONG-TERM OUTCOME FOLLOWING ANGIOPLASTY

1999 ◽  
Vol 161 (1) ◽  
pp. 28-32 ◽  
Author(s):  
JEAN-MICHEL HALIMI ◽  
AZMI AL-NAJJAR ◽  
MATTHIAS BUCHLER ◽  
BÉATRICE BIRMELE ◽  
FRANÇOIS TRANQUART ◽  
...  
Keyword(s):  
Renal Artery ◽  
Reperfusion Injury ◽  
Renal Artery Stenosis ◽  
Potential Role ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Term Outcome ◽  
Long Term Outcome
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