scholarly journals Spontaneous Splenic Rupture due to Metastatic Pancreatic Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
D. Politis ◽  
D. Myoteri ◽  
M. Bourou ◽  
C. Nastos ◽  
I. Papaconstantinou ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Splenic Rupture ◽  
Case Reports ◽  
Hypovolemic Shock ◽  
Rare Event ◽  
Malignant Neoplasm ◽  
Metastatic Pancreatic Cancer ◽  
Left Shoulder ◽  
Pathophysiological Mechanism ◽  
Spontaneous Splenic Rupture

Introduction. Nontraumatic splenic rupture is a rare event. On the other hand, splenic metastasis is also rare and usually found in the context of disseminated disease. Spontaneous splenic rupture caused by a metastatic deposit has been reported only as case reports. To the best of our knowledge, pancreatic cancer being the primary site has been reported in only a handful of cases. Case Presentation. A case of spontaneous splenic rupture in a 68-year-old male presenting with acute onset left shoulder pain, caused by metastatic pancreatic cancer to the spleen, is presented herein. During the investigation, the patient developed hypovolemic shock due to intra-abdominal hemorrhage, necessitating emergency splenectomy. The patient recovered well and was discharged from the hospital on the 8th postoperative day. Discussion. This study underlines the fact that the spleen is a rare site of metastasis, remaining mostly asymptomatic. However, it can nevertheless prove to be a life-threatening condition. The exact pathophysiological mechanism of splenic rupture due to metastasis still remains unknown, requiring further research. Emergency splenectomy remains the standard of care, and this clinical condition should be considered in the differential diagnosis of cases with acute abdomen and malignant neoplasm history.

scholarly journals Metastatic Pancreatic Cancer with BRAF and P53 Mutations: Case Report of Therapeutic Response to Doublet Targeted Therapy

2020 ◽  
Vol 13 (3) ◽  
pp. 1239-1243
Author(s):  
Shenthol Sasankan ◽  
Lorraine Rebuck ◽  
Gloria Darrah ◽  
Moises Harari Turquie ◽  
Ian Rabinowitz
Keyword(s):  
Pancreatic Cancer ◽  
Case Report ◽  
Targeted Therapy ◽  
Therapeutic Response ◽  
Case Reports ◽  
Clinical History ◽  
P53 Mutation ◽  
Metastatic Pancreatic Cancer ◽  
First Case ◽  
History Of

We report on the clinical history of a 49-year-old female with metastatic pancreatic cancer. She was initially treated with standard chemotherapy as per current guidelines. She was found to have both a BRAF and P53 mutation, and received dabrafenib and trametinib with deep responses, both radiographically and biochemically (CA19-9). Her response has been more clinically relevant than responses in previous case reports of patients with BRAF-positive pancreatic cancer treated with targeted therapy. To the best of our knowledge, this is the first case report showing a dramatic therapeutic response to combination therapy with dabrafenib and trametinib in metastatic pancreatic cancer.

scholarly journals Spontaneous Splenic Rupture and Rituximab-Induced Acute Thrombocytopenia in a Patient with High-Risk Mantle Cell Lymphoma

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Jared Williams ◽  
Shingi Chiruka
Keyword(s):  
High Risk ◽  
Mantle Cell Lymphoma ◽  
Rare Case ◽  
Splenic Rupture ◽  
Cell Lymphoma ◽  
Case Reports ◽  
Spontaneous Splenic Rupture ◽  
Rare Type ◽  
Mantle Cell ◽  
Life Threatening

Mantle cell lymphoma is a relatively rare type of mature B-cell non-Hodgkin’s lymphoma with an incidence of approximately 8 cases per million persons per year. In patients with mantle cell lymphoma, there are rare case reports of the potentially life-threatening consequences of splenic rupture and rituximab-induced acute thrombocytopenia (RIAT) occurring separately, but there are no reports of these occurring in the same patient. Whilst rare, they are important to be aware of as early detection may prevent fatal outcomes.

scholarly journals Splenic rupture after elective cardioversion

2019 ◽  
Vol 12 (4) ◽  
pp. e226679
Author(s):  
Farid John Kehdy ◽  
Emily Rapstine Bond
Keyword(s):  
Atrial Fibrillation ◽  
Decision Making ◽  
Blunt Trauma ◽  
Splenic Injury ◽  
Splenic Rupture ◽  
Case Reports ◽  
Uneventful Recovery ◽  
Spontaneous Splenic Rupture ◽  
Systemic Anticoagulation

Splenic laceration and rupture are common phenomena among patients in a traumatic setting, especially in blunt trauma. Much more unusual, however, is splenic injury without a known insult. Several case reports and studies have been written about spontaneous splenic injury in patients with viral, haematological or malignant processes. Recently, we encountered a patient with a spontaneous splenic rupture and no preceding trauma apart from semielective cardioversion. Operative decision-making was complicated by the fact that he required systemic anticoagulation for atrial fibrillation. He eventually underwent splenectomy and made an uneventful recovery.

scholarly journals Spontaneous Splenic Rupture as a Rare Initial Presentation in an Acute Lymphoblastic Leukemia Patient

Diagnostics ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 152
Author(s):  
Meng-Yu Wu ◽  
Woei-Yau Kao ◽  
Cheng-Yi Chan ◽  
Giou-Teng Yiang ◽  
Wan-Ting Liao ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Acute Abdomen ◽  
Splenic Rupture ◽  
Lymphoblastic Leukemia ◽  
Hypovolemic Shock ◽  
Spontaneous Splenic Rupture ◽  
Coronary Syndrome ◽  
Spleen Rupture ◽  
Traumatic Splenic Rupture ◽  
Rupture Of The Spleen

A spontaneous rupture of the spleen is a rare but critical diagnosis of an acute abdomen, which may accompany unspecific symptoms mimicking acute pancreatitis, rupture of aortic aneurism, or acute coronary syndrome, delaying diagnosis and treatment. In patients that have experienced a severe spleen rupture, hypovolemic shock may cause catastrophic clinical outcomes. Therefore, early diagnosis is very important in order for physicians to declare the etiology for prevention and timely correction of the shock status. Several causes of spontaneous splenic rupture have been reported, including infection, vasculitis, pancreatitis, or hematological malignancies. Acute lymphoblastic leukemia (ALL) remains a rare but important cause of non-traumatic splenic rupture that physicians are required to assess for. Here, we describe a case presenting an acute abdomen due to spontaneous spleen rupture as the first manifestation. The purpose of this case report was to highlight the importance of considering spontaneous ruptures of the spleen as a rare but critical differential diagnosis of an acute abdomen, especially in patients with acute lymphoblastic leukemia.

scholarly journals Spontaneous Splenic Rupture in Malaria Patients: Two Case Reports

Cureus ◽  
2021 ◽  
Author(s):  
Ahmed M Alani ◽  
Jouhar J Kolleri ◽  
Ahmad Al Ekeer ◽  
Zeinab Alsiddig A Ibrahim
Keyword(s):  
Splenic Rupture ◽  
Case Reports ◽  
Spontaneous Splenic Rupture

scholarly journals Spontaneous Splenic Artery Rupture as the First Symptom of Systemic Amyloidosis

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Øyvind Bruserud ◽  
Tor Henrik Anderson Tvedt ◽  
Aymen Bushra Ahmed ◽  
Olav Karsten Vintermyr ◽  
Tor Hervig ◽  
...  
Keyword(s):  
Splenic Artery ◽  
Splenic Rupture ◽  
Hypovolemic Shock ◽  
Plasma Cell Dyscrasia ◽  
Al Amyloidosis ◽  
Spontaneous Splenic Rupture ◽  
Chronic Infections ◽  
Transfusion Therapy ◽  
Life Threatening ◽  
Amyloid Light Chain

Spontaneous splenic rupture is a life-threatening condition leading to a rapidly progressing hypovolemic shock due to intra-abdominal blood loss, with a mortality rate of about 10%. Spontaneous splenic rupture can be caused by widely different disorders including acute and chronic infections, neoplastic disorders, and inflammatory noninfectious disorders. In this case report, we present a 67-year-old male patient with hemorrhagic shock caused by an acute bleeding from the splenic artery. The patient was massively transfused with blood products and fluids and underwent laparotomy for hemostatic control and clinical stabilization. Multiorgan involvement by amyloid light-chain amyloidosis (AL-amyloidosis) caused by plasma cell dyscrasia, specifically with infiltration of the spleen artery, was found to be the underlying cause of his life-threatening bleeding. Based on this case, we discuss the features of serious spleen bleeding, massive transfusion therapy in the intensive care setting, and AL-amyloidosis pathophysiology and treatment.

Spontaneous splenic rupture due to rivaroxaban

2018 ◽  
Vol 56 (11) ◽  
pp. 136-139 ◽  
Author(s):  
Vinayak Nagaraja ◽  
Greg Cranney ◽  
Virag Kushwaha
Keyword(s):  
Adverse Effects ◽  
Splenic Rupture ◽  
Case Reports ◽  
Spontaneous Splenic Rupture ◽  
Limited Knowledge

In conjunction withBMJ Case Reports,DTBwill feature occasional drug-related cases that are likely to be of interest to readers. These will include cases that involve recently marketed drugs for which there is limited knowledge of adverse effects and cases that highlight unusual reactions to drugs that have been marketed for several years.

scholarly journals Spontaneous Splenic Rupture Four Days after an Open Appendicectomy

2015 ◽  
Vol 97 (2) ◽  
pp. e23-e24
Author(s):  
R Parker ◽  
G Gravante ◽  
M Elshaer ◽  
N Humayun ◽  
H Ebdewi
Keyword(s):  
Splenic Rupture ◽  
Case Reports ◽  
Iliac Fossa ◽  
Postoperative Bleeding ◽  
Haemorrhagic Shock ◽  
Spontaneous Splenic Rupture ◽  
Open Appendicectomy ◽  
Predisposing Factor ◽  
Midline Laparotomy ◽  
The Right

Introduction Spontaneous splenic rupture is a rare but dangerous event that requires prompt diagnosis and frequently an emergency splenectomy. Previous case reports have described the occurrence in patients with medical conditions, anticoagulant treatments, endoscopic procedures, laparoscopic surgery or no particular predisposing factor. Our report is the first to describe the occurrence of spontaneous spleen rupture following a laparotomy conducted in the lower abdomen. Case History A 62-year-old woman presented with a 10-day history of right iliac fossa pain radiating to the right leg and associated vomiting. Following a routine blood check and computed tomography (CT), she underwent an open appendicectomy through a lower midline laparotomy for an appendicular abscess. Four days later, she experienced haemorrhagic shock and a second CT scan diagnosed a spontaneous splenic rupture that required a prompt splenectomy. Conclusions Our case is the first that describes the spontaneous rupture of the spleen following an open procedure conducted in the lower quadrants. This entity must still be considered as a rare but potential cause for postoperative bleeding when no other obvious sources are identified.

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