scholarly journals Suppression of Urokinase Receptor Expression by Thalidomide Is Associated with Inhibition of Nuclear Factor κB Activation and Subsequently Suppressed Ovarian Cancer Dissemination

2005 ◽  
Vol 65 (22) ◽  
pp. 10464-10471 ◽  
Author(s):  
Hiroshi Kobayashi ◽  
Tatsuo Yagyu ◽  
Toshiharu Kondo ◽  
Noriyuki Kurita ◽  
Kiyokazu Inagaki ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Nuclear Factor Κb ◽  
Urokinase Receptor ◽  
Receptor Expression ◽  
Nuclear Factor ◽  
Cancer Dissemination

scholarly journals Mildly oxidized low-density lipoproteins decrease early production of interleukin 2 and nuclear factor κB binding to DNA in activated T-lymphocytes

1999 ◽  
Vol 337 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Sylvie CASPAR-BAUGUIL ◽  
Jean TKACZUK ◽  
Marie-José HAURE ◽  
Martine DURAND ◽  
Julie ALCOUFFE ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
T Lymphocyte ◽  
Active Form ◽  
Nuclear Factor Κb ◽  
Low Density Lipoproteins ◽  
Receptor Expression ◽  
Low Density ◽  
Nuclear Factor ◽  
Oxidized Low Density Lipoproteins ◽  
Activated T Lymphocytes

Activated T-lymphocytes are found early in atherosclerosis lesions, but little is known about their role. Oxidized low-density lipoproteins (oxLDLs) are considered to be involved in the pathogenesis of the lesions, and we have previously demonstrated that oxLDLs inhibit not only interleukin (IL)-2-receptor expression on the surface of in vitro-activated T-lymphocytes but also their proliferation. We have now investigated the effect of oxLDLs on blast differentiation, on IL-2 synthesis and on the activation of the nuclear factor κB (NF-κB) system in activated lymphocytes. Mildly oxLDLs (50 and 100 µg/ml) decreased the number of lymphoblasts and the level of IL-2 concentration in the culture supernatants after activation of lymphocytes by phytohaemagglutinin and PMA+ionomycin. The inhibition of IL-2 production was observed in the CD3+ T-lymphocyte cytoplasm as early as 4 h after activation by PMA+ionomycin. The study of NF-κB showed that oxLDLs led to a decrease of activation-induced p65/p50 NF-κB heterodimer binding to DNA, whereas the presence of the constitutive nuclear form of p50 dimer was unchanged. This was correlated with an unchanged level of the active form of the cytosolic inhibitor protein IκB-α. Taken together, these observations suggest that the immunosuppressive effect of oxLDLs might operate via a dysregulation of the T-lymphocyte activation mechanisms.

scholarly journals Nuclear factor κB transcription factors are coexpressed and convey a poor outcome in ovarian cancer

Cancer ◽  
2010 ◽  
Vol 116 (13) ◽  
pp. 3276-3284 ◽  
Author(s):  
Christina M. Annunziata ◽  
Helene Tuft Stavnes ◽  
Lilach Kleinberg ◽  
Aasmund Berner ◽  
Lidia F. Hernandez ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Transcription Factors ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Poor Outcome

scholarly journals Inhibition of Inhibitor of Nuclear Factor-κB Phosphorylation Increases the Efficacy of Paclitaxel in in Vitro and in Vivo Ovarian Cancer Models

2004 ◽  
Vol 10 (22) ◽  
pp. 7645-7654 ◽  
Author(s):  
Seiji Mabuchi ◽  
Masahide Ohmichi ◽  
Yukihiro Nishio ◽  
Tadashi Hayasaka ◽  
Akiko Kimura ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Cancer Models

Smilax china L. rhizome extract inhibits nuclear factor-κB and induces apoptosis in ovarian cancer cells

2014 ◽  
Vol 21 (12) ◽  
pp. 907-915 ◽  
Author(s):  
Li-ling Hu ◽  
Dong-sheng Chen ◽  
Yan-yan Wang ◽  
You Qin ◽  
Pu Huang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Nuclear Factor Κb ◽  
Ovarian Cancer Cells ◽  
Nuclear Factor

Oxidative Stress Increases A1 Adenosine Receptor Expression by Activating Nuclear Factor κB

1998 ◽  
Vol 53 (4) ◽  
pp. 663-669 ◽  
Author(s):  
Zhongzhen Nie ◽  
Yun Mei ◽  
Mary Ford ◽  
Leonard Rybak ◽  
Adrianna Marcuzzi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adenosine Receptor ◽  
Nuclear Factor Κb ◽  
Receptor Expression ◽  
Nuclear Factor ◽  
A1 Adenosine Receptor

scholarly journals Nerve Growth Factor Regulates Dopamine D2 Receptor Expression in Prolactinoma Cell Lines via p75NGFR-Mediated Activation of Nuclear Factor-κB

2002 ◽  
Vol 16 (2) ◽  
pp. 353-366 ◽  
Author(s):  
Chiara Fiorentini ◽  
Nicoletta Guerra ◽  
Marco Facchetti ◽  
Alessandra Finardi ◽  
Laura Tiberio ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Lines ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Nuclear Factor Κb ◽  
Receptor Expression ◽  
Nuclear Factor ◽  
Nerve Growth ◽  
Dopamine D2

scholarly journals Pioglitazone Inhibits Toll-Like Receptor Expression and Activity in Human Monocytes and db/db Mice

Endocrinology ◽  
2007 ◽  
Vol 150 (8) ◽  
pp. 3457-3464 ◽  
Author(s):  
Mohan R. Dasu ◽  
Samuel Park ◽  
Sridevi Devaraj ◽  
Ishwarlal Jialal
Keyword(s):  
Nuclear Factor Κb ◽  
Receptor Expression ◽  
Peroxisome Proliferator ◽  
Nuclear Factor ◽  
Human Monocytes ◽  
Tlr4 Expression ◽  
Healthy Human ◽  
Peroxisome Proliferator Activated Receptor ◽  
Monocyte Chemoattractant Protein 1 ◽  
Antiinflammatory Effects

Toll-like receptors (TLRs) are key innate immune sensors of endogenous damage signals and play an important role in inflammatory diseases like diabetes and atherosclerosis. Pioglitazone (PIO), a peroxisome proliferator-activated receptor (PPAR)-γ agonist, has been reported to be an antiinflammatory agent. Thus, in the present study, we examined the antiinflammatory effects of PIO on TLR2 and TLR4 expression in human monocytes exposed to Pam3CSK4 (Pam; TLR2 ligand) and purified lipopolysaccharide (LPS; TLR4 ligand) using flow cytometry and real-time RT-PCR. Monocytes were isolated from healthy human volunteers and pretreated with PIO (1 μm) followed by Pam (170 ng/ml) and LPS (160 ng/ml) challenge. PIO significantly decreased Pam- and LPS-induced TLR2 (−56%) and TLR4 (−78%) expression (P < 0.05). In addition, PIO decreased TLR ligand-induced nuclear factor-κB activity (−63%), IL-1β (−50%), IL-6 (−52%), monocyte chemoattractant protein-1(−83%), and TNF-α (−87%) compared with control. Next, PIO-treated db/db mice (n = 6/group) showed decreased TLR2 (−60%) and TLR4 (−45%) expression in peritoneal macrophages compared with vehicle control mice (P < 0.001) with associated decrease in MyD88-dependent signaling and nuclear factor-κB activation. Data suggest that Pam- and LPS-induced TLR2 and TLR4 expression are inhibited by PIO in human monocytes and db/db mice. Thus, we define a novel pathway by which PIO could induce antiinflammatory effects.

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