Characterization of MicroRNA Expression Levels and Their Biological Correlates in Human Cancer Cell Lines

We synthesized 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP), characterized it by electrochemistry, spectroelectrochemistry, and electron paramagnetic resonance techniques, and evaluated its cytotoxicity to human cancer cell lines. The results revealed that HHTP has accessible higher-oxidation states, especially the tris-semiquinone monoradical. This species is stable and is formed after being stored for months. HHTP exhibited cytotoxic effects on 5 human cancer cell lines, including glioma and lung cancer cells. The cytotoxic effect was evaluated based on the decrease in cell viability, increases in the percentage of cells with fragmented DNA, and elevated numbers of annexin V–PI-positive cells after HHTP treatment.

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Biological characterization of the antiproliferative potential of Co(II) and Sn(IV) coordination compounds in human cancer cell lines: a comparative proteomic approach

Drug Metabolism and Drug Interactions ◽

10.1515/dmdi-2013-0015 ◽

2013 ◽

Vol 28 (3) ◽

Cited By ~ 32

Author(s):

Ana Silva ◽

Daniel Luís ◽

Susana Santos ◽

Joana Silva ◽

Ana Soraia Mendo ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Coordination Compounds ◽

Human Cancer ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Biological Characterization ◽

Human Cancer Cell Lines ◽

Proteomic Approach

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Purification and Characterization of a Lectin from Arisaema tortuosum Schott Having in-vitro Anticancer Activity against Human Cancer Cell Lines

BMB Reports ◽

10.5483/bmbrep.2005.38.5.526 ◽

2005 ◽

Vol 38 (5) ◽

pp. 526-532 ◽

Cited By ~ 16

Author(s):

Vikram Dhuna ◽

Jagmohan Singh Bains ◽

Sukhdev Singh Kamboj ◽

Jatinder Singh ◽

Shanmugavel ◽

...

Keyword(s):

Anticancer Activity ◽

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Purification And Characterization ◽

Human Cancer Cell Lines

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α-Tetralonyl Glucosides from the Green Walnut Husks of Juglans mandshurica and Their Antiproliferative Effects

Planta Medica ◽

10.1055/a-0832-2328 ◽

2019 ◽

Vol 85 (04) ◽

pp. 335-339

Author(s):

An-dong Wang ◽

Chao-jie Xie ◽

Yun-qiang Zhang ◽

Mei-chen Li ◽

Xia Wang ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

2D Nmr ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Juglans Mandshurica ◽

Antiproliferative Effects ◽

Human Cancer Cell Lines

AbstractTwo new α-tetralonyl glucosides, (4S)-4,5,8-trihydroxy-α-tetralone-5-O-β-D-glucopyranosyl(1 → 6)-β-D-glucopyranoside (1) and (4S)-4,8-dihydroxy-α-tetralone-4-O-β-D-glucopyranosyl(1 → 6)-β-D-glucopyranoside (2), together with eight known compounds (3 – 10) were isolated from the green walnut husks of Juglans mandshurica. The structural characterization of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR and HR-ESI-MS experiments. The isolated compounds were assayed for their cytotoxicity against two human cancer cell lines, A549 and HeLa. Four compounds (7 – 10) exhibited inhibitory effects against two human cancer cell lines with GI50 values between 1.3 and 5.8 µM.

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