scholarly journals Novel Genes Associated with Malignant Melanoma but not Benign Melanocytic Lesions

2005 ◽  
Vol 11 (20) ◽  
pp. 7234-7242 ◽  
Author(s):  
Dmitri Talantov ◽  
Abhijit Mazumder ◽  
Jack X. Yu ◽  
Thomas Briggs ◽  
Yuqiu Jiang ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Novel Genes ◽  
Melanocytic Lesions

scholarly journals Primary pineal malignant melanoma

2011 ◽  
Vol 1 (2) ◽  
pp. 31 ◽  
Author(s):  
Oderay Mabel Cedeño Díaz ◽  
Roberto Garcia Leal ◽  
Cesar La Cruz Pelea
Keyword(s):  
Differential Diagnosis ◽  
Radiation Therapy ◽  
Malignant Melanoma ◽  
World Literature ◽  
Rare Entity ◽  
Rare Tumour ◽  
Melanocytic Lesions ◽  
The World ◽  
Supracerebellar Infratentorial Approach ◽  
Visual Abnormalities

Primary pineal malignant melanoma is a rare entity, with only thirteen cases reported in the world literature to date. We report a case of a 70-year-old man, who consulted with gait disturbance of six months duration, associated in the last month with dizziness, visual abnormalities and diplopia. No other additional melanocytic lesions were found elsewhere. The magnetic resonance showed a 25 mm expansive mass in the pineal gland that was associated with hydrocephaly, ventricular and transependimary oedema. The lesion was partially excised by a supracerebellar infratentorial approach. The histological examination revealed a melanoma. The patient received radiation therapy, but died of disease 16 weeks later. We herein review the literature on this rare tumour and comment on its clinical, radiological and histopathological features and differential diagnosis.

scholarly journals A Case of Late Delayed Metastasis of Malignant Melanoma After 27 Years After First Excision

2020 ◽  
Vol 2 (2) ◽  
pp. 1-2
Author(s):  
Claudio Bravin ◽  
◽  
Carlo Braga ◽  
Gaetana Rizzi ◽  
◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Histological Examination ◽  
Mitotic Rate ◽  
Skin Tumor ◽  
Melanocytic Lesions ◽  
Long Term Follow Up ◽  
Neoplastic Process ◽  
Abdominal Lesion

We report a case of an ultra-late delayed metastasis of malignant melanoma 27 years after the excision of the first tumor. The patient is a 67 years old Italian woman. She underwent a primary excision of a skin lesion of 1cm in diameter on the lower third of the left leg in 1984 when she was 39. According to the histological examination the lesion was a lentigo malign melanoma with an epithelial histological pattern with intra- and subepidermal diffusion. The lesion was 2.2 mm in thickness (Breslow) and was a Clark level IV melanoma; mitotic rate was 6 mitosis/mm2. No melanocytic lesions were found on excision edges and no lymph nodes were removed and examined. In March 2011, when the woman was 67 years old, an inguinal lymph node and an intraabdominal lesion were considered suspect for neoplastic process during a clinical exam of the GP. A histological examination and an eco-imaging procedure described the lesions as metastasis of malignant melanoma probably related to the first skin tumor. Within a few days she was treated with the excision of the abdominal lesion, the total greater omentectomy and the lymphadenectomy of the left inguinal region. Histological examination confirmed the suspect of metastasis of the first melanoma with a predominant epithelioid growing pattern. This case underlines the need of a long-term follow-up period for patients with melanoma.

scholarly journals Frequency and Pattern of Malignant Lesions of Skin

KYAMC Journal ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 700-706
Author(s):  
Md Abdur Razzaque ◽  
Avisak Bhattacharjee ◽  
Urmi Bhattacharjee ◽  
Mohammad Asif Ekram Bhuiyan ◽  
Rashidul Hasan ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Malignant Melanoma ◽  
Lower Limb ◽  
Skin Lesions ◽  
P Value ◽  
Age Group ◽  
Elderly Age ◽  
Melanocytic Lesions ◽  
Malignant Skin ◽  
Head Neck

Malignant skin lesions can be widely categorized as melanoma and non-melanoma skin cancer. Skin cancer represents approximately two to four percent of all cancers in Asians. One in every three cancers diagnosed is a skin cancer and one in every five Americans will develop skin cancer in their lifetime.Objective: To determine the frequency and pattern of different malignant skin lesions in our situation.Methods: It was a prospective cross sectional study that was conducted in Surgery, Dermatology, Oncology & Plastic Surgery department of KYAMCH, Sirajgonj from January 2015 to June 2015. Total 60 patients were selected by purposive sampling as a diagnosed case of malignant skin lesion. The data were collected by the active participation of the patients' interviewed by the preformed proforma of data collection sheet and then data were gathered, decorated, tabulated after data cleaning and edition. Then the results were found and they were tested by chi-square test (qualitative data) to see their level of significance i,e p-value which was set as the cut off level at <0.05. So if p-value is >0.05 the results are not significant.Results: The data analysis of 60 patients yielded the following results. Malignant skin lesions were commonly found in the elderly age group (>60yrs) 38.33%. Majority of them had non-melanocytic cancer (56.67%). Mean age of the male respondent was 58.79±6.54 and female respondent was 55.20 6.29 years. Maximum patients were male 66.67%. The male to female ratio was 2:1. According to anatomical site head-neck (52.94%) is the commonest site for non-melanocytic carcinoma whereas lower limb is the commonest site for malignant melanoma (69.23%).Conclusion: Malignant skin lesions were commonly present as melanoma and non-melanocytic carcinoma where man were more affected due to sunlight exposure and non-melanocytic lesions were more than malignant melanoma. Elderly age group are commonly affected. Head-neck is the commonest site for non-melanocytic lesions and lower limb is the commonest site for malignant melanoma. All cases seek initial medical attention commonly in advanced stage.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 700-706

Digital dermatoscopic follow-up of 1027 melanocytic lesions in 121 patients at risk of malignant melanoma

2012 ◽  
Vol 27 (2) ◽  
pp. 180-186 ◽  
Author(s):  
T. Fikrle ◽  
K. Pizinger ◽  
H. Szakos ◽  
P. Panznerova ◽  
B. Divisova ◽  
...  
Keyword(s):  
At Risk ◽  
Malignant Melanoma ◽  
Melanocytic Lesions ◽  
Patients At Risk

scholarly journals Differentiation of Malignant Melanoma From Benign Nevus Using a Novel Genomic Microarray With Low Specimen Requirements

2012 ◽  
Vol 136 (8) ◽  
pp. 947-955 ◽  
Author(s):  
Wells M. Chandler ◽  
Leslie R. Rowe ◽  
Scott R. Florell ◽  
Mona S. Jahromi ◽  
Joshua D. Schiffman ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Sensitivity And Specificity ◽  
Clinical Course ◽  
Genetic Alterations ◽  
Molecular Testing ◽  
Melanocytic Nevi ◽  
Melanocytic Lesions ◽  
Formalin Fixed Paraffin Embedded ◽  
Genomic Microarray ◽  
Benign Melanocytic Nevi

Context.—Histologic examination of clinically suspicious melanocytic lesions is very sensitive and specific for the detection of malignant melanoma. Yet, the malignant potential of a small percentage of melanocytic lesions remains histologically uncertain. Molecular testing offers the potential to detect the genetic alterations that lead to malignant behavior without overt histologic evidence of malignancy. Objective.—To differentiate benign melanocytic nevi from malignant melanoma and to predict the clinical course of melanocytic lesions with ambiguous histology using a novel genomic microarray. Design.—We applied a newly developed single-nucleotide polymorphism genomic microarray to formalin-fixed, paraffin-embedded melanocytic lesions to differentiate benign nevi (n  =  23) from malignant melanoma (n  =  30) and to predict the clinical course of a set of histologically ambiguous melanocytic lesions (n  =  11). Results.—For cases with unambiguous histology, there was excellent sensitivity and specificity for identifying malignant melanoma with this genomic microarray (89% sensitivity, 100% specificity). For cases with ambiguous histology, the performance of this genomic microarray was less impressive. Conclusions.—Without microdissection and with quantities of DNA one-tenth what is required for more commonly used microarrays, this microarray can differentiate between malignant melanoma and benign melanocytic nevi. For histologically ambiguous lesions, longer clinical follow-up is needed to confidently determine the sensitivity and specificity of this microarray. Some of the previous technical hurdles to the clinical application of genomic microarray technology are being overcome, and the advantages over targeted fluorescence in situ hybridization assays currently in clinical use are becoming apparent.

Analysis ofras mutations in human melanocytic lesions: activation of theras gene seems to be associated with the nodular type of human malignant melanoma

1995 ◽  
Vol 121 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Mehrdad Jafari ◽  
Thilo Papp ◽  
Stephan Kirchner ◽  
Ulrike Kiener ◽  
Dietrich Henschler ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Human Malignant Melanoma ◽  
Melanocytic Lesions

scholarly journals Meyerson Nevus Mimicking Malignant Melanoma

2018 ◽  
Author(s):  
Filipa Tavares Almeida ◽  
Regina Caldas ◽  
Teresa Pereiro ◽  
Celeste Brito
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Sun Exposure ◽  
Melanocytic Nevus ◽  
Melanocytic Lesion ◽  
Melanocytic Lesions ◽  
Histopathological Evaluation ◽  
Intense Pruritus

Meyerson nevus represents an uncommon clinical and histological variation of melanocytic lesions that is characterized by an eczematous halo surrounding a melanocytic nevus.1It was first reported by Meyerson and it typically clears spontaneously or resolves with topical corticotherapy.2We report the case of an atypical Meyerson nevus in which, despite intense pruritus, both an eczematous eruption and dermoscopic patterns imputable to a melanocytic lesion were lacking. 1. Balato A, Lembo S, Cirillo T, Megna M, Napolitano M, Balat N. Meyerson phenomenon around naevi: resolution after sun exposure? Acta Dermato-Venereol. 2011; 91:352-3. doi: 10.2340/00015555-1059.2. Gabbi TV, Omar ED, Criado PR, Valente NY, Martins JE. Clinical, dermoscopic and histopathological evaluation of the Meyerson nevus: case report. An Bras Dermatol. 2010;85:681-3.

scholarly journals Follow-up of melanocytic lesions with use of dermoscopy (literature review)

2020 ◽  
pp. 66-71
Author(s):  
Yu. Yu. Sergeev ◽  
V. Yu. Sergeev ◽  
V. V. Mordovtseva
Keyword(s):  
High Risk ◽  
Malignant Melanoma ◽  
Literature Review ◽  
Preventive Measure ◽  
Dysplastic Nevus ◽  
Dysplastic Nevus Syndrome ◽  
Melanocytic Lesions ◽  
Diagnostic Biopsy

Regular follow-up is the most important preventive measure in patients with high risk for the development of melanoma. Particular attention is required for patients with dysplastic nevus syndrome, in which numerous lesions must be differentiated from malignant melanoma. General principles of monitoring of clinically atypical melanocytic lesions with the use of dermoscopy and indications for a diagnostic biopsy are discussed in the article.

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